• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.331-338
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• 2006

A rapid, selective and sensitive reverse-phase HPLC methods for the determination of atenolol and chlorthalidone in human serum and whole blood were validated, and applied to the pharmacokinetic study of atenolol and chlorthalidone combination therapy. Atenolol and an internal standard, pindolol, were extracted from human serum by liquid-liquid extraction, and analyzed on a $\mu$-Bondapak C18 $10-{\mu}$ column in a mobile phase of methanol-0.01 M potassium dihydrogenphosphate(30:70, v/v, adjusted to pH 3.5) and fluorescence detection(emission: 300 nm, excitation: 224 nm). Chlorthalidone and an internal standard, probenecid, were extracted form human whole blood by liquid-liquid extraction, and analyzed on a Luna C18 $5-{\mu}$ column in a mobile phase of acetonitrile containing 77% 0.01 M sodium acetate and UV detection at 214 nm. These analysis were performed at three different laboratories using the same quality control(QC) samples. The chromatograms showed good resolution, sensitivity, and no interference by human serum and whole blood, respectively. The methods showed linear responses over a concentration range of 10-1,000 ng/mL for atenolol and 0.05-20 ${\mu}g/mL$ for chlorthalidone, with correlation coefficients of greater than 0.999 at all the three laboratories. Intra- and inter-day assay precision and accuracy fulfilled international requirements. Stability studies(freeze-thaw, short-, long-term, extracted sample and stock solution) showed that atenolol and chlorthalidone were stable. The lower limit of quantitation of atenolol and chlorthalidone were 10 ng/mL and 0.05 ${\mu}g/mL$, respectively, which was sensitive enough for pharmacokinetic studies. These methods were applied to the pharmacokinetic study of atenolol and chlorthalidone in human volunteers following a single oral administration of Hyundai $Tenoretic^{\circledR}$ tablet(atenolol 50 mg and chlorthalidone 12.5 mg) at three different laboratories.

• Journal of Korean Society of Environmental Engineers
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• v.28 no.3
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• pp.270-275
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• 2006

The cultivated pearls collected for the study were pretreated through the removal of contaminants and the surface bleaching for easy dyeing. Coloring of pearls are necessary after selecting dyes adsorbable to the Conchiolin layer, a kind of hard protein formed in the seawater, covering the surface of the pretreated pearls. Dyes adsorbable to the Conchiolin layers are mostly basic dyes such as Rhodamine 6G(R6G), Rhodamine B(RB), Methylene Blue(MB) etc. and the binary and ternary competitive adsorption were performed by mixing two or three dyes together. The multi-dye adsorption data were compared with the predictions from the ideal adsorbed solution theory(IASI) combined with the single-dye adsorption model, the Langmuir or the Redlich-Peterson(RP) model. The quality of prediction was compared by using determination coefficient($R^2$) and standard deviation(SSE) values. Predictions from the IAST were found to be in good agreement with the data for the R6G/RB binary adsorption to the pearl layers not fractionated with their size, except for the adsorption data for RB at high concentrations. Among the three binary adsorption systems, R6G/RB, R6G/MB, and MB/RB, only the RB sorption data in the R6G/RB binary system was in poor agreement with the IAST prediction. Competitive adsorption data in ternay systems were in good agreement with the predictions from the IAST except for the RB data.

• Journal of Korean Academy of Nursing
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• v.20 no.1
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• pp.16-37
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• 1990

