• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.2100-2104
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• 2008

현재 전국적으로 하천을 횡단하는 보에 어도시설이 되어 있는 곳은 4.6%에 불과하고, 기존에 설치된 어도의 경우에도 설계단계에서부터 회유성 어류의 통로로 부적합하거나, 시공 후 관리부실로 하상이 세굴되거나 퇴적되어 어도로서의 기능을 상실한 경우가 많은 실정이다. 또한 어도의 위치는 통수장애 및 퇴적을 고려하여 하천의 유심(流心)과 연결되는 위치에 설치해야 함에도 불구하고 엄밀한 수리계산 없이 어도의 설계가 이루어지는 경우가 많다. 따라서 본 연구에서는 1차원 및 2차원 흐름해석을 통해 어도 효율을 높일 수 있는 방안을 강구하였다. 흐름해석 대상구간은 왕숙천의 퇴계원 수위표 지점부터 상류 약 4km 구간이며, 이 구간에 3개의 보가 존재한다. 상하류 연속성 확보를 위해 어도 설치시 고려 대상 종으로 왕숙천 중류에만 출현하는 긴몰개를 삼았다. 보에 어도가 없는 상태에서 흐름 및 하상변동 해석을 수행하여 이를 바탕으로 어도를 설치하기에 적정한 위치를 도출하였다. 2차원 흐름모형의 하나인 RMA-2를 사용하여 유심선을 파악하였으며, 하상변동 해석 모형인 SED-2D를 이용하여 홍수시 어도 입,출구에 예상되는 세굴 및 퇴적양상을 확인하였다. 갈수시 설치된 어도에 충분한 유량이 확보되는가를 확인하기 위해 HEC-RAS를 이용하여 1차원 흐름해석도 병행하였다. 2차원 흐름해석 결과 대상구간의 좌안쪽으로 유심선이 발생하므로 어도는 이를 따라 보체의 좌안쪽에 설치함이 타당하다. 그러나 홍수시 하상변동해석 결과, 좌안쪽에 상당량의 퇴적이 발생하는 경우에는 퇴적이 진행되지 않는 보의 중앙부에 어도를 설치함이 타당하다고 사료된다.

• Journal of Korean Society of Water and Wastewater
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• v.11 no.4
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• pp.91-98
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• 1997

At present, automated monitoring of water quality in Han river has been operated at each water treatment plant. But the automated measurement sites must be choosen newly because water source in Seoul move to the upper stream of Chamshil weir. In this study, automated monitoring sites in Han river were reviewed, and the proper sites for automated monitoring of water quality have been selected by Qual2E model, RMA model, water sampling guidline, Sanders' method and topograpical characteristics of Han river in order to resonable operate. 8 sites have been selected as follows: (1) the site of immediately after Paldang drainage (2) the left site and a right site of $Gu{\check{u}}i$ water intake (3) the left site and a right site at Noryangjin(Han river bridge) (4) the site between Shingok weir and Anyangchun confluence point(Hangju bridge) (5) the site of Chungryangchun downstream(existence) (6) the site of Tanchun downstream(existence) (7) the site of Anyangchun downstream(existence) (8) the site of Wangsukchun downstream. The results proposed resonable operating management of network and economical system built up.

• Journal of The Korean Society of Agricultural Engineers
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• v.49 no.5
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• pp.11-20
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• 2007

In this study, we reviewed the optimal space for the fishway and fish storage establishment in the section between the downstream of the Hwacheon dam and the confluence of the Pungsan river. The hydraulic stability of these facilities was also examined. In the section between the downstream of Hwacheon dam and the confluence of Pungsan river, the release flow of Hwacheon dam was set at $5,495m^3/s,\;6,110m^3/s$ and $7,537m^3/s$, and numerical simulations were executed for each instance using the HEC-RAS model and RMA-2. In the analysis of the flow velocity distributions in the subject section by release flows of Hwacheon dam, it was shown that there was over 5.0m/s of high flow velocity at Sta. $#1{\sim}Sta.$ #3, Sta. $#4{\sim}Sta.$ #6, and Sta. $#12{\sim}Sta.$ #13 of the sections analyzed in this study. The Sta. $#0{\sim}Sta.$ #1 was considered appropriate for the fishway and fish storage establishment. As seen in the results of the numerical stability review by release flow conditions of Hwacheon dam subject to the selected available areas fur fishway and fish storage, the topographically available section for the establishment of fishway and fish storage exists at Sta. $#1{\sim}Sta.$ #3 when the release flow of Hwacheon dam is $5,495m^3/s$, whereas Sta. $#0{\sim}Sta.$ #1 should be reviewed for the subject section for the establishment of fishway at release flows of $6,110m^3/s$ and $7,537m^3/s$, in addition to the figures gathered at the $5,495m^3/s$ release flow. Finally, the available section for the establishment of fishway and fish storage was determined to be Sta. $#0{\sim}Sta.$ #3. Further, if fishway and fish storage are established in the outer bank within this section, the high flow velocity section should be avoided. An alternative would be to establish for the fishway in the inner band on the section of Sta. #1 or Sta. #3.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.189-193
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• 2010

