• Journal of Biomedical Engineering Research
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• v.44 no.1
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• pp.33-40
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• 2023

Transcutaneous auricular vagus nerve stimulation (taVNS) is known to be effective in improving symptoms of numerous diseases such as depression and epilepsy by increasing vagus nerve activity through electrical stimulation. The purpose of this study is to investigate the effect of vagus nerve stimulation on the activity of autonomic nervous system and the changes in postprandial blood glucose levels. Seven healthy adults participated in a non-invasive transcutaneous auricular vagus nerve stimulation experiment. taVNS (25 Hz, 200 ㎲, biphasic pulse) was applied to the cymba concha (taVNS group) or the earlobe (Sham-taVNS group) of the left ear. As autonomic nervous system signals, skin conductance level, skin temperature, and heart rate were recorded during the application of taVNS. Postprandial blood glucose changes due to food intake were recorded at 5 min intervals for 25 minutes after taVNS or sham-taVNS. The taVNS showed a significantly lower skin conductance level than the shamtaVNS (p < 0.05). The increase rate of postprandial blood glucose was significantly lower in the taVNS than in the sham-taVNS (p < 0.05). These results showed that taVNS reduced the activity of the sympathetic nerve system and alleviated early rise in postprandial blood glucose. Although further studies in diabetic patients are needed, this study suggest that taVNS has a potential for clinical use to improve postprandial blood glucose.

• Nutritional Sciences
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• v.8 no.2
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• pp.83-88
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• 2005

This study was to investigate the effect of psyllium seed husk (PSYL) on postprandial glucose control and insulin secretion dynamics in Sprague-Dawley rats. In experiment 1, the rise in postprandial serum glucose was monitored during a 240-min period using a maltose loading test In normal rats given 16.6 mg/l00 g B.W./ml of PSYL orally, all the blood glucose levels during the 240-min period did not show statistically significant differences from the corresponding levels in normal rats given water. However, in streptozotocin-induced diabetic rats given the same amount of PSYL, the blood glucose level at 30 min was significantly lower than that in diabetic rats given water, and the peak time of the rise in the postprandial glucose was delayed In experiment 2, the normal (N) and diabetic (Db) rats were given PSYL (25 mg/l00 g B.W./ml/day) orally for 5 days. Blood samples were collected in order to measure the s-glucose and s-insulin levels. The final s-glucose level at day 5 in Db-PSYL was significantly lower than that in the corresponding control rats (Db-CONT) and the final s-insulin level in Db-PSYL was significantly greater than that in Db-CONT. In vitro 40-min pancreas perfusion was performed at day 5 in order to examine the insulin secretion dynamics. Results showed that the amounts of insulin secreted during the first phase (11-20 min) and the second phase (21-40 min) in the Db-PSYL were significantly greater than those in Db-CONT. Therefore, it is concluded that psyllium seed husk could be beneficial for controlling postprandial glucose levels in the stretozotocin-induced diabetic rats, and it may be partially mediated by insulin secretion dynamics.

• Journal of the Korean Home Economics Association
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• v.33 no.1
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• pp.169-180
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• 1995

To determine the effects of guar suksolgi on blood glucose and lipids in type-ll diabetic subjects, a piece of guar suksolgi(36.3g, 54Kcal) was administered to eight patients for 3 weeks every meal. No significant differences occured indietary intakes and body weight before and after the treatment. Fasting blood glucose levels were decreased from 132.38mg/dI to 114.75mg/dI after the treatment, but not statistically significant. Blood TG levels were increased from 159.13mg/dI to 175.00mg/dI after the treatment, but not statistically significant. Excluding one patient who had extremely high TG level, blood TG levels tended to be decreased from 148.00mg/dI to 121.00mg/dI. TC LDL-c, HDL-c levels were decreased after the treatment, but not statistically significant. HbAIC concentrations were decreased from 8.54mg/kI to 7.80mg/dI after the treatment, but not statistically significant. In the case of three patients who had had normal fasting blood glucose levels, blood glucose levels tended to be decreased at postprandial 30, 60 minutes, and blood insulin levels tended to be decreased at postprandial 30, 60, 90, 120 minutes, although none of the levels were statistically significant. Therefore, if guar suksolgi is adinistered to type-ll diabetic subjects being more hyperglycemic than our patients, their blood glucose and lipids will be decreased significantly.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.6
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• pp.821-824
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• 2005

