• Investigative Magnetic Resonance Imaging
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• v.23 no.2
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• pp.125-135
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• 2019

Purpose: The purpose of this study was to evaluate dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI), and diffusion-weighted imaging (DWI) variables, for axillary lymph node (ALN) metastasis in the early stage of breast cancer. Materials and Methods: January 2011-April 2015, 787 patients with early stage of breast cancer were retrospectively reviewed. Only cases of invasive ductal carcinoma, were included in the patient population. Among them, 240 patients who underwent 3.0-T DCE-MRI, including DWI with b value 0 and $800s/mm^2$ were enrolled. MRI variables (adjacent vessel sign, whole-breast vascularity, initial enhancement pattern, quantitative kinetic parameters, signal enhancement ratio (SER), tumor apparent diffusion coefficient (ADC), peritumoral ADC, and peritumor-tumor ADC ratio) clinico-pathologic variables (age, T stage, multifocality, extensive intraductal carcinoma component (EIC), estrogen receptor, progesterone receptor, HER-2 status, Ki-67, molecular subtype, histologic grade, and nuclear grade) were compared between patients with axillary lymph node metastasis and those with no lymph node metastasis. Multivariate regression analysis was performed, to determine independent variables associated with ALN metastasis, and the area under the receiver operating characteristic curve (AUC), for predicting ALN metastasis was analyzed, for those variables. Results: On breast MRI, moderate or prominent ipsilateral whole-breast vascularity (moderate, odds ratio [OR] 3.45, 95% confidence interval [CI] 1.28-9.51 vs. prominent, OR = 15.59, 95% CI 2.52-96.46), SER (OR = 1.68, 95% CI 1.09-2.59), and peritumor-tumor ADC ratio (OR = 6.77, 95% CI 2.41-18.99), were independently associated with ALN metastasis. Among clinico-pathologic variables, HER-2 positivity was independently associated, with ALN metastasis (OR = 23.71, 95% CI 10.50-53.54). The AUC for combining selected MRI variables and clinico-pathologic variables, was higher than that of clinico-pathologic variables (P < 0.05). Conclusion: SER, moderate or prominent increased whole breast vascularity, and peritumor-tumor ADC ratio on breast MRI, are valuable in predicting ALN metastasis, in patients with early stage of breast cancer.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.37 no.1
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• pp.19-28
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• 2019

Images captured by drone have the advantage of quickly constructing spatial information in small areas and are applied to fields that require quick decision making. If an image registration technique that can automatically register the drone image on the ortho-image with the ground coordinate system is applied, it can be used for various analyses. In this study, a methodology for geo-referencing of a single image and sequential images using drones was proposed even if they differ in spatio-temporal resolution using linear features and distinct points. Through the method using linear features, projective transformation parameters for the initial geo-referencing between images were determined, and then finally the geo-referencing of the image was performed through the template matching for distinct points that can be extracted from the images. Experimental results showed that the accuracy of the geo-referencing was high in an area where relief displacement of the terrain was not large. On the other hand, there were some errors in the quantitative aspect of the area where the change of the terrain was large. However, it was considered that the results of geo-referencing of the sequential images could be fully utilized for the qualitative analysis.

• Science of Emotion and Sensibility
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• v.22 no.1
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• pp.45-54
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• 2019

Empathy has been observed to be pivotal in enhancing both social relations and the efficiency of task performance. Empathetic interaction has been shown to begin with individuals mirroring each other's facial expressions, vocal tone, actions, and so on. The internal responses of the cardiovascular activity of people engaged in empathetic interaction are also known to be synchronized. This study attempted to objectively and quantitatively define the rules of empathy with regard to the synchronization of cardiac rhythm between persons. Seventy-four subjects participated in the investigation and were paired to imitate the facial expressions of their partner. An electrocardiogram (ECG) measurement was taken as the participants conducted the task. Quantitative indicators were extracted from the heart rhythm pattern (HRP) and the heart rhythm coherence (HRC) to determine the difference of synchronization of heart rhythms between two individuals as they pertained to empathy. Statistical significance was confirmed by an independent sample t-test. The HRP and HRC correlation(r) between persons increased significantly with empathy in comparison to an interaction that was not empathetic. A difference of the standard deviation of NN intervals (SDNN) and the dominant peak frequency decreased. Therefore, significant parameters to evaluate empathy have been proposed through a step-wise discrimination analysis. Empathic interactions may thus be managed and monitored for high quality social interaction and communication.

