• 대한한의학회지
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• 제18권1호
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• pp.157-168
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• 1997

The purpose of this study is the separation of biologically active ingredients from Coptidis Rhizoma which has been widely used as one of oriental herbal medicine for body fever. In this study, berberine-type alkaloids were tested on their biological activities in the aspect of antibacterial, antitumor, anti-herpetic and anti-HIV activity. Contents of five major alkaloids for the various origin of Coptidis Rhizoma were assayed by HPLC. As the results, the content of berberine from Coptis chinensis and Coptis japonica were 6.78% and 7.09%, respectively. The contents of coptisine, jatrorrhizine, berberastine from Coptis chinensis were higher than those of Coptis japonica. The amount of palmatine from both species were almost the same. Surprisingly for antitumor experiment, all compounds have been shown remarkable activity, especially against SNU-l(human stomach cancer) cell line. Among the compounds purified through column chromatography, palmatine, coptisine, and jatrorrhizine inhibited the growth of K-562(human chronic myelogenous leukemia) cell line whereas jatrorrhizine has been shown the effective inhibition of A-549 (human lung) cell line at the same time.

• 한국제4기학회지
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• 제18권2호통권23호
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• pp.1-2
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• 2004

The Ilkwang Fault is NNE-striking, elongated 40 Km between Ulsan and Haendae-ku, Busan in southeastem part of the Korean Peninsula(Kim, D.H. et al., 1989; Kim, J.S. et al., 2003). This paper is mainly concemed about the ages of the fault activities especially in the Quatemary, infered from classification of geomorphic surface and trench excavation for the construction of Singori nuclear power plant. The geomorphi surfaces are classified into the Beach and the Alluvial plain, the 10 m a.s.l. Marine terrace, the 20 m a.s.l. Marine terrace, the Reworked surface of 45 m a.s.l. Marine terrace and the Low relief erosional surface, from lower to higher altitude. The Beach and the Alluvial plain are elongated to the Holocene terrace(ist terrace, choi, 2003). The 10 m a.s.l. Marine terrace is correlated to 2nd terrace (MIS 5em 125 Ka. y. B.P., Choi, 1998). The 45 m a.s.l. Marine terace is correlated to the Lower marine terrace (MIS 7,220 Ka. y. B.P., Choi, 2003 or MIS 9,320 y. B.P.) to the Gwanganri terrace(Penultimate interglacial age, 200-200 Ka. Y. B.P., Oh, 1981). The Low relief erosional surface is distributed coastal side, the Reworked surface of 45 m a.s.l. Marine terrace inland side by the Ilkwang Fault Line as the boundary line. But the former is above 10 m higher in relative height than the latter. The 20 m a.s.l. Marine terrace on the elongation line of the Ilkwang Fault reveals no dislocation. A site was trenched on the straight contract line with $N30^{\circ}$ E-striking between the 10 m a.s.l. Marine terrace and the 20 m a.s.l. Marine terrace. Fault line or dislocation was not observable in the trench excavation. Accordingly, the straight contact line is inferred as the ancient shoreline of the 10 m a.s.l. Marine terrace. The Ages of the Fault activities are inferred after the formation of the Ichonri Formation - before the formation of the 45 m a.s.l. Marine terrace (220 Ka. y. B.P. or 320 Ka. y. B.P.). The Low relief erosional surface was an island above the sea-level during the formation of the 45 m a.s.l. Marine terrace in the paleogeography.

• Natural Product Sciences
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• 제16권4호
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• pp.228-232
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• 2010

Bioactivity-guided fractionation using on-line HPLC biochemical detection system on $CHCl_3$-soluble fraction of Lycoris radiata led to the isolation of deoxylycorenine (1), O-demethylhomolycorine (2), galanthamine (3), lycoramine (4), mixture of $6{\alpha}$-and $6{\beta}$-haemanthidine (5), and lycorine (6), identified by spectroscopic data and physicochemical property. Among the isolated compounds, 1, 3 and 6 showed acetylcholinesterase inhibitiory activities with $IC_{50}$ values of 18.0, 12.0 and $16.6\;{\mu}M$, respectively, in in vitro colorimetric microplate assay.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2000년도 하계학술대회 논문집 C
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• pp.1909-1911
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• 2000

Recently many research activities on the diagnosis of stator winding insulation of large rotating machines have been reported. Capacitive couplers are widely used as sensors for on-line partial discharge (PD) measurement of high voltage rotating machines. This paper presents laboratory test to compare Stator Slot Coupler (SSC), Resistance Temperature Detector (RTD), 80 [pF] coupler and 500 [pF] coupler for on-line PD measurement of rotating machines.

• 한국어병학회지
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• 제20권1호
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• pp.71-81
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• 2007

넙치, Paralichthys olivaceus 병어에서 분리된 Photobacterium damselae subsp. damselae와 Vibrio spp.(V. anguillarum, V. splendidus, V. harveyi and V. ordalii)의 병원성을 in vitro에서 조사하였다. Extracellular products (ECPs)의 성상은 효소 활성, 양과 넙치 적혈구에 대한 용혈능과 cell-line에 대한 세포 독성을 조사하였다. 그리고 세균의 internalization에서 signal transduction pathways를 signal transduction inhibitor를 이용하여 조사하였다.P. damselae는 phospholipase 활성, 넙치 적혈구에 대한 용혈능, 세포독성이 높게 나타났으며, 분리된 vibrios 균주에 비하여 internalization에서 다양한 경로를 나타내었다. 따라서 이러한 활성은 P. damselae의 병원성과 관련이 있을 것으로 생각된다.

