• Biomolecules & Therapeutics
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• v.21 no.1
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• pp.49-53
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• 2013

A number of naturally-occurring or synthetic chemicals have been reported to exhibit prostate chemopreventive effects. Synthetic $5{\alpha}$-reductase (5-AR) inhibitors, e.g. finasteride and durasteride, gained special interests as possible prostate chemopreventive agents. Indeed, two large-scale epidemiological studies have demonstrated that finasteride or durasteride significantly reduced the incidence of prostate cancer formation in men. However, these studies have raised an unexpected concern; finasteride and durasteride increased the occurrence of aggressive prostate tumor formation. In the present study, we have observed that treatment of finasteride did not affect the growth of androgen-refractory PC-3 prostate cancer cells. Finasteride also failed to induce apoptosis or affect the expression of proto-oncogenes in PC-3 cells. Interestingly, we found that treatment of finasteride induced the expression of Nrf2 and HO-1 proteins in PC-3 cells. In particular, basal level of Nrf2 protein was higher in androgen-refractory prostate cancer cells, e.g. DU-145 and PC-3 cells, compared with androgen-responsive prostate cancer cells, e.g. LNCaP cells. Also, treatment of finasteride resulted in a selective induction of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells. In view of the fact that upregulation of Nrf2-mediated phase II cytoprotective enzymes contribute to attenuating tumor promotion in normal cells, but, on the other hand, confers a selective advantage for cancer cells to proliferate and survive against chemical carcinogenesis and other forms of toxicity, we propose that finasteride-mediated induction of Nrf2 protein might be responsible, at least in part, for an increased risk of high-grade prostate tumor formation in men.

• Korean Journal of Applied Biomechanics
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• v.14 no.1
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• pp.145-160
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• 2004

The purposes of this study to provide quantitative data in necessary to advance techniques kinematic analysis of Cucarachas which is an action of Rumba. Then, this study is performed on 5 female players who have won within the third prize at a national athletic meeting. When whole foot reached to floor, Displacement of right-left hip joint (until $E1{\sim}E3$ average moved 15.15cm)is found at right-left direction since the hip joint is turned to right back. On the other side, large displacement is shown because Rumba Cucaracha Movement is expressed by maximum shift of hip joint to right and left direction. Displacement of right hip joint(E3$57.40{\pm}7.46$) is found in front and in rear direction since hip joint is moved in rear and in front to turn the hip joint. It may be stated that this is ideal displacement expressed by movement of whole body with artistic poise and presentation because role of hip joint is very important in technical and artistic side. Angle of right shoulder joint E2($105.44{\pm}9.64$) is got wider. It may be stated that player shifts up and abduct elbow joint to right since center of gravity of player is exceedingly shifted to right in this motion of Cucarachas. On the other hand, since this motion is abducted right elbow and shrunk external abdominal oblique to him center of body to left front of hip joint, the angle becomes narrow. It is shown that angle of knee in right knee joint E4($75.44{\pm}2.61$) is large since right leg and hip joint is turned by foot using reaction of ground and so center of body is shifted to left. Large angle of ankle E4($134.40{\pm}10.50$) in Cucaracha Movement is shown by the action of twist force using narrow part of foot and compression force against ground with adduction speed of arm. The various kinematic analyses associated with motions of dance sport have not been sufficiently peformed so far, and thus a number of research projects for dance sport should be proposed and performed to be continuous.

• Journal of Families and Better Life
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• v.31 no.4
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• pp.145-164
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• 2013

This study analyzed qualitative data to examine the attitude toward the conditions of and the barriers to the work- family balance among unmarried workers. The data was drawn from 5 focus groups consisting of 4 workers each. The 20 participants, aged 21 through 38, were interviewed in mini groups composed of 2 male workers and 2 female workers each. The research depicts four main themes about their work-family balance: the image of a dual-earner family, women's market labor, housework, and the ideal conditions of a dual-earner family. This research concluded that unmarried workers desperately want to be part of a dual earning family for economic survival. However, they also know that it would be very difficult to make ends meet and to live as dual-earner families because of the lack of a proper social support system. However, most of them believe that they must solve these problems on their own, and they do not expect to receive help from systematic public policies. They think that they should find solutions by rearranging the role divisions between the husband and the wife or by asking for help from their parents or other relatives. The only assistance they expect from the government are reliable child care facilities and governmental incentives to promote stimulate the family-friendly workplace.

• Korean Institute of Interior Design Journal
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• v.26 no.6
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• pp.145-154
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• 2017

Industrial paradigm change and awareness change based on development of transportation and communication technology, many idle facilities had been occurred. These idle facilities become the factor which hinder image and environment of the surroundings. In recent years, social, cultural and economic value of idle facilities has been acknowledged and is regarded as an object of rehabilitation as part of urban problem solving. The purpose of this study is to analyze the characteristics of recycling design in the exhibition space used as a domestic idle facility and to utilize it as a basic data for creating an exhibition space using idle facilities in the future. The scope of the study was selected from 8 cases which were reproduced as exhibition space within the last 10 years mainly in Seoul and metropolitan area. It is analyzed by five characteristics of historicity, symbolism, preservability, connectivity, and placeness that are analyzed by the characteristics of rehabilitaion design. The conclusion is as follows. First, idle facilities can be divided into idle industrial facilities and idle non - industrial facilities. Second, the analysis of the characteristics of rehabilitaion design of idle facilities showed that the symbolism was much higher than other rehabilitaion design characteristics. Third, as a result of comparative analysis between idle industrial facility exhibition space and idle non - industrial facility exhibition space, historicity, preservability, and connectivity were high in the idle industrial facility exhibition space. In the exhibition space of idle non-industrial facilities, symbolism and placeness were high.

