• 정신신체의학
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• 제22권2호
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• pp.138-142
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• 2014

구강 작열감 증후군(Burning mouth syndrom)은 기질적인 질환 없이 구강이 타는 듯한 통증을 호소하는 질환이다. 병인으로는 신경병증, 폐경, 영양불균형 등 여러 요인이 관련되어 있을 것으로 추정되며, 정신의학적으로는 우울증이 가장 잘 동반된다. 진통소염제, 호르몬제, 항전간제 및 항우울제 등이 치료로 시도되었으나 효과는 비특이적이다. 이 증례보고는 폐경 후 여성에서 우울증에 동반된 구강 작열감 증후군에 대한 gabapentin의 효과를 보고한다. 항우울제는 우울증상을 호전시켰지만 구강증상에는 효과가 없었다. Gabapentin을 12주간 하루 300mg 용량으로 추가 투여 후 구강증상은 주관적으로 유의하게 감소되었다. 폐경 후 여성에서 항우울제로 개선되지 않는 구강 작열감 증후군 환자에서 gabapentin의 추가 투여가 효과적일 수 있다.

• 운동과학
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• 제28권1호
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• pp.82-90
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• 2019

PURPOSE: The purpose of this study was to examine the association of waist to height ratio (WHtR) and resting heart rate (RHR) with cardio-metabolic risk factors among Korean postmenopausal women. METHODS: A cross-sectional analysis was performed using the 2015 Korea National Health and Nutrition Examination Survey. The analysis included a total of 1,540 postmenopausal women. RESULTS: Individuals with higher WHtR (>0.56) showed significantly higher glucose, triglyceride, insulin, Homeostatic Model Assessment for Insulin resistance (HOMA-IR), total cholesterol, systolic and diastolic blood pressure compared with ones with lower WHtR (≤0.51). Similar findings were found in those with higher RHR (≥90 bpm) compared with ones with lower RHR (<60 bpm) for glucose and HOMA-IR. When determining the combined effects of WHtR and RHR on the prevalence of metabolic syndrome, individual with WHtR above 0.5 and RHR above 80 bpm showed 10.39 times higher prevalence of metabolic syndrome compared with those with WHtR below 0.5 and RHR below 70 bpm. We further performed multiple linear regression analysis to understand how WHtR and RHR contribute to fasting glucose, and found that both WHtR and RHR contribute to fasting glucose levels independent of age, education level, marital status and income level. CONCLUSIONS: The current study showed that the WHtR and RHR are associated with cardio-metabolic risk factor and prevalence of metabolic syndrome in Korean postmenopausal women.

• 대한임상검사과학회지
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• 제48권4호
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• pp.287-295
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• 2016

본 연구는 국가자료인 2010~2012년도 국민건강영양조사 자료를 이용하여 제 2형 당뇨병을 가진 대한민국 20세 이상 성인 16,096명(남성, 6,840명; 폐경 전 여성, 4,916명; 폐경 후 여성, 4,340명)을 대상으로 대사증후군(MetS) 및 대사증후군 위험요소의 증가(MSS)와 혈청 Ferritin수준의 관련성을 평가하고자 실시하였다. 대사증후군의 발생률은 16,096명 중 3,978명으로 24.7%(남성, 24.6%; 폐경 전 여성, 11.1%; 폐경 후 여성, 40.3%)이었다. 본 연구의 주요결과는 첫째, 관련변수를 보정한 후의 결과에서, 혈청 ferritin 수준은 비 대사증후군(남성, $111.08{\pm}1.01ng/mL$; 폐경 전 여성, $32.26{\pm}0.50ng/mL$; 폐경 후 여성, $63.26{\pm}0.98ng/mL$)에 비하여 대사증후군(남성, $132.25{\pm}1.98ng/mL$; 폐경전 여성, $39.89{\pm}1.49ng/mL$; 폐경 후 여성, $73.45{\pm}1.14ng/mL$)에서 유의하게 증가하였다(p<0.001). 둘째, 남성과 폐경 전 및 폐경 후 여성 모두에서, 혈청 ferritin 수준은 대사증후군 위험요소의 증가함에 따라 증가하였다(p<0.001). 결론적으로, 대한민국 성인에서 대사증후군 및 대사증후군 위험요소의 증가는 혈청 ferritin 수준을 증가시킨다.

