• Genomics & Informatics
• /
• 제20권4호
• /
• pp.49.1-49.7
• /
• 2022

Many packages for a meta-analysis of genome-wide association studies (GWAS) have been developed to discover genetic variants. Although variations across studies must be considered, there are not many currently-accessible packages that estimate between-study heterogeneity. Thus, we propose a python based application called Beta-Meta which can easily process a meta-analysis by automatically selecting between a fixed effects and a random effects model based on heterogeneity. Beta-Meta implements flexible input data manipulation to allow multiple meta-analyses of different genotype-phenotype associations in a single process. It provides a step-by-step meta-analysis of GWAS for each association in the following order: heterogeneity test, two different calculations of an effect size and a p-value based on heterogeneity, and the Benjamini-Hochberg p-value adjustment. These methods enable users to validate the results of individual studies with greater statistical power and better estimation precision. We elaborate on these and illustrate them with examples from several studies of infertility-related disorders.

• 한국항행학회논문지
• /
• 제25권5호
• /
• pp.377-383
• /
• 2021

본 논문에서는 항공기에 탑재되는 무장관리컴퓨터의 하드웨어 검증을 위한 자동시험 장비 개발 사례를 기술한다. 최근 항공기에 요구되는 기능이 다양해지고, 항공전자 장비의 관련 기술이 발전함에 따라 항공전자 장비에 필요한 인터페이스의 종류와 수량이 증가하였다. 무장관리컴퓨터 또한 기존 구형 무장 이외에도 신형 무장에 대한 요구사항이 추가됨에 따라 다량은 인터페이스 제어가 필요하다. 이와 같은 이유로 항공전자 장비의 점검에 투입되는 시간과 인력 소요 또한 증가하고 있으며, 항공전자 장비의 시험 과정을 자동화 및 무인화 할 수 있다면, 더 효율적인 점검 시스템 운용이 가능해질 것이다. 따라서 본 논문에서는 무장관리컴퓨터 하드웨어 기능 검증에 필요한 시험장비의 구조설계 내용과 검증 과정을 자동화하기 위한 시험 소프트웨어 및 시험 시나리오 설계 사례를 소개한다.

• 한국항행학회논문지
• /
• 제18권5호
• /
• pp.445-454
• /
• 2014

본 논문에서는 다목적 디스플레이의 인증 과정에서 수행 했던 시험 중 간접 낙뢰의 영향성을 검증하기 위한 RTCA DO-160 F, Section 22 시험 수행을 위한 대책 설계 내용 및 시험 과정을 소개한다. 낙뢰 유도 전압은 항공기 전기 전자장비의 기능 장애또는 손상을 가져다 주는 데 이것을 낙뢰의 간접영향이라 한다. 이러한 항공기의 낙뢰 간접영향으로부터 항공전자장비를 보호하기 위해서는 항공기에 대한 낙뢰의 영향과 항공기 내부 시스템을 분석하고 해당 부품에 대한 위협 내용에 대한 보호 설계가 필요하다. 본 논문에서는 이와 같은 항공기용 다목적 디스플레이의 낙뢰에 대한 보호를 위하여 대책 수준을 결정을 위한 RTCA DO-160 F, Section 22 category 선정 방법 및 선정된 레벨에 따른 부품 선정 방법 등을 소개한다. 또한 선정된 부품의 설계 유효성을 확인하기 위하여 실제 시험 과정을 소개한다. 이와 같은 각 단계별 과정 소개를 통하여 향후 개발 예정인 항공전자 장비에 대한 낙뢰 대책 설계의 좋은 사례가 될 것으로 예상한다.

• 한국주조공학회지
• /
• 제20권5호
• /
• pp.330-335
• /
• 2000

Functional metal prototypes are often required in numerous industrial applications. These components are typically needed in the early stage of a project to determine form, fit and function. Recent R/P(Rapid Prototyping) part are made of soft materials such as plastics, wax, paper, these master models cannot be employed durable test in real harsh working environment. Parts by direct metal rapid tooling method, such as laser sintering, by now are hard to get net shape, pores of the green parts of powder casting method must be infiltrated to get proper strength as tool, and new type of 3D direct tooling system combining fabrication welding arc and cutting process is reported. But a system which can build directly 3D parts of high performance functional material as metal park would get long period of system development, massive investment and other serious obstacles, such as patent. In this paper, through the rapid tooling process as silicon rubber molding using R/P master model, and fabricate wax pattern in that silicon rubber mold using vacuum casting method, then we translated the wax patterns to numerous metal tool prototypes by new investment casting process combined conventional investment casting with rapid prototyping & rapid tooling process. With this wax-injection-mold-free investment casting, we developed new investment casting process of fabricating numerous functional metal prototypes from one master model, combined 3-D CAD, R/P and conventional investment casting and tried to expect net shape measuring total dimension shrinkage from R/P pare to metal part.

