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The Effect of Pulsatile Flow on Ultrafiltration In-Vitro Study and Comparison with Roller Pump  

Lee K. (Interdisciplinary Program in Medical and Biomedical Engineering Major, Seoul National University, Institute of Medical Engineering, Medical Research Center, Seoul National University, Cancer Research Center, Seoul National University Hospital, Korea Artificial Organ Center, Korea University)
Jeong J. H. (Interdisciplinary Program in Medical and Biomedical Engineering Major, Seoul National University, Institute of Medical Engineering, Medical Research Center, Seoul National University, Cancer Research Center, Seoul National University Hospital, Korea Artificial Organ Center, Korea University)
Mun C. H. (Interdisciplinary Program in Medical and Biomedical Engineering Major, Seoul National University, Institute of Medical Engineering, Medical Research Center, Seoul National University, Cancer Research Center, Seoul National University Hospital, Korea Artificial Organ Center, Korea University)
Lee J. C. (Interdisciplinary Program in Medical and Biomedical Engineering Major, Seoul National University, Institute of Medical Engineering, Medical Research Center, Seoul National University, Cancer Research Center, Seoul National University Hospital, Korea Artificial Organ Center, Korea University)
Min B. G. (Department of Biomedical Engineering, College of Medicine, Seoul National University, Institute of Medical Engineering, Medical Research Center, Seoul National University, Cancer Research Center, Seoul National University Hospital, Korea Artificial Organ Center, Korea University)
Publication Information
Journal of Biomedical Engineering Research / v.26, no.5, 2005 , pp. 337-341 More about this Journal
Abstract
Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.
Keywords
Ultrafiltration; Pulsatile blood flow; TMP; Pulse frequency; Hemofiltration;
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