• Proceedings of the Korea Contents Association Conference
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• 2014.11a
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• pp.301-302
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• 2014

질병의 발병기작과 같이 생명현상을 이해하기 위해서는 질병관점에서 생명현상을 분석하는 연구가 필요하며, 이를 지원하기 위한 질병과 관련된 임상 및 바이오 정보의 통합된 데이터베이스가 필요하다. 통합된 데이터베이스를 구축하기 위해서는 다양한 출처로부터 수집되는 다양한 임상 및 바이오 정보를 하나로 통합하여 저장 및 관리하는 기법이 필요하다. 따라서 본 논문에서는 임상 및 바이오 정보 통합 데이터베이스를 위한 범용적 임포팅 시스템을 설계하고 구현한다. 제안하는 시스템을 통해 사용자는 다양한 출처로부터 수집되는 임상 및 바이오 정보를 데이터 형태에 상관없이 하나의 통합 데이터베이스에 입력할 수 있다.

• Proceedings of the Korea Contents Association Conference
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• 2014.11a
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• pp.299-300
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• 2014

생명과학분야에서는 생명현상을 이해하기 위해 신호 전달 네트워크에 대한 연구가 진행되고 있다. 하지만 신호전달 네트워크와 임상 정보를 결합하여 질병관점에서 신호 전달 네트워크를 통합하고 결합하는 관점의 연구가 부족하다. 따라서 본 논문에서는 빅데이터 기술을 활용하여 임상 및 신호전달 정보를 연계 분석할 수 있는 시스템을 구축하고자 빅데이터 분석을 위한 임상 및 바이오 정보 통합 데이터베이스를 설계한다. 설계한 임상 및 바이오 정보 통합 데이터베이스는 빅데이터 분석 기술을 적용한 확장 분석 기법 및 통합 분석 시스템 개발에 활용할 수 있다.

• Journal of The Korean Dental Society of Anesthesiology
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• v.13 no.3
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• pp.133-137
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• 2013

Three patients who underwent orthognathic surgery under general anesthesia complained about difficulty in vocalization and hoarseness after surgery. Intubation granuloma was diagnosed by the department of otorhinolaryngology in our hospital and the masses were excised by laryngoscopy assisted surgery. Chief complaints and symptoms of patients were relieved after surgery. These cases report with review of articles is presented, and the etiology, diagnosis, treatment and prognosis of intubation granuloma after orthognathic surgery are evaluated.

• Journal of Veterinary Clinics
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• v.32 no.6
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• pp.523-526
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• 2015

A 9-year-old, castrated male Malamute dog was presented with chronic cough. On thoracic computed tomography, non-tapered and dilated peripheral bronchi were detected. Bronchoarterial ratio was about 2.2. The dilated bronchi appeared as a cluster of grapes especially in left cranial, left caudal and right middle lung lobe. Based on the computed tomographic findings, the diagnosis was made as the saccular type of bronchiectasis.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.6.1-6.10
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• 2018

Bmal1 is one of the key molecules that controls the mammalian molecular clock. In humans, two isoforms of Bmal1 are generated by alternative RNA splicing. Unlike the extensively studied hBmal1b, the canonical form of Bmal1 in most species, the expression and/or function of another human-specific isoform, hBmal1a, are poorly understood. Due to the lack of the N-terminal nuclear localization signal (NLS), hBMAL1a does not enter the nucleus as hBMAL1b does. However, despite the lack of the NLS, hBMAL1a still dimerizes with either hCLOCK or hBMAL1b and thereby promotes cytoplasmic retention or protein degradation, respectively. Consequently, hBMAL1a interferes with hCLOCK:hBMAL1b-induced transcriptional activation and the circadian oscillation of Period2. Moreover, when the expression of endogenous hBmal1a is aborted by CRISPR/Cas9-mediated knockout, the rhythmic expression of hPer2 and hBmal1b is restored in cultured HeLa cells. Together, these results suggest a role for hBMAL1a as a negative regulator of the mammalian molecular clock.

