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Antidiabetic Coumarin and Cyclitol Compounds from Peucedanum japonicum  

Lee, Sung-Ok (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Choi, Sang-Zin (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Lee, Jong-Hwa (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Chung, Sung-Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University)
Park, Sang-Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University)
Kang, Hee-Chol (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology)
Yang, Eun-Young (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology)
Cho, Hi-Jae (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology)
Lee , Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Publication Information
Archives of Pharmacal Research / v.27, no.12, 2004 , pp. 1207-1210 More about this Journal
Abstract
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-${\beta}$ -D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).
Keywords
Peucedanum japonicum; Umbelliferae; Coumarin; Inositol;
Citations & Related Records

Times Cited By Web Of Science : 7  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
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