• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.1
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• pp.94-99
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• 2007

Many cases of acute cardiac shock and cardiac arrest in emergency room and ICU have been increasing. In this case, ECMO with centrifugal pump has been used generally. However, due to the heavy weight and big size, the system is not adequate for emergency cases. And other defects of this system are that membrane oxygenator's pressure is high and blood are exposed to the air. There was some tries of ECMO using pulsatile pump, but it was found that the weak point of these system is high peak pressure and hemolysis. The mechanism of twin pulsatile pump is that Membrane oxygenator Outlet Pump(MOP) make negative pressure when Membrane oxygenator Inlet Pump(MIP) provides high positive pressure, and the negative pressure will decrease positive pressure of Membrane Oxygenator. Our group analyzed this advantage through In-Vitro and 12 Cases In-Vivo test.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.4
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• pp.22-28
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• 2013

It is important to begin left ventricular assist device (LVAD) treatment at appropriate time for heart failure patients who expect cardiac recovery after the therapy. In order to predict the optimal timing of LVAD implantation, we predicted pumping efficacy of LVAD according to the severity of heart failure theoretically. We used LVAD-implanted cardiovascular system model which consist of 8 Windkessel compartments for the simulation study. The time-varying compliance theory was used to simulate ventricular pumping function in the model. The ventricular systolic dysfunction was implemented by increasing the end-systolic ventricular compliance. Using the mathematical model, we predicted cardiac responses such as left ventricular peak pressure, cardiac output, ejection fraction, and stroke work according to the severity of ventricular systolic dysfunction under the treatments of continuous and pulsatile LVAD. Left ventricular peak pressure, which indicates the ventricular loading condition, decreased maximally at the 1st level heart-failure under pulsatile LVAD therapy and 2nd level heart-failure under continuous LVAD therapy. We conclude that optimal timing for pulsatile LVAD treatment is 1st level heart-failure and for continuous LVAD treatment is 2nd level heart-failure when considering LVAD treatment as "bridge to recovery".

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.9 no.4
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• pp.561-571
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• 1997

In this paper, the fundamental equations are developed for the pulsatile laminar flow generated by changing the oscillatory flow with $0{\leq}f{\leq}48Hz$ into a steady one with $0{\leq}Re{\leq}2500$ in a rigid circular pipe. Analytical solutions for the wave propagation factor k, the axial distributions of cross-sectional mean velocity $u_m$ and pressure p are schematically derived and confirmed experimentally. The axial distributions of centerline velocity and pressure were measured by using Pitot-static tubes and strain gauge type pressure transducers, respectively. The cross-sectional mean velocity was calculated from the centerline velocity by applying the parabolic distribution of the laminar flow and it was confirmed by using the ultrasonic flowmeter. It was found that the axial distributions of cross-sectional mean velocity and pressure agree well with theoretical ones and depend only on the Reynolds number Re and angular velocity $\omega$.

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.337-341
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• 2005

Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.

• Korea-Australia Rheology Journal
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• v.20 no.4
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• pp.189-196
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• 2008

The pulsatile flow of blood through a stenosed artery under the influence of external periodic body acceleration is studied. The effect of non-Newtonian nature of blood in small blood vessels has been taken into account by modeling blood as a Casson fluid. The non-linear coupled equations governing the flow are solved using perturbation analysis assuming that the Womersley frequency parameter is small which is valid for physiological situations in small blood vessels. The effect of pulsatility, stenosis, body acceleration, yield stress of the fluid and pressure gradient on the yield plane locations, velocity distribution, flow rate, shear stress and frictional resistance are investigated. It is noticed that the effect of yield stress and stenosis is to reduce flow rate and increase flow resistance. The impact of body acceleration is to enhance the flow rate and reduces resistance to flow.

• The Journal of the Acoustical Society of Korea
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• v.36 no.5
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• pp.361-369
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• 2017

Hemodynamic information in the carotid artery bifurcation is very important for understanding the development and progression mechanisms of cerebrovascular disease and for its early diagnosis and prediction of the progress. In this paper, we constructed a mock pulsatile blood circulation system using an anthropomorphic elastic vessel of the carotid artery bifurcation and ex vivo pig blood to acquire ultrasound images from blood and vessels synchronized with internal pressure while controlling the blood flow. Echogenicity, blood flow velocity, and blood vessel wall motion from the ultrasound images, and internal blood pressure were extracted over a cycle averaged from five cycles when the pulsatile pump rates are 20 r/min, 40 r/min, and 60 r/min. As a result, respectively, the peak systolic blood flow velocities were 20 cm/s, 25 cm/s, and 40 cm/s, the blood pressure differences were 30 mmHg, 70 mmHg, and 85 mmHg, the arterial walls were expanded to 0.05 mm, 0.15 mm, and 0.25 mm. Time-delayed cyclic variation of echogenicity compared to blood flow and pressure was observed, but the variation was minimal at 20 r/min. Time-synchronized cyclic variations of these parameters are important information for accurate input parameters and validation of the computational hemodynamic experiments which will provide useful information for the development and progress mechanisms of carotid artery stenosis.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.11
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• pp.891-896
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• 2008

