• Journal of Microbiology
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• v.41 no.1
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• pp.46-51
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• 2003

RAD6 in yeast mediates postreplication DNA repair and is responsible for DNA-damage induced mutations. RAD6 encodes ubiquitin-conjugating enzyme that is well conserved among eukaryotic organisms. However, the molecular targets and consequences of their ubiquitination by Rad6 have remained elusive. In Aspergillus nidulans, a RAD6 homolog has been isolated and shown to be an allele of uvs). We screened a CDNA library to isolate UVSJ-interacting proteins by the yeast two-hybrid system. JIPA was identified as an interactor of UVSJ. Their interaction was confirmed in vitro by a GST-pull down assay. JIPA was also able to interact with mutant UVSJ proteins, UVSJl and the active site cysteine mutant UVSJ-C88A. The N- and the C-terminal regions of UVSJ required for the interaction with UVSH, a RAD18 homolog of yeast which physically interacts with Rad6, were not necessary for the JIPA and UVSJ interactions. About 1.4 kb jipA transcript was detected in Northern analysis and its amount was not significantly increased in response to DNA-damaging agents. A genomic DNA clone of the jipA gene was isolated from a chromosome I specific genomic library by PCR-sib selection. Sequence determination of genomic and cDNA of jipA revealed an ORF of 893 bp interrupted by 2 introns, encoding a putative polypeptide of 262 amino acids. JIPA has 33% amino acid sequence identity to TIP41 of Saccharomyces cerevisiae which negatively regulates the TOR signaling pathway.

• Journal of Ginseng Research
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• v.14 no.3
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• pp.357-363
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• 1990

When mice irradiated by neutron (Be) are fed with ginseng concentrate, ginseng powder, and adaptagen of which the major ingredient is ginseng alkaloid to neutron (Be source) irradiated mouse, the following results are obtained. 1. The 50% lethal dose (LD50) for the neutron irradiation were 4 days at 600 rad, 7 days at 500 rad, 16 days at 400 rad, 33 days at 375 rad, and 55 days at 350 rad. In thistest, the standard amollntofirradiation was set at 375 rad/8 min. 2. Some spots appeared in the tail of the neutron-irradiated mouse because of blood congestion, and some had its tip tails cut. But the group administered with adaptagen did not show any of these symptoms. 3. The neutron irradiated mouse showed darkening the color of their lung-chloasmas while none of the adaptagen group had this symptom. 4. The lung tissue of the neutron irradiated mouse showed an increase of the karyolysis and cytoplasmic vacuole. 5. When both neutron irradiation and the ginseng sllbstances were given to the mouse at the same day, the 50% lethal days were increased to 29-33 days for the group administered with ginseng extract. 67 days for the group given with the ginseng powder. and 80 days for the groilp arith the adaptagen. 6. The survival rate of those fed with adaptagen for 33 days before the neutron-irradiation was 100%, while the 50% lethal daysofthe group fed with ginsengextract were 39 days and that of the group fed with ginseng powder were 69 days. 7. The serum valued of ${\gamma}$-globulin, IgG, and albumin were returned to normal condition in the group fed with adaptagen for 33 days before the neutron-irradiation. But those of the group which were given the irradiation and the ginseng substances at the same day did not show such a recovery.

• The Korean Journal of Pain
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• v.35 no.1
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• pp.86-96
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• 2022

Background: To explore the association between low back pain (LBP) and pelvic pain (PP) and rectus abdominis diastasis (RAD) in postpartum women and identify the characteristics and risk factors. Methods: Women diagnosed with RAD and a history of labor and delivery, between 2009 and 2018, were identified from six hospitals within the Partners Healthcare System. Univariate and multivariable binary logistic regression analyses were used to identify the risk factors associated with pain. Results: Age at onset of RAD in the non-cesarean delivery group was earlier than those in cesarean delivery (CD) group (P = 0.017). Women who underwent CD demonstrated 4.5 times greater risk of RAD than those who had no CD exposure. The cumulative composition ratio of LBP at every age stage of the period from 8 years pre-first delivery to 8 years post-first delivery was significantly higher than the other five conditions (RAD, umbilical hernia, PP, depressive disorder [DD], and strain of muscle, fascia, and tendon [SMFT]) (P for trend < 0.001). Women with DD, SMFT, and PP were more likely to have LBP (odds ratio [OR] = 1.91, 95% confidence interval [CI] 1.06 to 3.47, P = 0.032; OR = 4.50, 95% CI 1.64 to 12.36, P = 0.003; OR = 2.14, 95% CI 1.17 to 3.89, P = 0.013; respectively). Conclusions: In postpartum women with RAD, DD, SMFT, and PP were found to be risk factors contributing to the development of LBP. Race and LBP also played roles in the development of PP.

