Biomolecules & Therapeutics
- Volume 4 Issue 3
- /
- Pages.239-243
- /
- 1996
- /
- 1976-9148(pISSN)
- /
- 2005-4483(eISSN)
Micronucleus Test of DW-116, a Novel Antibacterial Quinolone
신규 퀴놀론 항균제 DW-116의 소핵시험
- Moon, Eun-Yi (Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.) ;
- Lee, Jin (Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.) ;
- Choi, Chung-Ha (Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.) ;
- Lee, Chi-Woo (Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.) ;
- Chung, Yong-Ho (Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.) ;
- Yoon, Sung-June (Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.) ;
-
Lee, Dog-Keun
(Research Laboratories of Dong-Wha Pharm. Ind. Co. Ltd.)
- 문은이 (동화약품공업(주) 중앙연구소) ;
- 이진 (동화약품공업(주) 중앙연구소) ;
- 최청하 (동화약품공업(주) 중앙연구소) ;
- 이치우 (동화약품공업(주) 중앙연구소) ;
- 정용호 (동화약품공업(주) 중앙연구소) ;
- 윤성준 (동화약품공업(주) 중앙연구소) ;
-
이덕근
(동화약품공업(주) 중앙연구소)
- Published : 1996.09.01
Abstract
DW-116 {(1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride) is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(-) bacteria. DW-116 was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after intraperitoneal and oral single administration. We prepared the bone marrow cells at 30hr after drug administration and they were used for measuring PCE with micronucleus. The results showed there was no statistically significant increase in the numbers of PCEs with micronucleus in all DW-116 administered groups compared with a negative control group. The results also showed that the ratio of normochromatic erythrocytes(NCEs) to PCEs of all DW-116 administered groups was not significantly different from that of a negative control group. These results suggested that DW-116 may not cause any chromosomal damage and it has no in vivo mutagenic potential under these experimental conditions.