In the present computational study, simple stenotic artery models using pulsatile flow condition were investigated. A 1 Hz non-reversing sinusoidal velocity for pulsatile flow was imposed at the flow inlet and the corresponding Womersley number based on the vessel radius is 2.75. The simple stenotic geometries have been used that consist of 25%, 50% and 75% semicircular constriction in a cylindrical tube. In this paper, numerical solutions are presented for a first harmonic oscillatory flow using commercial software ADINA 8.4. As stenosis and Reynolds number increase, the maximum wall shear stress(WSS) increases while the minimum WSS decreases. As the stenotic rate increases, the pressure drop at the throat severely decreases to collapse the artery and plaque. It is found that the fluid mechanical disturbances due to the constriction were highly sensitive with rate of stenosis and Reynolds number. When Reynolds number and stenosis increase, the larger recirculation region exists. In this recirculation region the possibility of plaque attachment is increasingly higher. The present results enhance our understanding of the hemodynamics of a stenotic artery.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.11
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• pp.3607-3619
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• 1996

Experimental and numerical studies for three-dimensional pulsatile flows are conducted to investigate the flow characteristics in the bifurcated tubes. Velocity measurements in experimental study were made by both Pulsed Doppler Ultrasound(PDU) machine and Laser Doppler Anemometer(LDA) system. Glycerin is used for experimental study. Experimental results are used to verify the results of the numerical simulation. Flow characteristics of Newtonian fluid and blood in the bifurcated tubes under the steady and pulsatlie flows are numerically investigated. Finite volume method is employed for three-dimensional numerical simulations. Blood is considered as a non-Newtonian fluid and the constitutive equation of blood is used for the numerical analysis. Numerical analyses are focused on the flow patterns for various branch angles ranging from 30.deg. to 90.deg. and diameter ratios such as 1.0, 0.8, and 0.6. Pulsatile flow characteristics of blood are compared with those of Newtonian fluid. Parameter effects on axial velocity, pressure and wall shear stress distribution along the bifurcated tubes are discussed in terms of the branch angle, diameter ratio, and Reynolds number.

• Journal of Biomedical Engineering Research
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• v.29 no.5
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• pp.376-383
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• 2008

High-flux dialysis treatment removes various toxins via diffusion as well as convection, which is induced by ultrafiltration and backfiltration. In this study, in vitro (Using the distilled water and the bovine's blood) comparison test was performed to determine whether utilization of a high flux dialyzer paired with different pumps would increase the efficiency of convection. At the same blood flow rates, a pulsatile pump and a roller pump were employed to propel the distilled water and bovine whole blood to a high flux dialyzer. Pressures at the dialyzer inlet and outlet in the blood circuit and in the dialysate circuit were measured, respectively. From these data, we calculated the transmembrane pressure and predicted the ultrafiltration and backfiltration rates developed by both pumps. Using the bovine's blood experiment, ultrafiltration and backfiltration rates were 1.6 times higher with the pulsatile pump than with the roller pump. We conclude that utilization of a pulsatile pump in high flux hemodialysis treatments increases ultrafiltration volume, compared with a roller pump under conditions of the same blood flow rate.

• Journal of Sensor Science and Technology
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• v.9 no.1
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• pp.51-60
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• 2000

This paper outlines the development of a non-pulsatile axial flow type blood pump control system. By utilizing blood pressure and heart rate, this system can assist the left ventricle in controlling blood pressure and blood volume. The system is comprised of a blood pump, signal sensor, signal interface, and signal-processing component. A control algorithm is also proposed which can control non-pulsatile, continuous blood flow in the human circulatory system. To facilitate the control required for non-pulsatile blood pump in a physiological system, an experimental control rule was developed utilizing ECG and blood pressure data, both of which are easily detectable variables in the body. The system was then tested using a mock-up circulation system and we found that it is possible that this systems could be temporarily used in clinic.