• Korean Journal of Clinical Pharmacy
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• v.23 no.2
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• pp.129-136
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• 2013

Objectives: Among many new drugs that are under investigation with intent to treat cancer, oral kinase inhibitors are proven to be effective in numerous clinical trials and easy to administer. Due to these advantages the use of oral kinase inhibitors is increasing. Oral kinase inhibitors are metabolized by CYP450 which can result either increase of adverse effect or decrease of drug effect by drug interaction when used concurrently with other agents. In this research, the medication records of patients on oral kinase inhibitors from Oct. 2010 to Nov. 2011 were reviewed to investigate potential drug interactions. Methods: From Oct. 2010 to Nov. 2011, cancer patients in Inha University Hospital who took oral kinase inhibitors more than once were included. The patients' medication records were reviewed to list out concurrent medications that have interaction potential with oral kinase inhibitors, the frequency of concurrent use, and the severity of interaction result using Micromedex$^{(R)}$ and Lexicomp-online$^{(R)}$ as references. Results: As a result, 90 cases of drug with interaction potential were prescribed by Micromedex$^{(R)}$ and 179 cases by Lexicomp-online$^{(R)}$ data. In case of severity, 33.3% by Micromedex$^{(R)}$ and 26.3% by Lexicomp-online$^{(R)}$ were categorized as Major and 65.6% by Micromedex$^{(R)}$ and 72.6% by Lexicomp-online$^{(R)}$ as Moderate. The number of adverse events was 92 cases which 58.7% were on skin and 19.6% on Gastro-intestinal tract. Conclusions: Considerable number of drug with interaction potential was used though each oral kinase inhibitors showed differences in extent. Hence there exists the risk of drug interaction in patients taking oral kinase inhibitors with other drugs.

• Bulletin of the Korean Chemical Society
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• v.27 no.2
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• pp.197-202
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• 2006

In the reaction A + B $^\rightarrow_\leftarrow$ C, where A and B are ionic reactants having opposite charges, a B molecule approaching an A will experience a switching of the interaction potential when the A molecule is captured by one of the other B molecules in the medium. In the reversible case, the former B molecule still has a chance to react with the A, so that one needs to take into account the switched interaction between the reactant B and the product C as well as that between the reactants to treat the kinetics accurately. It is shown that this kind of interaction potential switching affects the relaxation kinetics in an intriguing way as observed in a recent experiment on an excited-state proton transfer reaction.

• Korean Journal of Clinical Pharmacy
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• v.25 no.3
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• pp.138-144
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• 2015

Objective: It is to evaluate the drug interaction monitoring program as a pilot project to develop a pharmaceutical care model in a medical intensive care unit and to analyze the influencing factors of drug interactions. Method: Electronic medical records were retrospectively investigated for 116 patients who had been hospitalized in a medical intensive care unit from October to December in 2014. The prevalence of adverse reaction with risk rating higher than 'D' was investigated by Lexi-$Comp^{(R)}$ Online database. The factors related with potential drug interaction and with treatment outcomes were analyzed. Results: The number of patients with a potential interaction of drug combination was 92 (79.3%). Average ages, the length of stay in the intensive care unit and the numbers of prescription drugs showed significant differences between drug interaction group and non-drug interaction group. Opioids (14.4%), antibiotics (7.2%), and diuretics (7.2%) were most responsible drug classes for drug interactions and the individual medications included furosemide (6.4%), tramadol (4.9%), and remifentanil (4.5%). There were 950 cases with a risk rating of 'C' (84.6%), 142 cases with a risk rating of 'D' (12.6%), and 31 cases with a risk rating of 'X' (avoid combination) (2.8%). The factors affecting drug interactions were the number of drugs prescribed (p < 0.0001) and the length of stay at intensive care unit (p < 0.01). The patients in intensive care unit showed a high incidence of adverse reactions related to potential drug interaction. Therefore, drug interaction monitoring program as a one of pharmaceutical care services was successfully piloted and it showed to prevent adverse reaction and to improve therapeutic outcomes. Conclusion: Active participation of a pharmacist in the drug management at the intensive care unit should be considered.

• Bulletin of the Korean Chemical Society
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• v.16 no.10
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• pp.952-957
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• 1995

In order to ease the treatment of anisotropic potential when developing the variational RRKM theory, we applied Fano-Racah's recoupling theory to the multipole-multipole interaction, resulting in the great simplification of the anisotropic potentials. The treatment appears as a generalization of Keesom transformation in case of dipole-dipole interaction and provides us with great insights to the characteristics of tensorial interactions in the multipole-multipole interaction system.

