• 벤처창업연구
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• 제14권3호
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• pp.39-46
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• 2019

기업의 내적 R&D 열의를 키우기 위해 외부 파트너와의 제휴가 가치 있다는 연구가 많이 진행돼 왔다. 하지만 혁신적 성과를 창출하기 위해 전략적 제휴가 가진 잠재적 역할을 활용하는 방법에 대해서는 잘 알려져 있지 않다. 본 연구는 전략적 제휴의 가치를 연구하고, 전략적 제휴의 혁신 성과에 대한 영향에 인적 자본이 어떤 역할을 하는 지를 분석한다. 본 연구는 인적 자본의 흡수역량이 전략적 제휴와의 상호작용을 통해 기업의 혁신에 끼치는 영향에 초점을 맞춘다. 2,205개의 대한민국 벤처기업을 대상으로 한 분석에서 전략적 제휴는 혁신 성과에 정의 유의한 영향을 미치는 것으로 나타났다. 하지만 전략적 제휴와 혁신 성과 간의 관계에서 인적 자본의 조절 역할은 부의 유의한 영향을 보여준다. 이것은 외부의 파트너로부터 얻은 지식과 정보를 내재화시키는 능력이 중요함을 보여준다. 본 연구는 인적자본의 상호작용을 고려함으로써 전략적 제휴의 효과성을 증진시키고자 하는 경영자에게 가치 있는 시사점을 제공한다.

• Journal of Gastric Cancer
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• 제8권2호
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• pp.57-64
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• 2008

현재 국소 위암에서 유일한 완치적 치료법은 수술적 절제이나 적절한 수술적 치료에도 불구하고 상당 수의 환자들이 재발을 경험한다. 이에 다학제적 병용 치료 전략에 대해 많은 관심이 있어왔고 특히 최근에는 암의 병기 감소, 근치적 절제률의 증가, 미세 원격전이의 조기 치료 등의 가능성을 가지는 수술 전 선행항암화학요법에 대한 관심이 증대되고 있다. 최근의 3상 임상 연구인 MAGIC trial은 수술 전후 항암화학요법이, 수술 단독에 비해, 병리학적 병기를 감소시키며 국소 재발과 원격 전이를 감소시켜 생존율을 향상시킴을 보고하였고 또 다른 3상 연구인 FNLCC 94012/FFCD 9703 trial 역시, 수술 전후 항암화학요법이 근치적 절제율과 생존율을 향상시킴을 보고하였다. 두 연구는 수술 전후 항암화학요법에 대한 것이지만 수술 후 보조항암화학요법의 불량한 치료 순응도에 비추어 볼 때 치료성적의 향상은 주로 수술 전 선행항암화학요법에 기인하는 것으로 생각된다. 상기 연구들이 이루어진 서양과 달리 광범위(D2) 림프절 절제술을 표준적 치료로 시행하고 있는 한국의 현실에서 이들 연구결과를 그대로 적용하기에는 어려움이 있으나 한국에서 이루어진, 국소 진행성 위암 환자를 대상으로 한 몇 가지 임상 연구 역시 선행항암화학요법을 통한 근치적 절제률의 증가 및 병기 감소 효과를 시사하였다. 이러한 고무적인 치료 성적에 근거하여 향후 수술 전 또는 수술 전후 항암화학요법이 국소 위암에서 표준적인 치료 전략으로 자리잡을 수 있을 지 결론을 짓기 위해서는 대규모 임상 연구가 시행되어야 할 것이다.

• Journal of Chest Surgery
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• 제53권5호
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• pp.301-305
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• 2020

Background: Radiographic modalities have been commonly used to evaluate pectus carinatum (PC), and compressive orthotic bracing is the most widely accepted treatment method. The aim of this study was to determine the efficacy of 3-dimensional (3D) body surface scanning as an alternative modality for the evaluation of PC. Methods: The medical records of 63 patients with PC who were treated with compressive orthotic bracing therapy between July 2017 and February 2019 were retrospectively analyzed. Using both 2-view chest radiography (posteroanterior and lateral view) and 3D body scanning, the height of maximal protrusion of the chest wall was measured both before and after 2 weeks of bracing therapy. The difference between the pre- and post-treatment measurements was calculated for both modalities, and these differences were compared and analyzed. Results: Based on the comparison between the pre- and post-treatment radiographs, bracing therapy produced favorable outcomes in all patients (p<0.001). The measurements obtained via 3D scanning were strongly correlated with those obtained via chest radiography (r=0.60). Conclusion: Based on the findings of this study, 3D body surface scanning appears to be an effective, radiation-free, and simple method for the post-treatment follow-up evaluation of PC, and thus can be considered an alternative to radiography.

