• 제목/요약/키워드: Pioneering

검색결과 255건 처리시간 0.029초

트렌드 창출을 통한 삼성물산 래미안의 브랜드 마케팅전략 (Making Trend-Based on Brand Marketing Strategy of Samsung Raemian)

  • 전중옥;조봉진;이명식
    • Asia Marketing Journal
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    • 제6권3호
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    • pp.123-141
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    • 2004
  • 국내 아파트 시장에서 래미안을 통해 브랜드 마케팅을 본격적으로 도입한 삼성물산 건설부문은 고객의 추구가치를 마케팅믹스전략에 철저히 반영하는 한편 새로운 브랜드 마케팅전략의 트렌드를 창출하고 주도한 결과, 업계 최고의 파워브랜드 구축과 함께 괄목할 만한 경영성과를 단기간에 이룰 수 있었다. 본 사례는 삼성물산 건설부문이 래미안을 최고의 파워 브랜드로 만들기 위해 기울인 체계적 노력을 브랜드 마케팅전략을 중심으로 소개하고, 주요 성공요인이 무엇인지 알아본 후, 시사점과 함께 향후 래미안의 전략적 과제를 제시하고 있다.

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Regulation of CMGC kinases by hypoxia

  • KyeongJin Kim;Sang Bae Lee
    • BMB Reports
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    • 제56권11호
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    • pp.584-593
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    • 2023
  • Hypoxia, a widespread occurrence observed in various malignant tumors, results from rapid tumor growth that outpaces the oxygen supply. Tumor hypoxia precipitates several effects on tumor biology; these include activating angiogenesis, intensifying invasiveness, enhancing the survival of tumor cells, suppressing anti-tumor immunity, and fostering resistance to therapy. Aligned with the findings that correlate CMGC kinases with the regulation of Hypoxia-Inducible Factor (HIF), a pivotal modulator, reports also indicate that hypoxia governs the activity of CMGC kinases, including DYRK1 kinases. Prolyl hydroxylation of DYRK1 kinases by PHD1 constitutes a novel mechanism of kinase maturation and activation. This modification "primes" DYRK1 kinases for subsequent tyrosine autophosphorylation, a vital step in their activation cascade. This mechanism adds a layer of intricacy to comprehending the regulation of CMGC kinases, and underscores the complex interplay between distinct post-translational modifications in harmonizing precise kinase activity. Overall, hypoxia assumes a substantial role in cancer progression, influencing diverse aspects of tumor biology that include angiogenesis, invasiveness, cell survival, and resistance to treatment. CMGC kinases are deeply entwined in its regulation. To fathom the molecular mechanisms underpinning hypoxia's impact on cancer cells, comprehending how hypoxia and prolyl hydroxylation govern the activity of CMGC kinases, including DYRK1 kinases, becomes imperative. This insight may pave the way for pioneering therapeutic approaches that target the hypoxic tumor microenvironment and its associated challenges.

상생형 스마트공장 도입기업과 미도입기업의 성과분석에 관한 연구 (A Study on Performance Analysis of Companies Adopting and Not Adopting Win-win Smart Factories)

  • 황중하;김태성
    • 대한안전경영과학회지
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    • 제26권1호
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    • pp.45-53
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    • 2024
  • A Smart factories are systems that enable quick response to customer demands, reduce defect rates, and maximize productivity. They have evolved from manual labor-intensive processes to automation and now to cyber-physical systems with the help of information and communication technology. However, many small and medium-sized enterprises (SMEs) are still unable to implement even the initial stages of smart factories due to various environmental and economic constraints. Additionally, there is a lack of awareness and understanding of the concept of smart factories. To address this issue, the Cooperation-based Smart Factory Construction Support Project was launched. This project is a differentiated support project that provides customized programs based on the size and level of the company. Research has been conducted to analyze the impact of this project on participating and non-participating companies. The study aims to determine the effectiveness of the support policy and suggest efficient measures for improvement. Furthermore, the research aims to provide direction for future support projects to enhance the manufacturing competitiveness of SMEs. Ultimately, the goal is to improve the overall manufacturing industry and drive innovation.

가천대학교 의과대학 졸업 후 진로지도 프로그램 설계와 운영 (Design and Implementation of a Career Guidance Program at Gachon University College of Medicine)

  • 박귀화
    • 의학교육논단
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    • 제26권1호
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    • pp.41-47
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    • 2024
  • The ultimate goal of career guidance is to help medical students develop a career plan that matches their personal characteristics, allows them to train in their desired subspecialty, and helps them to adapt well to medical practice after graduation. Gachon Medical School has designed a longitudinal career guidance program called GLORI (Gachon Longitudinal Orientation and Career Development), which is based on the outcome of each phase. The program consists of regular courses and portfolio-based career guidance from a mentor professor. In phase 2 (basic medical science), the "Career Seminar" course was developed. This course focuses on self-understanding through a psychological inventory, exploration of postgraduate career paths, and interviews with professors in specialties of interest. In phase 3 (the integration of basic and clinical science), the "Exploring Nonclinical Career Options" course was introduced. This course presents perspectives from doctors who have followed various pioneering career trajectories, including biomedical engineering, medical journalism, writing, public health, health care administration, the pharmaceutical and medical device industries, and other areas. All teaching methods were designed to encourage student participation. The assessment methods are assignment-based, including self-reflective reports and presentations. In addition, a portfolio-based career guidance program is implemented in phases 3 and 4 (clinical clerkship). It is expected that this case study will serve as a practical example for developing comprehensive career guidance programs for medical schools.

