• 한국가스학회:학술대회논문집
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• 한국가스학회 2004년도 추계학술발표회 논문집
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• pp.113-118
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• 2004

• 한국한의학연구원논문집
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• 제7권1호
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• pp.77-84
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• 2001

A survey was conducted to investigate the attitudes of pharmaceutical companies toward the status and permission of R & D of herbal products. The survey's results showed that some of them(42.9%) was conducting the R&D, and others(57.1%) were not conducting. As the results of analysis on the reason of R&D conducting, some of them(42.3%) answered that R&D of herbal products is more effective and powerful than these of synthetic products. And 23.1% answered that the cost of R&D is low and the time required is short. And another 23.1% answered that it has marketability and competitive power. As the results of analysis on the marketability of herbal products in Pharmaceutical Market, most of them(78.6%) answered that it seems enough. As the result of the comparison of synthetic drug and herbal products, the proportion of R&D investment on herbal products was lower than synthetic products in the preclinical study, the first clinical study and the second clinical study, and higher than in the third clinical study and the NDA. And the periods of R&D was long in most procedure except synthesis of new materials. As the results of analysis on the recognition of related regulation, most of them(73%) was yes. And 35.2% of the subjects thinks it enough.

• 방사선산업학회지
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• 제8권2호
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• pp.133-140
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• 2014

The sterilization of health care products is widely used to choose conventional Ethylene Oxide gas sterilization in South Korea. But the method has brought serious issues because of the toxic residual gas and global warming of $CO_2$ evacuation after the sterilization process. This study is carried out to confirm the application possibility of gamma sterilization instead of Ethylene Oxide in sanitary aid products. Four kinds of products (gauze, menstrual pad, bandage, menstrual tampon) were treated with gamma irradiation of 15 kGy, then analyzed the achievement of the sterility assurance level (SAL) $10^{-6}$ through BI test. The cytotoxicity of accelerated samples of 6 months elapse evaluated by means of colony forming rate at various concentration of the extracts. pH and UV measurements at extract concentrations were tested according to the MFDS (Ministry of food & drug safety) guideline to verify a stability & safety of product sterilized. The results revealed that the extracts did not show any significant changes in cytoxicity assay as well as pH and UV values by gamma sterilization. All extract concentration was observed high cell viability, pH and UV values were calculated within the acceptable range prescribed by the guideline. It indicates that gamma sterilization could effectively substitute for conventional sterilization such as Ethylene Oxide sterilization in the sanitary aid products.

• 대한예방한의학회지
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• 제6권1호
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• pp.36-50
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• 2002

Health industry, a knowledge based high value-added industry, is being considered as a strategic area for the 21C and many advanced countries are making every endeavors for the promotion of health industry along with information technology, new materials, and mechatronics. Korean health industry, however, has been excluded from the governmental supports as well as bound by strict regulation so far, and there is a significant gap in technology compared with advanced countries. In 21C, technology is the main factor of national competitiveness and that is why the role of R&D institutes are so important in the high level of competition to cope with the technology protection policies of advanced countries. In this article, with Directory of Korean R&D Institutes published by Korea Industry Technology Association, I reviewed the trends of R&D institute of health industry. Main findings of the research can be summarized as follows. The portion of health industry R&D institute is 3.6% of total R&D institute but the amount of R&D investment is over than 5% This means health industry are knowledge based and R&D intensified industry, meanwhile the variations of same industry R&D institutes of health industry is huge in R&D investments and other activities. Regional distributions of health industry institutes show some kind of different patterns in each industry areas. Medical devices and Medical informatics's preference of metropolitan region are distinguished with other industry areas. Many of the institutes are located in same site of it's company rather than operating separate building for R&D specific uses. It is better for transforming ideas to products and close cooperation of research body with product lines, but it is a handicap for networking and communicating with other research institutions too. It takes 18.4yrs for bearing R&D institute on the average. For a long times 'copy products' or 'me too products' policies were easy way to maintain business entities. But recently, it is recognized that research activities are essential component of sustaining it's own business firms. This means technology itself is leading power of corporation itself in the high level of competition.

