• Title/Summary/Keyword: PiD

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A Study about the Mechanism of $Ca^{2+}$ and Pi Homeostasis by Estradiol 17$\beta$ in Proximal Tubule Cells in the Osteoporosis

  • Han Ho-jae;Park Soo-Hyun
    • Biomedical Science Letters
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    • v.10 no.4
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    • pp.375-383
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    • 2004
  • It has been reported that osteoporosis induced by the deficiency of estrogens in menopause is associated with the unbalance of Ca/sup 2+/ and Pi levels. Proximal tubule is very important organ to regualte Ca/sup 2+/ and Pi level in the body. However, the effect of estrogens on Ca/sup 2+/ and Pi regulation was not elucidated. Thus, we examined the effect of 17-β estradiol (E₂) on Ca/sup 2+/ and Pi uptake in the primary cultured rabbit renal proxiaml tubule cells. In the present study, E₂(> 10/sup -9/M) decreases Ca/sup 2+/uptake and stimulates Pi uptake over 3 days. E₂-induced decrease of Ca/sup 2+/ uptake and stimulation of Pi uptake were blocked by actinomycin D (a gene transcription inhibitor), cycloheximide (a protein synthesis inhibitor). tamoxifen, and progesterone (estrogen receptor antagonists). E₂-induced decrease of Ca/sup 2+/ uptake and stimulation of Pi uptake were blocked by SQ22536 (an adenylate cyclase inhibitor), Rp-cAMP (a cAMP antagonist), and PKI (a protein kinase A inhibitor). Indeed, E₂ increased cAMP formation. In addition, E₂-induced decrease of Ca/sup 2+/ uptake and stimulation of Pi uptake were blocked by staurosporine, H-7, and bisindolylmaleimide I (protein kinase C inhibitors) and E₂ translocated PKC from cytoslic fraction to membrane fraction. In conclusion, E₂ decreased Ca/sup 2+/ uptake and stimulated Pi uptake via cAMP and PKC pathway in the PTCs.

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Robust Multiloop Controller Design of Uncertain Affine TFM(Transfer Function Matrix) System (불확실한 Affine TFM(Transfer Function Matrix) 시스템의 강인한 다중 루프 제어기 설계)

  • Byun Hwang-Woo;Yang Hai-Won
    • The Transactions of the Korean Institute of Electrical Engineers D
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    • v.54 no.1
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    • pp.17-25
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    • 2005
  • This paper provides sufficient conditions for the robustness of Affine linear TFM(Transfer Function Matrix) MIMO (Multi-Input Multi-Output) uncertain systems based on Rosenbrock's DNA (Direct Nyquist Array). The parametric uncertainty is modeled through a Affine TFM MIMO description, and the unstructured uncertainty through a bounded perturbation of Affine polynomials. Gershgorin's theorem and concepts of diagonal dominance and GB(Gershgorin Bands) are extended to include model uncertainty. For this type of parametric robust performance we show robustness of the Affine TFM systems using Nyquist diagram and GB, DNA(Direct Nyquist Array). Multiloop PI/PB controllers can be tuned by using a modified version of the Ziegler-Nickels (ZN) relations. Simulation examples show the performance and efficiency of the proposed multiloop design method.

Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis

  • Gao, Qun;Frohman, Michael A.
    • BMB Reports
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    • v.45 no.1
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    • pp.7-13
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    • 2012
  • Phospholipase D (PLD), a superfamily of signaling enzymes that most commonly generate the lipid second messenger Phosphatidic Acid (PA), is found in diverse organisms from bacteria to man and functions in multiple cellular pathways. A fascinating member of the family, MitoPLD, is anchored to the mitochondrial surface and has two reported roles. In the first role, MitoPLD-generated PA regulates mitochondrial shape through facilitating mitochondrial fusion. In the second role, MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. This spermatocyte-specific RNAi, known as piRNA, is generated in the nuage, an electron-dense accumulation of RNA templates and processing proteins that localize adjacent to mitochondria in a structure also called intermitochondrial cement. In this review, we summarize recent findings on these roles for MitoPLD functions, highlighting directions that need to be pursued to define the underlying mechanisms.

Senseless Control of PMSM using Current Regulator Output Voltage in the Synchronous D-axis (자속축 전류제어기 출력전압를 이용한 PMSM 센서리스 제어)

  • Lee, Jong-Kun;Seok, Jul-Ki;Lee, Dong-Choon
    • Proceedings of the KIEE Conference
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    • 2004.04a
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    • pp.147-149
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    • 2004
  • This paper presents a new velocity estimation strategy of a non-salient permanent magnet synchronous motor(PMSM) drive without high frequency signal injection or special PWM pattern. This approach is based on the d-axis current regulator output voltage of the drive system which has the information of rotor position error. The rotor velocity can be estimated through a rotor position tracking PI controller that controls the position error to zero. For zero and low speed operation, the PI gains of rotor position tracking controller have a variable structure. The PI tuning formulas are derived by analyzing this control system using the frequency domain specifications such as phase margin and bandwidth assignment.

