PPARα-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition |
Hong, Allen Eugene
(Ajou Graduate School of medicine)
Ryu, Min Sook (BK Plus program, Department of Biomedical Sciences, Ajou University Graduate School of Medicine) Kim, Seung Jun (R&D center, BioCore Co. Ltd.) Hwang, Seung Yong (R&D center, BioCore Co. Ltd.) Lim, In Kyoung (Ajou Graduate School of medicine) |
1 | Lim, I.K. (2006). TIS21/BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule. J. Cancer Res. Clin. Oncol. 132, 417-426. DOI |
2 | Lim, I.K., Lee, M.S., Lee, S.H., Kim, N.K., Jou, I., Seo, J.-S., and Park, S.C. (1995). Differential expression of TIS21 and TIS1 genes in the various organs of Balb/c mice, thymic carcinoma tissues and human cancer cell lines. J. Cancer Res. Clin. Oncol. 121, 279-284. DOI |
3 | Lim, S.-K., Choi, Y.W., Lim, I.K., and Park, T.J. (2012). BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria. Clin. Exp. Metastasis 29, 901-913. DOI |
4 | Mao, B., Zhang, Z., and Wang, G. (2015). BTG2: A rising star of tumor suppressors. Int. J. Oncol. 46, 459-464. DOI |
5 | Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., and Ohsumi, Y. (2004). In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111. DOI |
6 |
Mootha, V.K., Lindgren, C.M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstrale, M., and Laurila, E. (2003). PGC- |
7 | Park, T.J., Kim, J.Y., Oh, S.P., Kang, S.Y., Kim, B.W., Wang, H.J., Song, K.Y., Kim, H.C., and Lim, I.K. (2008). TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. Hepatology 47, 1533-1543. DOI |
8 | Newberry, E.P., Xie, Y., Kennedy, S., Han, X., Buhman, K.K., Luo, J., Gross, R.W., and Davidson, N.O. (2003). Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J. Biol. Chem. 278, 51664-51672. DOI |
9 | Page, J.L., Strom, S.C., and Omiecinski, C.J. (2007). Regulation of the human cathepsin E gene by the constitutive androstane receptor. Arch. Biochem. Biophys. 467, 132-138. DOI |
10 | Park, S., Lee, Y.J., Lee, H.-J., Seki, T., Hong, K.-H., Park, J., Beppu, H., Lim, I.K., Yoon, J.-W., and Li, E. (2004). B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol. Cell. Biol. 24, 10256-10262. DOI |
11 | Passeri, D., Marcucci, A., Rizzo, G., Billi, M., Panigada, M., Leonardi, L., Tirone, F., and Grignani, F. (2006). Btg2 enhances retinoic acidinduced differentiation by modulating histone H4 methylation and acetylation. Mol. Cell. Biol. 26, 5023-5032. DOI |
12 | Rabinowitz, J.D., and White, E. (2010). Autophagy and metabolism. Science 330, 1344-1348. DOI |
13 |
Sundaramoorthy, S., Ryu, M.S., and Lim, I.K. (2013). B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NF |
14 | Rakhshandehroo, M., Knoch, B., Muller, M., and Kersten, S. (2010). Peroxisome proliferator-activated receptor alpha target genes. PPAR Res. 2010. |
15 | Rouault, J.P., Falette, N., Guehenneux, F., Guillot, C., Rimokh, R., Wang, Q., Berthet, C., Moyret-Lalle, C., Savatier, P., Pain, B., et al. (1996). Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat. Genet. 14, 482-486. DOI |
16 | Schupp, M., Chen, F., Briggs, E.R., Rao, S., Pelzmann, H.J., Pessentheiner, A.R., Bogner-Strauss, J.G., Lazar, M.A., Baldwin, D., and Prokesch, A. (2013). Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. BMC Genomics 14, 758. DOI |
17 | Shannon, P., Markiel, A., Ozier, O., Baliga, N.S., Wang, J.T., Ramage, D., Amin, N., Schwikowski, B., and Ideker, T. (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498-2504. DOI |
18 | Subramanian, A., Tamayo, P., Mootha, V.K., Mukherjee, S., Ebert, B.L., Gillette, M.A., Paulovich, A., Pomeroy, S.L., Golub, T.R., and Lander, E.S. (2005). Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550. DOI |
19 | Terra, R., Luo, H., Qiao, X., and Wu, J. (2008). Tissue-specific expression of B-cell translocation gene 2 (BTG2) and its function in Tcell immune responses in a transgenic mouse model. Int. Immunol. 20, 317-326. DOI |
20 | Wu, H., Xing, K., and Lou, M.F. (2010). Glutaredoxin 2 prevents H2O2-induced cell apoptosis by protecting complex I activity in the mitochondria. Biochim. Biophys. Acta -Bioenergetics 1797, 1705-1715. DOI |
