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http://dx.doi.org/10.4162/nrp.2011.5.2.107

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus  

Kim, Ji-Hye (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University)
Kang, Min-Jung (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University)
Choi, Ha-Neul (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University)
Jeong, Soo-Mi (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University)
Lee, Young-Min (Department of Nutrition, Pusan Paik Hospital)
Kim, Jung-In (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University)
Publication Information
Nutrition Research and Practice / v.5, no.2, 2011 , pp. 107-111 More about this Journal
Abstract
The objective of this study was to investigate the hypoglycemic effects of quercetin (QE) in animal models of diabetes mellitus (DM). A starch solution (1 g/kg) with and without QE (100 mg/kg) or acarbose (40 mg/kg) was orally administered to streptozotocin (STZ)-induced diabetic rats after an overnight fast. Postprandial plasma glucose levels were measured and incremental areas under the response curve were calculated. To study the effects of chronic feeding of QE, five-week-old db/db mice were fed an AIN-93G diet, a diet containing QE at 0.08%, or a diet containing acarbose at 0.03% for 7 weeks after 1 week of adaptation. Plasma glucose and insulin, blood glycated hemoglobin, and maltase activity of the small intestine were measured. Oral administration of QE (100 mg/kg) or acarbose (40 mg/kg) to STZ-treated rats significantly decreased incremental plasma glucose levels 30-180 min after a single oral dose of starch and the area under the postprandial glucose response, compared with the control group. QE (0.08% of diet) or acarbose (0.03% of diet) offered to db/db mice significantly reduced both plasma glucose and blood glycated hemoglobin compared to controls without significant influence on plasma insulin. Small intestine maltase activities were significantly reduced by consumption of QE or acarbose. Thus, QE could be effective in controlling fasting and postprandial blood glucose levels in animal models of DM.
Keywords
Quercetin; glucose; glycated hemoglobin; postprandial hyperglycemia; db/db mouse;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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