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A Preliminary Study of Virtual-micro Intensity Modulated Radiation Therapy (가상 미세 세기조절방사선치료(Virtual micro-IMRT;VMIMRT) 기법의 임상 적용을 위한 예비적 연구)

  • 김상노;조병철;서택석;배훈식;최보영;이형구
    • Progress in Medical Physics
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    • v.13 no.1
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    • pp.32-36
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    • 2002
  • For Intensity Modulated Radiation Therapy(IMRT), the spatial resolution of intensity map(IM) is limited by the width of multi-leaf collimator, which would make an effect on the conformity of the target, as well as organs at risk. Several Methods are suggested to increase the spatial resolution, which can be categorized by the hardware-dependent technique and the software-based technique. However the best solution might be to make the width of MLC finer. it has several obstacles in the respects of technical difficulty and cost. This preliminary study is designed to investigate the clinical effectiveness of the virtual-micro IMRT(VMIMRT) technique, one of the software-based technique. A particular intensity map was created, which has 42$\times$54 pixel dimension ,0.5cm pixel size and 15 intensity levels. Using this intensity map, segment fields of IMRT were generated with 1$\times$lcm, 0.5$\times$1cm, 0.5$\times$0.5cm(VMIM) beamlet size, respectively As results, we found that there was no evidence of improvement for VMIMRT, compared with the 0.5$\times$lcm beamlet size which can be delivered by 1cm width MLC. The reason seems to be due to the constraint of VMIMRT. Further study is required to prove the benefit of the VIMRT in clinical case like head and neck cancer, where is expected that higher resolution than 1cm is necessary.

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A Study on Consistency of Numerical Solutions for Wave Equation (파동방정식 수치해의 일관성에 관한 연구)

  • Pyun, Sukjoon;Park, Yunhui
    • Geophysics and Geophysical Exploration
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    • v.19 no.3
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    • pp.136-144
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    • 2016
  • Since seismic inversion is based on the wave equation, it is important to calculate the solution of wave equation exactly. In particular, full waveform inversion would produce reliable results only when the forward modeling is accurately performed because it uses full waveform. When we use finite-difference or finite-element method to solve the wave equation, the convergence of numerical scheme should be guaranteed. Although the general proof of convergence is provided theoretically, the consistency and stability of numerical schemes should be verified for practical applications. The implementation of source function is the most crucial factor for the consistency of modeling schemes. While we have to use the sinc function normalized by grid spacing to correctly describe the Dirac delta function in the finite-difference method, we can simply use the value of basis function, regardless of grid spacing, to implement the Dirac delta function in the finite-element method. If we use frequency-domain wave equation, we need to use a conservative criterion to determine both sampling interval and maximum frequency for the source wavelet generation. In addition, the source wavelet should be attenuated before applying it for modeling in order to make it obey damped wave equation in case of using complex angular frequency. With these conditions satisfied, we can develop reliable inversion algorithms.

Study on the Scale Effect of Viscous Flows around the Ship Stern (선미 점성 유동장에 미치는 척고효과에 관한 연구)

  • Kwak, Y.K.;Min, K.S.;Oh, K.J.;Kang, S.H.
    • Journal of the Society of Naval Architects of Korea
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    • v.34 no.1
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    • pp.1-10
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    • 1997
  • Viscous flow around actual ship is calculated by an use of RANS equations. The propriety of this computing method, usefulness to hull form design and the scale effect which is the effect of viscous flow depending on the scale of ship model are investigated. Reynolds stress is modelled by using k-${\varepsilon}$ turbulence model and the law of wall is applied near the body. Body fitted coordinates are introduced for the treatment of the arbitrary 3-dimensional shape of the ship hull form. The transformed equations in the computational domain are numerically solved by an employment of FVM. In the calculation of pressure, SIMPLE method is adopted and the solution of the discretized equation is obtained by the line-by-line method with the use of TDMA The calculations of two ships, 4410 TEU container carrier and 50,000 DWT class bulk carrier, are performed at model and actual ship scale. The results are compared and discussed with the model test results which are viscous resistance, nominal wake distribution at propeller plane and limiting streamline on the hull surface. They describe the effect of stem form and the scale effect very well. In particular, the calculated nominal wake distribution and limiting streamline are agreed qualitatively with the experiments and the viscous resistance values are estimated within ${\pm}5%$ difference from the resistance tests.

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Effects of Irradiation on Color Values of Food Colorants (감마선 조사가 식용색소의 색도에 미치는 영향)

  • Kim Byeong-Keun;Lim Sang-Yong;Song Hyun-Pa;Chung Jin-Woo;Sung Bo-Kyung;Kim Dong-Ho
    • Food Science and Preservation
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    • v.13 no.1
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    • pp.115-118
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    • 2006
  • As a study on the physico-chemical stability of irradiated food and cosmetics, the effect of gamma irradiation on the color values of some food colorants was evaluated. Amaranth, Fast Green FCF, and Indigo Carmine solutions were prepared with different concentration (0.01 and $0.10\%$), gamma irradiated (0.25, 0.5, 1 and 3 kGy), and then Hunters color (L, a, b, ${\Delta}E$) values were determined. The. gamma irradiation process induced decoloration of the coloring agents. In particular, $0.01\%$ solution showed significant differences in the overall color difference$({\Delta}E)$. The lightness (L value) of Amaranth and Indigo Carmine was increased in proportion to irradiation dose, and their redness (a value) and yellowness (b value) also were increased. The redness (a value) and yellowness (b value) of Fast Green FCF $(0.01\%)$ were increased by gamma irradiation. However, there were no significant spectroscopic differences in $0.10\%$ concentrations of the samples.