• Korean Journal of Plant Taxonomy
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• v.39 no.3
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• pp.125-129
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• 2009

The genetic diversity plays a significant role in determining a species' survival and perseverance. Endangered species often lack genetic variation, which makes them vulnerable to numerous dangers of extinction including selection, genetic drifts and human interference. Knowing an endangered species' genetic background greatly enhances conservation efforts since it reveals why, what and how to conserve that species. Cotoneaster wilsonii is an endangered plant species endemic to Ulleung island, but not enough genetic research has been done on this taxon for its effective conservation plans. In this study, three populations of C. wilsonii in Ulleung island underwent allozyme analysis through starch gel electrophoresis. 10 loci were analyzed and F-statistics was calculated. Overall data indicated that C. wilsonii possessed low genetic diversity with intense inbreeding, heterozygote deficiency and low differentiation among populations. These results implied that C. wilsonii was recently introduced to the Ulleung island from ancestor species, and did not have much time to differentiate. Current status of C. wilsonii habitats is very fragile and vulnerable, with increasing tourism constantly threatening the species' survival. It is very likely that C. wilsonii will become extinct in near future unless organized conservation protects its populations and genetic diversity.

• Current Photovoltaic Research
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• v.9 no.3
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• pp.106-109
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• 2021

In order to perform photovoltaic (PV) operation and management (O&M) efficiently, individual PV module monitoring is becoming more important. In this research, we developed wireless IoT sensor which can monitor individual photovoltaic modules. This IoT sensor can detect the output voltage, current and module temperature of individual modules and provide monitored data by wireless communication. Measured voltage error was 1.23%, and it shows 16.6 dBM, 0.42sec and 7.1 mA for voltage, transmittance output, response time and mean power consumption, respectively. IoT sensors were demonstrated in the test field with real climate environment condition and each of 5 sensors showed precise results of voltage, current and temperature. Also, sensors were compared with commercial power-optimizers and showed result difference within 5%.

• Journal of Science Education
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• v.43 no.1
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• pp.173-193
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• 2019

An expert teachers' instruction can be helpful to other teachers because good teaching effectively guides students to develop meaningful learning. Feynman is an excellent physics lecturer as well as one of the greatest physicists of the 20th century who presented and explained physics with his unique teaching style based on his great store of knowledge. However, it is not easy to capture and visualize teaching because it is not only the complex phenomena interrelated to various factors with the content to be taught but also the tacit representation. In this study, the framework of knowledge & belief based on the integrated mental model theory was used as a tool to capture and visualize complex and tacit representation of Feynman's teaching of 'The theory of gravitation,' a chapter in The Feynman Lectures on Physics. Feynman's teaching was found to go beyond the transmission of physics concepts by showing that components of the framework of knowledge & belief were effectively intertwined and integrated in his teaching and the storyline was well-organized. On the basis of these discussions, the implications of Feynman's teaching analyzed within the framework of knowledge & belief for physics teacher education are derived. Finally, the characteristics of the framework of knowledge & belief as tools for the analysis of teaching are presented.

• Proceedings of the KIPE Conference
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• 2018.11a
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• pp.86-88
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• 2018

The three level(3L) neutral point clamped (NPC) voltage source converter (VSC) topology is widely used for grid interface in high power wind energy due to its superior performance as compared to the two level(2L) VS. However, one of the major drawbacks of this topology is the unequal dispersion of loss and therefore the junction temperature among the power devices. The 3L ANPC topology derived from the NPC topology was proposed to resolve this drawback of unequal loss profile of 3L NPC. The 3L ANPC can work under various switching strategies. In this paper a comparative study of the various switching strategies of 3L ANPC using the recently developed 10kV IGCTs which has the capability to raise the current and voltage rating of the wind turbines is carried out. The comparison is performed using ABB make 10kV IGCT 5SHY17L9000 and PLECs simulations.

• Journal of the Korean Society of Visualization
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• v.18 no.3
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• pp.84-89
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• 2020

Cancer cells secrete angiogenic factors, and nearby vasculatures make new blood vessels essential for cancer development and metastasis in response to these soluble factors. Many efforts have been made to elucidate cancer-endothelial cell interactions in vitro. However, not much is known due to the lack of a suitable co-culture platform. Here, we introduce a 3D printing-based microfluidic system that mimics the in vivo-like cancer-endothelial cell interactions. The tumoroids and endothelial cells are co-cultured, physically separated by porous fibrin gel, allowing communication between two cell types through soluble factors. Using this microfluidic system, we were able to visualize new vessel formation induced by tumoroids of different origins, including liver, breast, and ovary. We confirmed that the ovarian tumoroids most induced angiogenesis while the other two cancer types suppressed it. Utilization of the proposed co-culture platform will help the researchers unveil the underlying mechanisms of the dynamic interplay between tumor and angiogenesis.