• 한국컴퓨터정보학회논문지
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• 제22권3호
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• pp.131-138
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• 2017

New drug development is time-consuming and costly. Hence, it is necessary to repurpose old drugs for finding new indication. We suggest the way that repurposing old drug using massive literature data and biological network. We supposed a disease-drug relationship can be available if signal pathways of the relationship include significant genes identified in literature data. This research is composed of three steps-identifying significant gene using co-occurrence in literature; analyzing the shortest path on biological network; and scoring a relationship with comparison between the significant genes and the shortest paths. Based on literatures, we identify significant genes based on the co-occurrence frequency between a gene and disease. With the network that include weight as possibility of interaction between genes, we use shortest paths on the network as signal pathways. We perform comparing genes that identified as significant gene and included on signal pathways, calculating the scores and then identifying the candidate drugs. With this processes, we show the drugs having new possibility of drug repurposing and the use of our method as the new method of drug repurposing.

• 대한후두음성언어의학회지
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• 제27권2호
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• pp.78-83
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• 2016

Laryngopharyngeal reflux (LPR) disease is an extraoesophageal variant of gastro-esophageal reflux disease that can affect the larynx and pharynx. LPR is associated with symptoms of laryngeal irritation such as throat clearing, coughing, and hoarseness. The main diagnostic methods currently used are laryngoscopy and pH monitoring. The most common laryngoscopic signs are redness and swelling of the throat. However, these findings are not specific of LPR and may be related to other causes or can even be found in healthy individuals. Furthermore, the role of pH monitoring in the diagnosis of LPR is controversial. A therapeutic trial with proton pump inhibitors (PPIs) has been suggested to be cost-effective and useful for the diagnosis of LPR. However, the recommendations of PPI therapy for patients with a suspicion of LPR are based on the results of uncontrolled studies, and high placebo response rates suggest a much more complex and multifactorial pathophysiology of LPR than simple acid reflux. Laryngoscopy and pH monitoring have failed as reliable tests for the diagnosis of LPR. Empirical therapy with PPIs is widely accepted as a diagnostic test and for the treatment of LPR. However, further research is needed to develop a definitive diagnostic test for LPR.

• 소성∙가공
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• 제20권7호
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• pp.518-523
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• 2011

The three dimensional geometries of an aluminum open cell foam before and after uniaxial compressive loading were investigated using the X-ray micro CT(computed tomography). Aluminum 6101-T6 open cell foams of 10, 20, 40 ppi (pore per inch) were considered in this work. After the serial sectioning CT images of aluminum foams were obtained from non-destructive X-ray images, the exact 3D structure were reproduced and visualized with commercial image processing program. The relative density ratio was around the 7.0 to 9.0 range, the unit cells showed anisotropic shapes having the different dimensional ratios of 1.1 to 1.3 between the rise and the transverse directions. The yield stress increased with the relative density ratio and the volumetric strain increased proportionally with compressive strain. The plateau stress in the compressive stress-strain curve was caused by the buckling of ligaments.

• Mass Spectrometry Letters
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• 제9권2호
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• pp.51-55
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• 2018

Capture of non-glycoproteins during lectin affinity chromatography is frequently observed, although it would seem to be anomalous. In actuality, lectin affinity chromatography works at post-translational modification (PTM) sites on a glycoprotein which is not involved in protein-protein interactions (PPIs). In this study, serial affinity column set (SACS) using lectins followed by proteomics methods was used to identify PPI mechanisms of captured proteins in human plasma. MetaCore, STRING, Ingenuity Pathway Analysis (IPA), and IntAct were individually used to elucidate the interactions of the identified abundant proteins and to obtain the corresponding interaction maps. The abundant non-glycoproteins were captured with the binding to the selected glycoproteins. Therefore, depletion process in sample pretreatment for abundant protein removal should be considered with more caution because it may lose precious disease-related low abundant proteins through PPIs of the removed abundant proteins in human plasma during the depletion process in biomarker discovery. Glycoproteins bearing specific glycans are frequently associated with cancer and can be specifically isolated by lectin affinity chromatography. Therefore, SACS using Lycopersicon esculentum lectin (LEL) can also be used to study disease interactomes.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2006년도 정기학술발표대회 논문집
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• pp.378-383
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• 2006

본 연구에서는 최근 활성화 되고 있는 BTL 사업의 재원조달 방법을 다양화함과 동시에 중소건설사의 민간투자사업 참여활성화를 위하여 자산유동화증권 제도의 도입을 검토하고 도입에 따른 효과와 장단점 등을 사례에 대한 민감도분석 등을 통하여 제시하고자 하였다. 이를 위하여 두 가지 형태의 ABS 도입 구조를 제안하고 절차를 제시하였으며 도입에 따른 효과 분석을 위하여 학교시설 신축 사업을 대상으로 조달금리 변화에 따른 사업자의 수익률 변화와 정부의 정부지급금 변화를 분석함으로서 도입의 효과를 계량화 하고자하였으며 ABS 제도의 도입에 필요한 향후 개선 과제를 제시하였다.