The purpose of this study is to investigate tile effects of the Paecilomyces japonica on blood glucose in non-insulin dependent diabetes mellitus volunteers. During the 3 months of the experimental period, freeze-dried powder of Paecilomyces japonica (2 g/meal) was given to the subjects right before each meal. Paecilomyces japonica caused a significant decrease of $27.5\%\;and\;35.5\%$ in fasting and postprandial blood glucose levels, respectively. There were significant reductions of $28.5\%\;and\;33.5\%$ in fasting and postprandial blood glucose levels of the male subjects, respectively Paecilomyces japonica also significantly decreased in fasting and postprandial blood glucose levels of $26.1\%\;and\;37.3\%$ in female patients after treatment. This study shows that Paecilomyces japonica supplementation significantly lowered the fasting and postprandial glucose levels in NIDDM patients. These effects presumably contribute to the hypoglycemic activity.

• Nutrition Research and Practice
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• v.5 no.2
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• pp.107-111
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• 2011

The objective of this study was to investigate the hypoglycemic effects of quercetin (QE) in animal models of diabetes mellitus (DM). A starch solution (1 g/kg) with and without QE (100 mg/kg) or acarbose (40 mg/kg) was orally administered to streptozotocin (STZ)-induced diabetic rats after an overnight fast. Postprandial plasma glucose levels were measured and incremental areas under the response curve were calculated. To study the effects of chronic feeding of QE, five-week-old db/db mice were fed an AIN-93G diet, a diet containing QE at 0.08%, or a diet containing acarbose at 0.03% for 7 weeks after 1 week of adaptation. Plasma glucose and insulin, blood glycated hemoglobin, and maltase activity of the small intestine were measured. Oral administration of QE (100 mg/kg) or acarbose (40 mg/kg) to STZ-treated rats significantly decreased incremental plasma glucose levels 30-180 min after a single oral dose of starch and the area under the postprandial glucose response, compared with the control group. QE (0.08% of diet) or acarbose (0.03% of diet) offered to db/db mice significantly reduced both plasma glucose and blood glycated hemoglobin compared to controls without significant influence on plasma insulin. Small intestine maltase activities were significantly reduced by consumption of QE or acarbose. Thus, QE could be effective in controlling fasting and postprandial blood glucose levels in animal models of DM.

• Nutrition Research and Practice
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• v.13 no.1
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• pp.11-16
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• 2019

BACKGROUND/OBJECTIVES: Fasting and postprandial hyperglycemia should be controlled to avoid complications of diabetes mellitus. This study investigated the effects of autumn olive (Elaeagnus umbellata Thunb.) berry (AOB) on fasting and postprandial hyperglycemia in mice. MATERIALS/METHODS: In vitro ${\alpha}$-glucosidase inhibitory effect of AOB was determined. Maltose solution (2 g/kg) with and without AOB extract at 500 mg/kg or acarbose at 50 mg/kg was orally administered to normal mice after overnight fasting and glucose levels were measured. To study the effects of chronic consumption of AOB, db/db mice received the basal diet or a diet containing AOB extract at 0.4% or 0.8%, or acarbose at 0.04% for 7 weeks. Blood glycated hemoglobin and serum glucose and insulin levels were measured. Expression of adiponectin protein in epididymal white adipose tissue was determined by Western blotting. RESULTS: In vitro inhibitory effect of AOB extract on ${\alpha}$-glucosidase was 92% as strong as that of acarbose. The AOB extract (500 mg/kg) or acarbose (50 mg/kg) significantly suppressed the postprandial rise of blood glucose after maltose challenge and the area under the glycemic response curve in normal mice. The AOB extract at 0.4% or 0.8% of diet or acarbose at 0.04% of diet significantly lowered levels of serum glucose and blood glycated hemoglobin and homeostasis model assessment for insulin resistance values in db/db mice. The expression of adiponectin protein in adipose tissue was significantly elevated by the consumption of AOB at 0.8% of diet. CONCLUSIONS: Autumn olive (E. umbellata Thunb.) berry may reduce postprandial hyperglycemia by inhibiting ${\alpha}$-glucosidase in normal mice. Chronic consumption of AOB may alleviate fasting hyperglycemia in db/db mice partly by inhibiting ${\alpha}$-glucosidase and upregulating adiponectin expression.

