• Title/Summary/Keyword: Par-4

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A Study on the Isoprene Emissioin Rates from Deciduous Tree(Quercus Mongolica Fischer) (낙엽수(신갈나무)로부터 배출되는 이소프렌 배출속도 측정 연구)

  • Kim, Ki-Joon;Kim, Jo-Chun;Lim, Yong-Jae;Son, Youn-Suk;SunWoo, Young;Cho, Kyu-Tak
    • Journal of Environmental Science International
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    • v.16 no.3
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    • pp.269-275
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    • 2007
  • The standard emission rate(ERs) of isoprene was quantitatively measured in situ from Quercus mongolica Fischer that dominates more than about 85% of domestic oak trees. The ERs values in spring and summer were similar to 64.4 and 58.1 (${\mu}gC/gdw/hr$), respectively. The ERs in autumn, 7.06(${\mu}gC/gdw/hr$), was about $8{\sim}9$ times lower than those in spring and summer. The coefficient of determination ($r^2$) between ERs and $C_L\;C_T$ ranged from 0.593 to 0.836. The correlation coefficients between the ERs and PAR. the ER and temperature suggested that ERs have strong correlation with PAR(photosynthetically active radiation) and temperature. In addition, the high values of PAR, temperature, and ERs were found in the time zone of $15:00{\sim}17:00$(spring), $15:00{\sim}16:00$(summer), and $14:00{\sim}15:00$(autumn).

Individual Fit Testing of Hearing Protection Devices Based on Microphone in Real Ear

  • Biabani, Azam;Aliabadi, Mohsen;Golmohammadi, Rostam;Farhadian, Maryam
    • Safety and Health at Work
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    • v.8 no.4
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    • pp.364-370
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    • 2017
  • Background: Labeled noise reduction (NR) data presented by manufacturers are considered one of the main challenging issues for occupational experts in employing hearing protection devices (HPDs). This study aimed to determine the actual NR data of typical HPDs using the objective fit testing method with a microphone in real ear (MIRE) method. Methods: Five available commercially earmuff protectors were investigated in 30 workers exposed to reference noise source according to the standard method, ISO 11904-1. Personal attenuation rating (PAR) of the earmuffs was measured based on the MIRE method using a noise dosimeter (SVANTEK, model SV102). Results: The results showed that means of PAR of the earmuffs are from 49% to 86% of the nominal NR rating. The PAR values of earmuffs when a typical eyewear was worn differed statistically (p < 0.05). It is revealed that a typical safety eyewear can reduce the mean of the PAR value by approximately 2.5 dB. The results also showed that measurements based on the MIRE method resulted in low variability. The variability in NR values between individuals, within individuals, and within earmuffs was not the statistically significant (p > 0.05). Conclusion: This study could provide local individual fit data. Ergonomic aspects of the earmuffs and different levels of users experience and awareness can be considered the main factors affecting individual fitting compared with the laboratory condition for acquiring the labeled NR data. Based on the obtained fit testing results, the field application of MIRE can be employed for complementary studies in real workstations while workers perform their regular work duties.

Changes in Soil Temperature, Moisture Content, Light Availability and Diameter Growth After Thinning in Korean Pine (Pinus koraiensis) Plantation (잣나무 임분 내 간벌 후 토양 온도, 수분, 광 유효도 및 직경생장 변화)