• ALGAE
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• v.34 no.2
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• pp.111-126
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• 2019

The phototrophic dinoflagellate Biecheleriopsis adriatica is a small suessioid species characterized by a fragile thin wall. Although the morphology of this dinoflagellate is well established, there is currently little information available on its distribution and the environmental factors that influence this distribution. Thus, to investigate the spatial and seasonal distributions of the vegetative cells of B. adriatica in Korean waters, surface water samples were collected on a seasonal basis from 28 stations in the East, West, and South Sea of Korea and Jeju Island from April 2015 to October 2018, and abundances of the vegetative cells of B. adriatica were quantified using quantitative real-time polymerase chain reactions, for which we developed the species-specific primer and probe set. Simultaneously, major environmental parameters, including temperature, salinity, nutrient concentrations, and dissolved oxygen concentrations were measured. The vegetative cells of B. adriatica were detected at 20 of the 28 sampling stations: 19 stations in summer and 6 in autumn, although from no stations in either spring or winter. The ranges of water temperature and salinity at sites where this species was detected were $17.7-26.4^{\circ}C$ and 9.9-34.3, respectively, whereas those of nitrate and phosphate concentrations were not detectable-96.2 and $0.18-2.66{\mu}M$, respectively. Thus, the sites at which this species is found are characterized by a narrow range of temperature, but wide ranges of salinity and concentrations of nitrate and phosphate. The highest abundance of the vegetative cells of B. adriatica was $41.7cells\;mL^{-1}$, which was recorded in Jinhae Bay in July 2018. In Jinhae Bay, the abundance of vegetative cells was significantly positively correlated with the concentration of nitrate, but was negatively correlated with salinity. On the basis of these findings, it appears that the abundance of B. adriatica vegetative cells shows strong seasonality, and in Jinhae Bay, could be affected by the concentrations of nitrate.

• Journal of Wetlands Research
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• v.21 no.2
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• pp.114-124
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• 2019

The objective of this study is to reduce the uncertainty of the river discharge estimation method using the stage-discharge relation curve. It is necessary to consider the quantitative and accurate estimation method because the river discharge data is essential data for hydrological interpretation and water resource management. For this purpose, the parameters estimated by Bayesian and Bootstrap methods are compared with the ones obtained by stage-discharge relation curve. In addition, the Bayesian and Bootstrap methods are applied to assess uncertainty and then those are compared with the confidence intervals of the results from standard error method which has t-distribution. From the results of this study, The estimated value of the regression analysis developed through this study is less than 1 ~ 5%. Also It is confirmed that there are some areas where the applicability is better than the existing one according to the water level at each point. Therefore, if we use more suitable method according to the river characteristics, we could obtain more reliable discharge with less uncertainty.

• Journal of the Korean Society of Urban Environment
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• v.18 no.4
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• pp.547-555
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• 2018

In addition to North America and Europe, Korea is also responding to the toxic damage caused by the production and distribution of chemicals. Methods for assessing bio-toxicity of harmful substances have been widely introduced, but it is required of quantitative and speedy information for modeling. For 6 heavy metals, as zinc, copper, chrome, cadmium, mercury and lead, bio-toxicity assessment and kinetics model were constructed using Vibrio fischeri which is widely used luminous bacteria. The degree of luminescence activity and the toxicity of heavy metals were relative limunescence unit, RLU measured as by using a photomultiplier embedded device. The toxicity was assessed by the concentration levels giving under 20% lethality and lethal concentration, $EC_{50}$. In the results, the toxicity order were followed from mercury, lead, copper, chrome, zinc and cadmium. $EC_{{50},{\infty}}$ obtained by trends of $EC_{50}$ by time follows had highly linear agreement with main parameters of bio-toxicity modelling. The average error rates of the reproduced lethality obtained from DAM and TDM model on the basis of body residue, were 10.2% for mercury, lead, copper, chrome and 20.0 for the all 6 methals.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.1
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• pp.3-14
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• 2018

An apartment complex is a building use with great potential to contribute to solving problems related to urban ecological environment and climate change. The first goal of this study is to grasp the current situation of application and limitations of the ecological area rate, which is a representative evaluation index used to evaluate the environmental performance of the external space of an apartment complex in Green Standard for Energy and Environmental Design (G-SEED). The second goal is to propose a prototype of the evaluation index for evaluating greenhouse gas (GHG) reduction performance in order to supplement the evaluation index for the environmental performance of the external space in terms of response to climate change. We analyzed 43 cases of apartment complexes certified according to G-SEED, which was enforced since July 1, 2010, and found application characteristics of each space type and the limitations of ecological area rate. We analyzed overseas green building certification systems such as LEED and BREEAM that derived implications for supplementing the limitations of ecological area rate, which is focused on the evaluation of soil and water circulation function, and set up a development direction of complementary measures. Through analysis of previous studies, relevant regulations and standards, and technical documents of the manufacturer, the heat island mitigation performance of the pavement and roof surfaces of the apartment complex and the carbon uptake performance of the trees in the apartment complex was selected as parameters to yield the GHG reduction performance of the external space of the apartment complex. Finally, a quantitative evaluation method for each parameter and a prototype of the evaluation index for the GHG reduction performance were proposed. As a result of applying the prototype to an apartment complex case, the possibility of adoption and applicability as an evaluation index of G-SEED were proved.