A cost analysis for hospitalized patients was carried out based upon Patient Classification System(PCS) in order to determine an appropriate nursing fee. The data were collected from 21 nursing units of three teaching hospitals from April 1 to June 30, 1989. first, all of the 22,056 inpatients were classified into mildly ill(Class Ⅰ), moderately ill(Class Ⅱ), acutely ill(Class Ⅲ), and critically ill(Class Ⅳ) by the PCS which had been carefully developed to be suitable for the Korean nursing units. Second. PCS cost accounting was applied to the above data. The distribution of inpatients, nursing costs, and nursing productivity were as follows : 1) Patient distribution ranged from 45% to class Ⅰ, 36% to class Ⅱ, 15% to class Ⅲ, and 4% to class Ⅳ, the proportion of class Ⅳ in ‘H’ Hospital was greater than that of the other two hospitals. 2) The proportion of Class Ⅲ and Ⅳ in the medical nursing units was greater than that of surgical nursing units. 3) The number of inpatients was greatest on Tuesdays, and least on Sundays. 4) The average nursing cost per hour was W 3,164 for ‘S’ hospital, W 3,511 for ‘H’ hospital and W 4,824 for ‘K’ hospital. The average nursing cost per patient per day was W 14,126 for ‘S’ Hospital, W 15,842 for ‘H’ hospital and W 21,525 for ‘K’ hospital. 5) The average nursing cost calculated by the PCS was W 13,232 for class Ⅰ, W 18,478 for class Ⅱ, W 23,000 for class Ⅲ, and W 25,469 for class Ⅳ. 6) The average nursing cost for the medical and surgical nursing units was W 13,180 and W 13,303 respetively for class Ⅰ, W 18,248 and W 18,707 for class Ⅱ, W 22,303 and W 23,696 for class Ⅲ, and W 24,331 and W 26,606 for class Ⅳ. 7) The nursing costs were composed of 85% for wages and fringe benefits, 3% for material supplies and 12% for overhead. The proportion of wages and fringe benefits among the three Hospitals ranged from 75%, 92% and 98% for the ‘S’, ‘H’, ‘K’ hospitals respectively These findings explain why the average nursing cost of ‘K’ hospital was higher than the others. 8) According to a multi- regression analysis, wages and fringe benefits, material supplies, and overhead had an equal influence on determining the nursing cost while the nursing hours had less influence. 9) The productivity of the medical nursing units were higher than the surgical nursing units, productivity of the D(TS) - nursing units was the lowest while the K(Med) - nursing unit was the highest in 'S' hospital. In ‘H’ hospital, productivity was related to the number of inpatients rather than to the characteristics of the nursing units. The ‘K’ hospital showed the same trend as ‘S’ hospital, that the productivity of the medical nursing unit was higher than the surgical nursing unit. The productivity of ‘S’ hospital was evaluated the highest followed by ‘H’ hospital and ‘K’ hospital. Future research on nursing costs should be extended to the other special nursing areas such as pediatric and psychiatric nursing units, and to ICU or operating rooms. Further, the PCS tool should be carefully evaluated for its appropriateness to all levels of institutions(primary, secondary, tertiary). This study took account only of the quantity of nursing services when developing the PCS tool for evaluating the productivity of nursing units. Future research should also consider the quality of nursing services including the appropriateness of nursing activities.

• Spatial Information Research
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• v.17 no.3
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• pp.397-404
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• 2009

To solve the problems of distribution and quality on land gravity data, airborne gravity survey was performed in 2008 obtaining the airborne gravity data with accuracy of 1.56mGal. Since airborne gravity data is the obtained at the flight height, it is necessary to convert the airborne gravity data to the surface to combine various gravity data and compute precision geoid. In addition, Stokes' integral radius, Stokes' kernel and the radius of terrain effect computation should be optimally determined to calculate precision geoid. In this study, we made an effort to decide the optimal parameters based on the distribution and the characteristic of gravity data. Then, two geoid models were calculated using the selected parameters and the difference of geoid was calculated with mean of -16.95cm and the standard deviation of ${\pm}8.50cm$. We consider that this difference is due to the distribution and errors on the gravity data. For future work, the study on the effect of geoid with newly obtained land gravity data ship-borne gravity data and GPS/Leveling data should be conducted. Furthermore, the study on the downward continuation and terran effect calculation should be studied in detail for better precision geoid construction.

• Korean Business Review
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• v.13
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• pp.179-193
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• 2000

It is not simple to manage software quality, because software development process and product itself are very complex. Recently ISO/IEC 15504- international standard for software process improvement, capability determination and development - was completed and applied to many local trials, and their results are being reported as registered local trials. The first step of software process assessment is established by examining whether its base practices are performed and which level they are achieved. And as far as assessment responsibility and credibility are concerned, assessment is generally performed by team-based assessors. Therefore assessment team construction and its preference of practice importances have a great effect on the credibility and the objectivity of assessment. In this paper, we analyse a SPICE-based software process assessment trial by comparing base practice importances of assessed processes, which are expressed through a real assessment, with its final rating results. Survey data are collected from assessors and interviewees who were engaged in the SPICE trial that was performed by ISO/IEC 15504, and final data analysis are derived from the factor analysis method. It is convinced that the result of this paper is able to enhance the credibility of software process assessment by provisions of objective and rational criteria and preference information for assessment team construction and base practice importances in future.

• Korean Journal of Food Science and Technology
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• v.14 no.4
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• pp.364-369
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• 1982

Two varieties of potatoes, Irish cobbler and Shimabara stored for seven and nine months respectively by irradiation combined with natural low temperature (year-round temperature change:$2{\sim}17^{\circ}C)$ on a batch scale were investigated on the suitability for processing of potato chip. Nine months after storage, irradiated potatoes (Irish cobbler) tended to maintain somewhat-better texture and sensory quality than untreated in potato chip processing. Peel rate, closely related to potato chip yield, of untreated potatoes were $20{\sim}25%$ higher than those of irradiated and Agtron color determination of potato chip from both irradiated were commercially acceptable. Preservation of potatoes by irradiation combined with natural low temperature was evaluated as an alternative method of the supply for raw materials of potato chip processing in the off season in Korea.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.2
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• pp.139-147
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• 2009

