• Clinics in Shoulder and Elbow
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• v.15 no.2
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• pp.65-72
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• 2012

Purpose: To evaluate the differentiation potential of stem cells and their immunophenotype from 3 different sources. Methods: Our study involved three stem cell sources-subacromial bursal tissue, bone marrow, and umbilical cord blood. We obtained the subacromial bursal tissue and bone marrow from the patients undergoing shoulder surgery. After collecting the sample, we applied specific induction media for neurogenic, adipogenic and osteogenic differentiation. Also, flow-cytometry analysis was done to reveal the cell surface antigens. Results: We obtained 100% (8 cases) neural and adipogenic differentiation, but 62.5% (5 of 8 cases) osseous differentiation among the subacromial bursal tissue group. Bone marrow derived cells showed 100% neural (6 cases) and adipogenic (5 cases) differentiation, but 80% (4 of 5 cases) osseous differentiation. Umbilical cord blood derived cells revealed 97% (65 of 67 cases) neural, 53.7% (29 of 54 cases) adipogenic and 68.4% (39 of 57 cases) osseous differentiation. Immunophenotype analysis revealed that surface markers of bone marrow, subacromial bursal cell and umbilical cord blood derived mesenchymal stem cells are different from each other. Conclusions: Mesenchymal stem cells are potential agents in regenerative medicine and are characterized by expression of surface markers and by their differentiation potential. Our study with stem cells from subacromial bursal tissue, bone marrow and umbilical cord discovered that each stem cell has unique differentiation potential and function based on its origin. Various stem cells show multi-lineage differentiations in vitro which can be correlated to in vivo conditions.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.471-478
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• 2004

Electromyogram (EMC) signal generated by voluntary contraction of muscles is often used in a rehabilitation devices such as an upper limb prosthesis because of its distinct output characteristics compared to other bio-signals. This paper proposes an EMG-based human-computer interface (HCI) for the control of the above-elbow prosthesis or the wheelchair. To control such rehabilitation devices, user generates four commands by combining voluntary contraction of two different muscles such as levator scapulae muscles and flexor-extensor carpi ulnaris muscles. The muscle contraction is detected by comparing the mean absolute value of the EMG signal with a preset threshold value. However. since the time difference in muscle firing can occur when the patient tries simultaneous co-contraction of two muscles, it is difficult to determine whether the patient's intention is co-contraction. Hence, the use of the comparison method using a single threshold value is not feasible for recognizing such co-contraction motion. Here, we propose a novel method using double threshold values composed of a primary threshold and an auxiliary threshold. Using the double threshold method, the co-contraction state is easily detected, and diverse interface commands can be used for the EMG-based HCI. The experimental results with real-time EMG processing showed that the double threshold method is feasible for the EMG-based HCI to control the myoelectric prosthetic hand and the powered wheelchair.

• Anxiety and mood
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• v.15 no.2
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• pp.115-121
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• 2019

Objective : The purpose of this study was to investigate prevalence of psychiatric symptoms and determine predictors of emotional distress of military hospital surgical patients. Methods : This study examined 104 orthopedic patients admitted to the Armed Forces Military Hospital September-November 2018. For the study, every subject completed self-assessment inventories regarding depressive and anxiety symptoms (Hospital Anxiety and Depression Scale), sleep problems (Pittsburgh Sleep Quality Index), problematic alcohol and tobacco use (Cut off, Annoyed, Guilty, Eye-opener screening), and psychiatric history. We performed the Student's t-test and the chi-square test for the collected data to investigate the prevalence of psychiatric symptoms, including emotional distress. Logistic regression analysis was used to examine the risk factors related to emotional distress of hospitalized military personnel. Results : There were no significant differences in socio-demographic and psychiatric symptoms between soldiers and officers. The prevalence of depressive and/or anxiety symptoms (emotional distress) was 21.2% (n=21). In the logistic regression analysis, psychiatric history [Adjusted Odds Ratio (AOR)=18.99 ; 95% Confidence Interval (CI)=1.42-253.57 ; p=0.026] and low military life satisfaction (AOR=15.67; 95% CI=1.46-168.11 ; p=0.023) correlated with emotional distress. Conclusion : Soldiers admitted to the military hospital showed similar prevalence of emotional distress as those at general hospitals. Considering military circumstances, it is necessary to detect and intervene regarding soldiers with a psychiatric history and low military life satisfaction to promote mental health at military hospitals.