• 한국유통학회:학술대회논문집
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• 한국유통학회 2005년도 동계학술대회 발표논문집
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• pp.1-24
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• 2005

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6403-6407
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• 2012

Detoxifying enzymes are present in most epithelial cells of the human gastrointestinal tract where they protect against xenobiotics which may cause cancer. Induction of examples such as glutathione S-transferase (GST) and its thiol conjugate, glutathione (GSH) as well as NAD(P)H: quinoneoxidoreductase (NQO1) facilitate the excretion of carcinogens and thus preventing colon carcinogenesis. Pterostilbene, an analogue of resveratrol, has demonstrated numerous pharmacological activities linked with chemoprevention. This study was conducted to investigate the potential of pterostilbene as a chemopreventive agent using the HT-29 colon cancer cell line to study the modulation of GST and NQO1 activities as well as the GSH level. Initially, our group, established the optimum dose of 24 hours pterostilbene treatment using MTT assays. Then, effects of pterostilbene ($0-50{\mu}M$) on GST and NQO1 activity and GSH levels were determined using GST, NQO1 and Ellman assays, respectively. MTT assay of pterostilbene ($0-100{\mu}M$) showed no cytotoxicity toward the HT-29 cell line. Treatment increased GST activity in the cell line significantly (p<0.05) at 12.5 and $25.0{\mu}M$. In addition, treatment at $50{\mu}M$ increased the GSH level significantly (p<0.05). Pterostilbene also enhanced NQO1 activity significantly (p<0.05) at $12.5{\mu}M$ and $50{\mu}M$. Hence, pterostilbene is a potential chemopreventive agent capable of modulation of detoxifiying enzyme levels in HT-29 cells.

• 무역학회지
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• 제46권2호
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• pp.355-368
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• 2021

The purpose of this study is to analyze the factors affecting innovation activities related to the introduction of the 4th Industrial Revolution technology for Korean firms faced to the severe global trade and competition environments. This paper conducted an empirical analysis using the 'The Survey of Business Activities' distributed by the Statistics Korea in 2019. According to the results of the analysis, it was found that the firm size, labor cost, R&D, and intellectual property rights had a significant influence on the firms' adoption of the 4th industrial revolution technology. It was also found that the dummy variables such as strategic alliance between companies, review of entry into a new business, transfer of main business operations, and holding of subsidiaries had statistically significant effects on innovation activities. In addition, this paper showed that the firm characteristics had impacts on innovation activities of firms by the 4th industrial revolution technology type. In order for Korean firms to adapt to the challenges by the 4th Industrial Revolution, it is important to provide policy support and an environment in line with the characteristics of the firms.

• 한국콘텐츠학회논문지
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• 제10권12호
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• pp.366-377
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• 2010

인터넷과 모바일 등 정보화 사회가 급속한 변화를 가져오자 소비자 상호간의 관계를 어떻게 하느냐가 기업에 영향을 미치는 요인이 되었다. 기업들은 자사 브랜드를 중심으로 인터넷에 커뮤니티를 개설하고 있으며 소비자가 능동적으로 브랜드 커뮤니티를 형성하고 발전시키는 형태를 확산하고 있다. 따라서 소비자의 능동적 개입에 따른 커뮤니티 활동의 영향이 어느 정도이며 이에 대한 관리와 활용을 어떻게 효율적으로 할 것인가에 대한 방안을 분석을 통해 제시하고자 한다. 본 연구는 온라인 브랜드커뮤니티의 특성과 온라인 브랜드커뮤니티가 소비자태도에 어떤 영향을 미치는지 알아보고자 한다. 온라인 브랜드커뮤니티가 브랜드 선택시 커뮤니티 태도가 브랜드 결정과 구전커뮤니케이션에 어떤 영향을 미치는가를 연구하고자 한다. 연구는 온라인 대학생이 온라인 대학 선택시 커뮤니티 태도가 온라인 대학 브랜드결정과 구전커뮤니케이션에 어떤 영향이 있는지를 알아보고자 한 것으로 온라인 대학생들을 대상으로 설문조사를 실시하였다. 연구에 의하면 브랜드커뮤니티의 특성(정보의 신뢰성, 상호작용성, 편리성, 친밀성)에 긍정적 반응을 보였으며 소비자태도에서도 구매의도와 구전커뮤니케이션에서 긍정적 행동을 기대할 수 있다. 또한 브랜드커뮤니티의 특성이 구매의도, 구전커뮤니케이션에 영향을 미치는 것을 알 수 있다. 이런 연구를 바탕으로 소비자들이 브랜드커뮤니티 활동을 활발히 할 수 있도록 마케팅전략을 제시할 수 있다.

• 대한수학교육학회지:학교수학
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• 제4권1호
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• pp.1-13
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• 2002

The purpose of this study is to investigate the reasons and backgrounds of drawing auxiliary lines in the proof of geometry. In most of proofs in geometry, drawing auxiliary lines provide important clues, thus they play a key role in deductive proof. However, many student tend to have difficulties of drawing auxiliary lines because there seems to be no general rule to produce auxiliary lines. To alleviate such difficulties, informal activities need to be encouraged prior to draw auxiliary lines in rigorous deductive proof. Informal activities are considered to be contrasting to deductive proof, but at the same time they are connected to deductive proof because each in formal activity can be mathematically represented. For example, the informal activities such as fliping and superimposing can be mathematically translated into bisecting line and congruence. To elaborate this idea, some examples from the middle school mathematics were chosen to corroborate the relation between informal activities and deductive proof. This attempt could be a stepping stone to the discussion of how to teach auxiliary lines and deductive reasoning.