• The KIPS Transactions:PartD
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• v.14D no.2
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• pp.145-156
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• 2007

Recently, the needs for effective real time change detection algorithms for XML/HTML documents and increased in such fields as the detection of defacement attacks to web documents, the version management, and so on. Especially, those applications of real time change detection for large number of XML/HTML documents require fast heuristic algorithms to be used in real time environment, instead of algorithms which compute minimal cost-edit scripts. Existing heuristic algorithms are fast in execution time, but do not provide satisfactory edit script. In this paper, we present existing algorithms XyDiff and X-tree Diff, analyze their problems and propose algorithm X-tree Diff which improve problems in existing ones. X-tree Diff+ has similar performance in execution time with existing algorithms, but it improves matching ratio between nodes from two documents by refining matching process based on the notion of efficiency of matching.

• The KIPS Transactions:PartB
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• v.14B no.3 s.113
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• pp.145-152
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• 2007

In this paper, we propose an automatic extraction model for unknown translations and implement an unknown translation extraction system using the proposed model. The proposed model as a phrase-alignment model is incorporated with three models: a phrase-boundary model, a language model, and a translation model. Using the proposed model we implement the system for extracting unknown translations, which consists of three parts: construction of parallel corpora, alignment of Korean and English words, extraction of unknown translations. To evaluate the performance of the proposed system, we have established the reference corpus for extracting unknown translation, which comprises of 2,220 parallel sentences including about 1,500 unknown translations. Through several experiments, we have observed that the proposed model is very useful for extracting unknown translations. In the future, researches on objective evaluation and establishment of parallel corpora with good quality should be performed and studies on improving the performance of unknown translation extraction should be kept up.

• The KIPS Transactions:PartC
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• v.19C no.2
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• pp.145-148
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• 2012

In a distributed streaming system using an advanced coding scheme that encodes a video into multiple substreams, the capacity of the system depends on the amount of contribution of participating peers. Thus, an incentive mechanism for peers to contribute voluntarily is needed to increase system capacity. In addition, since peers are not only a provider but also a consumer in the system (i.e. prosumer), the overall capacity of the system must be allocated fairly among the peers while it must be allocated in a way that can maximize the net quality of experience of peers to increase system efficiency. In this paper, we propose a substream allocation method to solve the problems taking an optimization approach. Unlike the other optimization approaches, the proposed method is verified quantitatively in a simulation study that it can use the capacity of video streaming system efficiently while allocating fair amount of substreams among peers because it considers explicitly the prosumer characteristics of peers.

• Journal of the Korea Society of Computer and Information
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• v.16 no.11
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• pp.145-152
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• 2011

The study analyzed effects of the problem-based learning utilizing cognitive algorithms in elementary mathematics education in terms of academic achievement and math attitude changes. In order to solve the research questions, a cognitive algorithm-based PBL model was derived based on N. Landa's algorithm-based instructional design theory. And the model was applied to a part of second semester math curriculum for 4th grade of an elementary school located in Seoul. The results showed that the PBL utilizing algorithms can be said to have effects on academic achievement. The PBL model is also considered to have positive effects in enhancing mathematical attitudes of the learners.

• Journal of The Korean Association For Science Education
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• v.37 no.4
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• pp.705-717
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• 2017

The purpose of the study is to explore secondary science teachers' emotional display rules, types of emotional labor, science-specific emotional display rules and the episodes of emotional labor. For this purpose, the survey to measure emotional labor of science teachers (The Emotional Labor of Science Teaching Scale: TELSTS) was developed and the participants were 145 secondary science teachers in Korea. Results showed that first, secondary science teachers recognized the emotional display rules defined by their schools, especially, positive display rules. Second, secondary science teachers showed that they were carrying out emotional labor in order to keep their emotional display rules in check. The mean value of responses to deep acting was high. Also, there were statistically significant differences in emotional labor depending on whether they were full-time or part-time teachers and their teaching career. Third, as a result of analyzing the specificity of science teachers, it was mainly related to the objective and logical image of science, and experimental instruction. Seventy-four percent (74%) of responses were negative or neutral emotional display rules. Finally, implications for science education are discussed.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.2
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• pp.159-167
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• 2009

To obtain the gravity data with consistent quality and good distribution over Korea, to overcome the difficulties in constructing precision geoid from biased distribution of ground data, to resolve the discrepancy between the ground and ocean gravity data, an airborne gravity survey was conducted from Dec. 2008 to Jan. 2009. The data was measured at the average flying height of 3,000m and the data with cross-over error of 2.21mGal is obtained. The geoid constructed using this airborne gravity data shows the range of 9.34 $\sim$ 33.88m. Comparing the geoid with respect to the GPS/levelling data, a precision of 0.145m is obtained. After fitting, the degree of fit to GPS/levelling data was calculated about 5cm. It was found that there exists large biases in the area of south-western and northern part of the peninsular which is considered to be the effect of distorted vertical datum in Korea. Thus, more investigation on vertical datum would be needed in near future.