• 한국축산식품학회지
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• 제41권2호
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• pp.312-323
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• 2021

The purpose of this study was to use 1H nuclear magnetic resonance (1H NMR) to quantify taste-active and bioactive compounds in chicken breasts and thighs from Korean native chicken (KNC) [newly developed KNCs (KNC-A, -C, and -D) and commercial KNC-H] and white-semi broiler (WSB) used in Samgye. Further, each breed was differentiated using multivariate analyses, including a machine learning algorithm designed to use metabolic information from each type of chicken obtained using 1H-13C heteronuclear single quantum coherence (2D NMR). Breast meat from KNC-D chickens were superior to those of conventional KNC-H and WSB chickens in terms of both taste-active and bioactive compounds. In the multivariate analysis, meat portions (breast and thigh) and chicken breeds (KNCs and WSB) could be clearly distinguished based on the outcomes of the principal component analysis and partial least square-discriminant analysis (R2=0.945; Q2=0.901). Based on this, we determined the receiver operating characteristic (ROC) curve for each of these components. AUC analysis identified 10 features which could be consistently applied to distinguish between all KNCs and WSB chickens in both breast (0.988) and thigh (1.000) meat without error. Here, both 1H NMR and 2D NMR could successfully quantify various target metabolites which could be used to distinguish between different chicken breeds based on their metabolic profile.

• 한국의료질향상학회지
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• 제12권2호
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• pp.75-83
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• 2006

Background : Utilization review has been adopted as a vehicle for cost and utilization control of health care services. Its role was further stressed and expanded through the establishment of Health Insurance Review Agency in 2001. This article is to introduce concept, activities, and effect of utilization review based on the experiences of U.S. and to suggest important characteristics for ideal utilization review activities at the national level in Korea. Method : Twenty-five articles related with utilization review were reviewed after being selected through web site search through Med Line and Richis. Result : Utilization review was introduced mainly for health care expenditure control either by insurer, provider or the third parties under the pressure of increasing health care cost. It's activities can be categorized to prospective, concurrent and retrospective review according to the time of service provision. Based on most of studies, utilization review has been effective in controling rising health care cost and utilization. However it's effectiveness assumes a reimbursement structure of managed care like capitation payment. More worse, it is still unknown it's effectiveness on quality of care. Conclusion : Utilization review should be employed to increase the cost effectiveness of medical care by optimizing quality and patient's outcomes while also attempting to reduce the use of resources. So, it should consider outcomes before expenditures, check for both under and over-use, and construct an structure in which consumption is reduced equitably. Aggressive adoption of utilization review in Korean health care setting with fee-for-service reimbursement structure might not be a cost-effective approach before adoption of prospective payment system such as D.R.G. and capitation.

• 한국공간정보시스템학회 논문지
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• 제11권4호
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• pp.1-8
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• 2009

정부는 급격히 성장하고 있는 공간정보시장의 중요성을 인식하고 상용화가 가능한 기술개발을 위해 2006년부터 2012년까지 대형 국가R&D사업인 지능형국토정보기술혁신사업을 추진하고 있다. 이에 따라, 본 사업은 실제 현장에 바로 적용될 수 있는 검증된 연구 성과물을 도출하기 위해 성과물의 현장적용, 통합, 전시를 위한 테스트베드 구축이 계획되어 있다. 이 중 가장 먼저 해결해야 하는 것이 바로 합리적인 입지 선정이다. 본 논문에서는 지능형국토정보기술 테스트베드와 같이 공간정보기술 실험을 위한 테스트베드 구축과정에서 최적의 입지선정 방안을 도출하는데 목적을 두었다. 연구결과는 국내외 테스트베드 구축사례를 알아보고, 테스트베드에 적용되는 성과물의 특성 분석을 통해 입지선정을 위한 방안을 도출하였다.

• Archives of Plastic Surgery
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• 제48권6호
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• pp.599-606
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• 2021

Background Postoperative dehiscence and surgical site infection after spinal surgery can carry serious morbidity. Multidisciplinary involvement of plastic surgery is essential to minimizing morbidity and achieving definitive closure. However, a standardized approach is lacking. The aim of this study was to identify effective reconstructive interventions for the basis of an evidence-based management protocol. Methods A retrospective review was performed at a single tertiary institution for 45 patients who required 53 reconstruction procedures with plastic surgery for wounds secondary to spinal surgery from 2010 to 2019. Statistical analysis was performed for demographics, comorbidities, and treatment methods. Primary outcomes were postoperative complications, including dehiscence, seroma, and infection. The secondary outcome was time to healing. Results The overall complication rate was 32%, with dehiscence occurring in 17%, seroma in 15% and infection in 11% of cases. Median follow-up was 10 months (interquartile range, 4-23). Use of antibiotic beads did not affect rate of infection occurrence after wound closure (P=0.146). Use of incisional negative pressure wound therapy (iNPWT) was significant for reduced time to healing (P=0.001). Patients treated without iNPWT healed at median of 67.5 days while the patients who received iNPWT healed in 33 days. Demographics and comorbidities between these two groups were similar. Conclusions This data provides groundwork for an evidence-based approach to soft tissue reconstruction and management of dehiscence after spinal surgery. Timely involvement of plastic surgery in high-risk patients and utilization of evidence-based interventions such as iNPWT are essential for improving outcomes in this population.