  • Bae, Sang-Won;Hwang, Jae-Hong;Lee, Sang-Tae;Kim, Hyun-Seop;Jeong, Jun-Mo
    • Journal of Korean Society of Forest Science
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    • v.99 no.3
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    • pp.397-403
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    • 2010
  • This study was conducted to investigate the changes in soil temperature, soil moisture content, light availability (photosynthetically active radiation, PAR) and diameter growth in 46-year-old Korean pine (Pinus koraiensis Siebold et Zuccarini) plantation located in Gwangneung experimental forest after 4 years from thinning. Three different thinning intensities [control, 45%(T45), and 60%(T60) basal area reduction] were applied in 2004. Mean soil temperature and soil water content were $8.9^{\circ}C$ and 14.3% for control, $10^{\circ}C$ and 16.1% for T45 and $10.2^{\circ}C$ and 16.1% for T60, respectively. Mean soil temperature and moisture content were significantly different among the treatment plots (p<0.05). Mean PAR in control, T45 and T60 was 44, 143 and178 ${\mu}mol/m^2$/sec, respectively and the differences were also statistically significant among the treatment plots (p<0.05). Mean annual diameter growth in control, T45 and T60 was 0.4, 1.5 and 1.2 mm, respectively. Diameter growth of Pinus koraiensis was steadily increased after thinning in comparison to control. Consequently, the results suggested that soil temperature, soil moisture content and light availability were likely to last beyond the 4 years after thinning in this Korean pine plantation.

Quantitative evaluation and affecting factors of post-treatment relapse tendency (교정치료 후 나타나는 재발 경향에 대한 정량적 평가와 영향을 미치는 요소에 대한 연구)

  • Son, Woo-Sung;Cha, Kyung-Suk;Chung, Dong-Hwa;Kim, Tae-Woo
    • The korean journal of orthodontics
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    • v.41 no.3
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    • pp.154-163
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    • 2011
  • Objective: The purpose of this study was to quantitatively evaluate relapse tendency after orthodontic treatment and determine the contributing factors by using the American Board of Orthodontics objective grading system (ABO-OGS). Methods: The subjects were 80 patients with more than 2 years of retention period after completing orthodontic treatment at the dental hospitals of Busan University, Kyunghee University, and Dankook University. The posttreatment (T2) and post-retention (T3) ABO-OGS measurements were analyzed in relation to age, gender, Angle's classification, extraction, retention period, and pretreatment condition (initial peer assessment rating (PAR) index, T1) by multiple regression analysis. Results: Among the 7 ABO-OGS criteria, alignment worsened but occlusal contact and interproximal contact improved in T3, but not in T2 ($p$ < 0.01). The 4 other criteria showed no significant differences. Multiple regression analysis showed that alignment, occlusal relationship, overjet, and interproximal contact were significant linear models, but with a low explanation power. Age, gender, Angle's classification, extraction, retention period, and pretreatment condition (initial PAR index, T1) had little influence on the ABO-OGS changes between T3 and T2. Conclusions: An orthodontist's understanding of posttreatment relapse tendency can be useful in diagnosis and during patient consultation.

PDZ Domain-containing Proteins at Autotypic Junctions in Myelinating Schwann Cells (수초화 슈반세포 autotypic 세포연접의 PDZ 도메인 보유 단백질)

  • Han, Seongjohn;Park, Hyeongbin;Hong, Soomin;Lee, Donghyun;Choi, Maro;Cho, Jeongmok;Urm, Sang-Hwa;Jang, Won Hee;Seog, Dae-Hyun
    • Journal of Life Science
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    • v.25 no.1
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    • pp.101-112
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    • 2015
  • A type of cell junction that is formed between different parts within the same cell is called autotypic cell junction. Autotypic junction proteins form tight junctions found between membrane lamellae of a cell, especially in myelinating glial cells. Some of them have postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domains, which interact with the carboxyl (C)-terminal PDZ-binding motif of other proteins. PDZ domains are protein-protein interaction modules that play a role in protein complex assembly. The PDZ domain, which is widespread in bacteria, plants, yeast, metazoans, and Drosophila, allows the assembly of large multi-protein complexes. The multi-protein complexes act in intracellular signal transduction, protein targeting, and membrane polarization. The identified PDZ domain-containing proteins located at autotypic junctions include zonula occludens-1 (ZO-1), ZO-2, pals-1-associated tight junction protein (PATJ), multi-PDZ domain proteins (MUPPs), membrane-associated guanylate kinase inverted 2 (MAGI2), and protease-activated receptor (PAR)-3. PAR-3 interacts with atypical protein kinase C and PAR-6, forming a ternary complex, which plays an important role in the regulation of cell polarity. MAGI2 interacts with ${\alpha}$-amino-3-hydroxyl-5-methyl-4-isoxazole propionate (AMPA) receptor at excitatory synapses. PATJ is detected in paranodal loops associated with claudin-1. On the other hand, MUPP1 is found in mesaxons and Schmidt-Lanterman incisures with claudin-5. ZO-1, ZO-2, and PAR-3 are found at all three sites. Different distributions of PDZ domain-containing proteins affect the development of autotypic junctions. In this review, we will describe PDZ domain-containing proteins at autotypic tight junctions in myelinating Schwann cells and their roles.