• 한국전자통신학회논문지
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• 제8권4호
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• pp.649-658
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• 2013

본 연구는 우리나라 폐경기 여성의 신체활동 정도와 대사증후군과의 관계를 알아보고, 추후 대사증후군 환자의 건강증진을 위한 기초자료를 제공하기 위해 실시하였다. 국민건강영양조사 제4기 2차년도 자료 중 폐경기 여성 1,007명을 대상으로 알아본 결과 우리나라 폐경기 여성의 대사증후군은 연령이 증가할수록, 신체활동 정도가 낮을수록 유의하게 높았다는 결과를 얻었다. 폐경기 여성의 대사증후군을 관리 예방하기 위해서는 연령을 고려하여 환자의 운동 선호도, 운동제약 그리고 환자의 특성을 고려한 중간 신체활동프로그램 개발 및 프로그램 효과검증과 같은 연구가 매우 필요하다고 사료된다.

• Journal of Nutrition and Health
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• 제45권1호
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• pp.20-29
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• 2012

Metabolic syndrome (MetS) has become a global epidemic. In particular, it is known that there is a dramatic increase in the prevalence of MetS among women during the postmenopausal period. Recently, accumulating studies have suggested that vitamin D deficiency may be inversely associated with the risk factors regarding MetS. However, evidence from postmenopausal women is limited. In this study, we examined the association between the serum 25-hydroxyvitamin D [25(OH)D] and the MetS in Korean adult women aged 20-69 years (n = 2,618) by using the 2007-2008 Korean National Health and Nutrition Examination Survey data. The geometric mean of plasma 25(OH)D were $17.16{\pm}6.28\;ng$/mL and $20.20{\pm}7.69\;ng$/mL for premenopausal and postmenopausal women, respectively. The percentages of vitamin D deficiency [25(OH)D < 12 ng/mL] were 22.5% and 14.4%, respectively. MetS was more prevalent in postmenopausal women (43.0%) compared with premenopausal women (11.2%). When serum concentrations of 25(OH)D were categorized in quintiles, there was no relationship in the prevalence of MetS in both premonopausal and postmenopausal women. However, in premenopausal women, compared with the lowest 25(OH)D quintile, the odds ratio for hypertriglyceridemia in the highest quintile was 0.57 (95% CI 0.34-0.95, $P_{trend}$ = 0.041) and for low serum HDL cholesterol 0.60 (95% CI 0.42-0.85, $P_{trend}$ = 0.014) after adjusting for all potential confounders. On the other hand, we observed the tendency of an inverse relationship for 25(OH)D regarding low serum HDL cholesterol (OR 0.78, 95% CI 0.50-1.22, $P_{trend}$ = 0.029) and a direct relationship with abdominal obesity (OR 1.94, 95% CI 1.01, 3.74, $P_{trend}$ = 0.049) in postmenopausal women. Further studies are needed to confirm these findings in other research settings.

• 한국산학기술학회논문지
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• 제16권4호
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• pp.2704-2712
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• 2015

본 연구는 국민건강영양조사 2012년도 원시자료를 이용한 이차분석 연구로서, 연구 목적은 폐경이 대사증후군 유병율 및 구성요소에 미치는 영향을 확인하는 것이다. 층화집락복합표본추출로 선정된 총 8,058명 중 만 19세 이상 성인 여성이며 월경 및 폐경에 대한 정확한 정보를 제공한 2,746명을 대상으로 하였다. 연구결과, 폐경 여부에 따른 대사증후군 구성요소의 평균 차이는 모두 통계적으로 유의하였다. 대사증후군 유병율은 폐경 전 여성 13.2%, 폐경 후 여성 42.7%이었다. 폐경후 대사증후군에 이환될 확률은 4.88배(95% CI=3.888-6.126) 증가하고, 40세를 기준으로 나이가 5세 증가할 때마다 대사증후군에 이환될 확률은 각각 3.15배(95% CI=1.862-5.331), 4.159배(2.558-6.761), 5.971배(3.955-9.016), 9.52배(6.591-13.749) 증가하였다. 연구 결과를 바탕으로 폐경 후 여성의 대사증후군 예방 및 관리를 위한 중재 프로그램이 개발 및 적용되어야 할 것이다.

