• Archives of Pharmacal Research
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• v.5 no.2
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• pp.61-70
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• 1982

Sulfisoxazole, a chemotherapeutic agent, was microencapsulated with ethylcellulose by means of phase separation form cyclohexane by temperatture change. The size distribution was determined by use of standard sieves and the effect of core to wall ratio was noted. To examine their shapes and usrface characteristics, the microcapsules were observed with a scanning electron microscope. Release of the drug from microcapsules into pH 7.5 buffer medium was studied. The release pattern was found to have similar properties to the release of a drug from an insoluble porous matrix reported. The apparent diffusion coefficient of sulfisoxazole was measured for the transport of the drug from the core of microcapsules into the surronding sink condition. The apparent diffusion coefficient increased with increasing capsule size.

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.649-652
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• 2003

Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed monodispersity and good water-dispersibility. The loading content of EGF to the nanoparticles was very high due to electrostatic interaction between EGF and nanoparticles. EGF was released as a pseudo-zero order pattern after initial burst effect. The nanoparticles were sufficient for A431 cells proliferation.

• Steel and Composite Structures
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• v.51 no.1
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• pp.1-8
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• 2024

Transient dynamic behavior of a sandwich beam under thermal and impulsive loads has been researched in the context of higher-order beam theory. The impulse load of blast type has been enforced on the top exponent of the sandwich beam while it is in a thermal environment. The core of the sandwich beam is cellular with auxetic rectangular pattern, whereas the layers have been built with the incorporation of graphene oxide powder (GOP) and are micromechanically introduced through Halpin-Tsai formulization. Governing equations for the sandwich beam have been solved through inverse Laplace transform style for obtaining the dynamical deflections. The connection of beam deflections on temperature variability, GOP quantity, pulse load situation and core relative density has been surveyed in detail.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.7
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• pp.3194-3200
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• 2012

The aim of the paper is systematically to organize the historical facts of financial IT development process through various tracking and proved knowledge, it is to propose the direction and the advanced frame of core-banking model in next generation for the year 2020s. To achieve it, this study variously analyzed the meaningful pattern of development process of financial IT by backtracking life-cycle of Core-Banking model and it presented new model of Core-Banking for the past 40 years. In research findings, the life cycle of financial IT system and core-banking model have been analyzed about 10 years and the longest model of life cycle is about 33 years. As a result, It proved to be desirable that the advanced frame of the Core-Banking model adds the functions of business hub and product life cycle management to basic frame of its existing model in the future. In addition, big bang development method of new next generation system must be sublated. Also, They need to be initiated more business-oriented than IT-oriented. Along with this, the financial IT should be developed into the convergence industry, and it needs to extend the systematization of Core-Banking model studies and more professionals. Finally, this study has arranged the financial IT development process in domestic and presents new frame through analyzing intensively the Core-Banking model for the first time Therefore, it can be contributed to serve the guideline regarding the direction in new next generation system.

• Korean Journal of Breeding Science
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• v.41 no.4
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• pp.369-376
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• 2009

Cowpea might have been introduced from China to Korea and cultivated for several hundred years but it has never been a staple food crop in Korea. In this study, genetic diversity of 492 Korean cowpea landrace accessions that have passport information was estimated using six SSR markers. The mean of Weir's gene diversity was 0.665 from all accessions investigated in the study. Cowpea gene diversity of six local provinces in Korea was ranged from 0.370 in accessions of Gangwon to 0.680 in Jeonra provinces. Low gene diversity of the cowpea genepool of Gangwon province was probably derived from relatively few introductions. Especially SSR markers VM36 and VM39 seem to be good markers to distinguish the Gangwon accessions from others by occurring at a specific locus with higher than 78% of allele frequency. Except for the Gangwon province with the low genetic diversity, gene diversity of cowpea accessions from other provinces was ranged from 0.600 to 0.680 indicating no big differences among provinces. Distribution pattern of the allele frequencies was similar among the other provinces. This may reveal that Korean farmers might exchange cowpea seeds easily with even their neighbors with geographical barriers. A core collection, 100 landraces, ca. 20% of base collection, was developed at the 70% of a similarity coefficient level using random sampling approaches after stratification of the entire landrace collection based on the phenetic dendrogram. The variability of SSR in the base and core collections of Korean cowpea landrace was compared by calculating Weir's gene diversity. The mean of Weir's gene diversity of the core was 0.707 while that of the base collection was 0.665. The higher diversity index in the core collection indicates that it maintains the initial variability and well represents the base collection. The core collection included one of determinate accession (IT 216155) and two of no branching type accessions (IT 103959 and IT 161024). The core collection could be used to guide more efficient management and utilization of the entire collection. This core collection should be revised periodically as additional accessions are collected and further characterization is conducted.

