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Determination of Tiapride in Human Plasma Using Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry  

Moon, Ya (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Paek, In-Bok (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Kim, Hui-Hyun (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Ji, Hye-Young (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Lee, Hye-Won (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Park, Hyoung-Geun (Research Laboratories, Dong-A Pharm. Co., Ltd)
Lee, Hye-Suk (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Publication Information
Archives of Pharmacal Research / v.27, no.9, 2004 , pp. 901-905 More about this Journal
Abstract
A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric(HILIC-MS/MS) method for the determination of tiapride in human plasma was developed. Tiapride and internal standard, metoclopramide were extracted from human plasma with dichloromethane at basic pH and analyzed on an Atlantis HILIC silica column with the mobile phase of acetonitrile-ammonium formate (190 mM, pH 3.0) (94：6, v/v). The ana-Iytes were detected using an electrospray ionization tandem mass spectrometry in the multi-ple-reaction-monitoring mode. The standard curve was linear (r＝0.999) over the concentration range of 1.00-200 ng/mL. The coefficient of variation and relative error for intra- and inter-assay at three QC levels were 6.4∼8.8％ and -2.0∼3.6％, respectively. The recoveries of tiapride ranged from 96.3 to 97.4％, with that of metoclopramide (internal standard) being 94.2％. The lower limit of quantification for tiapride was 1.00 ng/mL using 1 00 $\mu$L of plasma sample.
Keywords
Tiapride; Human plasma; HILIC-MS／MS;
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Times Cited By Web Of Science : 9  (Related Records In Web of Science)
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1 Buna, M., Aaron, J. J., Prognon, P. and Mahuzier, G., Effects of pH and solvent on the fluorescence properties of biomedically important benzamides. Application to determination in drugs and in human urine. Analyst, 121, 1551-1556 (1996)   DOI   ScienceOn
2 Kamizono, A., Inotsume, N., Miyamoto, K., Ueda, K., Miyakawa, T., Arimoto, H., and Nakano, M., Determination of sultopride and tiapride in serum by gas chromatography using a surface ionization detector. J. Chromatogr., 567, 113-120 (1991)   DOI   PUBMED   ScienceOn
3 Guidance for Industry-Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine, May 2001, httpJ/www.fda. gov/cder/guidance/ index.htm
4 Robert, P. H. and Allain, H., Clinical management of agitation in the elderly with tiapride. Eur. Psychiatry, 16 (suppl 1), 42s-47s (2001)   DOI   ScienceOn
5 Naidong, W. and Eerkes, A., Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the analysis of paroxetine in human plasma. Biomed. Chromatogr., 18, 28-36 (2004)   DOI   ScienceOn
6 Kotzailias, N., Finsterer, J., Aull, S., Eichler, H.-G., Pratscher, B., and Jilma, B., Influence of tiapride on platelet counts in healthy volunteers and patients with movement disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry, 27, 595-599 (2003)   DOI   ScienceOn
7 Norman, T. R., James, R. H., and Gregory, M. S., Determination of tiapride in plasma by high-performance liquid chromatography. J. Chromatogr. B, 375, 197-201 (1986)   DOI   ScienceOn
8 Naidong, W., Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases. J. Chromatogr. B, 796, 209-224 (2003)   DOI   ScienceOn
9 Aly, F. A., Alarfaj, N. A., and Alwarthan, A. A, Flow-injection chemiluminometric analysis of some benzamides by their sensitizing effect on the cerium-sulphite reaction. Talanta, 54, 715-725 (2001)   DOI   ScienceOn
10 Heun, R., Rosler, M., and Allain, H., Tiapride in gerontopsy-chiatry. Eur. Psychiatry, 16 (suppl 1), 3s-4s (2001)
11 Chiba, R., Ogasawara, A., Kubo, T., Yamazaki, H., Umino, M., and Ishizuka, Y., Direct determination of benzamides in serum by column-switching high-performance liquid chromatography. Anal. Sci., 19,785-789 (2003)   DOI   ScienceOn