• Title/Summary/Keyword: Optimal control period

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Optimal Scheduling of Drug Treatment for HIV Infection;Continuous Dose Control and Receding Horizon Control

  • Shim, H.;Han, S.J.;Jeong, I.S.;Huh, Y.H.;Chung, C.C.;Nam, S.W.;Seo, J.H.
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.1951-1956
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    • 2003
  • It is known that HIV (Human Immunodeficiency Virus) infection, which causes AIDS after some latent period, is a dynamic process that can be modeled mathematically. Effects of available anti-viral drugs, which prevent HIV from infecting healthy cells, can also be included in the model. In this paper we illustrate control theory can be applied to a model of HIV infection. In particular, the drug dose is regarded as control input and the goal is to excite an immune response so that the symptom of infected patient should not be developed into AIDS. Finite horizon optimal control is employed to obtain the optimal schedule of drug dose since the model is highly nonlinear and we want maximum performance for enhancing the immune response. From the simulation studies, we find that gradual reduction of drug dose is important for the optimality. We also demonstrate the obtained open-loop optimal control is vulnerable to parameter variation of the model and measurement noise. To overcome this difficulty, we finally present nonlinear receding horizon control to incorporate feedback in the drug treatment.

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Study of New Control Method for Linear Periodic System

  • Jo, Janghyen
    • 제어로봇시스템학회:학술대회논문집
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    • 1999.10a
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    • pp.83-87
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    • 1999
  • The purpose of this study is to provide the new method for selection of a close to optimal scalar control of linear time-periodic system. The case of scalar control is considered, the gain matrix being assumed to be at worst periodic with the system period T. The form of gain matrix may have various kinds but must have same period, for example, one of each element being represented by Fourier series. As the optimal gain matrix I consider the matrix ensuring the minimum value of the larger real part of the Poincare exponents of the system. Finally we present a pole placement algorithm to make the given system be stable. It is possible to determine the stability of the given periodic system without get the analytic solution. The application of the method does not require the construction of the Floquet solution. At present state of determination of the gain matrix for this case will be done only by systematic numerical search procedures.

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An Optimal Pricing and Inventory control for a Commodity with Price and Sales-period Dependent Demand Pattern

  • Sung, Chang-Sup;Yang, Kyung-Mi;Park, Sun-Hoo
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2005.05a
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    • pp.904-913
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    • 2005
  • This paper deals with an integrated problem of inventory control and dynamic pricing strategies for a commodity with price and sales-period dependent demand pattern, where a seller and customers have complete information of each other. The problem consists of two parts; one is each buyer's benefit problem which makes the best decision on price and time for buyer to purchase items, and the other one is a seller's profit problem which decides an optimal sales strategy concerned with inventory control and discount schedule. The seller's profit function consists of sales revenue and inventory holding cost functions. The two parts are closely related into each other with some related variables, so that any existing general solution methods can not be applied. Therefore, a simplified model with single seller and two customers in considered first, where demand for multiple units is allowed to each customer within a time limit. Therewith, the model is generalized for a n-customer-classes problem. To solve the proposed n-customer-set problem, a dynamic programming algorithm is derived. In the proposed dynamic programming algorithm, an intermediate profit function is used, which is computed in case of a fixed initial inventory level and then adjusted in searching for an optimal inventory level. This leads to an optimal sales strategy for a seller, which can derive an optimal decision on both an initial inventory level and a discount schedule, in $O(n^2)$ time. This result can be used for some extended problems with a small customer set and a short selling period, including sales strategy for department stores, Dutch auction for items with heavy holding cost, open tender of materials, quantity-limited sales, and cooperative buying in the on/off markets.

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OPTIMAL LIQUIDATION OF A LARGE BLOCK OF STOCK WITH REGIME SWITCHING

  • Shin, Dong-Hoon
    • Bulletin of the Korean Mathematical Society
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    • v.48 no.4
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    • pp.737-757
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    • 2011
  • This work is concerned with an optimal selling rule for a large position of stock in a market. Selling a large block of stock in a short period typically depresses the market, which would result in a poor filling price. In addition, the large selling intensity makes the regime more likely to be poor state in the market. In this paper, regime switching and depressing terms associated with selling intensity are considered on a set of geometric Brownian models to capture movements of underlying asset. We also consider the liquidation strategy to sell much smaller number of shares in a long period. The goal is to maximize the overall return under state constraints. The corresponding value function with the selling strategy is shown to be a unique viscosity solution to the associated HJB equations. Optimal liquidation rules are characterized by a finite difference method. A numerical example is given to illustrate the result.

A Study on Dong Scheduling Using HIV Dynamics and Optimal Control (HIV 동역학과 최적 제어를 이용한 약물 치료에 관한 고찰)

  • 허영희;고지현;김진영;남상원;심형보;정정주
    • Journal of Institute of Control, Robotics and Systems
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    • v.10 no.6
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    • pp.475-486
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    • 2004
  • The interaction of HIV and human immune system was studied in the perspective of dynamics. We summarized the recent researches on drug scheduling using optimal control theory for HIV treatment. The drug treatment to make immune system to work properly is investigated based on mathematical models including memory CTLp. In the simulation results, it was verified that stopping medication after a certain period of treatment can lead a patient to be cured naturally by one s immune system. Also, we summarized and categorized the advantages and disadvantages of each HIV drug scheduling method. In conclusion, model-based predictive control is more efficient for making decision of drug dose than other methods, when there exist uncertainties on model parameters or state variables.