Spectrophotometric Determination of Palladium after Solid-liquid Extraction with 4-(2-Pyridylazo)-resorcinol at 90°C

  • Dong, Yanjie;Gai, Ke
    • Bulletin of the Korean Chemical Society
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    • v.26 no.6
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    • pp.943-946
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    • 2005
  • An effective spectrophotometric determination of palladium with 4-(2-pyridylazo)-resorcinol (PAR) using molten naphthalene as a diluent has been studied. A red complex of palladium with PAR is formed at 90 ${^{\circ}C}$. In the range of pH 9.0-11.0, the complex is quantitatively extracted into molten naphthalene. The organic phase is anhydrously dissolved in $CHCl_3$ to be determined spectrophotometrically at 520 nm against the reagent blank. Beer’s law is obeyed over the concentration range of 0.1-2 ${\mu}g{\cdot}mL^{-1}$. The molar absorptivity and Sandell’s sensitivity are 8.0 ${\times}\;10^5\;L{\cdot}mol^{-1}{\cdot}cm^{-}1\;and\;0.49\;{\mu}g{\cdot}cm^{-2}$ respectively. From the results of tolerance limits, it was found that there was no interferences were observed for most of the ions examined and those somewhat high interferences by Co(II), Fe(II) and Bi(III) could be effectively masked by EDTA.

Apoptosis-inducing Effect of Takrisodokyeum Extract in Androgen Independent Prostate Cancer Cells (남성호르몬 비의존형 전립선 암세포에서 탁리소독음(托裏消毒飮) 추출물의 세포고사 유도 효과)

  • Lee, Hyung-Jae;Kwon, Kang-Beom;Shin, Byung-Cheul;Kim, Eun-Kyung;Han, Mi-Jeong;Song, Mi-Young;Lee, Young-Rae;Park, Byung-Hyun;Ryu, Do-Gon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.4
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    • pp.861-865
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    • 2006
  • Takrisodokyeum (TRSDY) has been known to exert anti-tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that TRSDY induced apoptosis in androgen-independent prostate cancer DU145 cells as evidenced by DNA fragmentation and chromatine condensation in hoechst 33342 dye staining. Our data demonstrated that TRSDY-induced apoptotic cell death was accompanied by increases of PTEN and Par-4 in a time-dependent manner Taken together, these results suggest that TRSDY induce PTEN and Par-4 expression, and eventually lead to apoptotic cell death in androgen independent prostate cancer DU145 cells.

Relationship between Moxifloxacin Resistance Pheno- and Genotype of Moxifloxacin-Resistant Mycoplasma hominis Obtained in vitro (인위적으로 유도된 목시플로사신 내성 Mycoplasma hominis의 표현형과 유전자형의 연관성)

