• 대한조선학회논문집
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• 제29권2호
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• pp.115-122
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• 1992

Sandwich구조는 복합구조의 특별한 hybrid구조의 형태로써 두 층의 얇은 표면재와 가운데 두꺼운 층인 경량의 심재로 구성되어 있으며, 이는 표면재와 심재가 접착된 일체로써 서로의 단점을 보완하면서 구조 효율을 높인 형상이다. 또한 심재는 표면재에 비해서 상당히 두꺼운 두께를 갖기 때문에 전단 변형이 중요하므로 굽힘 강성도(bending stiffness) 계산에 전단효과가 고려되어야 한다. 구조 설계에서 중요한 목적은 중량 감소에 있기 때문에 본 논문에서는 sandwich panel의 설계시 표면재와 심재의 두께 및 재질을 변화시켜 제한조건에 맞는 최소 중량을 얻는 데 중점을 두었다. 본 해석에서 sandwich panel의 최소중량을 얻기 위하여 표면재와 전단력을 고려한 심재의 변형에 따른 변형에너지를 각각 계산한 후, 최소 potential 에너지 원리를 적용하여 목적함수의 최적치를 구하였다. 설계 제한조건으로는 허용 처짐, 허용 굽힘응력, 허용 전단응력과 국부적인 불안정 상태의 wrinkling 응력이 고려되었으며, 설계 모델은 수직 분포 하중에 의한 여러가지 경계조건에 따른 sandwich panel을 대상으로 하였다. 비선형 최적화 기법은 Nelder and Mead Simplex Search Method와 Hooke and Jeeves Pattern Search method에 External Penalty Function이 적용된 SUMT방법을 결합시킨 SUMTNM와 SUMTHJ를 사용하였으며, 해석 결과는 sandwich panel의 구조 설계에 활용할 수 있도록 표를 작성하였다.

• 한국실내디자인학회논문집
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• 제23권1호
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• pp.88-95
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• 2014

This study intended arousal of other viewpoints that deal with and understand spaces and shapes, by describing the concept of 'dimensions' into visual patterns. Above all, the core concept of spatial dimensions was defined as 'expandability'. Then, first, the 'golden ratio', 'Fibonacci sequence', and 'fractal theory' were defined as elements of each dimension by stage. Second, a 'unit cell' of one dimension as 'minimum unit particles' was set. Next, Fibonacci sequence was set as an extended concept into two dimensions. Expansion into three dimensions was applied to the concept of 'self-similarity repetition' of 'Fractal'. In 'fractal dimension', the concept of 'regularity of irregularity' was set as a core attribute. Plus, Platonic solids were applied as a background concept of the setting of the 'unit cell' from the viewpoint of 'minimum unit particles'. Third, while 'characteristic patterns' which are shown in the courses of 'expansion' of each dimension were embodied for the visual expression forms of dimensions, expansion forms of dimensions are based on the premise of volume, directional nature, and concept of axes. Expressed shapes of each dimension are shown into visually diverse patterns and unexpected formative aspects, along with the expression of relative blank spaces originated from dualism. On the basis of these results, the 'unit cell' that is set as a concept of theoretical factor can be defined as a minimum factor of a basic algorism caused by other purpose. In here, by applying diverse pattern types, the fact that meaning spaces, shapes, and dimensions can be extracted was suggested.

• 한국자기학회지
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• 제8권4호
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• pp.185-191
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• 1998

본 연구는 극박 35Si-Fe 방향성 규소강판을 권자심으로 사용하는 것을 목적으로 권자심의 곡률반경과 두께에 따른 탄성 및 소성변형솨 같은 변형 상태를 조사하였으며, 응력제거 열처리 온도에 따른 권자심의 응력의 완화와 자기특성의 변화를 자구구조와 관련지어 검토하였다. 시료의 두께와 곡률반경에 대해 소성변형의 경계가 간단한 식으로 얻어졌고, 실험치와 비교한 결과 일치하엿다. 극박규소강판을 권자심으로 감은 직후에는 시료의 내표면에 도입된 응역에 의해 180$^{\circ}$자벽은 관찰되지 dkag고 메이지 패턴의 자구구조가 관찰되었다. 열처리 온도가 $600^{\circ}C$에서 응력이 완하되기 시작하며 자기특성도 회복하였고 권자심 내표면에 180$^{\circ}$ 자벽이 회복되었다. 그러나 90$0^{\circ}C$$\times$30 min의 열처리를 하여도 권자심의 B8는 스트립상의 값으로 회복되지만 탄성변형역에 존재하는 시료에서조차도 Hc는 회복되지 않았다. 이는 내표면에 잔류하는 메이즈 패턴의 자구에 의한 것으로 생각된다. 이 실험으로부터 극박 ？향성 규소 강판을 이용하여 권자심을 제작할 때 권자심에 국부적으로 도입되는 응력에 대한 대책이 매우 중요하다고 생각된다.

