• 생명과학회지
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• 제31권9호
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• pp.818-826
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• 2021

5-ALA-p는 천연 아미노산인 5-ALA를 암모니아수로 용출하고 인산과 아세톤을 첨가하여 광역학 요법에 적합한 특성을 갖도록 개발된 물질이다. 그러나 항산화 및 항염증에 대한 잠재적인 기전을 포함한 약리학적 효능은 아직 명확하지 않다. 본 연구에서는 LPS로 자극된 RAW 264.7 세포에서 산화적 및 염증성 반응에 대한 5-ALA-p의 효과를 평가하였다. 본 연구의 결과에 의하면, 5-ALA-p는 LPS에 의한 RAW 264.7 세포의 과도한 식균 활성을 유의하게 억제하였고 산화적 스트레스를 약화시켰다. 5-ALA-p는 또한 LPS에 의해 감소된 미토콘드리아 생물 발생을 개선하였으며, 이는 5-ALA-p가 LPS로 인한 미토콘드리아 손상을 복원시켰음을 시사한다. 아울러 5-ALA-p는 NO와 TNF-α, IL-1β 및 IL-6과 같은 염증성 사이토카인의 생성을 현저히 억제하였으며, 이는 iNOS 및 각 사이토카인의 발현 감소와 연관성이 있었다. 나아가 5-ALA-p는 NF-κB의 핵 전이를 감소시키고 MAPKs의 인산화를 억제하여 5-ALA-p의 항염증 효과가 이들 신호전달 경로의 활성 억제와 매개되었음을 보여주었다. 이러한 결과들은 5-ALA-p가 산화적 및 염증성 스트레스를 줄이는 잠재적인 후보 약물로 적용될 수 있음을 의미한다.

• Asian-Australasian Journal of Animal Sciences
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• 제22권9호
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• pp.1225-1233
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• 2009

Fat composition of beef, taken here to mean marbling, can be manipulated by time on feed, finishing diet, and breed type. These three factors also strongly influence the fatty acid composition of beef. Both the amount of marbling and the concentration of monounsaturated fatty acids (MUFA) increase with time on feed in grain-fed and pasture-fed cattle, but much more dramatically in grain-fed cattle. High-concentrate diets stimulate the activity of adipose tissue stearoyl-CoA desaturase (SCD), which is responsible for the conversion of saturated fatty acids (SFA) to their $\Delta{9}$ desaturated counterparts. Also, grain feeding causes a depression in ruminal pH, which decreases those populations of ruminal microorganisms responsible for the isomerization and hydrogenation of polyunsaturated fatty acids (PUFA). The net result of elevated SCD activity in marbling adipose tissue and depressed ruminal isomerization/hydrogenation of dietary PUFA is a large increase in MUFA in beef over time. Conversely, pasture depresses both the accumulation of marbling and SCD activity, so that even though pasture feeding increases the relative concentration of PUFA in beef, it also increases SFA at the expense of MUFA. Wagyu and Hanwoo cattle accumulate large amounts of marbling and MUFA, and Wagyu cattle appear to be less sensitive to the effects of pastures in depressing overall rates of adipogenesis and the synthesis of MUFA in adipose tissues. There are small differences in fatty acid composition of beef from Bos indicus and Bos taurus cattle, but diet and time on feed are much more important determinants of beef fat content and fatty acid composition than breed type.

• 한국초전도ㆍ저온공학회논문지
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• 제13권1호
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• pp.6-11
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• 2011

The $BaHfO_3$ (BHO) buffer layer on the IBAD MgO template was turned to be effective for a successful fabrication of $GdBa_2Cu_3O_{7-{\delta}}$ (GdBCO) films with high critical current density ($J_c$). Both the BHO buffer layers and GdBCO films were prepared by pulsed laser deposition (PLD). The effects of the PLD conditions, including substrate temperature ($T_s$), oxygen partial pressure ($PO_2$), and deposition time on the in-plane texture, surface roughness, and microstructures of the BHO buffer layers on the IBAD MgO template were systematically studied for processing optimization. The c-axis oriented growth of BHO layers was insensitive to the deposition temperature and the film thickness, while the in-plane texture and surface roughness of those were improved with increasing $T_s$ from 700 to $800^{\circ}C$. On the optimally processed BHO buffer layer, the highest $J_c$ value (77 K, self-field) of 3.68 $MA/cm^2$ could be obtained from GdBCO film deposited at $780^{\circ}C$, representing that BHO is a strong candidate for the buffer layer on the IBAD MgO template.