RENE LAENNEC'S SYNDROME-BASED CLINICAL REASONING

  • Berezutskyi Volodymyr
    • 셀메드
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    • 제14권2호
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    • pp.4.1-4.4
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    • 2024
  • The development of clinical reasoning, which is the basis of medical education, is of great importance in medical universities. One of the founders of modern structural clinical reasoning, based on the knowledge of pathological physiology, is the inventor of the stethoscope Rene Laennec (1781-1826). He described the pioneering experience of clinical reasoning in the pages of his treatise A Treatise on the Diseases of the Chest and on Mediate Auscultation, which is of lasting value, since every rookie physicians in his professional development goes through the path of Laennec. Laennec's practice is of great importance for novice physicians since Laennec's treatise contains a diagnostic analysis of the most common clinical cases. Each such analysis demonstrates the algorithm of clinical reasoning. The purpose of this study was to analyze the approaches of clinical reasoning by René Laennec, which made it possible to identify two basic principles. Laennec's diagnostic reasoning involved two principles: pathogenetic analysis of clinical manifestations and a syndrome-based approach to differential diagnosis. These principles help distinguish between diseases with similar symptoms and physical findings are used to demonstrate the practical application of syndrome-based differential diagnosis. These principles can be easily mastered by understanding the pathogenesis of clinical manifestations. Thanks to the pathogenetic basis, the principles of clinical reasoning of Rene Laennec are universal and applicable to the analysis of any signs of the disease: not only physical but also laboratory and instrumental.

로이 풀러의 무대 의상에 관한 연구 (A Study of Costumes in the $Lo{\ddot{i}}e$ Fuller's Dance)

  • 최유진
    • 복식문화연구
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    • 제16권5호
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    • pp.878-890
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    • 2008
  • As a pioneer of modem dance, $Lo{\ddot{i}}e$ Fuller($1869\sim1928$) was important because she introduced a free style dance using a new style of stage costumes. Also, $Lo{\ddot{i}}e$ Fuller was an important motif in $fin-de-si{\grave{e}}cle$, French arts, posters, sculptures, and so forth. This study aimed to clarify the characteristics of Fuller's dance and costumes, and to analyze the modernism in both. To better understand Fuller's dance, this article talks about research on Fuller's career, dance, and Fuller's own biography. Stage costumes, letters for patent, and photographs were are also studied. The most important elements of Fuller's dance were her costumes and the electric lights which could make free style expressions a fantastic representation of dance. To clarify the modernity of Fuller's dance, first of all, this study researched Fuller's career in dance and then analyzed representations of Fuller's dances in visual arts; posters, sculptures and lastly, the characteristics of Fuller's stage costumes. As a result, this article analyzed characteristics of Fuller's dance in three points. First, Fuller used sculptures of silk cloth's drapery to express physical movements and actions. Second, Fuller used lighting and electrical effects that had just been developed in the late 19th Century. Third, Fuller made an application for patents against stage costume and stage mechanisms for her original shows. This study focused on $Lo{\ddot{i}}e$ Fuller's stage costumes which played a main role in expressing fantastic sculptures for the first time in costume, visual arts, and dance studies. This study clarifies the characteristics of the stage costumes in Fuller's dance and is estimated as pioneering and fundamental research.

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미술사에 표현된 여신의 헤어 아트 연구 (A Study on Goddesses Hair Arts Shown in History of Arts)

  • 이현진;김선아
    • 한국의류산업학회지
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    • 제9권6호
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    • pp.663-670
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    • 2007
  • Arts is the expression of reasoning and conscious life of human and arouse human the concept of existence, utmost emotion and excellent thoughts. Also it makes humans life very abundant. I make it come first to get rid of the art thirst on the opposite sight of technical one for hair as on part of humans body. Next purpose is that to confirm the esthetic value of 'hair arts' by solidify the academic ground of beauty arts through creating 'hair arts' works and learning and make the direction for the beauty industry and education of the next generation. In this study I investigated the Greek myth and the hair styles of ancient Greek Goddesses. On the basis of that symbols I elaborated hair formative works made of metal and studied, analyzed and displayed that. Work No.1 'aphne' pictures the second of changing into a laurel tree avoiding the love. Secondly 'Muse Erato' was exhibited the peaceful figure that have enough the fine melodies. 'Leda' brings out the feature of Leda resembling a swan and the fourth piece, 'Eos' conveys the brilliant and mystery of dawn. So this study conducted based on the concept of practical hair and have made efforts to be close to theoretical manufacturing research needed at making hair arts works and academic one needed at organic design composition for pioneering new field, 'art hair.' I hope these 'hair arts' works make creativity of the practise hair alive. It will be very thankful to me if this study can help even though slightly for splendid beauty arts to make its status firm as a one part of arts, and there are following studies.

