• Journal of Microbiology and Biotechnology
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• v.18 no.1
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• pp.110-117
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• 2008

Three kinds of prenylated flavonols, icariside I, icariside II, and icaritin, were isolated from an icariin hydrolysate and their effects on melanogenesis evaluated based on mushroom tyrosinase inhibition and quantifying the melanin contents in melanocytes. Although none of the compounds had an effect on tyrosinase activity, icariside II and icaritin both effectively inhibited the melanin contents with an $IC_{50}$ of 10.53 and $11.13{\mu}M$, respectively. Whereas icariside II was obtained from a reaction with ${\beta}$-glucosidase and cellulase, the icariin was not completely converted into icariside II. Thus, for the high-purity production of icariside II, the reaction was optimized using the response surface methodology, where an enzyme concentration of 5.0mg/ml, pH 7, $37.5^{\circ}C$, and 8 h reaction time were selected as the central conditions for the central composite design (CCD) for the enzymatic hydrolysis of icariin into icariside II using cellulase. Empirical models were developed to describe the relationships between the operating factors and the response (icariside II yield). A statistical analysis indicated that all four factors had a significant effect (p<0.01) on the icariside II production. The coefficient of determination $(R^2)$ was good for the model (0.9853), and the optimum production conditions for icariside II was an enzyme concentration of 7.5mg/ml, pH 5, $50^{\circ}C$, and 12 h reaction time. A good agreement between the predicted and experimental data under the designed optimal conditions confirmed the usefulness of the model. A laboratory pilot scale was also successful.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.1
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• pp.137-142
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• 1994

The present paper was carried out to investigate the inhibition of carcinogenic N-nitrosodimethylamine(NDMA) formation by Maillard reactiion products and nondialyzable melanoidins, obtiane dfrom the glucoseamino acids(Lys, Gly, Arg, His) model systems under different pH conditions(pH 1.2, 4.2 and 6.0). Maillard raction products and nondialyzable melanoidins, produced from the 4 model systems, had a inhibitory action of N-nitrosodimethylamine formation. The inhibitiondegree by the nondialyzable mealanoidins. at pH 1.2 was similar to that at pH 4.2 and that by ascorbic acid at pH 1.2 . Inhibitory action of N-nitrosodimehylamine formation by the reduced Maillard reaction products and nondialyzable melanoidins were lower than that of original samples. Accordingly, it is assumed that the inhibition of N-nitrosodimehtylamine formation of Maillard reaction products is due to their reducing powers.

• Korean Journal of Materials Research
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• v.29 no.7
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• pp.412-424
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• 2019

Global fitting functions for Fe-selective chlorination in ilmenite($FeTiO_2$) and successive chlorination of beneficiated $TiO_2$ are proposed and validated based on a comparison with experimental data collected from the literature. The Fe-selective chlorination reaction is expressed by the unreacted shrinking core model, which covers the diffusion-controlling step of chlorinated Fe gas that escapes through porous materials of beneficiated $TiO_2$ formed by Fe-selective chlorination, and the chemical reaction-controlling step of the surface reaction of unreacted solid ilmenite. The fitting function is applied for both chemical controlling steps of the unreacted shrinking core model. The validation shows that our fitting function is quite effective to fit with experimental data by minimum and maximum values of determination coefficients of $R^2$ as low as 0.9698 and 0.9988, respectively, for operating parameters such as temperature, $Cl_2$ pressure, carbon ratio and particle size that change comprehensively. The global fitting functions proposed in this study are expressed simply as exponential functions of chlorination rate(X) vs. time(t), and each of them are validated by a single equation for various reaction conditions. There is therefore a certain practical merit for the optimal process design and performance analysis for field engineers of chlorination reactions of ilmenite and $TiO_2$.

• Resources Recycling
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• v.28 no.2
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• pp.23-30
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• 2019

An color sorting technique was introduced to recycle End-of-life automobile shredded bumpers. The color sorting is a innovate method of separating the differences in the color of materials which are difficult to separate in gravity and size classification by using a camera and an image process technique. Experiments were planned and optimal conditions were derived by applying BBD (Box-Behnken Design) in the reaction surface method. The effects of color sensitivity, feed rate and sample size were analyzed, and a second-order reaction model was obtained based on the analysis of regression and statistical methods and $R^2$ and p-value were 99.56% and < 0.001. Optimum recovery was 94.1% under the conditions of color sensitivity, feed rate and particle size of 32%, 200 kg/h, and 33 mm respectively. The recovery of actual experiment was 93.8%. The experimental data agreed well with the predicted value and confirmed that the model was appropriate.