Optimal Parameter of Tuned Mass Damper for Controlling Seismic Response (지진응답제어를 위한 동조질량감쇠기의 최적설계지수(단단한 지반))

  • Lee, Joung-Woo;Woo, Sung-Sik;Lee, Sang-Hyun;Chung, Lan
    • Proceedings of the Korea Concrete Institute Conference
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    • 2006.11a
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    • pp.97-100
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    • 2006
  • This study performed numerical analysis for obtaining optimal frequency and damping ratio of tuned mass damper (TMD) using 20 seismic loads measured at rock site. The structures of $1{\sim}2$ second natural period were considered, and optimal frequency and damping ratio were estimated for different mass ratio in terms of displacement and absolute acceleration response control. Numerical results showed that the values of the optimal parameters were different those from previous study by Hartog.

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Optimal Operation Control for Energy Saving in Water Reuse Pumping System (에너지절감을 위한 물 재이용 펌프시스템의 최적운전 제어)

  • Boo, Chang-Jin;Kim, Ho-Chan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.5
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    • pp.2414-2419
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    • 2012
  • This paper presents an optimal operation control method for energy saving in the water reuse pumping system. A predictive horizon switching strategy is proposed to implement an optimal operation control and a linear programming (LP) algorithm is used to solve optimal problems in each time step. Energy costs are calculated for electricity on both TOU in the light, heavy, and maximum load time period and peak charges. The optimal operation in water reuse pumping systems is determined to reduce the TOU and peak costs. The simulation results show a power energy saving for water reuse pumping systems and power stability improvement.

Influence of Disturbances in Optimal Period Establishment for the Rapid Traffic Signal Control (신속교통신호제어를 위한 그 최적주기에 있어서의 외란의 영향)

  • 양흥석;김호윤
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.10 no.5
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    • pp.16-20
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    • 1973
  • The most important thing in locating disturbances in optimal rapid traffic singnal control is to collect information cocerning toraffit flow by means of a detection method. In order to set up an optimal traffic singnal period, the analysis of a delay time phenomena in the signal period must also be considered. In fact, each of the distributed traffic quantities on the road are not similar factors in view of speeds and distances of succeeding cars. The causing factors are analyzed by the method of control engineering analysis, and they are coincident with disturbance. Thus distubances cause errors. Distubances are fuctions of time, and are classified into three conditions: Natural road state and weather are the first. The second is structures and function of vehicles, and the third is inducedbydrivers. This thesis deals with the last two cases except the first one for maximum utilization of the existing road state and weather conditions. The first condition remains constant, and then there exist some relations between vehicles and drivers. In the long run, it can be shown that the scheme for minimizing whole errors in the optimal traffic signal time setting is definitely presented.

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A Study on Optimal Period for Mini Tomato to be Exported to Japan - With Special Reference to Puyo Mini Tomato - (방울토마토 대일(對日) 적정수출시기(適正輸出時期)에 관한 연구(硏究) - 부여 방울 토마토를 중심으로 -)

  • Lee, Dong-Jae;Kim, Chul-Ho
    • Korean Journal of Agricultural Science
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    • v.24 no.2
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    • pp.138-144
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    • 1997
  • Korean agricultural and rural economics has been gotten more difficult through the introduction of economics system under the control of IMF before problems from open market system under WTO get to be settled. Export should be promoted to get the advantage of open market system and to get over today's economic crisis from shortage of foreign currency. Fortunately, Korea adjoins Japan that is largest importing country of agricultural products in a world, therefore Korean Agricultural products has advantage in export to Japan through open market system. Puyo tomato, specialized agricultural products in Chungman province, has been exported 42.2M/T to Japan from 1994 year to 1996 year. But such exported amount was so small that is less than a 1% of total tomato product in Puyo area. Reasons why export volume to Japan was so small were non standard commodities, non performance of export contract, unfavorable price condition, etc.. But it was major reason that missed optimal exporting period. Therefore this study is aimed at finding optimal period exporting Puyo mini tomato to Japan. According to result of analysis based on monthly price and carried quality data of major tomato market between Korea and Japan, it has more comparative advantage that we export tomato during Period of Dec-Feb. rather than March-May which is currently major exporting period.

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Fuel-Optimal Altitude Maintenance of Low-Earth-Orbit Spacecrafts by Combined Direct/Indirect Optimization

  • Kim, Kyung-Ha;Park, Chandeok;Park, Sang-Young
    • Journal of Astronomy and Space Sciences
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    • v.32 no.4
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    • pp.379-386
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    • 2015
  • This work presents fuel-optimal altitude maintenance of Low-Earth-Orbit (LEO) spacecrafts experiencing non-negligible air drag and J2 perturbation. A pseudospectral (direct) method is first applied to roughly estimate an optimal fuel consumption strategy, which is employed as an initial guess to precisely determine itself. Based on the physical specifications of KOrea Multi-Purpose SATellite-2 (KOMPSAT-2), a Korean artificial satellite, numerical simulations show that a satellite ascends with full thrust at the early stage of the maneuver period and then descends with null thrust. While the thrust profile is presumably bang-off, it is difficult to precisely determine the switching time by using a pseudospectral method only. This is expected, since the optimal switching epoch does not coincide with one of the collocation points prescribed by the pseudospectral method, in general. As an attempt to precisely determine the switching time and the associated optimal thrust history, a shooting (indirect) method is then employed with the initial guess being obtained through the pseudospectral method. This hybrid process allows the determination of the optimal fuel consumption for LEO spacecrafts and their thrust profiles efficiently and precisely.