• 대한본초학회지
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• 제21권1호
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• pp.25-31
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• 2006

Objectives : We investigated the aniti-aging effects of the cosmetic products with Pinus densiflora on human skin by using non-invasive instruments. Methods : We made cosmetic products containing the extract of the needles of red pine, and measured physiological effects such as skin wrinkles, clarity, evenness, lifting, corneocyte exfoliation after volunteers applied the cosmetic products for 8 weeks. Results : We observed a skin lifting effect and a decrease in corneocytes amount after using the cosmetic products for 4 weeks. And the wrinkles, evenness and clarity of face skin improved significantly. Conclusion : We concluded that the cosmetic products containing the extract of the needles of reel pine had an anti-aging effect on the human face skin.

• 약학회지
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• 제42권1호
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• pp.89-94
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• 1998

Propionibacterium acnes is the pharmacological target site of antiacne drugs. We have examined the antiacne activity of ninety seven natural products which have been used as Korean traditional medicines in various skin disorders. The antibacterial activity of extracts from the natural products were evaluated against P. acnes ATCC 9616 by disc method. Twelve natural products showed the potent antibacterial activity against P. acnes, and were, selected for the minimal inhibitory concentration(MC) against P. acnes. MICs of nine extracts were below 0.3% (w/v) and Sophora flavescens showed the most potent activity with a MIC of less than 0.008%(w/v) against P. acnes. Thus, the results suggest that nine natural products including S. flavescens can be developed as sources of promising potent antiacne agents.

• 한국시스템다이내믹스연구
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• 제8권2호
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• pp.191-207
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• 2007

Nowadays almost nations try to promote the competition of nation through the development of national science technology. Also Korea has been engaging in this race of through public research&development institute. But recently the commercialization of R&D products appears a poor result in the royalty of technology according weak technology transfer toward IT small and medium-sized enterprises. Even If we have been trying to find the problems and causes, as yet it is true that we don't solve clearly the problem, make a diagnosis about it. This paper analyzes the process of commercialization in public R&D research institute(ETRI: Electronics and Telecommunications Research Institute) through system thinking and researches an interrelationship among government agency, public R&D research institute, and enterprise. This one can find the fact that between research fund and R&D products, transfer technology and royalty, and enterprise's operating profit and active technology transfer like adding technology development is a positive feedback loop. This positive feedback loop in the commercialization of public R&D research institute carries out very important role in examining problems in R&D product's commercialization. Also this paper looks forward to being a guide in the commercialization of public R&D research institute.

• 제품안전
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• 통권37호
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• pp.41-46
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• 1995

• 기술혁신학회지
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• 제16권3호
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• pp.650-671
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• 2013

제품은 소비자의 니즈를 충족시킴으로서 소비자의 구매행동을 이끌어내게 되며, 결국 제품은 니즈속성의 조합으로 인식된다. R&D란 이러한 니즈속성을 충족시키기 위한 일련의 기술개발 활동으로 정의할 수 있으며, 시장 지향적 R&D 시대에는 니즈속성에 기반을 둔 R&D를 전개함으로서 그 정당성을 얻을 수 있다. 이에 본 고에서는 소비자의 니즈속성을 통해 R&D 영역의 우선순위를 찾아보고자 하였다. 구체적으로는 소비자가 인식하는 특정 제품의 속성(기능)에 대한 중요성 정도와 그 속성을 충족시키기 위한 기술속성의 시급성에 따라 바람직한 단계별 R&D 진화 방향을 제시하고자 하였다. 이를 위해 융합제품으로서의 SMART TV를 대상으로 SMART TV분야의 R&D 우선순위를 도출하였다. 분석결과를 통해 향후 SMART TV 제품컨셉은 4단계로 진화(대형화면/고화질 TV, 개방형/참여형 TV, 실감형 TV, 개인화 TV)될 것으로 인식된다. 이러한 결과는 복수의 니즈속성을 가진 제품이 진화하는 과정에서, 시장에서 요구되는 니즈속성을 우선적으로 충족시키는 R&D를 추구함으로써 제품의 성공가능성을 제고할 수 있다는 점을 시사한다. 또한 R&D전략의 측면에서 R&D로드맵을 설계하는데 유용한 분석 틀을 제공한다.

• Archives of Pharmacal Research
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• 제27권12호
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• pp.1207-1210
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• 2004

The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-${\beta}$ -D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).