• BMB Reports
• /
• v.51 no.2
• /
• pp.98-103
• /
• 2018

Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.16 no.4
• /
• pp.684-695
• /
• 1992

The present study is concerned with the analysis of three-dimensional sheet metal forming process by the upper-bound method. For the analysis a systematic approach is necessary for the expression of geometric configuration of the deforming workpiece. In the present paper geometric configuration is constructed by three unit surfaces which are defined by sweeping the vertical section curves and boundary curve. The principal components of strain increment during the process is calculated directly from the change of geometric configuration for an arbitrary triangular element. The corresponding solution is found through optimization of the total energy consumption with respect to some parameters assumed in the velocity field and geometric profile. In order to verify the effectiveness of the present method, hydrostatic bulging of a rectangular disphragm is analyzed and the computation by the present method for the geometric shape renders the good result. From the comparison of the present results with the existing experimental results and elastic-plastic finite element solutions, good agreements have been obtained for the pressure curves, polar membrane strains and pressure distributions. The present method can thus be further applied to the analysis of other three-dimensional sheet metal forming processes.

• Journal of the Institute of Electronics Engineers of Korea SC
• /
• v.39 no.5
• /
• pp.26-33
• /
• 2002

The design method of robust $H_{\infty}$ filtering for discrete-time uncertain linear systems is investigated in this paper. The uncertain parameters are assumed to be unknown but belonging to known convex compact set of polytope type. The objective is to design a stable robust $H_{\infty}$ filter guaranteeing the asymptotic stability of filtering error dynamics and present an $L_2$ induced norm bound analytically for the modified $H_{\infty}$ performance measure. The sufficient condition for the existence of robust $H_{\infty}$ filter and the filter design method are established by LMI(linear matrix inequality) approach, which can be solved efficiently by convex optimization. The proposed algorithm is checked through an example.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.48 no.4
• /
• pp.86-97
• /
• 2011

This paper presents a novel algorithm to detect more accurate road lane with image sensor-based color classification and directional edge clustering. With treatment of road region and lane as a recognizable color object, the classification of color cues is processed by an iterative optimization of statistical parameters to each color object. These clustered color objects are taken into considerations as initial kernel information for color object detection and recognition. In order to improve the limitation of object classification using the color cues, the directional edge cures within the estimated region of interest in the lane boundary (ROI-LB) are clustered and combined. The results of color classification and directional edge clustering are optimally integrated to obtain the best detection of road lane. The characteristic of the proposed system is to obtain robust result to all real road environments because of using non-parametric approach based only on information of color and edge clustering without a particular mathematical road and lane model. The experimental results to the various real road environments and imaging conditions are presented to evaluate the effectiveness of the proposed method.

• Journal of the Optical Society of Korea
• /
• v.20 no.1
• /
• pp.94-100
• /
• 2016

A novel optical design for high resolution, large field of view (FOV) and multispectral remote sensing is presented. An f/7.3 Korsch and two f/17.9 Cook three-mirror optical systems are integrated by sharing the primary and secondary mirrors, bias of the FOV, decentering of the apertures and reasonable structure arrangement. The aperture stop of the Korsch system is located on the primary mirror, while those of the Cook systems are on the exit pupils. High resolution image with spectral coverage from visible to near-infrared (NIR) can be acquired through the Korsch system with a focal length of 14 m, while wide-field imaging is accomplished by the two Cook systems whose focal lengths are both 13.24 m. The full FOV is 4°×0.13°, a coverage width of 34.9 km at the altitude of 500 km can then be acquired by push-broom imaging. To facilitate controlling the stray light, the intermediate images and the real exit pupils are spatially available. After optimization, a near diffraction-limited performance and a compact optical package are achieved. The sharing of the on-axis primary and secondary mirrors reduces the cost of fabrication, test, and manufacture effectively. Besides, the two tertiary mirrors of the Cook systems possess the same parameters, further cutting down the cost.

• Journal of Energy Engineering
• /
• v.5 no.1
• /
• pp.72-79
• /
• 1996

The effect of controllers-Exciter, Power System Stabilizer, and Static Var Compensator-in one machine infinite bus system is investigated in this paper. The structure of generator state matrix with controllers is represented, while the Static Var Compensator is installed in generator terminal bus. Eigen-value analysis is performed and the effects of controllers to the dominant eigenvalue in one machine infinite bus system are represented by first order eigenvalue sensitivity coefficients while the operating conditions of the system are varied. Optimization of controller parameters using first order eigenvalue sensitivity coefficients is performed by the Simplex Method. It is proved that exciter control is the most efficient method to improve stability of the system and the effect of Static Var Compensator is small, in the case of one machine infinite bus system.

