• Steel and Composite Structures
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• v.36 no.3
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• pp.261-272
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• 2020

A novel precast concrete-encased steel composite beam, which can be abbreviated as PCES beam, is introduced in this paper. In order to investigate the shear behavior of this PCES beam, a test of eight full-scale PCES beam specimens was carried out, in which the specimens were subjected to positive bending moment or negative bending moment, respectively. The factors which affected the shear behavior, such as the shear span-to-depth aspect ratio and the existence of concrete flange, were taken into account. During the test, the load-deflection curves of the test specimens were recorded, while the crack propagation patterns together with the failure patterns were observed as well. From the test results, it could be concluded that the tested PCES beams could all exhibit ductile shear behavior, and the innovative shear connectors between the precast concrete and cast-in-place concrete, namely the precast concrete transverse diaphragms, were verified to be effective. Then, based on the shear deformation compatibility, a theoretical model for predicting the shear capacity of the proposed PCES beams was put forward and verified to be valid with the good agreement of the shear capacities calculated using the proposed method and those from the experiments. Finally, in order to facilitate the preliminary design in practical applications, a simplified calculation method for predicting the shear capacity of the proposed PCES beams was also put forward and validated using available test results.

• Journal of Multimedia Information System
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• v.1 no.1
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• pp.23-43
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• 2014

With the rapidity of the development on electronic technology, various mobile devices are produced to make human life more convenient. The user is always in constant search of middle with ease of deployment. Therefore, the development of infrastructure and application with ubiquitous nature gets a growing keen interest. Recently, the number of pervasive network services is expanding into ubiquitous computing environment. To get desired services, user presents personal details about this identity, location and private information. The information transmitted and the services provided in pervasive computing environments (PCEs) are exposed to eavesdropping and various attacks. Therefore, the need to protect this environment from illegal accesses has become extremely urgent. In this paper, we propose an anonymous authentication and access control scheme to secure the interaction between mobile users and services in PCEs. The proposed scheme integrates a biometric authentication in PKI model. The proposed authentication aims to secure access remote in PCE for guaranteeing reliability and availability. Our authentication concept can offer pervasive network service users convenience and security.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.34C no.5
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• pp.66-70
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• 1997

This paper presents a parallel combinatorial variant of evolution strategy (PCES) to solve well-known combinatorial optimization problems, Quadratic assignment problems (QAPs). The PCES reduces the possibility of getting stuck in local minima due to maintenance of subpopulation and thus it is more effective than the CES. Experiment results on two benchmark problems show that the PCES is better than the cES and the genetic algorithm(GA).

• Korean Journal of Acupuncture
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• v.36 no.1
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• pp.74-80
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• 2019

Objectives : TA, a polyherbal extract, typically is used for pharmacopuncture therapy on patients with traffic accident-related injuries and musculoskeletal diseases. This study was performed to evaluate the safety of the TA extract, using a micronucleus test. Methods : The dose range and sampling time were first established. An in vivo micronucleus test was then performed to determine the induction of micronuclei in mouse bone marrow cells after a single intramuscular administration of TA to 7-week-old ICR mice (0.2 ml/animal, at 24 hours post-dosing). Results : The incidence of micro-nucleated polychromatic erythrocytes (PCEs) in PCEs in the TA group was similar to that in the negative-control group, while that in the positive-control group was significantly greater. The positive- and negative-control groups did not differ in the ratio of PCEs to total erythrocytes. Conclusions : Our toxicity study indicates that the TA extract does not induce micronucleus formation in mouse bone marrow cells.

• Journal of Korean Society of Transportation
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• v.14 no.3
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• pp.61-73
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• 1996

The objective of this paper is to estimate the PCE(Passenger Car Equivalents) of various vehicle types on expressway work zones. Headway samples of 5,359 vehicles were collected in 6 work zones in the Kyungbu Expressway between September and November of 1995. Average headways of 8 vehicle types based on the vehicle classification method of the Department of Construction and Transportation were calculated. A statistical test of effects of the types of the preceding vehicles were performed for the average headways between a vehicle type preceded by other vehicle types. The results show that the effects of the type of preceding vehicles are significant (exceeded 5% and 10% significance levels) and the PCEs of heavy vehicles on expressway work zones are higher than that of basic expressway section. Therefore, different adjustment factors should be applied for heavy vehicles in estimating saturation flow rates of expressway work zones. The study also derives an equation to determine PCEs of these vehicle types.