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2311-2320
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• 2022

The main outcomes of the experiments H2P6 performed in the thermal-hydraulics large-scale PANDA facility at PSI in the frame of the OECD/NEA HYMERES-2 project are presented in this article. The experiments of the H2P6 series consists of two PANDA tests characterized by the activation of three (H2P6_1) or one (H2P6_2) cooler(s) in an initially stratified and pressurized containment atmosphere. The initial stratification is defined by a helium-rich region located in the upper part of the vessel and a steam/air atmosphere in the lower part. The activation of the cooler(s) results i) in the condensation of the steam in the vicinity of the cooler(s), ii) the corresponding activation of large scale natural circulation currents in the vessel atmosphere, with the result of iii) the re-distribution and mixing of the Helium stratification initially located in the upper half of the vessel and iv) the continuous pressure decay. The initial helium layer represents hydrogen generated in a postulated severe accident. The main question to be answered by the experiments is whether or not the interaction of the different, localized cooler units would be important for the application of numerical methods. The paper describes the initial and boundary conditions and the experimental results of the H2P6 series with the suggestion of simple scaling laws for both experiments in terms of i) the temperature difference(s) across the cooler(s), ii) the transient steam and helium content and iii) the pressure decay in the vessel. The outcomes of this scaling indicate that the interaction between separate, closely localized units does not play a prominent role for the present experiments. It is therefore reasonable to model several units as one large component with equivalent heat transfer area and total water flow rate.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.378-396
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• 2022

Several reconstructive methods have been reported to restore the continuity of the aerodigestive tract following resection of pharyngeal and hypopharyngeal cancers. However, high complication rates have been reported after voice prosthesis insertion. In this setting, the ileocolon free flap (ICFF) offers a tubularized flap for reconstruction of the hypopharynx while providing a natural phonation tube. Herein, we systematically reviewed the current evidence on the use of the ICFF for reconstruction of the aerodigestive tract. A systematic literature search was conducted across PubMed MEDLINE, Web of Science, ScienceDirect, Scopus, and Ovid MEDLINE(R). Data on the technical considerations and surgical and functional outcomes were extracted. Twenty-one studies were included. The mean age and follow-up were 54.65 years and 24.72 months, respectively. An isoperistaltic or antiperistaltic standard ICFF, patch flap, or chimeric seromuscular-ICFF can be used depending on the patients' needs. The seromuscular chimeric flap is useful to augment the closure of the distal anastomotic site. The maximum phonation time, frequency, and sound pressure level (dB) were higher with ileal segments of 7 to 15 cm. The incidence of postoperative leakage ranged from 0 to 13.3%, and the majority was occurring at the coloesophageal junction. The revision rate of the microanastomosis ranged from 0 to 16.6%. The ICFF provides a reliable and versatile alternative for reconstruction of middle-size defects of the aerodigestive tract. Its three-dimensional configuration and functional anatomy encourage early speech and deglutition without a prosthetic valve and minimal donor-site morbidity.

• Journal of Information Science Theory and Practice
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• 제10권spc호
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• pp.46-55
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• 2022

Eight years have passed since the Sponsoring Consortium for Open Access Publishing in Particle Physics (SCOAP3) was launched. SCOAP3 is one of the most successful global partnerships and funds for Open Access and has been benchmarked by other Open Access initiatives. The Korea Institute of Science and Technology Information (KISTI) joined as the first Asian partner in 2011, and has supported its shared vision and contributed its financial commitment since the beginning of SCOAP3. SCOAP3-Korea is the first bottom-up collaboration for local libraries to re-direct funds previously used for subscriptions to Open Access publishing. This paper explores the roles and responsibilities of KISTI in the Open Access quest. It describes the commitment to SCOAP3 in South Korea, including how the collaboration model for SCOAP3-Korea differs from the global model. This paper also discusses the impact of SCOAP3-Korea by analyzing publications affiliated by Korean authors in SCOAP3 journals for the last six years (2014-2019). We have integrated the national R&D project and research outcome data from NTIS (National Science and Technology Information Service) to investigate the research articles benefited by SCOAP3 and research publications in non-SCOAP3 journals. The positive impact of SCOAP3 in increasing research publication in the discipline was revealed compared to non-SCOAP3 journals. In addition, the financial benefit of SCOAP3-Korea has been proven. With regard to the investment for readers, $137,094 USD was saved during the SCOAP3 Phase 1 and 2, while $748,923 USD was saved with regard to publication fees. We discussed the lessons from SCOAP3-Korea for commitment to a larger-scale Open Access transition.