• 한국기계가공학회지
• /
• 제21권2호
• /
• pp.73-78
• /
• 2022

The test apparatus that can be protected from the high-temperature combustion flame and coolant injection was successfully manufactured. In this study, the coolant-injection module had a controllable consistent pressure, and the entire combustion module was protected using a nonflammable composite liner. Every flange was designed in accordance with the DIN standard, and the entire body of the module was designed in accordance with the EN 13445 code. Additionally, the hydraulic pressure test was performed in accordance with the 2014/68/EU directive and EN 13445 standard. Finally, after manufacturing, performance tests (such as pressure tests) were conducted to verify the reliability and safety.

• 실천공학교육논문지
• /
• 제6권2호
• /
• pp.127-134
• /
• 2014

Analyzing test data of a vehicle for evaluating its emission performance is an essential process in automotive development field, yet it is intricate and tedious task. In addition, clear understanding and care are required when the analysis process is carried out. Computer software solutions significantly reduce the time and the effort for such analysis. Developing a computer routine to analyze the emission data in a vehicle test demands a complete understanding of the emissions analysis and its related details. In this paper, the principals to develop a LabVIEW analysis routine (VI) are introduced helping automotive engineers comprehend the emission analysis process of a vehicle test data and instruct them to develop similar routines for such analysis.

• 한국기계가공학회지
• /
• 제17권6호
• /
• pp.151-157
• /
• 2018

In this study, we have developed a composite pressure vessel that is compact and can store refrigerant at high pressure to increase the refrigerant volume. The composite pressure vessel is made of aluminum-based duralumin, which has high rigidity and excellent elongation in the inner liner, considering the characteristics of products in the aerospace and defense industry, where the safety of the applied product is considered as a priority. High strength carbon fiber was applied to the outside. In order to evaluate the performance of the developed product, burst test and cycling test were carried out. In burst test, an excellent safety margin equivalent to 2.7 times the operating pressure was obtained. In cycling test, a stable failure mode in which 'pre-burst leak' occurs is proved and the soundness of the product is proved.

• 시스템엔지니어링학술지
• /
• 제13권2호
• /
• pp.34-41
• /
• 2017

The Pyro project, one of the large national R&D project to construct Korea Advanced Pyroprocessing Facility (KAPF), which has many goals such as development of pyro technology and process equipment, design of equipment and facility, construction, and test operation, is now under research and development. To reduce uncertainty and risk of such complex project, the technical management processes in systems engineering standards and NASA handbook were reviewed, and then the ten common technical management processes were selected for the large national R&D project to meet its goal successfully. And the essential technical management processes were finally suggested for Pyro project in consideration of current situation of the project.

• Journal of Welding and Joining
• /
• 제32권5호
• /
• pp.1-6
• /
• 2014

This study aims at manufacturing SA welded API-X70 line-pipe with sour gas resistance. A pipe was manufactured by JCO bending process and SA welding using the API-X70 plate guaranteed HIC resistance. SA welded pipe was expanded in order to reduce the residual stress. The evaluation of a pipe for resistance to HIC and SSCC were performed by the RS D 0004 and RS D 0005 standards. For verification that a pipe has acceptable resistance to HIC, fullscale test was carried out. Results showed no cracking for the HIC and SSCC.

• 청정기술
• /
• 제23권4호
• /
• pp.393-400
• /
• 2017

본 연구에서는 염화제이철의 재생공정으로 기존 용매추출법에서 사용하고 있는 용매인 TBP 및 Alamine336 대신에 새로운 용매를 통해 용액 내에 존재하는 Ni과 Fe를 분리 및 회수하는 공정을 개발하였다. Lab 실험을 통하여 실험조건을 최적화하였으며, 이를 바탕으로 상업화를 위한 $10L\;h^{-1}$급 파일럿 설비를 구축하였다. 또한 파일럿 실험을 통하여 양산을 위한 공정 데이터를 확보하였으며, 제조된 염화제이철의 부식실험을 통하여 사용할 수 있는 제품 품질에 문제없음을 확인하였다.