• Toxicological Research
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• v.18 no.4
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• pp.369-374
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• 2002

The present study was performed to validate an automated image analysis system (Loats Automated Micronucleus Scoring System) for the mouse bone marrow micronucleus assay, comparing with conventional microscopic scoring. Two studies were conducted to provide slides for a comparison of micro-nucleated polychromatic erythrocytes (MNPCEs) values collected manually to those collected by the auto-mated system. Test article A was used as an example of a compound negative for the induction of micronuclei and test article B was wed as a micronucleus-inducing agent to elicit a positive response. Cyclophosphamide was included to provide an positive control in two studies. Bone marrow samples were collected 24 h after administration of test article A and B in male ICR mice. The cells were fixed with absolute methanol and stained with May-Grunwald and Giemsa. The number of MNPCEs was determined by the analysis of 1000 total PCEs per bone marrow sample. In addition to micronucleus scoring, an index of bone marrow toxicity based on PCE ratio (% of PCEs to total erythrocytes) was determined for each sample. The automated and manual scoring was similar when the MNPCEs incidence induced by each test article was less than 10. However manual scoring was able to effectively enumerate micronucleated PCEs in mouse bone marrow when MNPCEs incidence was more than 10, such as cyclophosphamide treatment. Conversely, PCE ratio was superior in computer-assisted image analysis. Taken together, it is suggested that improvement of the automated image analysis may be necessary to render the automatic scoring as sensitive as manual scoring for routine counting of micronuclei, especially because it is superior in objectivity and high throughput scoring.

• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.239-243
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• 1996

DW-116 {(1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride) is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(-) bacteria. DW-116 was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after intraperitoneal and oral single administration. We prepared the bone marrow cells at 30hr after drug administration and they were used for measuring PCE with micronucleus. The results showed there was no statistically significant increase in the numbers of PCEs with micronucleus in all DW-116 administered groups compared with a negative control group. The results also showed that the ratio of normochromatic erythrocytes(NCEs) to PCEs of all DW-116 administered groups was not significantly different from that of a negative control group. These results suggested that DW-116 may not cause any chromosomal damage and it has no in vivo mutagenic potential under these experimental conditions.

• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.278-283
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• 1997

DW-166HC ($^{166}$ Holmium ($^{166}$ Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumoriginec spectrum, especially against human fepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous and intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I ($^{165}$ Ho-Chitosan complex cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC ($^{166}$ Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr and 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative control group but there was significant difference this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

• Journal of Pharmacopuncture
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• v.26 no.4
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• pp.366-372
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• 2023

Objectives: We aimed to evaluate the genotoxicity of a recently developed no-pain pharmacopuncture (NPP) targeting muscle relaxation and analgesia using the micronucleus test. Methods: To evaluate the potential of NPP extracts to induce micronuclei in rat bone marrow cells, a micronucleus test was performed using male Sprague-Dawley rats. The test substance NPP was administered intramuscularly at concentrations of 0.25, 0.5, and 1 mL/animal. Saline was used as the negative control and cyclophosphamide as the positive control. Results: No NPP treatment-related deaths or abnormal changes in general appearance were observed at any dose level during the experimental period. No statistically significant differences in body weight were observed in any of the NPP dose groups compared to the saline negative control group. NPP did not cause a significant increase in the incidence of micronucleated polychromatic erythrocytes (PCEs) and PCEs or in the ratio of PCE-to-total erythrocytes. Conclusion: The NPP extract did not exhibit genotoxic in Sprague-Dawley rat bone marrow cells under the conditions of this study. Further toxicity studies of the NPP extract are required.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.4
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• pp.52-61
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• 2015

PCE(Passenger Car Equivalents) is used to analysis of road capacity and LOS(Level of Service). In this study calculates PCE by number of lane and 12 vehicle type by MOLIT(Minister of Land, Infra Structure and Transport) using individual vehicle data. The results of the calculation, PCEs are increased when high vehicle classification level, many number of lanes and weekend. Heavy vehicle factors are smaller than KHCM on 4, 6 lane. Also, In this study estimates of PCE variation model by heavy vehicle percentage. Impact of Heavy vehicles on PCEs is the most sensitive on 2 lane. The results of the study, heavy vehicles low impact on PCE on multi-lane and business trips are a little in weekend.