• 한국식품영양학회지
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• 제28권6호
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• pp.988-994
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• 2015

Menopausal status and hormonal changes are important factors related to the prevalence of metabolic syndrome in women. Nutrient intake is also a risk factor for metabolic syndrome. Although, postmenopausal status and hormonal changes result in a 60% increased risk for metabolic syndrome, there has been no method to elucidate the effects of nutrient intake on metabolic syndrome following menopause. This study was conducted to evaluate the effects of nutrient intake by menopausal women on the prevalence of metabolic syndrome. All data were obtained from the Korean National Health and Nutrition Examination Survey 2007-2009. Menopausal women showed a 1.8-fold increase in the prevalence of metabolic syndrome. Metabolic syndrome group showed significantly lower values in calcium, iron, vitamin A, carotin, retinol and riboflavin intake than those of normal group in premenopausal women. In postmenopausal women, there are significant differences in crude fiber, calcium, iron, potassium, riboflavin and niacin. Indeed, different patterns of nutrient intake were observed by menopausal status and metabolic syndrome. As menopause cannot be controlled, a diet with adequate nutrient intake may be useful to control the rapid increase in the prevalence of metabolic syndrome due to menopause.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.139-146
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• 2012

Obese postmenopausal women increase their risk of developing breast cancer (BC), in particular if they display an android-type pattern of adiposity, which is also associated to increased risks of diabetes mellitus, hypertension and cardiovascular disease. In order to explore the associations among anthropometry (body mass index, body composition, somatotype), some specific items of medical history (diabetes, hypertension, dislypidemias, hyperuricemia) and the risk of BC in Uruguayan women, a case-control study was carried out between 2004-2009 at our Oncology Unit. 912 women of ages between 23-69 years (367 new BC cases and 545 non hospitalized, age-matched controls with a normal mammography) were interviewed. Twenty body measurements were taken in order to calculate body composition and somatotype. Patients were queried on socio-demographics, reproductive history, family history of cancer, a brief food frequency questionnaire and on personal history of diabetes, dislypidemias, hyperuricemia, hypertension and gallbladder stones. Uni- and multivariate analyses were done, generating odds ratios (ORs) as an expression of relative risks. A personal history of diabetes was positively associated to BC risk (OR=1.64, 95% CI 1.00-2.69), being higher among postmenopausal women (OR=1.92, 95% CI 1.04-3.52). The risks of BC for diabetes in postmenopausal women with overweight combined with dislypidemia (OR=9.33, 95% CI 2.10-41.5) and high fat/muscle ratio (OR=7.81, 95% CI 2.01-30.3) were significantly high. As a conclusion, a personal history of diabetes and overweight was strongly associated to BC. The studied sample had a subset of high-risk of BC featured by postmenopausal overweight and diabetic women, who also had a personal history of hypertension and/or dyslipidemia. The present results could contribute to define new high risk groups and individuals for primary as well as for secondary prevention, since this pattern linked to the metabolic syndrome is usually not considered for BC prevention.

• 대한한방부인과학회지
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• 제29권4호
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• pp.1-12
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• 2016

Objectives: The purpose of this study is to analyze the correlation between the pulse energy and hot flush in women who complain of climacteric syndrome. Methods: We analyzed the values of pulse energy on 78 of perimenopausal and postmenopausal women. The symptoms of patients were assessed by Kupperman’s index (KI) and Menopause Rating Scale (MRS). Statistical analysis was performed by Spearman correlation coefficient and student T-test, using SPSS 18.0 for window program. Results: The results were as follows. 1. There were no statistically significant relation between pulse energy of left Cheok subtracted from left Chon and KI, MRS hot flush score. 2. When divided depending on MRS hot flush score, There were no statistically significant differences on pulse energy. Conclusions: The results suggest that there is no correlation between hot flush score and pulse energy.

• 대한한방부인과학회지
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• 제36권2호
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• pp.1-19
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• 2023

Objectives: The purpose of this health promotion project for Korean medicine is to promote the health of climacteric women in Boeun-gun. Methods: During the project, pressure needle acupuncture treatment, herbal medicine treatment, meditation pore therapy, and health education were conducted. To evaluate the results, basic health surveys (body height, body composition test, blood pressure etc.), female hormone tests, Kupperman's index (KI), Menopause-specific quality of life questionnaire (MENQOL), and Perceived stress scales (PSS) were conducted. Results: No significant change was observed in the body composition test and blood pressure after the project. Follicle stimulating hormone (FSH) was significantly increased after the project, but Luteinizing Hormone (LH) and total estrogen levels were not significantly changed. KI and MENQOL scores significantly decreased after the project, and significantly decreased in 4 out of 11 items of KI and 3 out of 4 domains of MEMQOL. No significant change was observed in the PSS score after the project. Conclusions: From the results of this project, it can be seen that the Korean medicine health promotion project can help alleviate symptoms of climacteric syndrome and postmenopausal syndrome.