• Animal Bioscience
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• v.37 no.5
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• pp.807-816
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• 2024

Objective: This study aims to identify the significant regions and candidate genes of growth-related traits (adjusted backfat thickness [ABF], average daily gain [ADG], and days to 90 kg [DAYS90]) in Korean commercial GGP pig (Duroc, Landrace, and Yorkshire) populations. Methods: A genome-wide association study (GWAS) was performed using single-nucleotide polymorphism (SNP) markers for imputation to Illumina PorcineSNP60. The BayesB method was applied to calculate thresholds for the significance of SNP markers. The identified windows were considered significant if they explained ≥1% genetic variance. Results: A total of 28 window regions were related to genetic growth effects. Bayesian GWAS revealed 28 significant genetic regions including 52 informative SNPs associated with growth traits (ABF, ADG, DAYS90) in Duroc, Landrace, and Yorkshire pigs, with genetic variance ranging from 1.00% to 5.46%. Additionally, 14 candidate genes with previous functional validation were identified for these traits. Conclusion: The identified SNPs within these regions hold potential value for future marker-assisted or genomic selection in pig breeding programs. Consequently, they contribute to an improved understanding of genetic architecture and our ability to genetically enhance pigs. SNPs within the identified regions could prove valuable for future marker-assisted or genomic selection in pig breeding programs.

• New & Renewable Energy
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• v.20 no.3
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• pp.20-27
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• 2024

A Li-rich cathode material, Li_1.167Mn_0.548Ni_0.18Co_0.105O₂, with a spherical shape and high crystallinity, is prepared using flame spray pyrolysis. The post-heat treatment condition influences the properties of the prepared material, such as its structure, morphology, and chemical composition, and optimum performance is achieved at 900℃. Various excess Li contents (0-12 wt.%) are introduced in the precursor solution to compensate for volatilized Li during synthesis, bringing it close to the target composition. Compensation for volatilized Li enhances the electrochemical performance, i.e., the Li-compensated sample shows a good discharge capacity of 247 mAh g^-1 at a current density of 20 mA g^-1 in a potential window of 4.6-2.5 V. In addition, the prepared Li-rich cathode material supplemented with 9 wt.% of the Li source shows increased discharge capacity of 175 and 148 mAh g^-1 at 200 and 400 mA g^-1, respectively, compared with those of a bare sample (164 and 127 mAh g^-1, respectively).

• Korean Circulation Journal
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• v.52 no.4
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• pp.251-264
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• 2022

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure (HF) cases. The prevalence of HFpEF is increasing due to an aging population with hypertension, diabetes mellitus, and obesity. HFpEF remains a challenging clinical entity due to a lack of effective treatment options. Traditional HF medications have not been shown to reduce mortality of patients with HFpEF, and an implantable cardioverter-defibrillator is not indicated due to normal ejection fraction. Sudden death is the most common mode of death in patients with HFpEF; however, the underlying mechanisms of sudden death are not fully elucidated. Although ventricular arrhythmias are responsible for the majority of sudden deaths in general, their contribution to sudden deaths in HFpEF patients is likely less significant. The mechanisms of ventricular arrhythmias in HFpEF are 1) reduced conduction velocity due to ventricular hypertrophy, 2) delayed repolarization due to potassium current down-regulation, 3) calcium leakage due to altered excitation-contraction coupling, and 4) increased ventricular fibrosis caused by systemic inflammation. Hypertension and subsequent ventricular hypertrophy reduce the conduction velocity in HFpEF hearts via heterogeneous distribution of connexin 43. Delayed repolarization caused by potassium current down-regulation in HFpEF hearts provides a window for early afterdepolarization to trigger ventricular arrhythmias. Altered excitation-contraction coupling in HFpEF can cause calcium to leak and trigger delayed afterdepolarization. Increased systemic inflammation and subsequent ventricular fibrosis provide substrates for re-entry. Further research is warranted to investigate the detailed mechanisms of ventricular arrhythmias in HFpEF.