• Clinical and Experimental Pediatrics
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• v.46 no.6
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• pp.554-560
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• 2003

Purpose : To investigate the teratogenic effect of gamma-ray on the heart of chick embryo. Methods : 50 rad, 100 rad, 150 rad, 200 rad, 250 rad, and 300 rad of gamma-ray were used to irradiate three days old chick embryos. The control group was not irradiated. After three weeks, the embryos were sacrificed and examined for cardiovascular malformation. Results : The survival rate of the gamma-ray irradiated group was significantly lower than that of the control group(33.3-63.3% vs 76.4%, P=0.001). The cardiac malformation rate of the experimental group was 11.0%. In the control group, no congenital cardiac malformations were observed. The experimental groups had a significantly higher malformation rate(P=0.001). The types of malformation were ventricular septal defect, tricuspid atresia, Ebstein anomaly and aortic arch anomaly. In the gamma-ray irradiated group, the cardiac malformations were : 14 small ventricular septal defects (VSDs), five large VSDs, two tricuspid atresias, and one Ebstein anomaly. The higher the dose of radiation applied, the higher the incidence of cardiac malformation was noted. Conclusion : Gamma-ray irradiation of 3 days old chick embryos increased the rate of death and the rate of cardiac malformation significantly.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.109-112
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• 2002

Using Monte Carlo calculations the effects of longitudinal magnetic fields on the beam profiles produced by clinical electron beam were studied. The Monte Carlo calculations were performed using the EGS4 code system modified to account for external magnetic fields. The beam profiles for a 6 MeV electron beam with longitudinal magnetic fields of 0.5-3.0 T were calculated. As a result of these calculations we found that the penumbra widths can be reduced with increased magnetic fields. This means that the electron therapy benefits from the external magnetic fields.

• Journal of radiological science and technology
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• v.27 no.3
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• pp.43-50
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• 2004

The effects of ginseng extracts on liver damage induced by high energy x-ray were studied. To one group of ICR male mice were given white(50 mg/kg/day for 7 days, orally) and fermenta ginseng extracts(500 mg/kg/day for 7 days, orally)before irrdiation. To another group were irradiated by 5 Gy dose of high energy x-ray. Contrast group were given with saline(0.1 ml). This study also investigated the effect between MDA, protein content and ginseng extracts on hepatic damage. This study measured the level of MDA(malondialdehyde), protein content in liver tissue. Administrating orally white (50 mg/kg/day for 7 days, orally)and fermenta ginseng extracts(500 mg/kg/day), the level of MDA were generally decreased and the inhibition was increased. And the protein contents were identical with control group. After irradiation, the protein contents were increased and MDA(malondialdehyde) was increased. Therefore, ginseng extracts increased antioxidative enzyme activity. And We know that the antioxidatant effect of extracts from white and fermenta ginseng protect radiation damage by direct antioxidant effect involving SOD, CAT, GPX. It was included that ginsengs can protect against the lipid peroxidation in radiation damage through its antioxidatant properties.

• Honam Mathematical Journal
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• v.17 no.1
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• pp.7-14
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• 1995

The purpose of this study is to construct the structure of the connected Lie group G with its Lie algebra $g=rad(g){\oplus}sl(2, \mathbb{F})$, which conforms to Stellmacher's [4] Pushing Up. The main idea of this paper comes from Stellmacher's [4] Pushing Up. Stelhnacher considered Pushing Up under a finite p-group. This paper, however, considers Pushing Up under the connected Lie group G with its Lie algebra $g=rad(g){\oplus}sl(2, \mathbb{F})$. In this paper, $O_p(G)$ in [4] is Q=exp(q), where q=nilrad(g) and a Sylow p-subgroup S in [7] is S=exp(s), where $s=q{\oplus}\{\(\array{0&*\\0&0}\){\mid}*{\in}\mathbb{F}\}$. Showing the properties of the connected Lie group and the subgroups of the connected Lie group with relations between a connected Lie group and its Lie algebras under the exponential map, this paper constructs the subgroup series C_z(G)

• Bulletin of the Korean Mathematical Society
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• v.38 no.4
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• pp.709-718
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• 2001

In this paper we show that if D and G are continuous linear Jordan derivations on a Banach algebra A satisfying [D(x), x]x - x[G(x),x] $\epsilon$ rad(A)for all $\epsilon$ A, then both D and G map A into rad(A).

• Nuclear Engineering and Technology
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• v.4 no.1
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• pp.23-30
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• 1972

A study on the preparation of wood-plastic combinations by gamma-ray induced polymerization is carried out. In monomer impregnation, the rates and amounts are determined for various woods. The polymerization rates of various monomers and monomer mixtures impregnated mainly domestic woods are studied varying the total gamma-dose and gamma-dose rates. The obtained data indicate that; 1) in impregnation of monomer, populus deltoides is the fastest in rate, and the most impregnated in amount 2) the general trends of polymerization of monomers ill woods is in the order of vinyl acetate--methyl metacrylate--styrene, ranging from 3 to 15 Mard of total does in rate of 4$\times$10$^4$rad/hr., thus vinyl acetate or methyl metacrylate is suitable monomer in view of polymerization rate, 3) the successful woods in combination with monomer are pinus rigida and pinus densiflora in view of polymerization rate, 4) the monomers in woods are more easily polymerized under the conditions of moderately lower does rate, 2.1$\times$10$^4$rad/hr.

• Journal of the Chungcheong Mathematical Society
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• v.29 no.4
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• pp.523-530
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• 2016

Let R be a 3!-torsion free semiprime ring, and let $D:R{\rightarrow}R$ be a Jordan derivation on a semiprime ring R. In this case, we show that [D(x), x]D(x) = 0 if and only if D(x)[D(x), x] = 0 for every $x{\in}R$. In particular, let A be a Banach algebra with rad(A). If D is a continuous linear Jordan derivation on A, then we see that $[D(x),x]D(x){\in}rad(A)$ if and only if $[D(x),x]D(x){\in}rad(A)$ for all $x{\in}A$.