• Archives of Pharmacal Research
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• 제21권5호
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• pp.496-502
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• 1998

The present study was carried out to determine the possible use of cTn-I in the cardiac myofibrillar architecture, as a potential target for in vivo radioimmunodetection of cardiac damage in a brain death pig model. Radioiodiantion of the anti-cTn-I 5F4 McAb was carried out by lactoperoxidase method. the percentage iodine incorporation achieved was 70-75%. The radioiodinated McAbs were purified on Sephadex G-25 column and characterised by Paper chromatography, Phast Gel electrophoresis and electroimmunoblotting. Radioiodinated anticTn-I 5F4 McAbs were employed alongside Pyrophosphate($Tc_{99m}$-PPi$) and $Thallium^{201}$ chloride($TI^{201}$) in 24 landrace pigs (brain-dead=18 & sham-operated=6). The percentage cardiac uptake of the radiolabelled antibody injected dose was significantly higher in the brain dead animals(0.196%) as compared to that of sham-operated animals (0.11%). Specific in vivo localization of radiolabelled McAbs in the infarcted cardiac tissue was confirmed by computer-aided reconstruction of 3-D images of the isolated heart. The preliminary results of the study revealed preferential uptake of radiolabelled antibody at the site of myocyte damage resulting from artificially induced brain death.

• Journal of Animal Science and Technology
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• 제60권6호
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• pp.11.1-11.7
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• 2018

After pubertal, cohort of small antral follicles enters to gonadotrophin-sensitive development, called recruited follicles. This study was aimed to identify candidate genes in follicular cyclic recruitment via analysis of protein-protein interaction (PPI) network. Differentially expressed genes (DEGs) in ovine granulosa cells of small antral follicles between follicular and luteal phases were accumulated among gene/protein symbols of the Ensembl annotation. Following directed graphs, PTPN6 and FYN have the highest indegree and outdegree, respectively. Since, these hubs being up-regulated in ovine granulosa cells of small antral follicles during the follicular phase, it represents an accumulation of blood immune cells in follicular phase in comparison with luteal phase. By contrast, the up-regulated hubs in the luteal phase including CDK1, INSRR and TOP2A which stimulated DNA replication and proliferation of granulosa cells, they known as candidate genes of the cyclic recruitment.

• 한국주조공학회지
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• 제17권3호
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• pp.267-275
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• 1997

Fabrication of high strength Mg-Li-Al alloys by squeeze casting was established by the stabilization of melt and mold temperatures, applied pressure and the refining method. The entrapment of inclusions during pouring was prevented using 30 ppi alumina foam filter. The as-cast microstructure consists of a mixture of ${\alpha}$ and ${\beta}$ phases including AILi and $MgLi_2$, Al particles, which are distributed in the ${\beta}$ matrix. The grain sizes of gravity and squeeze casting alloys were 288 ${\mu}m$ and 207 ${\mu}m$ respectively. The addition of Al in Mg-Li alloys promoted the formation of second phase particles, which were adjusted to optimize the properties of Mg-Li-Al alloys. The Mg-10wt%Li-5wt%Al alloy after heat treatment at $350^{\circ}C$ for 1 hour showed the maximum hardness value. This is due to the facts that the amounts of ${\alpha}$ and ${\beta}$ phases and their distributions are dependent upon the solution treatment temperature, and that the amounts of AILi and $MgLi_2Al$ particles are dependent upon the Al content.

• 한국건설관리학회논문집
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• 제6권1호
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• pp.162-168
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• 2005

건설공사의 계약 이후에 발생하는 물가변동에 의한 계약금액의 조정방법으로 지수조정율 방식이 널리 활용되어 왔다. 그러나 지수조정율에 의한 방식에 사용되는 생산자물가지수는 건설공사의 특성이 반영되지 않은 범용적인 지수이기 때문에 실제 건설공사의 물가변동에 대한 설명력이 매우 부족하다. 이에 본 연구에서는 기존의 지수조정율에 의한 계약금액 조정방식의 문제점을 활용 지수측면에서 규명하고, 건설사업의 특성을 반영할 수 있는 건설공사비지수의 활용을 통하여 이러한 문제점을 개선하고자 하였으며, 사례연구를 통하여 그 효용성을 검증하였다.

• Journal of Information Display
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• 제3권2호
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• pp.1-5
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• 2002

A CMOS driving circuit for active matrix type polymer electroluminescent displays was designed to develop an on-chip microdisplay on the single crystal silicon wafer substrate. The driving circuit is a conventional structure that is composed of the row, column and pixel driving parts. 256 gray scales were implemented using pulse amplitude modulation method. The 2-transistor driving scheme was adopted for the pixel driving part. The layout was carried out considering the compatibility with the standard CMOS process. Judging from the layout of the driving circuit, it turns that it is possible to implement a high-resolution display about 400 ppi resolution. Through the HSPICE simulation, it was verified that this circuit is capable of driving a VGA signal mode display and implementing 256 gray levels.