21 | Yamamoto, K., Kawakubo, T., Yasukochi, A., and Tsukuba, T. (2012). Emerging roles of cathepsin E in host defense mechanisms. Biochim. Biophys. Acta -Bioenergetics 1824, 105-112. DOI |
22 | Zhang, F., Xu, X., Zhou, B., He, Z., and Zhai, Q. (2011). Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeeding. PloS one 6, e27553. DOI |
23 | Kageyama, T., Tatematsu, M., Ichinose, M., Yahagi, N., Miki, K., Moriyama, A., and Yonezawa, S. (1998). Development-dependent expression of cathepsins d and e in various rat tissues, with special reference to the high expression of cathepsin e in fetal liver. Zool. Sci. 15, 517-523. |
24 | Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M., and Tanabe, M. (2016). KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44, D457-D462. DOI |
25 | Kim, B.C., Ryu, M.S., Oh, S.P., and Lim, I.K. (2008). TIS21/BTG2 negatively regulates estradiol-stimulated expansion of hematopoietic stem cells by derepressing Akt phosphorylation and inhibiting mTOR signal transduction. Stem Cells 26, 2339-2348. DOI |
26 | Kim, Y.-D., Im, S.-S., Oh, B.-C., Bae, J.-H., and Song, D.-K. (2014). Bcell Translocation Gene 2 regulates hepatic glucose homeostasis via induction of orphan nuclear receptor Nur77 in diabetic mouse model. Diabetes 63, 1870-1880 DOI |
27 | Li, C., Yu, S., Zhong, X., Wu, J., and Li, X. (2012). Transcriptome comparison between fetal and adult mouse livers: implications for circadian clock mechanisms. PloS one 7, e31292. DOI |
28 | Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., and Uchiyama, Y. (2005). Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169, 425-434. DOI |
29 | Lee, Y.-H., Kim, H.-J., Lee, W.-Y., Kim, M.-J., Tark, D.-S., Cho, I.-S., and Sohn, H.-J. (2012). Gene expression profile of a persistently chronic wasting disease (CWD) prion-infected RK13 cell line. J. Prev. Veterinary Med. 36, 186-195. |
30 | Lee, J.M., Wagner, M., Xiao, R., Kim, K.H., Feng, D., Lazar, M.A., and Moore, D.D. (2014). Nutrient-sensing nuclear receptors coordinate autophagy. Nature 516, 112-115. |
31 | Kanehisa, M., and Goto, S. (2000). KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27-30. DOI |
32 | Choi, J., Jung, Y., Kim, J., Kim, H., and Lim, I. (2016). Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes. Oncogene 35, 83. DOI |
33 | Fletcher, B., Lim, R., Varnum, B., Kujubu, D., Koski, R., and Herschman, H. (1991). Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters. J. Biol. Chem. 266, 14511-14518. |
34 | Folch, J., Lees, M., and Sloane-Stanley, G. (1957). A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509. |
35 | Bradbury, A., Possenti, R., Shooter, E.M., and Tirone, F. (1991). Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. Proc. Natl. Acad. Sci. USA 88, 3353-3357. DOI |
36 | Hakvoort, T.B., Moerland, P.D., Frijters, R., Sokolovic, A., Labruyere, W.T., Vermeulen, J.L., van Themaat, E.V.L., Breit, T.M., Wittink, F.R., and van Kampen, A.H. (2011). Interorgan coordination of the murine adaptive response to fasting. J. Biol. Chem. 286, 16332-16343. DOI |
37 | Hu, X.-D., Meng, Q.-H., Xu, J.-Y., Jiao, Y., Ge, C.-M., Jacob, A., Wang, P., Rosen, E.M., and Fan, S. (2011). BTG2 is an LXXLLdependent co-repressor for androgen receptor transcriptional activity. Biochem. Biophys. Res. Commun. 404, 903-909. DOI |
38 | Huang, D.W., Sherman, B.T., and Lempicki, R.A. (2008). Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13. |
39 | Huang, D.W., Sherman, B.T., and Lempicki, R.A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protocols 4, 44. DOI |
40 | Hwang, S.-L., Kwon, O., Lee, S.J., Roh, S.-S., Kim, Y.D., and Choi, J.H. (2012). B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB. Biochem. Biophys. Res. Commun. 427, 801-805. DOI |
41 | Choi, J.-A., and Lim, I.K. (2013). TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDAMB-231 cells. J. Cancer Res. Clin. Oncol. 139, 1657-1665. DOI |
42 | Cahill Jr, G.F. (2006). Fuel metabolism in starvation. Annu. Rev. Nutr. 26, 1-22. DOI |
43 | Chlabicz, M., Gacko, M., Worowska, A., and Łapinski, R. (2011). Cathepsin E (EC 3.4. 23.34)-a review. Folia Histochem. Cytobiol. 49, 547-557. |
![]() |