• Economic and Environmental Geology
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• v.39 no.1 s.176
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• pp.39-51
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• 2006

Rare earth elements(REEs) in transgressive shelf core sediments were analysed to identify constraints of REE distribution patterns and sediment provenances in the northern East China Sea(ECS). Sediments of Chinese and Korean rivers, such as Huanghe and Yangtz rivers, Keum and Yeongsan rivers that supply sediments to the northern ECS, were also analysed to figure out their typical REE distribution patterns. The distribution patterns of Chinese and Korean river sediments, which are normalized with upper continental crust (UCC) REE values, appear to be enriched in middle rare earth elements (MREEs) in Chinese river sediments, whereas in light rare earth elements (LREEs) in Korean river sediments. We assign the MREE-enriched convex-type distribution pattern in Chinese river sediments as 'C-type', and the LREE-enriched linearly decreasing pattern in Korean river sediments as 'D-type'. A major constraint of the REE concentration in northern ECS core sediments is interpreted to be LREE-enriched monazite $((Ce,\;La)PO_4)$ that is ubiquitous in and around the study area. Meanwhile, the distribution pattern of northern ECS sediments appears to be between the C-type and the D-type. We suggest that the nothern ECS sediments are the mixture of China and Korea riverine sediments that have been accumulated in paleo-river mouth, paleo-coast, and present-day shelf environment as well.

• Journal of The Korean Society of Integrative Medicine
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• v.6 no.4
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• pp.39-45
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• 2018

Purpose : The purpose of this study is to investigate the effect of core motion pattern on abdominal muscle thickness on unstable support surface using sling suspension system and to provide an effective exercise program for therapeutic rehabilitation in clinical practice. Methods : In this study, we used the flank exercise using a sling. It was intended for 21 healthy men and 9 healthy women. Before and after the exercise of the subjects, abdominal muscles (EO, IO, TrA the thickness of the muscle) was determined using a diagnostic ultrasonic apparatus. The period of exercise was 3 times a week for 6 weeks. The exercise for each group started with 3 sets per week and 1 set per week was added. A description of the method and attitude of each exercise is as follows. First, the push-up flank 's exercise position is to put both feet on the sling and hold the floor with both hands. Second, the side flank's exercise postures take the side flanks, while the two legs hang on the sling and one arm supports the body with an articulated bend (about $90^{\circ}$). Third, the elbow flank's exercise position is to put the two legs on the sling, and take a flank posture with the arms bent and joint bending (about $90^{\circ}$). Results : There was a significant difference in the thickness of the muscle in the three flank movements after the exercise (p<.05). The most significant difference was in the change of the muscle thickness in the abdominal muscle, the outer muscle, and the stomach in the elbow flank exercise after exercise. There was a significant difference between the mean thickness of the abdominal muscles according to the flank type after exercise (p<.05). Conclusion : In flank exercise for core stabilization using sling, it is considered effective to strengthen the abdominal muscles by considering the support surface, difficulty level, change of movement pattern.

• International Area Studies Review
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• v.14 no.2
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• pp.251-272
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• 2010

This study was done through Panel Gravity Model to analyze the trade pattern of Korean motor industry and empirical analysis was also performed on the effect of regional economies joining to the Korean trade is to draw out some implications. Compared with per capita pattern regarding the income levels of both the countries, the results indicated that trade of Korean motor industry followed GDP pattern in accordance with the overall market. The results of effect on regional economic integration to Korean motor industry reflected 179% and 198% increase in motor trade industry and motor parts trade, respectively. To expand the trade of Korean motor industry at the international competitiveness level, focus should be made on smaller, smarter and greener car with lesser impact on the environment. Hence, the present investigation suggested that government should not delay in retaining the core technology as well as private sector should also aggressively invest in the market.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1269-1272
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• 2005

Sandwich structures, which are composed of thick core between two thin faces, are commonly used in many engineering applications because they combine high stiffness and strength with low weight. In this research, we have investigated the embossing configuration at the sheet metal shape through research with regard to the construction that the hardness and stiffness are excellent, and formability is advantage as inner structure. Through the FLD analysis according to the pattern changes, we have confirmed the forming possibility and variation of the aspect thickness. Also, we have fabricated the embossing press mold according to the pattern changes, and obtained the embossing inner structure the forming experiments.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.431-434
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• 2001

Knowledge discovery in databases(KDD) is the process for extracting valid, novel, potentially useful and understandable knowledge form real data. There are many academic and industrial activities with new technologies and application areas. Particularly, data mining is the core step in the KDD process, consisting of many algorithms to perform clustering, pattern recognition and rule induction functions. The main goal of these algorithms is prediction and description. Prediction means the assessment of unknown variables. Description is concerned with providing understandable results in a compatible format to human users. We introduce an efficient data mining algorithm considering predictive and descriptive capability. Reasonable pattern is derived from real world data by a revised neural network model and a proposed fuzzy rule extraction technique is applied to obtain understandable knowledge. The proposed neural network model is a hierarchical self-organizing system. The rule base is compatible to decision makers perception because the generated fuzzy rule set reflects the human information process. Results from real world application are analyzed to evaluate the system\`s performance.