• Preventive Nutrition and Food Science
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• v.21 no.3
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• pp.165-170
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• 2016

Recent trial results suggest that the consumption of a low glycemic index (GI) diet is beneficial in the prevention of high blood glucose levels. Identifying active hypoglycemic substances in ordinary foods could be a significant benefit to the management of blood glucose. It has been hypothesized that noodles with Bombyx mori powder are a low GI food. We evaluated GI and changes in postprandial glucose levels following consumption of those noodles and compared them with those following consumption of plain wheat flour noodles (control) and glucose (reference) in healthy subjects. Thirteen males (age: $34.2{\pm}4.5years$, body mass index: $23.2{\pm}1.1kg/m^2$) consumed 75 g carbohydrate portions of glucose and the 2 kinds of noodle after an overnight fast. Capillary blood was measured at time 0 (fasting), 15, 30, 45, 60, 90, 120, and 180 min from the start of each food intake. The GI values were calculated by taking the ratio of the incremental area under the blood glucose response curve (IAUC) for the noodles and glucose. There was a significant difference in postprandial glucose concentrations at 30 and 45 min between the control noodles and the noodles with Bombyx mori powder: the IAUC and GI for the noodles with Bombyx mori powder were significantly lower than those for glucose and plain wheat flour noodles. The wheat flour noodles with Bombyx mori powder could help prevent an increase in postprandial glucose response and possibly provide an alternative to other carbohydrate staple foods for glycemic management.

• Journal of Nutrition and Health
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• v.19 no.6
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• pp.402-408
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• 1986

Since diet is an essential component of the treatment for diabetic mellitus, a progressive educational plan was designed to educate diabetic children for the proper selection of their foods. Seven suspicious children were chosen according to the previous oral glucose tolerance test and present blood glucose levels (fasting and postprandial 2 hours). The education program includes the basic nutrition study, learning of the five basic food groups. familiarization with the food exchange lists. calorie calculation and menu planning, and follow-up evaluation by checking every day -food intake. The duration of the education was five weeks. The levels of fasting blood glucose and postprandial -2 hours blood sugar of the seven children were significantly reduced after the 5-weeks education:FBS:from 92-125mg% to 67-80mg%, pp-2hours BS: from 130-169mg% to 69-90mg%. The children have felt much better with profound self-confidence after to program . Their oral glucose tolerance test levels were also significantly decreased after the 5-weeks education in comparison with those of one year ago.

• Journal of Nutrition and Health
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• v.31 no.2
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• pp.117-125
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• 1998

Mulberry leaves(Mori folium) and silkworm(Bombyx mori) are potnet inhibiters of intestinal $\alpha$-glycosidase, and inhibit the digestion of starch and sucrose in the small intestine. They are able to prevent postprandial hyperglycemia and decrease blood insulin levels. In this study , a high-carbohydrate diet(CHO ; 67.5%, protein ; 20.8%, fat : 11.7%) was received by the control group. In contrast, the experimental groups received a high-carbohydrate diet with extracts of mulberry leaves and silkwork(50mg.100g diet), and acarbose(6.7mg/100g diet). after a 10 week study period , the experimental groups had lower blood glucose and triglyceride levels. The experimental groups tended to have lwer Hb Alc levels. Also, blood insulin levels were lower than the control groups in accordance with blood glucose levels. The activities of intestinal $\alpha$-glucosidase in the middle and distal parts of small intestine were induced by the extracts of mulberry leaves and silkworm in the experimental groups. However, the activities of liver lysosomal glucosidase and the contents of glycogen in the liver were not affected by the mulberry leave and silkworm extracts nor by acarbose. Mulberry leaves and silkworm were able to prevent sudden postprandial peaks in blood glucose as a result of $\alpha$-glycosidase, inhibition, there by decreasing unnecessary insulin secretion.

• Applied Biological Chemistry
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• v.50 no.1
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• pp.68-71
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• 2007

Cordyceps militaris, Artemisa capillaris, and Fagopyrum esculentum have been known to maintain normal blood sugar levels in folk medicine. We investigated the effects of these nutraceuticals extract supplementations on fasting and postprandial blood glucose in diabetes mellitus patients. The study population consisted of 50 diabetes subjects with a mean fasting blood glucose of 186.8${\pm}$6.2 mg/dl and postprandial blood glucose of 292.8${\pm}$10.3 mg/dl. They consumed 3 tea bags (3g per meal) of the extract of selected plants for 17 weeks. Patients treated with nutraceuticals extract supplementation showed a significant decrease of fasting blood glucose (118.4${\pm}$3.9 mg/dl) and postprandial blood glucose (160.5${\pm}$4.0 mg/dl) in 7 weeks. Nutraceticals extract supplemantation caused a significant decrease of 36.5% and 45% in fasting and postprandial blood glucose levels, respectively, and also significantly decreased HbA1c levels. This study shows that extract of nutraceuticals supplementation significantly lowered the fasting and postprandial blood glucose levels in NIDDM patients. These effects presumably contribute to the hypoglycemic activity.