The gravity data collected and reserved in Korea is seriously biased in its distribution. That is, only the west-southern part of the peninsula including Chungcheong and Jeonla area has dense distribution while only a part is covered in Gyoungsang area. Especially, the low density of the gravity data in mountainous area basically limits the accuracy of the gravimetric geoid in Korea. As one of the solution to overcome the problem, an airborne gravity survey were conducted from Dec. 2008 $\sim$ Jan. 2009. In this study, free-air gravity anomaly derived from the airborne gravity data which has consistent quality are presented. The data processing for the airborne gravity is composed of several corrections of errors such as errors from gravity measurement, errors from flight dynamics, errors from GPS, and errors from time synchronization. We presented detailed explanations on the data processing with the final cross-over results. The free-air anomaly from airborne gravity finally shows the cross-over accuracy of 2.21mGal which reflects the precision of each track is 1.56mGal. It is expected that the result from this study will play a role as input data in precision geoid determination with ground and ship-borne gravity data after appropriate fusion process.

• KSBB Journal
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• v.22 no.6
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• pp.438-442
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• 2007

A biosensor using electrochemically-active bacteria (EAB) enriched in three-electrode electrochemical cell, was developed for the determination of biochemical oxygen demand (BOD) in wastewater. In the electrochemical cell, the positively poised working electrode with applying a potential of 0.7 V was used as an electron acceptor for the EAB. The experimental results using artificial and raw wastewater showed that the current pattern generated by the biosensor and its Coulombic yield were proportional to the concentration of organic matter in wastewater. The correlation coefficients of BOD vs Coulombic yield and $BOD_5$ vs Coulombic yield were 0.99 and 0.98, respectively. These results indicate that the biosensor enriched with the EAB capable of transferring electrons directly toward the electrode can be utilized as a water-quality monitoring system due to a quick and accurate response.

• Journal of Korean Society for Atmospheric Environment
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• v.24 no.1
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• pp.16-29
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• 2008

Nitrous acid (HONO) can be produced by heterogenous reactions of nitrogen dioxide on surface materials and direct emission from combustion sources. However, a little is known of indoor HONO levels or the relationship between residential HONO, NO, and $NO_2$ concentrations in occupied houses. Therefore, we measured simultaneously NO, $NO_2$, and HONO concentrations in living room of an apartment using continuous analyzers to study the production of HONO (June $22{\sim}30$, 2006). The 4-min average concentrations of indoor NO, $NO_2$, and HONO were 4.3 (range: $0.4{\sim}214.3$), 10.3 ($2.0{\sim}87.3$), and 1.8 ppb ($0.3{\sim}7.7$), respectively. Peak levels of HONO up to 7.7 ppb and 24-hr averages as high as 1.7 ppb were measured. In agreement with previous studies, indoor HONO concentrations increased during operation of an unvented gas range. Examination of the observed kinetics suggests that the secondary production of indoor HONO, possibly as a result of heterogeneous reactions involving $NO_2$ and $H_2O$ is associated with $[NO_2]^2[H_2O]\;(r^2=0.88)$ rather than with $[NO][NO_2][H_2O]\;(r^2=0.75)$. Three combustion experiments at nighttime were also carried out to investigate the effects of vented combustion on the HONO, NO, and $NO_2$ concentrations. It was found to release HONO for $10{\sim}15$ minutes after NO and $NO_2$ source was turned off, and peak values were finally attained. Compared to unvented combustion, peak $NO_2$ and HONO concentrations were 3.2 and 2.0 times lower at weak vented combustion (air flow: $340\;m^3/hr$) and 4.9 and 2.4 times lower at strong vented combustion (air flow: $540\;m^3/hr$), respectively, emphasizing importance of operating ventilation hood fan during combustion to improve indoor air quality.

• Journal of Embryo Transfer
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• v.18 no.3
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• pp.203-213
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• 2003

Examination of correlation between blood compositions and economic traits is very important to improve selection accuracy and predict performance ability of Hanwoo, which may be impacted into the determination of feeding management as well as marketing places. This study was aimed to provide possible procedures of Hanwoo improvement as of early individual selection based on the phenotypic correlation between blood compositions and economic traits using 866 of Hanwoo managed at National Livestock Research Institute. Phenotypic correlation between blood compositions and economic traits was estimated for steer and bulls. BUN in steer and albumin and IGF-1 in bull were highly correlated with 24 mo of weight. Average daily gain of 21 to 24 mo was highly correlated with calcium in steer and albumin in bull. Back-fat thickness and marbling score were highly correlated with BUN in steer and bull, and meat yield index was highly correlated with calcium in steer and testosterone in bull. However, BUN, which is highly correlated with meat quality, was negatively correlated with meat yield index in steer and bull.