• Journal of the Korean Electrochemical Society
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• v.20 no.2
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• pp.34-40
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• 2017

Electric double layer capacitors (EDLC: electric double layer capacitors) have drew attention as an energy storage device for the next generation because of their outstanding power capability and durability. But their usage is somewhat limited due to low energy density over secondary batteries. One of methods to improve the energy of EDLC is expanding the voltage window of cell operation by increasing the charge cut-off voltage. In this study, $SBP-BF_4$ (spirobipyrrolidinium tetrafluoroborate), $TEA-BF_4$ (tetraethylammonium tetraflouroborate) and $EMI-BF_4$ (1-ethyl-3-methylimidazolium tetrafluoroborate) in AN (acetonitrile) were selected to evaluate the possibility of application at high voltage environment. The LSV (linear sweep voltammetry) measurements showed that the 1.5M SBP-BF4/AN electrolyte was stable over a wide potential window and showed the best electrochemical performance compared to other combinations of electrolytes at high voltage environments (over 3.0 V). Furthermore, TMSP (tris(trimethylsilyl) phosphite) was applied to 1.5M SBP-BF4/AN in order to maintain stable performance at high voltage for the long period of time. The electrolyte with TMSP additive showed the capacity retention of 93% after 10,000 cycles at 3.3 V.

• Management & Information Systems Review
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• v.33 no.5
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• pp.71-84
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• 2014

We examine evidence on the relationship between firms that targeted by the Financial Supervisory Service for allegedly manipulating annual earnings and accounting quality measured by the discretionary accruals, an issue with important public policy implications. The main purpose of this paper is to empirically investigate the extent to which Korean WDS(Window Dressing Settlement) firms identified by the financial supervisory service in their audit review exhibit higher level of accounting quality in order to avoid any potential negative effects and to regain public confidence after audit review. In this study, we analyzed 51 WDS firms and 102 control firms which traded in the Korean Stock Exchange market during the period from 2000 to the 2010. The number of observations subject to various tests are 251 and 502 firm-years for WDS and control samples respectively across the 5 year sample period. The results of the study show that the accounting quality after auditor review be significantly improved. This result suggests that the FSS's audit review system would control the accounting quality and then improve the transparency of the accounting information. Thus it may be suggested that the current audit review system is efficient ways to lead listed firms to provide transparent financial statements.

• 한국지구물리탐사학회:학술대회논문집
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• 2008.10a
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• pp.97-100
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• 2008

Mount Fuji is the focus of intense study because of its potential hazard signaled by seismic, geologic and historical activity. Based on extensive seismic data recorded in the vicinity of Mt. Fuji, coda quality factor ($Q_c^{-1}$) using a single scattering model hypothesis, and intrinsic and scattering quality factor $(Q_i^{-1}$ and $Q_s^{-1})$ using the Multiple Lapse Time Window Analysis (MLTW) method was measured. To focus the study on the magmatic structure below Mt. Fuji, to the data were separated into two groups: a near-Fuji region of rays traversing an area with radius 5 km around the summit (R < 5 km), and a far-Fuji region of rays beyond a radius of 20 km around the summit (R > 20 km). The results of the study have a small error range due to the large data sample, showing that all $Q^{-1}$ values in near-Fuji area are greater than those of far-Fuji area, and $Q_i^{-1}$ for both the near and far-Fuji area is higher than $Q_s^{-1}$ at high frequencies. The $Q_i^{-1}$ values of the near-Fuji area are lower than those of the other volcanic areas considered, while values of $Q_s^{-1}$ are not. The low $Q_i^{-1}$ for the volcanic region of near-Fuji suggests that the magmatic activity, or percent of partial melt, at Mt. Fuji is not as active as hot spot volcanoes such as Kilauea, Hawaii.

