• Title/Summary/Keyword: Q&A

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A Generic Craig Form for the Two-Dimensional Gaussian Q-Function

  • Park, Seung-Keun;Choi, U-Jin
    • ETRI Journal
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    • v.29 no.4
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    • pp.516-517
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    • 2007
  • In this letter we present a generic Craig form for the two-dimensional (2-D) Gaussian Q-function. The presented Craig form provides an alternative solution to the problems of computing probabilities involving a form of the 2-D Gaussian Q-function.

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UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53

  • Shafiee, Sayed Mohammad;Rasti, Mozhgan;Seghatoleslam, Atefeh;Azimi, Tayebeh;Owji, Ali Akbar
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.9
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    • pp.3723-3727
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    • 2015
  • The p53 tumor suppressor protein is a principal mediator of growth arrest, senescence, and apoptosis in response to a broad array of cellular damage. p53 is a substrate for the ubiquitin-proteasome system, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiquitination have not been well studied. UBE2Q1 is a novel E2 ubiquitin conjugating enzyme gene. Here, we investigated the effect of UBE2Q1 overexpression on the level of p53 in the MDA-MB-468 breast cancer cell line as well as the interaction between UBE2Q1 and p53. By using a lipofection method, the p53 mutated breast cancer cell line, MDA-MB-468, was transfected with the vector pCMV6-AN-GFP, containing UBE2Q1 ORF. Western blot analysis was employed to verify the overexpression of UBE2Q1 in MDA-MB-468 cells and to evaluate the expression level of p53 before and after cell transfection. Immunoprecipitation and GST pull-down protocols were used to investigate the binding of UBE2Q1 to p53. We established MDA-MB-468 cells that transiently expressed a GFP fusion proteins containing UBE2Q1 (GFP-UBE2Q1). Western blot analysis revealed that levels of p53 were markedly lower in UBE2Q1 transfected MDA-MB-468 cells as compared with control MDA-MB-468 cells. Both in vivo and in vitro data showed that UBE2Q1 co-precipitated with p53 protein. Our data for the first time showed that overexpression of UBE2Q1can lead to the repression of p53 in MDA-MB-468 cells. This repression of p53 may be due to its UBE2Q1 mediated ubiquitination and subsequent proteasome degradation, a process that may involve direct interaction of UBE2Q1with p53.

ON SOME PROPERTIES OF PRETOPOLOGICAL CONVERGENCE STRUCTURES

  • Park, Sang-Ho;Kang, Myeong-Jo
    • East Asian mathematical journal
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    • v.17 no.1
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    • pp.47-56
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    • 2001
  • In this paper we introduce generalized q-interior operator and n-th pretopological modification of q. Furthermore we establish a characterization of ${\pi}_n(q)=\lambda(q)$.

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Safety, High Quality, Confidence of Kaneka CoQ10

  • Fujii, Kenji
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2006.11a
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    • pp.139-145
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    • 2006
  • Kaneka Corporation (Kaneka) has been manufacturing CoQ10 under GMP regulation since 1977. Kaneka has a sophisticated quality control system and has been supplying high quality CoQ10 materials to the worldwide customers (Kaneka CoQ10) for about 30 years. Kaneka CoQ10 is characterized by a lot of safety data, which are derived from clinical trials with healthy volunteers (single-dose and 4-week multi-dose safety studies), animal studies (13-week sub-chronic study in dogs and 52-week chronic study in rats), three types of mutagenicity test, six type of skin irritation test (for cosmetics), and others. The risk assessment of CoQ10 was performed by Council for Responsible Nutrition (USA). They reviewed many of available clinical data including clinical trials using Kaneka Q10, and concluded that the upper level for supplements (ULS) of CoQ10 is 1,200 mg/day (Hathcock and Shao. 2006, Regulatory Toxicology and Pharmacology, 45, 282 - 288).

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CRITICAL FUJITA EXPONENT FOR A FAST DIFFUSIVE EQUATION WITH VARIABLE COEFFICIENTS

  • Li, Zhongping;Mu, Chunlai;Du, Wanjuan
    • Bulletin of the Korean Mathematical Society
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    • v.50 no.1
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    • pp.105-116
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    • 2013
  • In this paper, we consider the positive solution to a Cauchy problem in $\mathbb{B}^N$ of the fast diffusive equation: ${\mid}x{\mid}^mu_t={div}(\mid{\nabla}u{\mid}^{p-2}{\nabla}u)+{\mid}x{\mid}^nu^q$, with nontrivial, nonnegative initial data. Here $\frac{2N+m}{N+m+1}$ < $p$ < 2, $q$ > 1 and 0 < $m{\leq}n$ < $qm+N(q-1)$. We prove that $q_c=p-1{\frac{p+n}{N+m}}$ is the critical Fujita exponent. That is, if 1 < $q{\leq}q_c$, then every positive solution blows up in finite time, but for $q$ > $q_c$, there exist both global and non-global solutions to the problem.

SOME RESULTS ON D-ADMISSIBLE (Є, Є Vq)-Fuzzy SUBGROUPS

  • Kim, Dae-Sig
    • Bulletin of the Korean Mathematical Society
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    • v.41 no.4
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    • pp.723-730
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    • 2004
  • The definition of a D-admissible fuzzy subset for an operator domain D on a group G is modified to obtain new kinds of (${\in},\;{\in}\;{\vee}q$)-fuzzy subgroups such as an (${\in},\;{\in}\;{\vee}q$)-fuzzy normal subgroup, an (<${\in},\;{\in}\;{\vee}q$)-fuzzy characteristic subgroup, an (<${\in},\;{\in}\;{\vee}q$)-fuzzy fully invariant subgroup which are invariant under D. As results, some of the fundamental properties of such (${\in},\;{\in}\;{\vee}q$)-fuzzy subgroups are obtained.

A q-ANALOGUE OF QI FORMULA FOR r-DOWLING NUMBERS

  • Cillar, Joy Antonette D.;Corcino, Roberto B.
    • Communications of the Korean Mathematical Society
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    • v.35 no.1
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    • pp.21-41
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    • 2020
  • In this paper, we establish an explicit formula for r-Dowling numbers in terms of r-Whitney Lah and r-Whitney numbers of the second kind. This is a generalization of the Qi formula for Bell numbers in terms of Lah and Stirling numbers of the second kind. Moreover, we define the q, r-Dowling numbers, q, r-Whitney Lah numbers and q, r-Whitney numbers of the first kind and obtain several fundamental properties of these numbers such as orthogonality and inverse relations, recurrence relations, and generating functions. Hence, we derive an analogous Qi formula for q, r-Dowling numbers expressed in terms of q, r-Whitney Lah numbers and q, r-Whitney numbers of the second kind.