  • Park, In-Dal;Choi, Myung-Won
    • Journal of Life Science
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    • v.20 no.10
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    • pp.1544-1548
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    • 2010
  • Moxifloxacin (MF) - resistant mutants of Mycoplasma hominis (M. hominis) were generated by stepwise selection in increasing concentrations of MF, and six strains of MF resistant M. hominis mutants - M1, M4, M8, M16, M32, and M64 - in which MICs of MF were 0.5, 4, 8, 16, 32, 64 ${\mu}g$/ml, respectively, were generated. Compared to the sequence of M. hominis PG21, all mutants harbored amino acid substitutions of Arg-163 Thr in GyrA, and Pro-445 Gln in ParE. While the concentrations were getting higher, an additional amino acid substitution was found at Ser-153 Lys in GyrA (${\geq}4{\mu}g/ml$), Ser-91 Ile in ParC (${\geq}16{\mu}g/ml$), and Val-450 Phe (${\geq}64{\mu}g/ml$) in GyrB. These substitutions seem to have an impact on resistance to MF, and GyrB change was found only in the highest concentration and seems to be associated with high-level resistance to MF. This, as far as we know, is the first description of a relationship between MF resistance phenotype and genotype.

Proteomic Analysis and Growth Responses of Rice with Different Levels of Titanium Dioxide and UV-B (이산화티탄과 UV-B 수준에 따른 벼 생육과 프로테옴 해석)

  • Hong, Seung-Chang;Shin, Pyung-Gyun;Chang, An-Cheol;Lee, Ki-Sang;Lee, Chul-Won;Woo, Sun-Hee
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.52 no.1
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    • pp.69-80
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    • 2007
  • Among the photoactive semiconductors such as $TiO_2,\;ZnO,\;Fe_2O_3,\;WO_3,\;and\;CdSe,\;TiO_2$ is the most widely used as photocatalyst in different media, because of its lack of toxicity and stability. In this study, the effects of titanium dioxide were investigated to obtain the information of physiological change in rice plant. Light-adapted Chlorophyll flourescence index decreased and relative electron transport rate of rice leaves was activated by titanium dioxide under $2,400\;{\mu}mol\;m^{-2}\;s^{-1}$ PAR (Photosynthetic active radiation). Relative electron transport rate of rice leaf treated with titanium dioxide 10 ppm was high in order of $2,400\;{\mu}mol\;m^{-2}\;s^{-1}\;PAR,\;2,200\;{\mu}mol\;m^{-2}\;s^{-1}\;PAR,\;450\;{\mu}mol\;m^{-2}\;s^{-1}\;PAR$ and titanium dioxide 10 ppm (45.1%), control (32.4%), diuron 10 ppm (15.3%) under $2,400\;{\mu}mol\;m^{-2}\;s^{-1}\;PAR$. Titanium dioxide increased photosynthesis of the rice leaf under $13.6\;KJ\;m^{-2}\;day^{-1}$ UV-B only. With titanium dioxide 20 ppm, reduced UV-B ($0.15\;KJ\;m^{-2}\;day^{-1}$) intensity changed the induction of proteins and twenty-five proteins were identified. Among them, seventy proteins were up-regulated, four proteins were down-regulated and four proteins were newly synthesized. Function of these proteins was related to photosynthesis (52%), carbohydrate metabolism (4%), stress/defense (8%), secondary metabolism (4%), energy/electron transport (4%), and miscellaneous (28%).

Apoptotic Effects and Mechanism Study of Silymarin in DU145 Cells (전립선 암세포에서 silymarin의 고사 유도 효과 및 기전 연구)

  • Kwon Kang-Beom;Kim Eun-Kyung;Park Sung-Joo;Song Ho-Joon;Lee Young-Rae;Park Byung-Hyun;Park Jin-Wzoo;Ryu Do-Gon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.6
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    • pp.1552-1556
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    • 2005
  • Silymarin has been known to exert anti-tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that silymarin induced apoptosis in androgen-independent prostate cancer DU145 cells as confirmed by DNA fragmentation. Our data demonstrated that silymarin-induced apoptotic cell death was accompanied by activation of caspase-3 and subsequent cleavages of its substrates, poly(ADP-ribose) polymerase (PARP) in a time- and concentration-dependent manner. Also, silymarin-induced apoptotic mechanism of DU145 cells involved the induction of Par-4 protein expression. Taken together, these results suggest that silymarin induces the activation of caspase-3, degradation of PARP, increase of Par-4 expression, and eventually leads to apoptotic cell death.