• Steel and Composite Structures
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• 제17권4호
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• pp.405-429
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• 2014

In this paper, it is aimed to determine the structural behavior of suspension bridges considering construction stages and different soil conditions. Bosporus Suspension Bridge connecting the Europe and Asia in Istanbul is selected as an example. Finite element model of the bridge is constituted using SAP2000 program considering existing drawings. Geometric nonlinearities are taken into consideration in the analysis using P-Delta large displacement criterion. The time dependent material strength of steel and concrete and geometric variations is included in the analysis. Time dependent material properties are considered as compressive strength, aging, shrinkage and creep for concrete, and relaxation for steel. To emphases the soil condition effect on the structural behavior of suspension bridges, each of hard, medium and soft soils are considered in the analysis. The structural behavior of the bridge at different construction stages and different soil conditions has been examined. Two different finite element analyses with and without construction stages are carried out and results are compared with each other. At the end of the analyses, variation of the displacement and internal forces such as bending moment, axial forces and shear forces for bridge deck and towers are given in detail. Also, displacement and stresses for bridge foundation are given with detail. It can be seen from the analyses that there are some differences between both analyses (with and without construction stages) and the results obtained from the construction stages are bigger. It can be stated that the analysis without construction stages cannot give the reliable solutions. In addition, soil condition have effect on the structural behavior of the bridge. So, it is thought that construction stage analysis using time dependent material properties, geometric nonlinearity and soil conditions effects should be considered in order to obtain more realistic structural behavior of suspension bridges.

• 한국식품영양학회지
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• 제30권3호
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• pp.578-590
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• 2017

An agricultural waste, pomegranate (Punica granatum L.) peel is known to be rich in total phenolics, which are flavonoids having strong antioxidant effects. In this study, pomegranate peel sponge cakes were prepared with varying ratios of freeze dried pomegranate peel powder (0, 1, 3, 5, 7% (w/w)) to examine their effect on quality characteristics, retrogradation and antioxidant activities. The specific gravity and moisture contents of 3, 5, and 7% pomegranate peel powder showed higher values than the control and 1% group. Addition of pomegranate peel powder increased the batter yield, while there was a significant decrease in baking loss. Increasing pomegranate peel powder content significantly decreased the lightness (L) (from 75.03 to 57.04) and pH values, whereas redness (a), yellowness (b) and ${\Delta}E$ were increased. Increasing concentration of the peel powder also increased the hardness and chewiness, while the springiness and cohesiveness decreased. Considering the Avrami equation, Avrami exponene (n) decreased from 1.8055 (control) to 0.9199 (7% pomegranate peel powder). Time constant (1/k) was lowest in control (at 17.64) and highest in the 7% group (39.84). Total polyphenol, flavonoid content, DPPH and ABTS radical scavenging activities significantly increased with increments in the content of pomegranate peel powder. A sensory evaluation by the 7-point scaling method showed that the sponge cake containing 7% pomegranate peel powder had the highest scores in color, flavor, sweetness, chewiness and overall acceptability. Hence, it is considered that sponge cake supplemented with 7% pomegranate peel powder is the most appropriate for quality characteristics, retrogradation and antioxidant activities.

• 대한기계학회논문집B
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• 제28권12호
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• pp.1535-1548
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• 2004

Condensation heat transfer experiments were conducted with the oblong shell and plate heat exchanger without oil in a refrigerant loop using R-l34a, R-407C and R-410A. An experimental refrigerant loop has been developed to measure the condensation heat transfer coefficient h$_{r}$ and frictional pressure drop $\Delta$p$_{f}$ of the various refrigerants in a vertical oblong shell and plate heat exchanger. The effects of the refrigerant mass flux(40∼80kg/$m^2$s), average heat flux(4∼8kW/$m^2$), refrigerant saturation temperature(30∼4$0^{\circ}C$) and vapor quality of refrigerants on the measured data were explored in detail. Similar to the case of a plate heat exchanger, even at a very low Reynolds number, the flow in the oblong shell and plate heat exchanger remains turbulent. A comparison of the performance of the various refrigerants revealed that R-410A had the highest heat transfer performance followed by R-l34a, and R-407C had the lowest performance of the refrigerants tested. The pressure drops were also reported in this paper. The pressure drops for R-410A were approximately 45% lower than those of R-l34a. R-407C had 30% lower pressure drops than R-l34a. Experimental results were compared with several correlations which predicted condensation heat transfer coefficients and frictional pressure drops. Comparison with the experimental data showed that the previously proposed correlations gave unsatisfactory results. Based on the present data, empirical correlations of the condensation heat transfer coefficient and the friction factor were proposed.tor were proposed.sed.