• IMMUNE NETWORK
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• v.24 no.2
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• pp.17.1-17.16
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• 2024

We have reported that anterior cruciate ligament (ACL) injury leads to the differential dysregulation of the complement system in the synovium as compared to meniscus tear (MT) and proposed this as a mechanism for a greater post-injury prevalence of post traumatic osteoarthritis (PTOA). To explore additional roles of complement proteins and regulators, we determined the presence of decay-accelerating factor (DAF), C5b, and membrane attack complexes (MACs, C5b-9) in discarded surgical synovial tissue (DSST) collected during arthroscopic ACL reconstructive surgery, MT-related meniscectomy, osteoarthritis (OA)-related knee replacement surgery and normal controls. Multiplexed immunohistochemistry was used to detect and quantify complement proteins. To explore the involvement of body mass index (BMI), after these 2 injuries, we examined correlations among DAF, C5b, MAC and BMI. Using these approaches, we found that synovial cells after ACL injury expressed a significantly lower level of DAF as compared to MT (p<0.049). In contrast, C5b staining synovial cells were significantly higher after ACL injury (p<0.0009) and in OA DSST (p<0.039) compared to MT. Interestingly, there were significantly positive correlations between DAF & C5b (r=0.75, p<0.018) and DAF & C5b (r=0.64 p<0.022) after ACL injury and MT, respectively. The data support that DAF, which should normally dampen C5b deposition due to its regulatory activities on C3/C5 convertases, does not appear to exhibit that function in inflamed synovia following either ACL injury or MT. Ineffective DAF regulation may be an additional mechanism by which relatively uncontrolled complement activation damages tissue in these injury states.

• Journal of the Institute of Convergence Signal Processing
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• v.25 no.2
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• pp.77-85
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• 2024

The suspension device that connects the prosthetic leg and the residual limb allows lower limb amputees to wear prosthetic limbs, and is the most sensitive part when using prosthetic limbs as it is always in contact with the residual limb not only while walking but also in everyday life. In this paper, using the principles of attraction and repulsion of permanent magnets, we developed a magnetic lock suspension device that can fix the amputees and prosthetic legs of lower limb amputees by changing the polarity of the magnet. The operation method of the magnetic lock is that when neodymium magnets are placed on the left and right as NNSS based on a non-magnetic brass core, the magnetic force flows outward beyond the brass core using the adsorption member as a medium to generate bonding force. When rotated 90 degrees, the magnet moves to NSNS. The principle is that as the position moves, the magnetic force flows inward and cancels out.Based on this, we conducted a bonding test using tensile strength and a short-term comparative evaluation of the prosthesis with the shuttle lock suspension system, which was a comparison group, to verify reliability and evaluate satisfaction with the prototype. As a result, the tensile strength exceeding the appropriate bonding strength was confirmed, and the magnetic lock showed higher satisfaction than the shuttle lock. In the future, we plan to conduct long-term ADL clinical trials for commercialization and develop a product that can be distributed to actual amputees.

• Proceedings of the KIPE Conference
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• 2010.07a
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• pp.265-266
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• 2010

This paper propose the test method for performance of myoelectric hand prosthesis(MHP) according to myoelectric signal generated in the human muscle. The MHP consists of a mechanical hand, a surface myoelectric sensor(SMES) for measuring myoelectric signal, a control system and a charging battery. The propose test method is proved the reliability of MHP.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2009.03a
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• pp.16-16
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• 2009

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.06a
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• pp.203-204
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• 2007

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.6 no.2
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• pp.65-69
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• 2013

Rupture of biceps brchii is seen mainly in tendinous portion and intrasubstance rupture is rare. Author experienced 2 cases of intrasubstance rupture of biceps brachii diagnosed by sonographic examination which showed satisfactory result by conservative treatment.

• Proceedings of the KIPE Conference
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• 2007.07a
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• pp.340-342
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• 2007

This paper presents the grip force control of myoelectric hand prosthesis according to myoelectric signal generated in the human muscle. The control system consist of a controller for driving DC motor, torque sensor for measuring out torque of motor, slip sensor for detecting slip of torque. The experimental results proved the reliability of proposed control system.