사물인터넷(IoT) 산업 진흥을 위한 정부의 역할에 관한 연구 -AHP를 활용한 정책 중요도 분석을 중심으로- (Searching Role of Government for Promoting IoT Industry -Utilizing Importance of Individual Sub-Policies using AHP-)

  • 이용규;윤구홍
    • 디지털융복합연구
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    • 제14권5호
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    • pp.47-55
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    • 2016
  • 본 연구는 IoT 분야의 다양한 정부정책을 파악하고, 이들 간 상대적 중요성을 분석하고자 하였다. 이를 위해 전문가를 대상으로 Analytic Hierarchy Process(AHP)분석방법을 활용하였다. 그 결과, 첫째, IoT 관련 정책범위가 광범위함에도 불구하고, 학계, 산업계 등의 정책 전문가가 매우 제한적이었고, 둘째, 만족도관점에서 해외진출정책, R&D지원 정책, 벤처지원정책, 인력양성정책, 규제정책의 순이었으나 전반적인 만족도 수준은 낮았으며, 셋째, 중요성 관점에서 벤처지원이 가장 높았으며, 그 다음으로 R&D지원, 인력양성, 규제정립, 해외진출의 순으로 높았다. 종합하면 연구활동 지원, 해외시장 개척지원, 벤처제품우선구매, 산학협동 대학교육 강화 등의 선도자적 정부역할에 높은 중요성을 부여하고 있었던 반면에 조정자적 역할에 대한 중요도 인식은 상대적으로 낮았다. 그러나 전문가집단도 정부가 중요한 프로젝트에서는 기본적으로 시범사업이나 실태조사 등을 수행해 와서, 이의 중요성에도 불구하고 제대로 인식하지 못하였을 수 있다.

중소 금형업체 협업지원을 위한 핵심 제조역량 평가 모델 개발 (Assessment Model of Core Manufacturability to Promote Collaboration of Small and Medium Sized Mold Companies)

  • 신문수;이상일;류광열;주재구
    • 산업공학
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    • 제25권1호
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    • pp.52-63
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    • 2012
  • Up-to-date enlargement of the scale of global outsourcing has brought about the need of systematic and efficient tools for competitive supplier discovery located in various areas. A web-based business supporting system, referred to as Excellent Manufacturer Scouting System(EMSS), is being developed to serve core business functions including supplier discovery, negotiation, and collaboration between overseas buyers and domestic suppliers throughout the process of supply chain formation. In this paper, a supplier assessment model devoted to evaluation of core manufacturing capability is proposed by targeting small and medium sized mold companies. The assessment model will eventually be loaded to EMSS. Even if many well-designed models for supplier assessment have been presented in literature, most of them limit the evaluation criteria to somewhat general information on a given supplier, such as cost, delivery time, quality, rather than core manufacturing capability itself. This research is pioneering work on supplier assessment from the viewpoint of manufacturability. The proposed assessment model classifies assessment indices into six criteria, which have been drawn by intensive survey and analysis of the mold industry. Actual assessment indices for each criterion are also presented along with an exemplary evaluation result.

Effect of Encapsulating Nitrate in Sesame Gum on In vitro Rumen Fermentation Parameters

  • Mamvura, Chiedza Isabel;Cho, Sangbuem;Mbiriri, David Tinotenda;Lee, Hong-Gu;Choi, Nag-Jin
    • Asian-Australasian Journal of Animal Sciences
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    • 제27권11호
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    • pp.1577-1583
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    • 2014
  • Encapsulation is a method used to protect material from certain undesirable environments, for controlled release at a more favorable time and place. Animal productivity would be enhanced if feed additives are delivered to be utilized at their site of action, bypassing the rumen where they are likely to be degraded by microbial action. A novel method of encapsulation with sesame gum was used to coat nitrate, a known enteric methane mitigating agent, and tested for the effect on methane reduction and other in vitro fermentation parameters using rumen fluid from cannulated Hanwoo steers. Orchard grass was used as basal diet for fermentation. The treatments were matrix (1.1 g sesame gum+0.4 g sesame oil cake) only, encapsulated nitrate (matrix+nitrate [21 mM]), free nitrate (21 mM), and a control that contained no additive. Analyses of fermentation parameters were done at 0, 3, 6, 9, 12, 24, and 48 h time periods. In comparison to control, both free and encapsulated nitrate produced significantly reduced (p<0.01) methane (76% less) and also the total volatile fatty acids were reduced. A significantly higher (p<0.01) concentration of ammonia nitrogen was obtained with the encapsulated nitrate treatment (44%) compared to the free form (28%) and matrix only (20%) (p = 0.014). This might suggest slow release of encapsulated nitrate so that it is fully reduced to ammonia. Thus, this pioneering study found a significant reduction in methane production following the use of sesame gum encapsulated nitrate that shows the potential of a controlled release system in enhancing sustainability of ruminant production while reducing/eliminating the risk of nitrite toxicity.