• Journal of Korean Society of Steel Construction
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• v.19 no.6
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• pp.575-585
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• 2007

In this study, a new design equation was presented for square CFTs with high-strength concrete subjected to axial compression and bending. In a previous study, a design equation for square CFTs with normal strength concrete was proposed. A parametric study by fiber analysis was performed taking the width-to-thickness ratio (b/t) and the relative concrete strength to the yield strength of the steel tube (fck/Fy) as the main parameters of this study to determine the maximum moment and the axial load at the maximum moment. A new constitutive model for concrete was adopted for fiber analysis in order to take into account the effect of high-strength concrete. The results of the parametric study were embedded into the method which was presented in the previous study to formulate a new design equation that can be easily used for estimating the strength of square CFTs with high-strength concrete.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2003.10a
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• pp.452-461
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• 2003

The effect of initial combined load on the lateral free vibration of arches is investigated. For the analysis, P-M interaction own for the arches are obtained. The arches are circular arches which have constant cross-section and simply supported. Also, the arches are subjected both radial uniform distributed load which results in an axial compression on the cross-section and end moments that cause uniform bending action at the same time. All analysis are performed by finite element method based on Kang and Yoo's curved beam theory.

• Journal of the Korea Concrete Institute
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• v.14 no.5
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• pp.677-688
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• 2002

A analytical model is developed which can simulate a complete inelastic biaxial moment-curvature relations of a reinforced concrete column. The model can simulate sudden drop in moment capacity after peak moment and due to spalling of cover concrete. Parametric studies are performed examine the effects of constituent material properties as well as topological arrangement of reinforcements on moment-curvature relations and P-M interaction curve. It has been analytically observed that ductility of a reinforced concrete column is influenced mostly by magnitude of the axial load and spacings or the volume of lateral reinforcements. Compared to ACI P-M interaction curve, overall increase about 10％ in square root of sum of squares of axial force and moment, and about 20％ in peak load are observed for the columns reinforced according to ACI seismic design code.

• Geomechanics and Engineering
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• v.5 no.5
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• pp.379-399
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• 2013

In practice, analysis of laterally loaded piles is carried out using beams on non-linear Winkler springs model (often known as p-y method) due to its simplicity, low computational cost and the ability to model layered soils. In this approach, soil-pile interaction along the depth is characterized by a set of discrete non-linear springs represented by p-y curves where p is the pressure on the soil that causes a relative deformation of y. p-y curves are usually constructed based on semi-empirical correlations. In order to construct API/DNV proposed p-y curve for clay, one needs two values from the monotonic stress-strain test results i.e., undrained strength ($s_u$) and the strain at 50% yield stress (${\varepsilon}_{50}$). This approach may ignore various features for a particular soil which may lead to un-conservative or over-conservative design as not all the data points in the stress-strain relation are used. However, with the increasing ability to simulate soil-structure interaction problems using highly developed computers, the trend has shifted towards a more theoretically sound basis. In this paper, principles of Mobilized Strength Design (MSD) concept is used to construct a continuous p-y curves from experimentally obtained stress-strain relationship of the soil. In the method, the stress-strain graph is scaled by two coefficient $N_C$ (for stress) and $M_C$ (for strain) to obtain the p-y curves. $M_C$ and $N_C$ are derived based on Semi-Analytical Finite Element approach exploiting the axial symmetry where a pile is modelled as a series of embedded discs. An example is considered to show the application of the methodology.

• Archives of Pharmacal Research
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• v.27 no.9
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• pp.901-905
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• 2004

A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric(HILIC-MS/MS) method for the determination of tiapride in human plasma was developed. Tiapride and internal standard, metoclopramide were extracted from human plasma with dichloromethane at basic pH and analyzed on an Atlantis HILIC silica column with the mobile phase of acetonitrile-ammonium formate (190 mM, pH 3.0) (94：6, v/v). The ana-Iytes were detected using an electrospray ionization tandem mass spectrometry in the multi-ple-reaction-monitoring mode. The standard curve was linear (r＝0.999) over the concentration range of 1.00-200 ng/mL. The coefficient of variation and relative error for intra- and inter-assay at three QC levels were 6.4∼8.8％ and -2.0∼3.6％, respectively. The recoveries of tiapride ranged from 96.3 to 97.4％, with that of metoclopramide (internal standard) being 94.2％. The lower limit of quantification for tiapride was 1.00 ng/mL using 1 00 $\mu$L of plasma sample.

• Archives of Pharmacal Research
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• v.14 no.2
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• pp.181-187
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• 1991

The muscarinic antagonist 1-[benzilic 4, 4'-$[^3H]$ QUINUCLIDINYL BENZILATE $([^3H]$ QNB) bound to a single class of muscarinic receptors with high affinity in rabbit ileal membranes. The $K_D\;and\;B_{ max}$ values for $([^3H]$ QNB calculated from analysis of saturation isotherms were 52.5 pM AND 154 fmol/mg, respectively. Chlopheniramine (CHP), histamine $H_1$ blocker, increased $K_D$ vlue for $([^3H]$QNB without affecting the binding site concentrations and Hill coefficient. The $K_i$ value of CHP for inhibition of $([^3H]$QNB binding in ileal membranes was 1.44\mu{M}$ and the pseudo-Hill coefficient for CHP was close to unit. In the functional assay carbachol, muscarinic agonist, increased the contractile force of ileum with $ED_{50}$ value of $0.11\mu{M}$. CHP caused the rightward shift of the dose-response curve to carbachol. The $pA_2$ value of CHP determined from Schild analysis of carbacholinduced contraction was 5.77 and the slope was unity indicating competitive antagonism with carbachol. The dissociation constant $(K_i)$ of CHP obtained in competitive experiments with $([^3H]$ QNB was similar to the $K_A$ value (1.69 \mu{M)}$ of CHP as inhibitor of carbachol induced contraction in rabbit ileum. This result suggest that the binding of $H_i$ blocker. CHP, vs $([^3H]$QNB to muscarinic receptors in ileal membranes represents an interaction with a receptor of physiological relevance.

