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http://dx.doi.org/10.9718/JBER.2008.29.5.376

Improvement of Convection by Pulsatile Blood Pump in High Flux Hemodialysis System  

Choi, D.S. (Department of Biomedical Engineering, College of Medicine, Seoul National University)
Um, K.M. (Department of Mechanics & Biomedical Engineering, Kangwon National University)
Lee, J.C. (Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University)
Lee, S.R. (Korea Artificial Organ Center, Korea University)
Mun, C.H. (Korea Artificial Organ Center, Korea University)
Choi, H. (Korea Artificial Organ Center, Korea University)
Min, B.G. (BHK. CO., Ltd.)
Kim, H.C. (Department of Biomedical Engineering, College of Medicine, Seoul National University)
Publication Information
Journal of Biomedical Engineering Research / v.29, no.5, 2008 , pp. 376-383 More about this Journal
Abstract
High-flux dialysis treatment removes various toxins via diffusion as well as convection, which is induced by ultrafiltration and backfiltration. In this study, in vitro (Using the distilled water and the bovine's blood) comparison test was performed to determine whether utilization of a high flux dialyzer paired with different pumps would increase the efficiency of convection. At the same blood flow rates, a pulsatile pump and a roller pump were employed to propel the distilled water and bovine whole blood to a high flux dialyzer. Pressures at the dialyzer inlet and outlet in the blood circuit and in the dialysate circuit were measured, respectively. From these data, we calculated the transmembrane pressure and predicted the ultrafiltration and backfiltration rates developed by both pumps. Using the bovine's blood experiment, ultrafiltration and backfiltration rates were 1.6 times higher with the pulsatile pump than with the roller pump. We conclude that utilization of a pulsatile pump in high flux hemodialysis treatments increases ultrafiltration volume, compared with a roller pump under conditions of the same blood flow rate.
Keywords
High-flux dialysis; diffusion; convection; ultrafiltration; backfiltration; In vitro; pulsatile pump; roller pump;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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