Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antidiabetic Coumarin and Cyclitol Compounds from Peucedanum japonicum

  • Lee, Sung-Ok (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University) ;
  • Choi, Sang-Zin (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Jong-Hwa (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University) ;
  • Chung, Sung-Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University) ;
  • Park, Sang-Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University) ;
  • Kang, Hee-Chol (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology) ;
  • Yang, Eun-Young (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology) ;
  • Cho, Hi-Jae (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology) ;
  • Lee , Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
  • Published : 2004.01.01
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Abstract

The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-${\beta}$ -D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).

Keywords

References

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