• Korean Journal of Plant Resources
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• v.34 no.5
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• pp.462-469
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• 2021

Maesa japonica (Thunb.) Moritzi & Zoll. is a rare evergreen shrub that occurs in west Gotjawal, Jeju island, Korea. This study was conducted to investigate effects of an artificial shading on flowering and growth characteristics of M. japonica seedlings. The level of shading had been set to be 35%, 55% and 75% using shading net. The stage of flowering and flowering ratio, seedling height, the number of leaves and stems, leaf area were measured. Flowering timings were delayed by shading. The number of flowering seedlings per plot and inflorescences per seedling were the most in 55% shading level. Tendency of decreased seedling height with increased shading level was shown. The number of leaves and stems were the fewest values in 75% shading level. The increased biomass with decreased shading level was statistically significant. Aboveground and underground biomass were 2.1 and 1.7 times higher in shading 35% than in shading 75%, respectively. Meanwhile, all seedlings in non-shading plots were dead in winter. Such might be speculated as results of the light stress. As a result, we conclude that M. japonica vitally demands the shading for growth and the optimal shading levels for growth and flowering are 35% and 55%, respectively.

• Journal of Microbiology and Biotechnology
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• v.31 no.7
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• pp.933-941
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• 2021

Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities including antioxidant and anti-inflammatory properties in several cell types. The purpose of this study was to use an in vivo model of hair follicle (HF)-mimic based on a human dermal papilla (DP) spheroid system prepared by three-dimensional (3D) culture and to investigate the effect of Rg4 on the hair-inductive properties of DP cells. Treatment of the DP spheroids with Rg4 (20 to 50 ㎍/ml) significantly increased the viability and size of the DP spheres in a dose-dependent manner. Rg4 also increased the mRNA and protein expression of DP signature genes that are related to hair growth including ALP, BMP2, and VCAN in the DP spheres. Analysis of the signaling molecules and luciferase reporter assays further revealed that Rg4 induces the activation of phosphoinositide 3-kinase (PI3K)/AKT and the inhibitory phosphorylation of GSK3β, which activates the WNT/β-catenin signaling pathway. These results correlated with not only the increased nuclear translocation of β-catenin following the treatment of the DP spheres with Rg4 but also the significant elevation of mRNA expression of the downstream target genes of the WNT/β-catenin pathway including WNT5A, β-catenin, and LEF1. In conclusion, these results demonstrated that ginsenoside Rg4 promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway in DP spheres, suggesting that Rg4 could be a potential natural therapy for hair growth.

• Pediatric Infection and Vaccine
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• v.28 no.2
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• pp.66-81
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• 2021

The coronavirus disease 2019 pandemic has been continuously spreading throughout the world. As of July 15, 2021, there have been more than 188 million confirmed cases and more than 4.06 million deaths. Although the incidence of severe infections is relatively low in children and adolescents compared to adults, a complication called multisystem inflammatory syndrome in children (MIS-C) may occur in some cases at approximately 2-6 weeks after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. MIS-C can be seen in patients of various ages, from young infants to adolescents, and may present with diverse clinical manifestations. While fever present in a great majority of patients, symptoms suggesting the involvement of the digestive or nervous system and the skin and mucous membranes (Kawasaki disease-like symptoms) also appear in many cases. Cardiac involvement may also be observed, including left ventricular dysfunction, myocarditis, coronary artery dilatation, and coronary aneurysm. In some cases, hypotension or shock can occur, and mechanical ventilation or treatment in the intensive care unit may be necessary. Fortunately, recovery is generally reported after appropriate treatment. MIS-C is a rare but important complication of SARS-CoV-2 infection in children and adolescents. As such, it is important to recognize the clinical symptoms and provide appropriate treatment at an early stage. In this review, the epidemiology, clinical symptoms, suggested pathophysiology, diagnostic approach, and treatment of MIS-C will be discussed.