• Journal of Energy Engineering
• /
• v.25 no.4
• /
• pp.85-92
• /
• 2016

Since the power density of the VHTR(Very High Temperature Reactor) is lower, there is less possibility of core melt. VHTR has no risk of explosion caused by hydrogen generation when the loss of coolant accident occurs, which is another advantage. Along with safety benefit, it can be used as a process heat supplier near demand facilities because coolant temperature is very high enough to be used for industrial purpose. In this paper, we designed the primary system using VHTR and the secondary system providing electricity and process heat. Based on that 350 MW thermal reactor proposed by NGNP(Next Generation Nuclear Part), we developed conceptual model that the IHX(Intermediate Heat Exchanger) loop transports 300 MW thermal energy to the secondary system. In addition, we analyzed thermodynamic behavior and performed the efficiency analysis and optimization study depending on major parameters.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.23 no.3
• /
• pp.209-217
• /
• 2013

This paper presents an optimal design of a magnetorheological(MR) fluid-based mount(MR mount) that can be used for to vibration control in diesel engines of ships. In this work, a mount that uses mixed-modes(squeeze mode, flow mode, and shear mode) is proposed and designed. To determine the actuating damping force of the MR mount required for efficient vibration control, the excitation force from a diesel engine is analyzed. In this analysis, a model of a V-type engine is considered. The relationship between the velocity and pressure of gas in terms of the torque acting on the piston is derived. Subsequently, by integrating the field-dependent rheological properties of commercially available MR fluid with the excitation force, the appropriate size of the MR mount is designed. In addition, to achieve the maximum actuating force under geometric constraints, design optimization is undertaken using the ANSYS parametric design language software. Through magnetic density analysis, optimal design parameters such as the bottom gap and radius of coil are determined.

• Journal of the Korean Society for Precision Engineering
• /
• v.23 no.9 s.186
• /
• pp.54-60
• /
• 2006

Fitting process carried out in automobile transmission assembly line is classified into three classes; heat fitting, press fitting, and their combined fitting. Heat fitting is a method that heats gear to a suitable range under the tempering temperature and squeezes it toward the outer diameter of shaft. Its stress depends on the yield strength of gear. Press fitting is a method that generally squeezes gear toward that of shaft at room temperature by press. Another method heats warmly gear and safely squeezes it toward that of shaft. Warm shrink fitting process for automobile transmission part is now gradually increased, but the parts (shaft/gear) assembled by this process produced dimensional changes of gear profile in both radial and circumferential directions. So that it may cause noise and vibration between gears. In order to solve these problems, we need an analysis of warm shrink fitting process, in which design parameters are involved; contact pressure according to fitting interference between outer diameter of shaft and inner diameter of gear, fitting temperature, and profile tolerance of gear. In this study, an closed form equation to predict contact pressure and fitting load was proposed in order to develop optimization technique of warm shrink fitting process and verified its reliability through the experimental results measured in the field and FEM, that is, thermal-structural coupled field analysis. Actual loads measured in the field have a good agreement with the results obtained by theoretical and finite element analysis and also the expanded amounts of the gear profile in both radial and circumferential directions are within the limit tolerances used in the field.

• Journal of Welding and Joining
• /
• v.29 no.1
• /
• pp.80-84
• /
• 2011

The weight reduction of the transportations has become an important technical subject Al and Al alloys, especially Al 5052 alloys have been being applied as door materials for automobile. One of the most widely known car weight-reduction methods is to use light and corrosion-resistant aluminum alloys. However, because of high electrical and thermal conductivity and a low melting point, it is difficult to obtain good weld quality when working with the aluminum alloys. Also, Pulse MIG welding is the typical aluminum welding process, but it is difficult to apply to the thin plate, because of melt-through and humping-bead. In order to enhance weld quality, welding parameters should be considered in optimizing the welding process. In this experiment, Al 5052 sheets were used as specimens, and these materials were welded by adopting new Cold Metal Transfer (CMT) pulse process. The proper welding conditions such as welding current, welding speed, torch angle $50^{\circ}$ and gap 0~1mm are determined by tensile test and bead shape. Through this study, range of welding current are confirmed from 100A to 120A. And, the range of welding speed is confirmed from 1.2m/min to 1.5m/min.