• Molecules and Cells
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• 제41권2호
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• pp.140-149
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• 2018

The $TIS21^{/BTG2/PC3}$ gene belongs to the antiproliferative gene (APRO) family and exhibits tumor suppressive activity. However, here we report that TIS21 controls lipid metabolism, rather than cell proliferation, under fasting condition. Using microarray analysis, whole gene expression changes were investigated in liver of TIS21 knockout (TIS21-KO) mice after 20 h fasting and compared with wild type (WT). Peroxisome proliferator-activated receptor alpha ($PPAR{\alpha}$) target gene expression was almost absent in contrast to increased lipid synthesis in the TIS21-KO mice compared to WT mice. Immunohistochemistry with hematoxylin and eosin staining revealed that lipid deposition was focal in the TIS21-KO liver as opposed to the diffuse and homogeneous pattern in the WT liver after 24 h starvation. In addition, cathepsin E expression was over 10 times higher in the TIS21-KO liver than that in the WT, as opposed to the significant reduction of thioltransferase in both adult and fetal livers. At present, we cannot account for the role of cathepsin E. However, downregulation of glutaredoxin 2 thioltransferase expression might affect hypoxic damage in the TIS21-KO liver. We suggest that the $TIS21^{/BTG2}$ gene might be essential to maintain energy metabolism and reducing power in the liver under fasting condition.

• Structural Engineering and Mechanics
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• 제86권3호
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• pp.385-397
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• 2023

This study presents an experiment and analysis to compare the seismic behavior of full-scale reinforced concrete beam-column joint strengthened by prestressed steel strips, externally bonded steel plate, and CFRP sheets. For experimental investigation, five specimens, including one joint without any retrofitting, one joint retrofitted by externally bonded steel plate, one joint retrofitted by CFRP sheets, and two joints retrofitted by prestressed steel strips, were tested under cyclic-reserve loading. The failure mode, strain response, shear deformation, hysteresis behavior, energy dissipation capacity, stiffness degradation and damage indexes of all specimens were analyzed according to experimental study. It was found that prestressed steel strips, steel plate and CFRP sheets improved shear resistance, energy dissipation capacity, stiffness degradation behavior and reduced the shear deformation of the joint core area, as well as changed the failure pattern of the specimen, which led to the failure mode changed from the combination of flexural failure of beams and shear failure of joints core to the flexural failure of beams. In addition, the beam-column joint retrofitted by steel plate exhibited a high bearing capacity, energy consumption capacity and low damage index compared with the joint strengthened by prestressed steel strip, and the prestressed steel strips reinforced joint showed a high strength, energy dissipation capacity and low shear deformation, stirrups strains and damage index compared to the CFRP reinforced joint, which indicated that the frame joints strengthened with steel plate exhibited the most excellent seismic behavior, followed by the prestressed steel strips.

• 대한약침학회지
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• 제26권3호
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• pp.227-237
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• 2023