• Journal of the Korea Concrete Institute
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• v.29 no.4
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• pp.353-360
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• 2017

The objective of this study is theoretical and empirical evaluation of the flexural performance of concrete filled pretensioned spun high strength concrete pile with ring type composite shear connectors (CFP pile). The specimens are comprised of standard CFP pile, PHC pile+composite shear connector+filed concrete (CFP-N-N), standard CFP pile with $1^{st}$ reinforcements (H13-8ea), and standard CFP pile with $1^{st}$ and $2^{nd}$ reinforcements(H19-8ea). Flexural performance evaluation results showed that the ductility is improved with increased steel ratio, which leads to the increased maximum load by 46.4% (with $1^{st}$ reinforcement) and 103.9% (with $1^{st}$ and $2^{nd}$ reinforcements) compared to standard CFP ( CFP-N-N). Comparing with the predicted ultimate limit state values of the CFP pile design method and the experimental results, the design method presented in this study is reasonable since safety factor of 1.23 and 1.40 times for each reinforcement step are secured.

• YAKHAK HOEJI
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• v.34 no.4
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• pp.224-237
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• 1990

A single uniform population of specific, saturable, high affinity binding site of $[^3H]QNB$ guinuclidinyl benzilate(QNB) was identified in the rat cerebral microsomes. The Kd value(37.2 pM) for $[^3H]QNB$ calculated from the kinetically derived rate constants was in agreement with the Kd value(48.9 pM) determined by analysis of saturation isotherms at various receptor concentrations. Dimenhydrinate(DMH), histamine $H_1-blocker$, increased Kd value for $[^3H]QNB$ QNB without affecting the binding site concentrations and this effect resulted from the ability of DMH to slow $[^3H]QNB-receptor$ association. Pirenzepine inhibition curve of $[^3H]QNB$ binding was shallow(nH = 0.52) indicating the presence of two receptor subtypes with high ($M_1-site$) and low($M_2-site$) affinity for pirenzepine. Analysis of these inhibition curves yielded that 68% of the total receptor populations were of the $M_1-subtype$ and the remaining 32% of the $M_2-subtype$. Ki values for the $M_1-$ and $M_2-subtypes$ were 2.42 nM and 629.3 nM, respectively. Ki values for $H_1-blockers$ that inhibited $[^3H]QNB$ binding varied with a wide range ($0.02-2.5\;{\mu}M$). The Pseudo-Hill coefficients for inhibition of $[^3H]QNB$ binding by most of $H_1-blockers$ examined except for oxomemazine inhibition of $[^3H]QNB$ binding were close to one. The inhibition curve for oxomemazine in competition with $[^3H]QNB$ was shallow(nH = 0.74) indicating the presence of two receptor populations with different affinities for this drug. The proportion of high and low affinity was 33:67. The Ki values for oxomemazine were $0.045{\pm}0.016\;{\mu}M$ for high affinity and $1.145{\pm}0.232\;{\mu}M$ for low affinity sites. These data indicate that muscarinic receptor blocking potency of $H_1-blockers$ varies widely between different drugs and that most of $H_1-blockers$ examined are nonselective antagonist for the muscarinic receptor subtypes, whereas oxomemazine might be capable of distinguishing between subclasses of muscarinic receptor.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.05a
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• pp.62-65
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• 2006

This study investigated the behavior of R/C column confined with headed crossties subjected to eccentric loading. The 16 specimens are designed to have adequate confinement steel, determined by ACI seismic design. The variables studied in this research test are eccentricity to depth ratios, spacing of lateral steel and the anchor type of end of crossties. From the test results, all columns showed similar behavior up to the peak load but those columns laterally confined with head presented more ductile behavior after the peak load. The comparisons indicate that the flexural behavior of confined-concrete columns can be computed resonable accurately by P-M interaction curve.

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.553-558
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• 2012

A simple new method was developed for the determination of betaine in Fructus Lycii using hydrophilic interaction liquid chromatography with evaporative light scattering detection (HILIC-ELSD). Good chromatographic separation and reasonable betaine retention was achieved on a Kinetex HILIC column ($2.1{\times}100mm$, $2.6{\mu}m$) packed with fused-core particle. The mobile phase consisted of (A) acetonitrile and (B) 10 mM ammonium formate (pH 3.0)/acetonitrile (90/10, v/v). It was used with gradient elution at a flow rate of 0.7 mL/min. The column temperature was set at $27.5^{\circ}C$ and the injection volume was $10{\mu}L$. The ELSD drift tube temperature was $50^{\circ}C$ and the nebulizing gas (nitrogen) pressure was 3.0 bar. Stachydrine, a zwitterionic compound, was used as an internal standard. Calibration curve over $10-250{\mu}g/mL$ showed good linearity ($R^2$ > 0.9992) and betaine in the 70% methanol extract of Fructus Lycii was well separated from other peaks. Intraand inter-day precision ranged from 1.1 to 3.0% and from 2.4 to 5.3%, respectively, while intra- and inter-day accuracy ranged from 100.0 to 107.0% and from 94.3 to 103.9%, respectively. The limit of quantification (LOQ) was $10{\mu}g/mL$ and the recoveries were in the range of 98.2-102.7%. The developed HILIC-ELSD method was successfully applied to quantitatively determine the amount of betaine in fourteen Fructus Lycii samples from different locations, demonstrating that this method is simple, rapid, and suitable for the quality control of Fructus Lycii.