• Journal of Gastric Cancer
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• v.1 no.1
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• pp.10-16
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• 2001

Purpose: The p53 protein is a tumor supressor gene, and its mutation is associated with biologic aggressiveness. CD44v6, one of the CD44 family, is a cell surface glycoprotein that plays a role in cancer invasion and metastasis. Vascular endothelial growth factor (VEGF) is another recently identified growth factor with significant angiogenic properties. The purpose of this study was to investigate p53, CD44v6, and VEGF expressions to determine whether degree of expression was related to pathological parameters such as Lauren's classification, depth of invasion, and lymph node metastasis. Materials and Methods: Immunohistochemical stains of p53, CD44v6, and VEGF in formalin-fixed paraffin-embedded tissue sections of 125 gastric adenocarcinomas were done. Results: The overall expression rates of p53, CD44v6, and VEGF were $54.4\%$ (68/125), $36.8\%$ (46/125), and $48.0\%$ (60/125), respectively. The p53, not CD44v6 and VEGF was higher in intestinal-type gastric carcinomas by Lauren's classification. The expressions of p53, CD44v6, and VEGF were statistically correlated with depth of tumor invasion. The expression of CD44v6 was higher in the lymph node metastatic group than in the negative group. The p53 expression was significantly associated with VEGF expression. Conclusions: These data suggest that the expressions of p53, CD44v6, and VEGF are biologically related to malignancy. The p53 and CD44v6 expressions are independent; however, p53 gene mutation is one of the contributing factors to VEGF expression in gastric adenocarcinoma.

• Journal of IKEEE
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• v.26 no.2
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• pp.329-332
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• 2022

In this paper, retention characteristics of lateral charge migration according to parameters of 3D NAND flash memory to which ferroelectric (HfO₂) structure is applied and ∆V_th were analyzed. The larger the P_s, the greater maximum polarization possible in ferroelectric during Programming. Therefore, the initial V_th increases by about 1.04V difference at P_s 70µC/cm² than at P_s 25µC/cm². Also, electrons trapped after the Program operation causes lateral charge migration over time. Since ferroelectric maintains polarization without applying voltage to the gate after Programming, regardless of P_s value, polarization increases as P_r increases and the ∆V_th due to lateral charge migration becomes smaller by about 1.54V difference at P_r 50µC/cm² than P_r 5µC/cm².

• Journal of applied mathematics & informatics
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• v.29 no.3_4
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• pp.921-936
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• 2011

In this paper, our main purpose is to establish the existence of weak solutions of a weak solutions of a class of p-q-Laplacian system involving concave-convex nonlinearities: $$\{\array{-{\Delta}_pu-{\Delta}_qu={\lambda}V(x)|u|^{r-2}u+\frac{2{\alpha}}{\alpha+\beta}|u|^{\alpha-2}u|v|^{\beta},\;x{\in}{\Omega}\\-{\Delta}p^v-{\Delta}q^v={\theta}V(x)|v|^{r-2}v+\frac{2\beta}{\alpha+\beta}|u|^{\alpha}|v|^{\beta-2}v,\;x{\in}{\Omega}\\u=v=0,\;x{\in}{\partial}{\Omega}}$$ where ${\Omega}$ is a bounded domain in $R^N$, ${\lambda}$, ${\theta}$ > 0, and 1 < ${\alpha}$, ${\beta}$, ${\alpha}+{\beta}=p^*=\frac{N_p}{N_{-p}}$ is the critical Sobolev exponent, ${\Delta}_su=div(|{\nabla}u|^{s-2}{\nabla}u)$ is the s-Laplacian of u. when 1 < r < q < p < N, we prove that there exist infinitely many weak solutions. We also obtain some results for the case 1 < q < p < r < $p^*$. The existence results of solutions are obtained by variational methods.

• Bulletin of the Korean Mathematical Society
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• v.55 no.5
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• pp.1441-1462
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• 2018

In this paper, we investigate the fractional p&q-Kirchhoff type system $$\{M_1([u]^p_{s,p})(-{\Delta})^s_pu+V_1(x){\mid}u{\mid}^{p-2}u\\{\hfill{10}}={\ell}k^{-1}F_u(x,\;u,\;v)+{\lambda}{\alpha}(x){\mid}u{\mid}^{m-2}u,\;x{\in}{\Omega}\\M_2([u]^q_{s,q})(-{\Delta})^s_qv+V_2(x){\mid}v{\mid}^{q-2}v\\{\hfill{10}}={\ell}k^{-1}F_v(x,u,v)+{\mu}{\alpha}(x){\mid}v{\mid}^{m-2}v,\;x{\in}{\Omega},\\u=v=0,\;x{\in}{\partial}{\Omega},$$ where ${\Omega}{\subset}{\mathbb{R}}^N$ is an unbounded domain with smooth boundary ${\partial}{\Omega}$, and $0<s<1<p{\leq}q$ and sq < N, ${\lambda},{\mu}>0$, $1<m{\leq}k<p^*_s$, ${\ell}{\in}R$, while $[u]^t_{s,t}$ denotes the Gagliardo semi-norm given in (1.2) below. $V_1(x)$, $V_2(x)$, $a(x):{\mathbb{R}}^N{\rightarrow}(0,\;{\infty})$ are three positive weights, $M_1$, $M_2$ are continuous and positive functions in ${\mathbb{R}}^+$. Using variational methods, we prove existence of infinitely many high-energy solutions for the above system.