Objectives: Pharmacopuncture is considered a unique new type of acupuncture in Korean medicine (KM). This study was performed to investigate the research trends regarding pharmacopuncture through a bibliometric analysis using VOSviewer. Methods: The Web of Science Core Collection was searched for this study. The search terms were pharmacopuncture and pharmaco-puncture. The search was conducted on May 23, 2023, and 185 studies retrieved up to this date were included. Software VOSviewer version 1.6.19 was used to perform the bibliometric analysis. After data clearing, keyword co-occurrence and cooperation pattern analyses were performed. Results: The number of studies on pharmacopuncture have gradually increased since the mid-2000s, with the most published in 2020 (46 studies). The quality of the studies has also steadily increased, and recently, several randomized controlled trials of pharmacopuncture have been conducted. Moreover, this treatment has been investigated in the context of KM clinical practice guideline development in Korea. The scope of pharmacopuncture studies to date seems to be limited to musculoskeletal pain and bee venom pharmacopuncture. The researchers from Jaseng Medical Foundation have been the core researchers in the field of pharmacopuncture in Korea. They collaborated with researchers from universities or government-funded research institutes. However, small-scale research teams from KM clinics and university researchers were also identified as independent clusters. Conclusion: Pharmacopuncture research has grown both quantitatively and qualitatively, but the scope needs to be further expanded. There is also a gap between the use of pharmacopuncture by KM doctors in clinical settings and pharmacopuncture research. Based on these findings, some suggestions for future studies in this field are discussed. Furthermore, these findings may be used as data to expand and globalize pharmacopuncture research in the future.

• Animal Bioscience
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• 제36권12호
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• pp.1905-1917
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• 2023

Objective: Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2). It is an epiblast lineage marker in mammalian pre-implantation embryos and exhibits a species-specific expression pattern. Therefore, it is important to understand the lineage of NANOG, the trophectoderm, and the primitive endoderm in the pig embryo. Methods: A loss- and gain-of-function analysis was done to determine the role of NANOG in lineage specification in parthenogenetic porcine blastocysts. We analyzed the relationship between NANOG and pluripotent core transcription factors and other lineage makers. Results: In NANOG-null late blastocysts, OCT4-, SOX2-, and SOX17-positive cells were decreased, whereas GATA binding protein 6 (GATA6)-positive cells were increased. Quantitative real-time polymerase chain reaction revealed that the expression of SOX2 was decreased in NANOG-null blastocysts, whereas that of primitive endoderm makers, except SOX17, was increased. In NANOG-overexpressing blastocysts, caudal type homeobox 2 (CDX2-), SOX17-, and GATA6-positive cells were decreased. The results indicated that the expression of primitive endoderm markers and trophectoderm-related genes was decreased. Conclusion: Taken together, the results demonstrate that NANOG is involved in the epiblast and primitive endoderm differentiation and is essential for maintaining pluripotency within the epiblast.

• Investigative Magnetic Resonance Imaging
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• 제17권2호
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• pp.101-109
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• 2013

목적: 초음파 유도 하 중심부 침생검으로 진단된 2 cm 이상의 관상피내암종 저평가 수술 전 예측에 역동적 유방 자기공명 영상 및 확산강조영상의 역할을 규명하고자 한다. 대상과 방법: 14 gauge침을 이용한 초음파 유도 하 중심부 침생검을 통해 관상피내암종으로 진단된 22명의 환자를 대상으로 하였다. 환자는 조직병리 결과에 의거하여 관상피내암종 저평가 유무에 따라 두 군으로 나뉘었다. 모든 환자에서 역동적 유방 자기공명 영상 및 확산강조영상을 포함한 3 테슬라 유방 자기공명 영상을 획득하였다. 생검으로 확인된 악성 종괴에 대해, 병변의 형태 (종괴 혹은 비종괴), 조영 증강 형태, 조영 증강 최고점, 및 현성 확산 계수를 CADstream 소프트웨어를 이용하여 획득 하였으며, Fisher's exact test및 Mann Whitney test 이용하여 이 항목을 비교, 분석하였다. 결과: 총 22명의 환자 중 8명의 환자가 저평가 군으로 분류되었다. 병변의 형태 및 조영증강 형태는 두 군의 통계학적 차이가 없었다 (P values = 1.000 및 0.613). 조영 증강 최고점의 중앙값은 저평가 군에서 159.5% 로 저평가 되지 않은 군의 133.5% 보다 높았으나 통계학적 유의한 차이를 보이지 않았다 (P value = 0.413). 저평가 군의 현성 확산 계수는 $1.26{\times}10^{-3}mm^2/sec$로 저평가 되지 않은 군의 $1.35{\times}10^{-3}mm^2/sec$ 보다 낮았다 (P value = 0.094). 결론: 현성 확산 계수는 초음파 유도한 중심부 침생검에 의한 관상피내암종 저평가 수술 전 예측에 도움이 될 가능성 있으며 추후 전향적 연구를 통해 이 연구 결과를 확인하는 것이 필요하겠다.