Stability Evaluation of Vitamin-C Inclusion Complexes Prepared using Supercritical ASES Process (초임계 ASES 공정으로 제조된 Vitamin-C 포접복합체의 안정성 평가)

  • Yang, Jun-Mo;Kim, Seok-Yun;Han, Ji-Hyun;Jung, In-Il;Ryu, Jong-Hoon;Lim, Gio-Bin
    • KSBB Journal
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    • v.21 no.2
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    • pp.157-163
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    • 2006
  • A supercritical fluid process, called aerosol solvent extraction system(ASES), is especially suitable to the pharmaceutical, cosmetic and food industries due to its environmentally-friendly, non-toxic and residual solvent-free properties. In particular, the application of the ASES process to the processing of thermo-labile bioactive compounds has received attention of many scientists and engineers because of its low-temperature operating conditions. Unstable substances such as Vitamin-C and Vitamin-A can be effectively protected from degradation during the preparation process, because the ASES process is free from oxygen and moisture. In this study, Vitamin-C was formulated with 2-hydroxypropyl-${\beta}$-cyclodextrin (HP-${\beta$-CD) for enhancement of Vitamin-C stability and bioavailability using the ASES process. To investigate the influence of the preparation process on the stability of Vitamin-C, Vitamin-C/HP-${\beta}$-CD inclusion complexes were prepared using both conventional solvent evaporation method and ASES process, and stored in a 50 mM phosphate buffer solution of pH 7.0 at $25^{\circ}C$ for 24 hours. From the experimental results, the stability of the Vitamin-C/HP-${\beta}$-CD inclusion complex prepared from the ASES process was found to be much higher than that of pure Vitamin-C and the Vitamin-C/HP-${\beta}$-CD inclusion complex prepared by the solvent evaporation method. The stability of Vitamin-C was observed to increase with the decrease of temperature at a constant pressure or with the increase of pressure at a constant temperature.

The Effect of Alcohol Administration on Selenium Concentration and Cell Morphology of Heat and Liver of Rats Fed with the Different Levels of Selenium and Vitamin E (알코올의 섭취가 식이내 Selenium과 Vitamin E 수준을 달리한 흰쥐의 체내 Selenium 수준과 심장 및 간조직에 미치는 영향)

  • 김갑순;채기수;정승용
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.22 no.6
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    • pp.664-672
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    • 1993
  • The purpose of this study was to investigate the effect of alcohol administration on selenium concentration and cell morphology in tissurs of rats fed with the different levels of selenium (Se) and vitamin E. Seventy two male rats of Sprague-Dawley strain weighing about 58~62g were divided into 12 groups. The dietary Se levels were 0mg(L-), 0.4mg(C-) and 10mg(H-), and the dietary vitamin E levels were 0mg(-L) and 150mg(-C) per kg diet, respectively. Alcohol-adminstrated groups(--A) received the triple distilled potable water solution containing 10% of ethanol from the 3rd week of experimental periods. The obtained experimental results are summarized as follows. Se concentration in blood and urine made difference in accordance with Se level in diet and tended to be low in alcohol administrated groups. Se concentration in liver and kidney was also directly proportional to the dietary Se level, and it tended to be low in each alcohol group, but Se concentration in kidney tended to be increased by alcohol administration. Myocardium in rats showed lysosome increasing, fat droplet, mitochondrial swelling, and in particular, bad intracellular edema, in H-group fed with high Se and in L-group with low Se. It also showed such phenomena in the alcohol administrated group. In HC-group fed with excessive Se and normal vitamin E. there appeared no noticeable change in liver tissue. However, in the alcohol administrated HCA-group, there came out fat droplet. Especially, in the alcohol administrated LLA-group, not fed with sufficient Se and vitamin, E, there were found lysosome increasing and a number of fat droplet.

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Weathering Characteristics according to Seawater Immersion of the Magai Wareiishi Jizo (Buddhist Statue Carved on Rock Surface) in Hiroshima, Japan (일본 히로시마현 마애화령석지장(磨崖和靈石地藏)의 해수 침수에 의한 풍화특성)

  • Lee, Sun Myung;Lee, Myeong Seong;Chun, Yu Gun;Lee, Jae Man;Morii, Masayuki
    • Journal of Conservation Science
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    • v.28 no.4
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    • pp.329-341
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    • 2012
  • Magai Wareiishi Jizo (Buddhist statue carved on rock surface) is close to shoreline and a part of rock block is periodically immersed by seawater. Rock material of the Wareiishi-jizo statue is composed mainly of medium or coarse-grained biotite granite and very durable. However, physical properties of the rock have been changed according to the complex interactions of the salt solution and surrounding environment. Exfoliation of the rock surface is a serious condition by salt crystallization. Exfoliation (14.6%) is concentrated on the upper part of the rock block with mainly boundary of seawater as the center. On the other hand, lower part of the rock block show black layers by contaminants deposition. In addition, brown discoloration and biological contaminants is overlapped. Rock surface show high discoloration rate of 50.5% (black discoloration, 29.2% > yellow discoloration, 14.1% > brown discoloration, 4.4% > green discoloration, 2.9%). Upper part of the rock block had a lot of change in the physical properties than lower part that is immersed by seawater. In particular, surface properties of the rock block was very weak state at the boundary surface of seawater permeation.

