Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Improvement of Convection by Pulsatile Blood Pump in High Flux Hemodialysis System

고 유량 혈액 투석 시스템에서 박동류 펌프에 대한 대류 향상에 관한 연구

  • Choi, D.S. (Department of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Um, K.M. (Department of Mechanics & Biomedical Engineering, Kangwon National University) ;
  • Lee, J.C. (Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University) ;
  • Lee, S.R. (Korea Artificial Organ Center, Korea University) ;
  • Mun, C.H. (Korea Artificial Organ Center, Korea University) ;
  • Choi, H. (Korea Artificial Organ Center, Korea University) ;
  • Min, B.G. (BHK. CO., Ltd.) ;
  • Kim, H.C. (Department of Biomedical Engineering, College of Medicine, Seoul National University)
  • 최대석 (서울대학교 의과대학 의공학 교실) ;
  • 임기무 (강원대학교 기계의용공학과) ;
  • 이정찬 (서울대학교 의과대학 의학연구원) ;
  • 이사람 (한국인공장기센터, 고려대학교) ;
  • 문초혜 (한국인공장기센터, 고려대학교) ;
  • 최혁 (한국인공장기센터, 고려대학교) ;
  • 민병구 ((주)BHK) ;
  • 김희찬 (서울대학교 의과대학 의공학 교실)
  • Published : 2008.10.31
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Abstract

High-flux dialysis treatment removes various toxins via diffusion as well as convection, which is induced by ultrafiltration and backfiltration. In this study, in vitro (Using the distilled water and the bovine's blood) comparison test was performed to determine whether utilization of a high flux dialyzer paired with different pumps would increase the efficiency of convection. At the same blood flow rates, a pulsatile pump and a roller pump were employed to propel the distilled water and bovine whole blood to a high flux dialyzer. Pressures at the dialyzer inlet and outlet in the blood circuit and in the dialysate circuit were measured, respectively. From these data, we calculated the transmembrane pressure and predicted the ultrafiltration and backfiltration rates developed by both pumps. Using the bovine's blood experiment, ultrafiltration and backfiltration rates were 1.6 times higher with the pulsatile pump than with the roller pump. We conclude that utilization of a pulsatile pump in high flux hemodialysis treatments increases ultrafiltration volume, compared with a roller pump under conditions of the same blood flow rate.

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References

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