• Journal of Biosystems Engineering
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• 제42권1호
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• pp.44-55
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• 2017

Background: Heat recovery is one of the prominent ways to save a considerable amount of conventional fossil fuel and minimize its adverse effects on the environment. The rotary heat exchanger is one of the most effective and efficient devices for heat recovery or heat exchanging purposes. It is a regenerative type of heat exchanger, which has been studied and used for many heat recovery purposes. However, regenerative thermal wheels have been mostly used as heat recovery systems in buildings. For modeling a rotary regenerator, it is very important to numerically consider all the factors involved, such as effectiveness, rotational speed, geometrical size and shape, and pressure drop (${\Delta}p$). In recent times, several researchers have actively studied the rotary heat exchangers, both theoretically and experimentally. Reviews: In this paper different advances in the numerical modeling of regenerative rotary heat exchangers in relation to fluid flow and heat transfer have been discussed. Researchers have indicated that the effectiveness of the regenerative rotary heat exchanger depends on various factors including, among many others, rotational speed, rotational period and combustion power. It is reported that with the increase of periodic rotation the deviation of theoretical results from the experimental result increases. The available literature indicates that regenerative heat exchangers are having relatively more effectiveness (60-80%), compared to other heat exchangers. It is also observed that the finite difference method and finite volume methods are mostly used for discretizing the heat transfer governing equations, under some assumptions. Research also indicates that for the effectiveness calculation the ${\varepsilon}-NTU$ method is the most popular and convenient.

• 한국강구조학회 논문집
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• 제16권5호통권72호
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• pp.629-639
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• 2004

철골조는 작용하중을 지탱하기 위한 구조시스템 중의 하나로 널리 사용되고 있고, 보와 기둥의 강성, 보와 기둥의 강성, 지점조건, 보강의 유무, $P-{\Delta}$효과 등의 변화에 따른 영향들을 포함하는 최적의 설계를 필요로 한다. 본 연구는 볼트 수의 변화에 의한 더블앵글 접합부의 회전강성 변화가 철골조의 거동에 미치는 영향을 파악하기 위하여 진행되었다. 또한, 수평 수직하중을 동시에 받는 더블앵글로 접합된 골조의 처짐에 대한 제한 조건을 만족하도록 하는 최대 허용하중 산정에 관한 연구도 병행하였다. 더블앵글 접합부의 회전강성을 얻기 위하여 접합부 실험을 수행하였고, 골조의 처짐 및 최대 작용하중을 정확하게 파악하기 위한 단순해석 모델도 제안하였다.

• Smart Structures and Systems
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• 제18권1호
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• pp.75-92
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• 2016

The design of a semi-active (SA) control system addressed to mitigate wind induced structural demand to high wind turbine towers is discussed herein. Actually, the remarkable growth in height of wind turbines in the last decades, for a higher production of electricity, makes this issue pressing than ever. The main objective is limiting bending moment demand by relaxing the base restraint, without increasing the top displacement, so reducing the incidence of harmful "p-delta" effects. A variable restraint at the base, able to modify in real time its mechanical properties according to the instantaneous response of the tower, is proposed. It is made of a smooth hinge with additional elastic stiffness and variable damping respectively given by springs and SA magnetorheological (MR) dampers installed in parallel. The idea has been physically realized at the Denmark Technical University where a 1/20 scale model of a real, one hundred meters tall wind turbine has been assumed as case study for shaking table tests. A special control algorithm has been purposely designed to drive MR dampers. Starting from the results of preliminary laboratory tests, a finite element model of such structure has been calibrated so as to develop several numerical simulations addressed to calibrate the controller, i.e., to achieve as much as possible different, even conflicting, structural goals. The results are definitely encouraging, since the best configuration of the controller leaded to about 80% of reduction of base stress, as well as to about 30% of reduction of top displacement in respect to the fixed base case.

• 약학회지
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• 제55권2호
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• pp.168-171
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• 2011

Chrysosplenol C [5,6-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxychromen-4-one] is a flavonoid found in Miliusa balansae and Pterocaulon sphacelatum. We have recently shown that chrysosplenol C has positive inotropic effect in isolated rat ventricular myocytes. In the present study, we explored a possible mechanism for the positive inotropic effect of chrysosplenol C by examining intracellular $Ca^{2+}$ transients during action potentials. The intracellular $Ca^{2+}$ transients were measured by confocal $Ca^{2+}$ imaging in field-stimulated single rat ventricular myocytes. Chrysosplenol C (50 ${\mu}M$) significantly increased the magnitudes (${\Delta}F/F_0$) of $Ca^{2+}$ transients (control, $1.08{\pm}0.05$; chrysosplenol C, $1.25{\pm}0.03$; n=8, P<0.01). Half decay time of the action potential-induced $Ca^{2+}$ transient was not altered by chrysosplenol C (50 ${\mu}M$) (control, $154{\pm}6$ ms; chrysosplenol C, $167{\pm}11$ ms; n=21). The $Ca^{2+}$ content in the sarcoplasmic reticulum (SR), measured as caffeine (10 mM)-induced $Ca^{2+}$ transient, was significantly decreased by chrysosplenol C (50 ${\mu}M$). These results indicate that chrysosplenol C increases $Ca^{2+}$ transients without altering $Ca^{2+}$ removal kinetics in ventricular myocytes, providing a possible mechanism for its positive inotropic effect.