• Journal of the Korean Geotechnical Society
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• v.24 no.6
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• pp.5-16
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• 2008

This study investigated the existing theoretical backgrounds in order to examine the stability control method of lateral flow caused by the Plasticity of soils when unsymmetrical surcharge works on polluted soils and then compared and analyzed the results measured through model tests. Ultimate bearing power of ML and $ML_{p1}$ and $ML_{p2}$ obtained at surcharge(q)-settlement$(S_v)$ curve showed similar trends to ultimate bearing power obtained from control chart of deflection $(S_v-Y_m)$ by Tominaga.Hashimoto, that of $S_v-(Y_m/S_v)$ by Matsuo.Kawamura and that of $(q/Y_m)-q$ by Shibata.Sekiguchi and so it is considered that it has no problem in actual applicability. ${S_v-(Y_m/S_v)}$ of control chart of $ML_{p1}$ by Matsuo.Kawamura showed smaller value than ultimate bearing capacity value from surcharge-settlement curve $(q-S_v)$. Expression of ML of fracture baseline at stability control charge by Matsuo Kawamura is ${S_v=3.21exp}\{-0.48(Y_m/S_v)\}$ and expression of $ML_{p1}$ is ${S_v=3.26exp}\{-0.96(Y_m/S_v)\}$ and expression of $ML_{p2}$ is ${S_v=6.33exp}\{-0.45(Y_m/S_v)\}$.

• Journal of Chest Surgery
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• v.14 no.3
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• pp.235-240
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• 1981

A total of 102 patients who had an Open Heart Surgery from April 1976 to July 1981 were reviewed. 55 paeitnts were congenital heart disease and 47 patients were acquired heart disease. Among SS patients of congenital heart disease, 18 T 0 F, 18 V S D, 8 A S D, and each one case of l\ulcorner 0 R V, Truncus arteriosus, Ebstein anomaly, Single ventricle, P D A, P 5, A S D + P 5, E C D, V 5 D + P D A, A - P window, D C R V were noted respectively. In 47 patients of acquired heart disease and one Ebstein patient, 46 prosthetic values were implanted: 17 had M V R, 4 had A V R, 2 had M V R + A V R, and 4 had M V R + T V R and one T V R. The operative mortality was 8.S% in acquired heart disease and 17% in congenital heart disease. The follow up period was between 6 months and 6 years. There were 3 cases of late mortality in acquired heart disease and one case in congenital heart disease.

• Journal of the Korean Chemical Society
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• v.17 no.6
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• pp.428-433
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• 1973

The quantitative separations of a mixture containing equal amount of each anion such as Si(IV), As(V), P(V), S(VI), W(VI) and Cr(VI) are carried out by the elution through 20${\times}3.14cm^2$ column of anion exchange resin, Dowex 1${\times}$8. The eluents are a mixture of 0.07 M hydrochloric acid and 0.03 M sodium chloride (pH = 1.30) for Si(IV), As(V) and P(V) species, a mixture of 0.6 M sodium chloride and 0.3 M sodium hydroxide for S(VI), W(VI) and Cr(VI) species, and 0.1 N sodium sulfite (pH = 3.48) for P(V) and As(V) species. The subsidiary anions in a standard mixture such as Si(IV), As(V), S(VI), P(V) and W(VI) are separated together from large amount of Fe(III) by the elution through 30cm${\times}3.14cm^2$ column of the resin, Dowex${\times}$50w${\times}$12, using a mixture of 0.1 M sodium nitrate and 2 percent dimethylsulfoxide aqueous solution as an eluent. Si(IV), As(V), S(VI), P(V) and W(VI) eluted together are separated quantitatively under the same conditions as in the separations of the anion mixture. By the conditions obtained in the separations of the standard mixture, Fe(III) and all of the subsidiary anions in steel are quantitatively separated.

• Molecules and Cells
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• v.43 no.11
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• pp.953-963
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• 2020

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious disease with multiple severe symptoms, such as fever over 37.5℃, cough, dyspnea, and pneumonia. In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, and hsa-miR-196a-1-3p) were found to commonly bind to SARS-CoV, MERS-CoV, and SARS-CoV-2. We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. Especially, hsa-miR-15b-5p and hsa-miR-195-5p showed a large difference in expression, indicating that they may potentially be diagnostic biomarkers for SARS-CoV-2 infection.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.04b
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• pp.157-159
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• 2000

Vanadate glass in the $Li_2O-P_2O_5-V_2O_5$ system with 60mol% $V_2O_5$ was prepared by melting the bath in pt. crucible followed by quenching on the copper plate. We found that $Li_2O-P_2O_5-V_2O_5$ glass ceramics obtained from nucleation of $Li_2O-P_2O_5-V_2O_5$ glass showed significantly higher capacity and longer cycle life than conventionally made crystalline $LiV_3O_8$. In the present paper, We describe the charge/discharge properties during crystallization process and find the best crystallization condition of $Li_2O-P_2O_5-V_2O_5$ glass as cathode material. The Charge and discharge capacity of $Li_2O-P_2O_5-V_2O_5$ glass was about 220mAh/g for the cell heat-treated at $250^{\circ}C$ for 2.5hr.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.11
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• pp.57-62
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• 1998

In this paper, tunable transconductor shows good linearity over a wide input voltage range are proposed. The proposed transconductor employ operating in the nonsaturation(ie., linear) region to improve circuit simplicity and tunability and 6.8V$\_$p-p/ wide input range. Also the circuit employ source-coupled differential pair to provide true differential input and can achieve both positive and negative transconductance values. The proposed circuits are implemented using a 1.2 $\mu\textrm{m}$ single poly double metal n-well CMOS technology. The THD characteristic of proposed circuit is less than 1% for a differential input voltage of up to 6V$\^$p-p/ when supply bias condition is V$\_$DD/=-V$\_$ss/=5V, I$\_$B/=20, 40${\mu}$A, and frequency of input signal is 1KHz.