• The Journal of Korean Society for Radiation Therapy
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• v.7 no.1
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• pp.92-96
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• 1995

All patients who will Undergo irraidiation of the oral cavity cancer will need dental before and during Radiotherapy. The extent of the region and the presence of numerous critical normal tissues(mucosa, gingiva, teeth and the alveolar ridge, alveolar bony structure, etc) in the oral cavity area, injury to which could result in serious functional impairment. Therefore I evaluate the Usefulness of custom-made intraoral shielding device before and during Radiotherapy in oral cavity cancer. Materials and Methods(1) : Manufacture process of Custom-made intraoral shielding device Containing Cerroband. A. Acquisition of impression B. Matrix Constitution C. Separation by Separator D. Sprincle on method E. Trimming F. Spacing G. Fill with Cerroband Materials and Methods (2) A. Preannealing B. TLD Set up C. Annealing D. TLD Reading = Results = Therefore dosimetric characteristics in oral cavity by TLD Compared to isodose curve dose distribution Ipsilateral oral mucosa, Contralateral oral mucosa, alveolar ridge, tongue, dose was reduced by intraoral shielding device containning Cerroband technique Compard to isodose plan = Conclusions = The custom-made intra-oral shielding device containing Cerroband was useful in reducing the Contralateral oral mucosa dose and Volume irradiated.

• Journal of the Semiconductor & Display Technology
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• v.6 no.4
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• pp.43-47
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• 2007

In this paper, we propose a novel sensor system for measuring the arterial pulse in an oral cavity. In order to measure pulse wave in oral cavity, the proposed system is designed with reflection type arterial wave sensor, not by using transmission type arterial pulse wave sensor. Driving circuit through pulse current is designed for solving self-heating problem of LED. The effectiveness of the proposed sensor system is compared with pulse wave between pulse wave of oral cavity and other body parts as well as with characteristic measurements. The experiment shows that the proposed sensor system is adaptive to capturing consecutive and meaningful biometric signals through the variation of pulse wave changes in oral cavity when exercising. The study result expects to design and develop mobile sensors which could be adapted to healthcare devices.

• Journal of radiological science and technology
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• v.22 no.1
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• pp.35-42
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• 1999

This study was undertaken to take the correct vocal technique(especially about the resonance of oral cavity). The resonance of oral and pharyngeal cavity is the principle which can vocalize well without any abnormal signs in the throat. Therefore it is important for us to understand how to use the correct resonance of oral and pharyngeal cavity. Shimadzu X-ray remote control TV system and Shimadzu magnet $nex-{\alpha}$ (SMT-50CX/H) were used for checking the movements of T-M joint and diaphragmatic respiration. The results obtained were summerized as follows: 1. While opening T-M joint space like the vowel "A" [a], We should vocalize five fundamental vowel [a,e,i,o,u] with diaphragmatic respiration holded. 2. Diminuendo must be expressed by increasing a breath volume while descending a mandible gradually because we can not ascend maxilla. So we can make a delicate expression. 3. The resonance of oral cavity must be scattered by elevating the soft palatine lightly with relax of throat.

• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.113-118
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• 2010

Pharmaceutical technology has primarily focused on the development of the best dosage forms depending on the route of administration. The design of dosage forms is greatly influenced by the route of administration. Due to a variety of advantages such as avoidance of first-pass effect, abundant blood supply and easy access to the absorption site, the oral cavity has frequently been selected as a site for drug delivery. Since the oral cavity is relatively unique from the anatomical and physiological viewpoint, one should always consider these conditions when designing the drug delivery systems for the oral cavity. In this regard, the current review paper was prepared to summarize the essential features of the drug delivery systems utilized in the oral cavity, along with the introduction of various dosage forms developed to date.

• Genomics & Informatics
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• v.19 no.1
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• pp.4.1-4.9
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• 2021

Lip and oral cavity cancer, which can occur in any part of the mouth, is the 11th most common type of cancer worldwide. The major obstacles to patients' survival are the poor prognosis, lack of specific biomarkers, and expensive therapeutic alternatives. This study aimed to identify the main genes and pathways associated with lip and oral cavity carcinoma using network analysis and to analyze its molecular mechanism and prognostic significance further. In this study, 472 genes causing lip and oral cavity carcinoma were retrieved from the DisGeNET database. A protein-protein interaction network was developed for network analysis using the STRING database. VEGFA, IL6, MAPK3, INS, TNF, MAPK8, MMP9, CXCL8, EGF, and PTGS2 were recognized as network hub genes using the maximum clique centrality algorithm available in cytoHubba, and nine potential drug candidates (ranibizumab, siltuximab, sulindac, pomalidomide, dexrazoxane, endostatin, pamidronic acid, cetuximab, and apricoxib) for lip and oral cavity cancer were identified from the DGIdb database. Gene enrichment analysis was also performed to identify the gene ontology categorization of cellular components, biological processes, molecular functions, and biological pathways. The genes identified in this study could furnish a new understanding of the underlying molecular mechanisms of carcinogenesis and provide more reliable biomarkers for early diagnosis, prognostication, and treatment of lip and oral cavity cancer.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.33 no.1
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• pp.73-76
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• 2011

Gastrointestinal cyst found within the oral cavity has been reported as a rare occurrence with less than 40 cases. The tongue is the preferred site with almost 60% of cysts occurring within oral cavity. The cyst usually shows an asymptomatic swelling in the floor of the mouth, about 30% of affected individuals have symptoms related to difficulties with feeding, swallowing and respiration. The histopathologic features of the cyst vary with respect to the type of epithelium lining; gastric, squamous, intestinal and respiratory epithelium. The pathogenesis is not known, but it may be related to entrapment of undifferentiated endoderm within oral cavity during early fetal development. In this article, we report a case of a gastrointestinal cyst of the tongue in a 16-month-old girl.