• Korean Chemical Engineering Research
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• v.56 no.6
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• pp.914-920
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• 2018

The intrinsic kinetic parameters of steam-methane reforming reactions over commercial nickel-based catalyst were determined. The reaction rate equations were derived from the reaction mechanism-based Langmuir-Hinshelwood chemisorption theory. As the experimental variables for the kinetic study, the reaction temperature ranged from 630 to $750^{\circ}C$ and the steam-to-carbon ratio also varied from 2.7 to 3.5. Based on the experimental data, the efficient optimization algorithm was used to determine the intrinsic kinetic parameters due to the high-dimensional objective function. It is confirmed that the parameter estimation results showed good agreement with the experimental values. Thus, this proposed mathematical reaction model can be used as the basic information to design a catalytic reactor and to optimize operating conditions.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.1
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• pp.128-138
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• 2015

Carbonation is one of the most critical deterioration phenomena to concrete structures exposed to high $CO_2$ concentration, sheltered from rain. Lots of researches have been performed on evaluation of carbonation depth and changes in hydrate compositions, however carbonation modeling is limitedly carried out due to complicated carbonic reaction and diffusion coefficient. This study presents a simplified carbonation model considering diffusion coefficient, solubility of $Ca(OH)_2$, porosity reduction, and carbonic reaction rate for low concentration. For verification, accelerated carbonation test with varying temperature and MIP (Mercury Intrusion Porosimetry) test are carried out, and carbonation depths are compared with those from the previous and the proposed model. Field data with low $CO_2$ concentration is compared with those from the proposed model. The proposed model shows very reasonable results like carbonation depth and consuming $Ca(OH)_2$ through reduced diffusion coefficient and porosity compared with the previous model.

• Journal of Mechanical Science and Technology
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• v.15 no.4
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• pp.473-481
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• 2001

By depicting the transfer of heat and combustion reaction to take place within thin gas layers close to the propellant surface burning in a steady-state fashion, a mathematical equation has been deduced to describe the burning rate of solid propellant as a function of initial grain temperature and chamber pressure. It has been also assumed that chemical reaction could take place in premixing-diffusing zone but were carried out mainly in the reaction-flame zone. All these phenomena taken place in each zone of combustion have been assumed to be steady-state. In the present investigation, the equation, γ=$\kappa$$.$(1/R(T(sub)i+C))(sup)n$.$exp(-E(sub)a/R(T(sub)i+C))(P/z) is being presented and it is compared with experimental data. The proposed model has been tested and evaluated vis-a-vis strand burner data for three different propellants based on CTPB, and it has been found that the deviation of the computed burning rates from the measured rates ranged up to 2%.

• Computers and Concrete
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• v.12 no.5
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• pp.627-650
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• 2013

This paper deals with application of a non-linear continuum model for reinforced concrete affected by alkali-aggregate reaction (AAR) to analysis of some nuclear structures. The macroscopic behaviour of the material affected by AAR is described by incorporating a homogenization/averaging procedure. The formulation addresses the main stages of the deformation process, i.e., a homogeneous deformation mode as well as that involving localized deformation, associated with formation of macrocracks. The formulation is applied to examine the mechanical behaviour of some reinforced concrete structures in nuclear power facilities located in Quebec (Canada). First, a containment structure is analyzed subjected to 45 years of continuing AAR. Later, an inelastic analysis is carried out for the spent fuel pool taking into account the interaction with the adjacent jointed rock mass foundation. In the latter case, the structure is said to be subjected to continuing AAR that is followed by a seismic event.

• Journal of the Korean Chemical Society
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• v.51 no.3
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• pp.227-231
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• 2007

We improve Wilehemski-Fixmann theory for intrachain reaction dynamics of a polymer chain by taking into account excluded volume effects between reactive groups in the polymerchain. An approximate analytic expression for the intra-chain reaction dynamics is obtained for Gaussian chain model and compared to Brownian dynamics simulation results. The results of the present theory are in a better agreement to Brownian dynamics simulation results than those calculated by previously reported theories.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.644-647
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• 2003

Materials currently used as an injectable bulking agent in the dermatologic and urologic fields revealed several drawbacks such as particles migration, inflammatory reaction, allergic reaction, rapid volume shrinkage, and necessity of a donor site. In this study, we have developed injectable biomaterial comprising poly (DL- lactide-co-glycolide)(PLGA) and hyaluronic acid gel to overcome these problems. PLGA is a biocompatible synthetic material and hyaluronic acid is a common substance found in living organisms. We examined the feasibility of injection through needle and tested biocompatibility in animal model. After transplantation, injected sites and distant organs were examined histologically to verify a new tissue formation, inflammation, and particles migrations. Injected volume was maintained approximately 80 percent for 2 months. Results demonstrated that the developed material was injectable through various gauges of needles and induced a new bulking tissue formation without serious inflammatory reaction.