Effect of Chlorine Dioxide Treatment on Microbial Growth and Qualities of Fish Paste during Storage (이산화염소 처리가 어묵의 저장 중 미생물학적 변화 및 품질에 미치는 영향)

  • Shin, Hee-Young;Lee, Yeon-Ju;Park, In-Young;Kim, Ju-Yeon;Oh, Su-Jin;Song, Kyung-Bin
    • Applied Biological Chemistry
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    • v.50 no.1
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    • pp.42-47
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    • 2007
  • Effect of chlorine dioxide ($ClO_2$) treatment on the microbial and physicochemical changes of fish paste was investigated. Fish paste samples were treated with 5, 10, and 50 ppm of $ClO_2$ solution, respectively, After $ClO_2$ treatment, fish paste samples were individually packaged and stored at 4$^{\circ}C$. The initial microbial loads of samples were 3.8 log CFU/g in total bacterial count, and 2.5 log CFU/g in yeasts and molds. Microbial growth of fish paste during storage showed that populations of total bacteria, yeast and mold were significantly reduced by $ClO_2$ treatment. In particular, the treatment of 50 ppm $ClO_2$ decreased total bacterial count the most significantly among the $ClO_2$ treated fish pastes. The pH and VBN of fish paste decreased with increasing $ClO_2$ concentration. Thiobarbituric acid reacted substance (TBARS) values of treated fish paste increased during storage, regardless of $ClO_2$ concentration. This study showed that 50 ppm chloride dioxide was the optimum dose level to extend the shelf-life of fish paste.

A study on analysis model for real radio spectrum data correlation in High-Mountain Area (고지대에서의 전파도달범위 분석을 위한 실측 데이터 기반 전파도달 상관관계 분석모델 연구)

  • Han, In-Sung;Sohn, Ju-Hang;Park, Moo-Sung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.5
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    • pp.697-708
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    • 2016
  • As the needs for fast wireless communication technology in various fields, including companies, individuals, etc., grows, many research projects related to the coverage of propagation are being carried out for plaining optimized communication services. On the other hand, there are some limitations in surveying and analyzing propagation in highland areas. To provide a better communication service of a new service, a range of radio environment conditions based on a wide radio bandwidth (selection of propagation model, correction of value in accordance with radio bandwidth, etc.) should be considered. In particular, radio environment conditions are becoming increasingly sophisticated. By the early detection of real-time changes in the radio spectrum, which is based on an examination and research of regional occupied band width condition, proper measures should be established. To make a proper solution of above, the basic real-time analysis of spectrum distribution status by regional groups is necessary. In addition, the establishment of prompt measures should be enable by stored or analyzed radio data. In an attempt to predict reliable propagation coverage, this thesis examines the limited propagation data with HTZ Warfare, which were collected from domestic high land sites faced with limited access. Furthermore, a comparative result value evaluation for an optimized propagation model was performed through testing simulations, and frequency-dependent and propagation model-dependent analysis.

(An HTTP-Based Application Layer Security Protocol for Wireless Internet Services) (무선 인터넷 서비스를 위한 HTTP 기반의 응용 계층 보안 프로토콜)

  • 이동근;김기조;임경식
    • Journal of KIISE:Information Networking
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    • v.30 no.3
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    • pp.377-386
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    • 2003
  • In this paper, we present an application layer protocol to support secure wireless Internet services, called Application Layer Security(ALS). The drawbacks of the two traditional approaches to secure wireless applications motivated the development of ALS. One is that in the conventional application-specific security protocol such as Secure HyperText Transfer Protocol(S-HTTP), security mechanism is included in the application itself. This gives a disadvantage that the security services are available only to that particular application. The other is that a separate protocol layer is inserted between the application and transport layers, as in the Secure Sockets Layer(SSL)/Transport Layer Security(TLS). In this case, all channel data are encrypted regardless of the specific application's requirements, resulting in much waste of network resources. To overcome these problems, ALS is proposed to be implemented on top of HTTP so that it is independent of the various transport layer protocols, and provides a common security interface with security applications so that it greatly improves the portability of security applications. In addition, since ALS takes advantages of well-known TLS mechanism, it eliminates the danger of malicious attack and provides applications with various security services such as authentication, confidentiality integrity and digital signature, and partial encryption. We conclude this paper with an example of applying ALS to the solution of end-to-end security in a present commercial wireless protocol stack, Wireless Application Protocol.