• Journal of the Korean Society of Radiology
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• v.14 no.7
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• pp.965-973
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• 2020

The purpose of this study was to quantitatively correlate the change of flow velocity and signal voiding in TOF-MRA. We made our phantom to control the flow velocity, and changed the flow velocity in 16 steps from 8.0 to 127.3 mc/s. The TOF-MRA test was performed using a 3.0T MRI system and the signal intensity was measured by classifying the signal voiding length and image into the In flow, Mid flow, and Out flow. The length of signal voiding was the longest when the flow velocity was 127.3 cm/s and the signal intensity decreased with increasing flow velocity(p<0.05). In flow(-.547) and Mid flow(-.643) were negatively correlated with flow velocitys(p<0.05). In conclusion, it was confirmed that the increase in flow velocity was a major factor causing signal voiding in TOF-MRA. In the future, this study will provide basic data when studying sequences and parameters to reduce signal voiding in models with a high flow velocity.

• Animal Bioscience
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• v.34 no.4
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• pp.662-669
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• 2021

Objective: Effects of linseed oil (LO) supplementation on the fat content and fatty acid profile of breast meat, and the expression of three genes in the liver, breast muscle and fat tissues of commercial 154-day-old hybrid male turkeys were investigated. Methods: The animals in the control group were fed a commercially available feed and received no LO supplementation (n = 70), whereas animals in the LO group (n = 70) were fed the same basic diet supplemented with LO (day 15 to 21, 0.5%; day 22 to 112, 1%). The effect of dietary LO supplementation on fatty acid composition of breast muscle was examined by gas chromatography, and the expression of fatty acid desaturase 2 (FADS2), peroxisome proliferator activated receptor gamma (PPARγ), and insulin-like growth factor 1 (IGF1) genes was analysed by means of quantitative reverse transcription polymerase chain reaction. Results: The LO supplementation affected the fatty acid composition of breast muscle. Hepatic FADS2 levels were considerably lower (p<0.001), while adipose tissue expression was higher (p<0.05) in the control compared to the LO group. The PPARγ expression was lower (p<0.05), whereas IGF1 was higher (p<0.05) in the fat of control animals. There were no significant (p>0.05) differences in FADS2, PPARγ, and IGF1 gene expressions of breast muscle; however, omega-6/omega-3 ratio of breast muscle substantially decreased (p<0.001) in the LO group compared to control. Conclusion: Fatty acid composition of breast meat was positively influenced by LO supplementation without deterioration of fattening parameters. Remarkably, increased FADS2 expression in the liver of LO supplemented animals was associated with a significantly decreased omega-6/omega-3 ratio, providing a potentially healthier meat product for human consumption. Increased PPARγ expression in fat tissue of the LO group was not associated with fat content of muscle, whereas a decreased IGF1 expression in fat tissue was associated with a trend of decreasing fat content in muscle of the experimental LO group.

• Journal of Korea Water Resources Association
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• v.55 no.3
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• pp.245-255
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• 2022

Evaluating the qualitative the qualitative process of water resources by using various indicators, as one of the most prevalent methods for optimal managing of water bodies, is necessary for having one regular plan for protection of water quality. In this study, zoning maps were developed on a yearly basis by collecting and reviewing the process, validating, and performing statistical tests on qualitative parameters҆ data of the Iranian aquifers from 1995 to 2020 using Geographic Information System (GIS), and based on Inverse Distance Weighting (IDW), Radial Basic Function (RBF), and Global Polynomial Interpolation (GPI) methods and Kriging and Co-Kriging techniques in three types including simple, ordinary, and universal. Then, minimum uncertainty and zoning error in addition to proximity for ASE and RMSE amount, was selected as the optimum model. Afterwards, the selected model was zoned by using Scholar and Wilcox. General evaluation of groundwater situation of Iran, revealed that 59.70 and 39.86% of the resources are classified into the class of unsuitable for agricultural and drinking purposes, respectively indicating the crisis of groundwater quality in Iran. Finally, for validating the extracted results, spatial changes in water quality were evaluated using the Groundwater Quality Index (GWQI), indicating high sensitivity of aquifers to small quantitative changes in water level in addition to severe shortage of groundwater reserves in Iran.