• Journal of Yeungnam Medical Science
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• v.38 no.3
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• pp.208-218
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• 2021

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH. Methods: The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated. Results: Sixty patients with HLH (35 children and 25 adults) were included. The median age at diagnosis was 7.0 years (range, 0.1-83 years), and the median follow-up duration was 8.5 months (range, 0-204 months). Four patients had primary HLH, 48 patients had secondary HLH (20 infection-associated, 18 neoplasm-associated, and 10 autoimmune-associated HLH), and eight patients had HLH of unknown cause. Infection was the most common cause in children (14/35, 40.0%), whereas neoplasia was the most common cause in adults (13/25, 52.0%). Twenty-eight patients were treated with HLH-2004/94 immunochemotherapy. The 5-year overall survival (OS) rate for all HLH patients was 59.9%. The 5-year OS rates for patients with primary, infection-associated, neoplasm-associated, autoimmune-associated, and unknown cause HLH were 25.0%, 85.0%, 26.7%, 87.5%, and 62.5%, respectively. Using multivariate analysis, neoplasm-induced HLH (p=0.001) and a platelet count <50×10⁹/L (p=0.008) were identified as independent risk factors for poor prognosis in patients with HLH. Conclusion: Infection was the most common cause of HLH in children, while it was neoplasia in adults. The 5-year OS rate for all HLH patients was 59.9%. HLH caused by an underlying neoplasm or a low platelet count at the time of diagnosis were risk factors for poor prognosis.

• Journal of Internet Computing and Services
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• v.22 no.4
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• pp.1-11
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• 2021

As the Internet developed, various and complex cyber attacks began to emerge. Various detection systems were used outside the network to defend against attacks, but systems and studies to detect attackers inside were remarkably rare, causing great problems because they could not detect attackers inside. To solve this problem, studies on the lateral movement detection system that tracks and detects the attacker's movements have begun to emerge. Especially, the method of using the Remote Desktop Protocol (RDP) is simple but shows very good results. Nevertheless, previous studies did not consider the effects and relationships of each logon host itself, and the features presented also provided very low results in some models. There was also a problem that the model could not explain why it predicts that way, which resulted in reliability and robustness problems of the model. To address this problem, this study proposes an interpretable RDP-based lateral movement detection system using page rank algorithm and SHAP(Shapley Additive Explanations). Using page rank algorithms and various statistical techniques, we create features that can be used in various models and we provide explanations for model prediction using SHAP. In this study, we generated features that show higher performance in most models than previous studies and explained them using SHAP.

• Pediatric Infection and Vaccine
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• v.27 no.3
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• pp.198-204
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• 2020

Cytomegalovirus (CMV) disease is rare in children who receive anticancer chemotherapy and have no history of stem cell transplantation (SCT). We report a case of CMV retinitis that developed during maintenance chemotherapy for acute leukemia. A 7-year-old boy developed decreased visual acuity and persistent pancytopenia during maintenance chemotherapy. Laboratory investigations initially showed significant CMV antigenemia (51 positive cells/200,000 leukocytes); however, antiviral therapy was not deemed necessary in this patient who had no history of SCT. CMV antigenemia worsened to 170 positive cells/200,000 leukocytes over 3 weeks. Ophthalmological examination revealed multiple bilateral retinal infiltrates and granular lesions. He was diagnosed with CMV retinitis and was treated with a 4-week course of intravenous ganciclovir and intravitreal injection of ganciclovir 6 times, followed by a 1-month course of orally administered valganciclovir. A CMV antigenemia assay showed negative results, and follow-up fundoscopy revealed lesser retinal infiltration after the sixth intravitreal ganciclovir injection. Future studies should focus on the development of standardized screening methods and preemptive therapeutic strategies for CMV disease in high-risk children.

• Journal of Wetlands Research
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• v.24 no.4
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• pp.354-366
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• 2022

To analyze the distribution of plant communities growing in river wetlands and the relationship between biotic and abiotic environmental factors, plant communities and environmental factors were investigated in river wetlands in the Boseong River. The Boseong River Wetland, the research site, consists of Hwapyeong Wetland, Bangujeong Wetland, and Seokgok Wetland. From June to September 2022, a plant community survey was conducted from the perspective of physiognomical vegetation, and the coverage of the emerging species followed the Braun-Blanquet scale. Plant species and the coverage of each species were recorded in the quadrant for plant community survey, and the cover of the quadrant, the total number of species, and the number of exotic species were measured as biological factors. As abiotic factors, altitude, orientation, inclination, soil texture, litter layer depth, dominant species diameter at breast height, and topography were recorded. In a total of 50 square plots, the most common Salix koreensis and Phragmites japonicus communities were found, and the community with the highest Shannon species diversity index was Phragmites japonicus-Echinochloa caudata community. As a result of ordination analysis by DCCA, the most significant clusters were separated according to topographic factors such as leeve, leeve slope, upper floodplain, lower floodplain, upper waterside, middle waterside, lower waterside, river island and opem water. As rare plants that need to be preserved in river wetlands, Hydrocharis dubia and Penthorum chinense were found in lower waterside, and it was found that the management of the river in the reservoir is necessary in line with the topographical distribution of ecosystem-disrupting plants, such as Paspalum distichum var. indutum.