• Rapid Communication in Photoscience
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• v.5 no.1
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• pp.8-10
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• 2016

The potential curves of OH bonds of liquid water are inhomogeneous because of a variety of interactions with other molecules and this leads to a wide distribution of vibrational frequency which hampers our understanding of the structure and dynamics of water molecules. Mixed quantum/classical (QM/CM) calculation methods are powerful theoretical techniques to help us analyze experimental data of various vibrational spectroscopies to study such inhomogeneous systems. In a type of those approaches, the interaction energy between OH bonds and other molecules is approximately represented by the interaction between the charges located at the appropriate interaction sites of water molecules. For this purpose, we re-calculated the values of charges by comparing the approximate interaction energies with quantum chemical interaction energies. We determined a set of charges at the TIP4P charge sites which better represents the quantum mechanical potential curve of OH bonds of liquid water.

• Steel and Composite Structures
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• v.47 no.3
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• pp.383-393
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• 2023

Conventional reinforced concrete design codes assume ideal strain evolution in semi-deep beams with externally bonded fiber-reinforced polymer (EB-FRP) web strips. However, there is a strain interaction between internal stirrups and web strips, leading to a notable difference between code-based and experimental shear strengths. Current study provides an experiment-verified detailed numerical framework to assess the potential strain interaction under quasi-static monotonic load. Based on the observations, steel stirrups are effective only for low EB-FRP amounts and the over-strengthening of semi-deep beams prevents the stirrups from yielding, reducing its shear strength contribution. A notable difference is detected between the code-based and the study-based EB-FRP strain values, which is a function of the normalized FRP stress parameter. Semi-analytical relations are proposed to estimate the effective strain and stress of the components considering the potential strain interaction. For the sake of simplification, a linearized correction factor is proposed for the EB-FRP web strip strain, assuming its restraining effect as constant for all steel stirrup amounts.

• 한국가시화정보학회:학술대회논문집
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• 2005.12a
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• pp.103-106
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• 2005

Lattice Boltzmann method is a new numerical method of investigating the fluid flow which have been solved by Navier-Stokes equation recently. It is known that making the single and parallel algorithms of the Lattice Boltzmann equation is easier than those of Navier-Stokes equations. Also, we can simulate the two phase flow using either the 'Interaction Potential model ' introduced by Shan and Chen. In this paper, we first compared the 3D cavity results of Lattice Boltzmann method with other numerical results for validation and showed the 3D phase transition and its simple application by using the ' Interaction Potential model'

• Textile Coloration and Finishing
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• v.25 no.3
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• pp.159-164
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• 2013

Pyrene based molecule has been synthesized through the reaction of pyrene-1-carboxaldehyde and 4- phenylthiosemicarbazide in this research. The pyrene based molecule showed specific optical properties such as absorption and emission changes after mixing with fluoride in DMSO. The phenomenon is induced by the interaction of the molecule and fluoride. This interaction may affect to electron distributions and potential energy levels. In this regard, synthesized pyrene based molecule has been investigated for its electron distributions and HOMO/LUMO energy levels depending on interaction with fluoride. The absorption measurement, cyclicvoltammograms and computational method were investigated to calculate and compare energy potential levels.

• Archives of design research
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• v.17 no.2
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• pp.463-470
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• 2004

This paper studied tangible interaction design of VR platform and its applications that are economic In development process and cost, flexible by contents and installation conditions, and that has business potential for consumer market. The design solution uses video based virtual world and tangible interaction by motion tracking. Our platform enables a user to monitor their action and to collaborate with other users of remote place within attractive interaction feedback. We developed two design applications, Glass Xylophone 2003 and VR Class, in our platform. Glass Xylophone 2003 provides interactive music performance and helps self practice of glass xylophone. VR Class gives more serious distance learning experience with tutoring and group collaboration. They are presented in public exhibitions and tested by exhibition visitors. They showed application potential of this design solution in interactive game, distance learning, and entertainment field.

• Macromolecular Research
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• v.14 no.6
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• pp.654-658
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• 2006

Recent developments in equations of state for molecular fluids have demonstrated the feasibility of using the hard-sphere equation to describe the effects of repulsive forces in simple fluids. By including a suitable term for attractive forces, most conveniently a uniform background potential, the properties of bio-macromolecular interaction can be roughly calculated. However, the choice of the potential used in perturbed hard-sphere chain (PHSC) theory for describing the attractions between macromolecules is rather complicated. For hard-sphere chains, the prediction accuracy from each model strongly depends on the choice of potential function.