• Journal of the Korean Electrochemical Society
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• v.6 no.3
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• pp.169-173
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• 2003

Electrochemical capacitor made with metal oxide electrode uses rapid and reversible protonation/deprotonation of metal oxide material under the aqueous acidic solution, generally. Electrochemical stability window of aqueous electrolyte-type capacitor is narrow compared to that of organic electrolyte-type capacitor. Electrochemical characteristics of electrochemical capacitor made with metal oxide electrode and lithium or ammonium cation based organic electrolyte were evaluated. Electrochemical capacitor based on $RuO_2$ electrode material and 1M $LiPF_6$ in mixed solvents of EC, DEC, and EMC has anodic and cathodic specific capacitance of 145 and $142F/g-RuO_2{\cdot}nH_2O$, respectively, by using cyclic voltammetry with scan rate of 2mV/sec $g-RuO_2$ in potential range of $2.0\~4.2V(Li|Li^+))$.

• Bulletin of the Korean Chemical Society
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• v.35 no.5
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• pp.1349-1355
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• 2014

A three-dimensional (3D) $Co_3O_4$/mildly oxidized multiwalled carbon nanotubes (moCNTs)/reduced mildly oxidized graphene oxide (rmGO) ternary composite was prepared via a simple and green hydrolysishydrothermal approach by mixing $Co(Ac)_2{\cdot}4H_2O$ with moCNTs and mGO suspension in mixed ethanol/$H_2O$. As characterized by scanning electron microscopy and transmission electron microscopy, $Co_3O_4$ nanoparticles with size of 20-100 nm and moCNTs are effectively anchored in mGO. Cyclic voltammetry and galvanostatic charge-discharge measurements were adopted to investigate the electrochemical properties of $Co_3O_4$/moCNTs/rmGO ternary composite in 6 M KOH solution. In a potential window of 0-0.6 V vs. Hg/HgO, the composite delivers an initial specific capacitance of 492 $Fg^{-1}$ at 0.5 $Ag^{-1}$ and the capacitance remains 592 $Fg^{-1}$ after 2000 cycles, while the pure $Co_3O_4$ shows obviously capacitance fading, indicating that rmGO and moCNTs greatly enhance the electrochemical performance of $Co_3O_4$.

• Industrial Engineering and Management Systems
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• v.7 no.2
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• pp.171-181
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• 2008

Home care, known also as domiciliary care, is part of the community care service that is a responsibility of the local government authorities in the UK as well as many other countries around the world. The aim is to provide the care and support needed to assist people, particularly older people, people with physical or learning disabilities and people who need assistance due to illness to live as independently as possible in their own homes. It is performed primarily by care workers visiting clients' homes where they provide help with daily activities. This paper is concerned with the dispatching of care workers to clients in an efficient manner. The optimized routine for each care worker determines a schedule to achieve the minimum total cost (in terms of distance traveled) without violating the capacity and time window constraints. A collaborative population-based meta-heuristic called Particle Swarm Optimization (PSO) is applied to solve the problem. A particle is defined as a multi-dimensional point in space which represents the corresponding schedule for care workers and their clients. Each dimension of a particle represents a care activity and the corresponding, allocated care worker. The continuous position value of each dimension determines the care worker to be assigned and also the assignment priority. A heuristic assignment scheme is specially designed to transform the continuous position value to the discrete job schedule. This job schedule represents the potential feasible solution to the problem. The Earliest Start Time Priority with Minimum Distance Assignment (ESTPMDA) technique is developed for generating an initial solution which guides the search direction of the particle. Local improvement procedures (LIP), insertion and swap, are embedded in the PSO algorithm in order to further improve the quality of the solution. The proposed methodology is implemented, tested, and compared with existing solutions for some 'real' problem instances.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.4
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• pp.10-15
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• 2013

In order to fabricate high sensitive and stable biosensors, we require the material with superior biocompatibility and physical-chemical stability. Many kinds of biomaterials have been evaluated to apply for bioindustry. Recently, carbon based diamond thin films have been focal pointed as bio-applications and their possibility has been evaluated. Diamond thin film has many advantages for electrochemical and biological applications, such as wide potential window (3.0-3.5V), low background current and chemical-physical stability. In this work, we have cultured neuroblastoma cell (SH-SY5Y) on the crystalline diamond films. We use MTT assay to evaluate the characteristic of cell culture on the substrates. As a result, neuroblastoma cell was cultured on the crystalline diamond film as similar as cell culture dish.