• Journal of Korean society of Dental Hygiene
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• v.20 no.4
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• pp.447-455
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• 2020

Objectives: This study was conducted to analyze the factors affecting discomfort in the oral cavity for the elderly and to provide basic data for improving oral health in the elderly. Methods: It was conducted with ethical approval, and all subjects were explained about the research method and purpose before conducting the questionnaire. The final 178 were analyzed through a self-written questionnaire. SPSS 25.0 was used for statistical analysis of the collected data, and the significance level was 0.05. Results: Dental caries was 51.7%, periodontal disease was 69.1%, and lost tooth was 71.9%.The average score of discomfort in the oral cavity was 2.62±0.96. The factors affecting discomfort in the oral cavity were found to affect discomfort in the oral cavity in groups with education, periodontal disease, and missing teeth. Conclusions: Therefore, it is necessary to proceed with the oral health program according to the educational background of the elderly. Find out how to reduce oral discomfort caused by periodontal disease. It is believed that there is a need to expand health insurance for preventive care rather than treatment.

• International Journal of Oral Biology
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• v.48 no.2
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• pp.9-18
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• 2023

The rapid detection of bacteria in the oral cavity, its species identification, and bacterial count determination are important to diagnose oral diseases caused by pathogenic bacteria. The existing clinical microbial diagnosis methods are time-consuming as they involve observing patients' samples under a microscope or culturing and confirming bacteria using polymerase chain reaction (PCR) kits, making the process complex. Therefore, it is required to analyze the development status of substances and systems that can rapidly detect and analyze pathogenic microorganisms in the oral cavity. With research advancements, a close relationship between oral and systemic diseases has been identified, making it crucial to identify the changes in the oral cavity bacterial composition. Additionally, an early and accurate diagnosis is essential for better prognosis in periodontal disease. However, most periodontal disease-causing pathogens are anaerobic bacteria, which are difficult to identify using conventional bacterial culture methods. Further, the existing PCR method takes a long time to detect and involves complicated stages. Therefore, to address these challenges, the concept of point-of-care (PoC) has emerged, leading to the study and implementation of various chair-side test methods. This study aims to investigate the different PoC diagnostic methods introduced thus far for identifying pathogenic microorganisms in the oral cavity. These are classified into three categories: 1) microbiological tests, 2) microchemical tests, and 3) genetic tests. The microbiological tests are used to determine the presence or absence of representative causative bacteria of periodontal diseases, such as A. actinomycetemcomitans, P. gingivalis, P. intermedia, and T. denticola. However, the quantitative analysis remains impossible, and detecting pathogens other than the specific ones is challenging. The microchemical tests determine the activity of inflammation or disease by measuring the levels of biomarkers present in the oral cavity. Although this diagnostic method is based on increase in the specific biomarkers proportional to inflammation or disease progression in the oral cavity, its commercialization is limited due to low sensitivity and specificity. The genetic tests are based on the concept that differences in disease vulnerability and treatment response are caused by the patient's DNA predisposition. Specifically, the IL-1 gene is used in such tests. PoC diagnostic methods developed to date serve as supplementary diagnostic methods and tools for patient education, in addition to existing diagnostic methods, although they have limitations in diagnosing oral diseases alone. Research on various PoC test methods that can analyze and manage the oral cavity bacterial composition is expected to become more active, aligning with the shift from treatment-oriented to prevention-oriented approaches in healthcare.

• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.503-513
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• 2018

The purpose of this study was to identify the effectiveness of oral care protocol including individual oral care education, cryotherapy and benzydamine gargling on oral cavity status and self-care performance in solid cancer patients receiving chemotherapy. Thirty-one patients were enrolled by convenience sampling in this study and allocated to control (n=18) and experimental group (n=13). In the intervention group, individual oral care education, oral cryotherapy and benzydamine gargling were applied, while the control group received pre-existed oral care. Oral cavity status and self-oral care behavior were measured in five periods. The data were analyzed using the Mann-Whitney test, Friedman test, and Chi-square test. There was no significant difference in oral cavity status between the groups. But the two groups showed the poorest oral cavity status on $14^{th}$ day. Self-care behavior was significantly higher in the intervention group than the control group. This effect had maintained for 4months after completion of study. The results showed that individual oral care education by oncology nurse is effective to encourage patients to do self-care behavior and a further study is needed to explore the effect of cryotherapy and benzydamine gargling on oral cavity status of patient with solid tumor.

• Korean Journal of Bronchoesophagology
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• v.10 no.1 s.19
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• pp.35-40
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• 2004

Adhesion molecules have been implicated in tumor progression. In this study, we aimed to investigate serum soluble intercellular adhesion molecule-1 (ICAM-1) and sialic acid (SA) levels in oral cavity cancer and laryngeal cancer and correlate their levels with cancer progression. Method : The sera from 31 patients with advanced oral cavity cancer (5 at stage III, 10 at stage IV) and advanced laryngeal cancer (1 at stage III, 15 at stage IV) were extracted before treatment. The concentrations of ICAM-1 was measured by Endogen kit (measured absorbance at 490nm) and the concentration of SA was measured by Roche kit (measured absorbance at 550nm). Respectively, gained data was compared with those from a control group (n=12). Result : Mean serum ICAM-1 and SA levels were found to be higher in oral cavity cancer group and laryngeal cancer group than control group. But statistical meaning was at SA (p<0.001, oral cavity cancer and laryngeal cancer versus control). Conclusion : These data reveal that the significant correlations serum SA level in advanced oral cavity cancer and laryngeal cancer. Serum ICAM-1 level was higher at advanced oral cavity cancer and laryngeal cancer than at control group but that was not significant.