• Journal of Wetlands Research
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• v.24 no.4
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• pp.268-287
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• 2022

This study reports newly discovered seven forest wetlands in the western part of the Korean Demilitarized Zone-Civilian Control Zone ecoregion. The wetland assessment criteria proposed by National Arboretum were adopted to evaluate four fields: vegetation and landscape, biogeochemical cycle, hydraulics and hydrology, and social-cultural-historical landscape and disturbances. Among seven wetlands located in Gimpo and Paju, five were of the fallow field type and two were of the natural type. A total of 474 plant species were recorded, including nine rare plants, such as the Carex capricornis Meinsh. ex Maxim. Three forest wetlands were sorted into A-grade, three into B-grade, and one into C-grade. Monitoring forest wetlands scattered across the border area ruled by military regulations can be challenging; still, as forest wetlands with high conservation value turned out, further investigations through remote sensing and cooperation by the relevant agencies will be required.

• Korean Journal of Plant Taxonomy
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• v.50 no.4
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• pp.453-474
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• 2020

Here, we present an updated checklist based on voucher specimens of vascular plants for Gasan Mt. which is located in Chilgok-gun, Gyeongsangbuk-do, South Korea. The list includes 322 taxa in 212 genera and 81 families of vascular plants, of which 14 are endemic, six are rare plants, 48 are floristic target species, and 14 are considered naturalized in Korea. Based on voucher specimens, Gasan Mt. was the southern limit of Cimicifuga heracleifolia var. bifida Nakai and Iris odaesanensis Y. N. Lee on the Korean peninsula. Moreover, we confirmed a hybrid plant deriving from two Iris parents, I. minutoaurea Makino and I. odaesanensis, in a mountain fortress of Gasan Mt. We also present online databases including 325 voucher specimens deposited at the Korea Institute of Oriental Medicine (KIOM; http://oasis.kiom.re.kr/herblib). This study has great significance as the first floristic study of Korean plants sharing virtual specimens online.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.2
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• pp.19-27
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• 2011

By studying 'Sauidangzi' written by Honggyungmo(1774~1851), this paper shows on the location, the space organization, and the landscape culture of 'Sauidang' which was upper class's house in late period of the Joseon. Sauidang was the residence of about 530 kan(about $1,750m^2$) which was given to Jeongmyunggongju(daughter of Sunzo) by Injo when she married with Hongjuwon, located at the good place where Mt. Mokmyuk, Mt. Dobong, Mt. Inwang, and Janwon peak are harmonized all together. The residence was on the foothill of Mt. Mokmyuk, facing to the northeast. The main house was facing to the east with the inner and back yards, and the separate house(Sauidang) was facing to the west with the garden, and a vegetable field was set in the outer yard where is connected with a main road where willow trees were lined up, 'Sauidang' was called as "the garden of princess", and a stair-shaped flower garden was made to the south, and one could look down the Hanyang castle as a whole. In the garden, there were trees and house plants enriching one's mind to wish an eternal life with oddly shaped stones or flowers, and symbolizing a fairly land. There were 38 types of trees that were planted either on the ground or in pots as various bundles like 1 tree, 2 trees, 3 trees, 4 trees, 5 trees, 8 trees, and 9 trees. Taehosuk, oddly shaped stones, stone panels, stone pillars, jade panels, sundial, walls and fences, stone stairs, steppingstones, and buildings were set for the landscape. Also, the residence had rare luxuries of landscaping culture like Wangheeji's Nanjungsoogyeseo, Sosik's Cheeongjeongi, Jomangboo's Jeokbyukboo, and Anpyungdaegoon's Behaedangcheop.