RMA-2, Telemac-2D, River2D 등 기존의 대부분 국내외 상용모형에서는 내부 경계인 하천구조물과 외부 경계인 측벽에서의 경계조건을 활동조건(slip condition)으로 가정하여 흐름장을 계산하였다. 그러나 실제로 벽면에서는 마찰력에 의해 흐름이 존재하지 않는 무활조건(no slip condition)이 물리적으로 타당하다. 따라서 본 연구에서는 내부구조물인 교각이 존재하는 영역에서의 수평 2차원 유속분포를 구하기 위해 천수방정식을 Galerkin법과 Newton-Raphson법에 의해 이산화한 수치모형을 개발하였다. Yulistiyanto 등(1998)이 수치모의 및 수리실험에 사용한 조건을 채택하여 벽면에서의 접선방향 유속이 존재하는 활동조건과 벽면에서 유속이 없는 무활조건을 부여하고 교각을 포함한 수로에서 유속, 수위 및 전단분포를 해석하였다. 활동경계조건을 적용한 경우 교각 표면을 따라 큰 유속이 분포하고 후면에서도 관성력에 의해 흐름방향 유속이 두드러지게 나타났으나 무활조건을 적용한 경우 교각 후면에서 와가 형성되고 후류현상이 두드러지게 나타났다. 무활조건을 적용한 경우 교각 전면부에서는 선수파(bow wave)가 4 cm정도 높게 나타났으며 교각 측면부에서는 2 cm 높게 나타났다. 반면 교각 후면에서는 후류의 영향으로 수면이 2 cm 낮게 분포하였다. 교각부에 작용하는 전단력을 분석한 결과 무활조건을 적용한 경우가 활동조건을 적용한 경우에 비해 최대 6배 높은 전단력이 나타났다.

• KSBB Journal
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• v.10 no.4
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• pp.428-434
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• 1995

Target-sensitive(TG-S) liposomes, which have the antibodies coupled on the surface of liposome and can release their entrapped contents by the binding of antibodies with the specigic target cells, were prepared and employed to study the release of calcein and the selective delivery of an anticancer agent, doxorubicin(DOX). The monoclonal antibody, Y3, used for the preparation of the TG-S liposome was one against major histocompatibility complex class 1 of mouse(MHCI, H-2Kｂtype) and the target cells were EL-4 and RMA, which have the MHC1, H-2Kbtype on their membrane surfacem. The release of calcein from TG-S liposome occurred when the target cells were contacted with liposomes and it was proportionally increased with the rise of binding capacity of antibody coupled on the surface of liposome to the target cells. The experimental results of drug delivery were similar to the cases of calcein release. The viability of specific target cell, EL-4 with liposomal DOX was not so different from that with the free DOX, while for the non-specific target cell, Yacl(H-2Kf), the cell viability with Iiposomal DOX was much higher than that with free DOX. This shows the fact that the liposomal DOX can be efficiently delivered to the specific target cells, while it was not the case for the non-specific target cells. And the drug delivery was lnhibited when the free antibody of Y3 was added in the contact process between EL-4 and TG-S liposomes, which means the drug delivery occurred mainly by the destabilization of TG-S liposomes. From these results, we could conclude that the selective drug delivery to specific target cell using the TG-S liposome would be feasible.

• The KIPS Transactions:PartA
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• v.11A no.4
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• pp.257-266
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• 2004

Mobile agents are defined as processes which can be autonomously delegated or transferred among the hosts in a network in order to perform some computations on behalf of the user and co-operate with other agents. Currently, mobile agents are used in various fields, such as electronic commerce, mobile communication, parallel processing, search of information, recovery, and so on. In pure P2P network environment, if mobile agents that require computing resources rashly migrate to another peers without consideration on the peer's capacity of resources, the peer may have a problem that the performance of the peer is degraded due to lack of resources. To solve this problem, we propose resource reservation based load balancing scheme of using RMA(Resource Management Agent) that monitors workload information of the peers and that decides migrating agents and destination peers. In mobile agent migrating procedure, if the resource of specific peer is already reserved, our resource reservation scheme prevents other mobile agents from allocating the resource.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.4
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• pp.325-331
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• 2000

Tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$ plays important roles in inflammatory responses. Some of tetrahydroisoquinoline (THI) compounds exhibited to inhibit iNOS expression in animal studies and RAW 264.7 cells, but the action of THI on inflammatory reaction was not fully investigated. In the present study, we examined a limited series of THIs (higenamine, YS-51 and THI-52) on the $TNF-{\alpha}$ mRNA expression in mouse peritoneal macrophages by Northern analysis. When thioglycollate-stimulated peritoneal macrophages were incubated with LPS (100 ng/ml), expression of $TNF-{\alpha}$ mRNA was evident and reached its maximum at 2.5 h, which was reduced concentration-dependently by treatment with THIs. When the $TNF-{\alpha}$ activity of macrophage-conditioned media was measured using a TNF-sensitive L929 fibroblast cell line, CCL 1, all THIs increased the cell viability in a concentration dependent manner. The concentrations of THIs used are not cytotoxic by itself when analysed by MTT. Furthermore, nitrite/nitrate level was significantly reduced by the presence of THIs in cells treated with $LPS+interferon-{\gamma}\;(IFN-{\gamma}).$ It is concluded, thus, that these results strongly indicated that THIs can suppress the $TNF-{\alpha}$ expression and reduce NO, which may be useful for the inflammatory disorders.

• Journal of Wetlands Research
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• v.14 no.4
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• pp.715-723
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• 2012

The Hoelyongpo in the Naeseong River as tributary basin of the Nakdong River is broadly well-known a tourist attraction, which is made of sandy beach, and is called "Island of Inland". But Construction of the Dam was planned at upstream of river. In other words, an influx of sediment is blocked from upstream of river. In this situation, through sediment discharge coming from tributary of the Naeseong river, the whether to go ahead of sand beach of the Hoelyongpo is analyzed by using 1-D and 2-D model. The sediment discharge is estimated through ratio raw with basin area, and the instream flow requirement of river coming from dam and the flow rate and sediment coming from tributary are inputted for model. The 1-D model uses HEC-6 and the 2-D model uses SMS(RMA2 and SED2D). The analysis using the HEC-6 is performed from cross section data 10 year ago to the present cross section. Consequently, Yang equation presenting similar result to the present cross section data is determined, using this, the prediction is conducted for the cross section after 20 years. The 2-D analysis is conducted for the present cross section data. The value of distinction between a deposition and erosion with the results presented in the 1, 2-D models is occur, however, the appearance between the deposition and the erosion is similar.

• IMMUNE NETWORK
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• v.4 no.1
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• pp.31-37
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• 2004

Background: 1-8D gene is a member of human 1-8 interferon inducible gene family and is shown to be overexpressed in fresh colon cancer tissues. Three peptides 1-6, 3-5 and 3-7 derived from 1-8D gene were shown to have immunogenicity against colon cancer. Methods: To study tumor immunotherapy of these peptides we established an adoptive transfer model. $D^{b-/-}{\times}{\beta}2$ microglobulin (${\beta}2m$) null mice transgenic for a chimeric HLA-A2.1/$D^b-{\beta}2m$ single chain (HHD mice) were immunized with irradiated peptide-loaded RMA-S/HHD/B7.1 transfectants. Spleens were removed after last immunization, and splenocytes were re-stimulated in vitro. Lymphocytes from vaccinated HHD mice were transferred together with IL-2 to the tumor bearing nude mice that were challenged S.C. with the HCT/HHD/B7 colon carcinoma cell line that was found to grow in these mice. Results: Peptide 3-5 was found to be highly effective in CTL activity. Adoptively transferred anti-peptide 3-5 cytolytic T lymphocytes caused significant retardation in tumor growth. Conclusion: This study shows that peptide 3-5 can be the most effective candidate for the vaccine of adoptive immunotherapy against colon cancer.

• Journal of Information Technology Application
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• v.2 no.1
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• pp.83-111
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• 2000

To preserve competitiveness in rapidly changing world military market and to adapt themselves to newly-developed warfare, many developed counties have been readjusting their military organizations and technical procedures. In a private sector, business reengineering and other innovative efforts were made to respond to this change, using structural approaches. In the military sector, the United States is the one leading this move. She has been trying to reorganize her military structure to hold her hegemony in world politics for the coming 21st century. The purpose of this paper, is, (1) to analyze the information technology on the military revolution, (2) to deduce what to be changed, and (3) to infer how to change. The comparison between Korea and U.S. in terms of the real military situation was made to analyze these three research questions. The study was based on the structural contingency theory, one of the environmental analysis models, being introduced to explore the Revolution in Military Affairs(RMA) case in United States and Korea. The conclusion may be summarized as follows; First, information-based society which is characterized by the development of information technology and environmental, complexity and weakness in security affairs will affect the military factors such as the issue of holding information superiority, changing warfare in proportion to the military-scientific development and weakness in military security. This trend will be more deep-rooted and multiple in its influence on the military affairs.