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Inelastic Electron Tunneling Spectroscopy of 1-layer Arachidicacid films using a Polyimide barrier (Polyimide 터널 장벽을 이용한 Arachidicacid 단분자막의 비탄성 터널 스펙트라)

  • Lee, Won-Jae;Kang, Dou-Yol;Iwamoto, Mitsumasa
    • Proceedings of the KIEE Conference
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    • 1994.11a
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    • pp.234-236
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    • 1994
  • We fabricated Au/PI/Pb and Au/PI/1-layer Arachidic acid/Pb structures in order to electron transport properties through the junctions. It was found that 9-layer PI LB films function as a good tunneling barrier from the I-V properties. And several peaks originating in the vibrational modes of the constituent molecules of 1-layer arachidicacid LB films were clearly observed in $d^2V/dI^2-V$ curves.

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Experimental Evidence for New Pinning Conditions in Strongly Pinned Permalloy Film

  • Han, Kyung-Hunn;Cho, Jae-Hun;Lee, Suk-Mock
    • Journal of Magnetics
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    • v.12 no.1
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    • pp.27-30
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    • 2007
  • Experimental evidence suggests that spin pinning conditions for standing spin mode in polycrystalline $Ni_{84}Fe_{16}$ alloy film, is confirmed using the four categories of Camley et al. and the value of q$\bot$ for the pinning conditions, this was achieved by performing Brillouin light scattering measurements. The value of q$\bot$ was observed, in order to increase at a rate of $\pi$/2 with an increasing mode number. With this condition, the coexistence of standing spin wave modes was shown, with intermediate pinning, in addition to free and strong pinning. The values for spin-wave-stiffness constant ($D_B$), g-factor (g), and surface magnetization (4$\pi$M) of the Permalloy film were obtained from the results of BLS, and determined to be $D_B=1.85{\pm}0.05Oecm^2$, $g=2.11{\pm}0.02$, and 4$\pi$M=8.7 kG, respectively.

Controller Design of DC Motor Drive System Using dSPACE System (dSPACE 시스템을 이용한 직류 전동기 구동 시스템의 제어기 설계)

  • Ji, Jun-Keun;Lee, Yong-Seok
    • Proceedings of the KIEE Conference
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    • 2005.07a
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    • pp.878-880
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    • 2005
  • 본 논문에서는 직류전동기의 속도 및 전류제어를 위하여 dSPACE 시스템을 이용하여 전류 궤환을 갖는 속도 제어시스템을 구현하였다 속도 및 전류제어기의 설계는 MATLAB/SIMULINK 프로그램을 사용하여 간편하고 손쉽게 구현하였으며 직류전동기 속도제어의 안정성과 응답성을 향상시킬 수 있었다. 직류전동기의 전류제어 및 속도제어는 DSP 보드와 dSPCE 시스템을 사용하여 수행하였으며, 속도의 궤환은 속도센서인 엔코더 펄스를 이용해서 QEP로 처리하였고 전류의 궤환은 전류센서인 홀센서를 통해서 A/D 변환기로 처리하였다. 제어기들은 각각 PI 속도제어기 및 PI 전류제어기를 설계하였고 시뮬레이션과 실험을 통해서 속도 및 전류 응답을 확인하였다.

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EFFICINET GENERATION OF MAXIMAL IDEALS IN POLYNOMIAL RINGS

  • Kim, Sunah
    • Bulletin of the Korean Mathematical Society
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    • v.29 no.1
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    • pp.137-143
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    • 1992
  • The purpose of this paper is to provide the affirmative solution of the following conjecture due to Davis and Geramita. Conjecture; Let A=R[T] be a polynomial ring in one variable, where R is a regular local ring of dimension d. Then maximal ideals in A are complete intersection. Geramita has proved that the conjecture is true when R is a regular local ring of dimension 2. Whatwadekar has rpoved that conjecture is true when R is a formal power series ring over a field and also when R is a localization of an affine algebra over an infinite perfect field. Nashier also proved that conjecture is true when R is a local ring of D[ $X_{1}$,.., $X_{d-1}$] at the maximal ideal (.pi., $X_{1}$,.., $X_{d-1}$) where (D,(.pi.)) is a discrete valuation ring with infinite residue field. The methods to establish our results are following from Nashier's method. We divide this paper into three sections. In section 1 we state Theorems without proofs which are used in section 2 and 3. In section 2 we prove some lemmas and propositions which are used in proving our results. In section 3 we prove our main theorem.eorem.rem.

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Controller Design of DC Motor Drive System Using dSPACE System (dSPACE 시스템을 이용한 직류 전동기 구동 시스템의 제어기 설계)

  • Ji, Jun-Keun;Lee, Yong-Seok
    • Proceedings of the KIEE Conference
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    • 2005.07d
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    • pp.3090-3092
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    • 2005
  • 본 논문에서는 직류전동기의 속도 및 전류제어를 위하여 dSPACE 시스템을 이용하여 전류 궤환을 갖는 속도 제어시스템을 구현하였다 속도 및 전류제어기의 설계는 MATLAB/SIMULINK 프로그램을 사용하여 간편하고 손쉽게 구현하였으며 직류전동기 속도제어의 안정성과 응답성을 향상시킬 수 있었다. 직류전동기의 전류제어 및 속도제어는 DSP 보드와 dSPCE 시스템을 사용하여 수행하였으며, 속도의 궤환은 속도센서인 엔코더 펄스를 이용해서 QEP로 처리하였고 전류의 궤환은 전류센서인 홀센서를 통해서 A/D 변환기로 처리하였다. 제어기들은 각각 PI 속도제어기 및 PI 전류제어기를 설계하였고 시뮬레이션과 실험을 통해서 속도 및 전류 응답을 확인하였다.

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