• Restorative Dentistry and Endodontics
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• 제21권1호
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• pp.136-149
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• 1996

The effects of various All-Etching Agents (10% phosphoric acid, 10% maleic acid and 10 % citric acid) and 32 % phosphoric acid and varied etching time were evaluated by observing the morphology of the etched enamel surfaces using Scanning electron microscopy and by measuring the shear bond strength of a composite resin to human enamel. A total of 156 extracted premolar and molar teeth free of irregularities were employed in this study. Specimens for the observation of enamel morphology were divided into 12 groups of 3 teeth each, based on the type of etchant used and application time. After exposure to the etching agent specimens were washed air-dried and then glued to aluminum stubs and coated with a layer of gold for examination in the scanning electron microscope. Specimens for the evaluation of bond strength were divided into 12 groups of 10 teeth each also based on the type of etchant used and application time. After exposure to the etching agent the specimens were washed, air-dried and a thin layer of bonding agent was applied using a brush. Z 100 composite resin was light cured to the surface and stored at $37^{\circ}C$, 100% humidity for 7 days. An Instron Universal Testing Machine was used to apply a shearing force at $90^{\circ}$ angle from the enamel surface. It is concluded from this study that commercial All-etching agents can be used with a 15-second etching without adversely affecting retention of dental resin materials. At the same time, the acid concentration is probably a suitable compromise regarding the acid's function as a dentin demineralizing all-etch conditioning agent. The following results were obtained. 1. Specimens etched with 10 % citric acid showed a random superficial etching pattern which could not be related to prism morphology. 2. Specimens etched with 10 % and 32 % phosphoric acid and 10 % maleic acid showed a type I pattern in which core material was preferentially removed leaving the prism peripheries relatively intact or a type II pattern in which prism peripheries were preferentially removed. This delineation became more distinguished as etching time was increased. 3. All-Etching Agents and 32 % phosphoric acid showed a statistically significant higher shear bond strength at 15 seconds etching time.(p<0.05) 4. 10 % maleic acid and 32 % phosphoric acid exhibited a statistically significant higher shear bond strength than 10 % phosphoric and citric acid at 15 seconds etching time.(p<0.05).

• 대한치과보철학회지
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• 제43권4호
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• pp.544-561
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• 2005

Purpose : This study was to assess the loading distributing characteristics of implant systems with internal connection or external connection under vertical and inclined loading using finite element analysis. Materials and methods : Two finite element models were designed according to type of internal connection or external connection The crown for mandibular first molar was made using cemented abutment. Each three-dimensional finite element model was created with the physical properties of the implant and surrounding bone This study simulated loads of 200N at the central fossa in a vertical direction (loading condition A), 200N at the centric cusp tip in a 15$^{\circ}$ inward inclined direction (loading condition B), or 200N at the centric cusp tip in a 30$^{\circ}$ outward inclined direction (loading condition C) respectively. Von Mises stresses were recorded and compared in the supporting bone, fixture, abutment and abutment screw. Results : 1. In comparison with the whole stress or the model 1 and model 2, the stress pattern was shown through th contact of the abutment and the implant fixture in the model 1, while the stress pattern was shown through the abutment screw mainly in the model 2. 2. Without regard to the loading condition, greater stress was taken at the cortical bone, and lower stress was taken at the cancellous bone. The stress taken at the cortical bone was greater at the model 1 than at the model 2, but the stress taken at the cortical bone was much less than the stress taken at the abutment, the implant fixture, and the abutment screw in case of both model 1 and model 2. 3. Without regard to the loading condition, the stress pattern of the abutment was greater at the model 1 than at the model 2. 4. In comparison with the stress distribution of model 1 and model 2, the maximum stress was taken at the abutment in the model 1. while the maximum stress was taken at the abutment screw in the model 2. 5. The magnitude of the maximum stress taken at the supporting bone, the implant fixture, the abutment, and the abutment screw was greater in the order of loading condition A, B and C. Conclusion : The stress distribution pattern of the internal connection system was mostly distributed widely to the lower part along the inner surface of the implant fixture contacting the abutment core through its contact portion because of the intimate contact of the abutment and the implant fixture and so the less stress was taken at the abutment screw, while the abutment screw can be the weakest portion clinically because the greater stress was taken at the abutment screw in case of the external connection system, and therefore the further clinical study about this problem is needed.