• Title/Summary/Keyword: On Line Maintenance

Search Result 629, Processing Time 0.031 seconds

Temporal Regulation of Ovine Interferon-tau Gene by the Transcription Factor Eomesodermin in the Peri-Implantation Period

  • Kim, Min-Su;Lim, Hyun-Joo;Lee, Ji Hwan;Hur, Tae Young;Son, Jun Kyu
    • Journal of Animal Reproduction and Biotechnology
    • /
    • v.34 no.4
    • /
    • pp.292-299
    • /
    • 2019
  • Interferon tau (IFNT) regulation, an anti-luteolytic factor produced by conceptuses of the ruminant ungulates, is essential for the maintenance of early pregnancy, but a definitive mechanism for its temporal transcription has not been elucidated. We and others have observed the T-box protein eomesodermin (EOMES) exhibited high mRNA expression in the ovine embryonic trophectoderm; thus, both caudal-relatedhomeobox-2 (CDX2) and EOMES coexist during the early stages of conceptus development. Objective of this study was to examine the effect of EOMES on ovine IFNT gene transcription when evaluated with CDX2, ETS2 and AP1 transcription factors implicated in the control of cell differentiation in the trophectoderm. In this study, quantitatively via reverse transcription-polymerase chain reaction (RT-PCR) analysis between ovine trophoblast cells was initially performed, finding that transcription factors CDX2 and 'EOMES transcription factor mRNAs' were specific to trophectoderm cells. These mRNAs were also found in days 15, 17, and 21 ovine conceptuses. Furthermore, human choriocarcinoma JEG3 cells (trophoblast cell line) were cotransfected with an ovine IFNT (-654bp)-luciferase reporter (-654-oIFNT-Luc) construct and several transcription factor expression plasmids. Cotransfection of the reporter construct with CDX2, ETS2 and AP1 increased transcription of -654-oIFNT-Luc by about 11-fold compared with transfection of the construct alone. When cells were initially transfected with EOMES followed by transfection with CDX2, ETS2 and/or AP1, the expression of -654-oIFNT-Luc was decreased. Also, EOMES factor inhibited the stimulatory activity of CDX2 alone. These results suggest that when conceptuses attach to the uterine epithelium, ovine IFNT gene transcription is down-regulated by an increase of EOMES factor expression in the attached ovine trophoblast cells.

Real-time impact location monitoring using the stabilized Bragg grating sensor system (안정화된 광섬유 브래그 격자 센서 시스템을 이용한 실시간 충격위치검출에 관한 연구)

  • Bang, Hyung-Joon;Hong, Chang-Sun;Kim, Chun-Gon
    • Journal of the Korean Society for Aeronautical & Space Sciences
    • /
    • v.32 no.7
    • /
    • pp.37-42
    • /
    • 2004
  • In order to monitor the impact locations in smart structures, multipoint ultrasonic sensors are to be employed. In this study, a multiplexing demodulator with wide dynamic range was proposed to detect the impact locations using FBG sensors, and a stabilization controlling system was also developed for the maintenance of maximum sensitivity of sensors. Two FBG sensors were attached on the bottom side of the aluminum beam specimen and low velocity impact tests were performed to detect the one-dimensional impact locations. As a result, multiplexed in-line FBG sensors could detect the moment of impact precisely, and found the impact locations with the average location error below 0.58mm.

Re-engineering framework for improving reusability of embedded software (임베디드 소프트웨어의 재사용성 향상을 위한 리엔지니어링 프레임워크)

  • Kim, Kang-Tae
    • Journal of the Korea Society of Computer and Information
    • /
    • v.13 no.4
    • /
    • pp.1-9
    • /
    • 2008
  • Most consumer electronics companies hold numerous line-ups to cope with divergent customer's needs. To cope with current situation, most products are derived from the 'base product' which is developed for brand new features with respect to the change requests. That is called derivation. After 'base code' is developed for newly introduced products, some modification will occur corresponding to the derivative product models. So, quality attributes of 'base code' affects quality and productivity of 'derived code'. But in the middle of continuous modification to 'base code', violation of architectural design decision and unauthorized or maybe unsophisticated change to source code willing to happen and thus it cause critical problem. Those code has 'aging symptom' both architectural and code level in nature. In this paper, we introduced reengineering framework which guide the procedure and tactics to find and fix 'aging symptom' for improvement on quality attribute of 'base code'.

  • PDF

An Exploratory Study on the Ecosystem Service and Benefit Indicators of Natural Seaweed Beds (천연 해조장 생태계 서비스 및 편익지표에 관한 탐색적 연구)

  • Kang, Seok-Kyu
    • The Journal of Fisheries Business Administration
    • /
    • v.47 no.3
    • /
    • pp.53-69
    • /
    • 2016
  • The purpose of this study is to explore the ecosystem service and benefit indicators of natural seaweed beds. Ecosystems of natural seaweed beds provide a wide range of services and benefits to human society including provisioning services, regulating services, supporting services, and cultural services. Indicators for each of the ecosystem services are chosen by marine plants ecologists and as follows. Ecosystem indicators of natural seaweed beds for provisioning services are well-being food(amount of seaweed harvested/amount of fish landed, fish biomass, area of natural seaweed beds, the number of species, contribution to the second production), raw materials(amount of biomass by breed, amount of aquaculture feed), genetic resources(amount of genetic material extracted, amount of genetic material contained by age and habitat), and medicinal resources(amount of medicinal material extracted). Ecosystem indicators of natural seaweed beds for regulating services are air purification(amount of fine dust/NOx or $SO_2$ captured), climate regulation(amount of $CO_2$ sequestered), waste treatment(amount of N, P stored, biochemical degradation capacity COD), and costal erosion prevention(length and change of natural coast line, amount of sediment prevented). Ecosystem indicators of natural seaweed beds for supporting services are lifecycle and maintenance(primary production, contribution to the second production) and gene pool protection(amount of compositional factors in ecosystem, introduced species). Ecosystem indicators of natural seaweed beds for cultural services are recreation and tourism(the number of visits of an area) and information for cognitive development(amount of time spent in education, research and individual learning about ecosystem of natural seaweed beds).

Crack Control of the Upside of Double Tee Slab and Inversed Tee Beam Joint (더블티 슬래브-역티형 보 접합부 상부의 균열억제를 위한 실험연구)

  • Nam, Sang-Uk;Song, Han-Beom;Yi, Waon-Ho;Yang, Won-Jik;Baik, Young-Soo;Tae, Kyung-Hoon
    • Proceedings of the Korea Concrete Institute Conference
    • /
    • 2008.04a
    • /
    • pp.345-348
    • /
    • 2008
  • Recently, demand is caused that new building environment of value added rising demand on the lines of becoming bigger, manhattanize of structure and becoming high standard of structure in a construction site and influx of advanced foreign nation technique. To satisfy these requirements for alternative, structures applied to the PSC, PC is increasing. Double Tee Slab is possible for long length structure and applied to the method of construction. When assembling Double Tee Slab produced by the factory in the field, becamed carry-out topping concrete in upper, but occurred crack to slab line. There is no structural problem to crack occurred in upper, waterproof in maintenance and repair of structure due to a conservative cause several problems.

  • PDF

A New R-IPC Protocol for a High-speed Router System to Improve the System Performance (고속 대용량 라우터의 성능 향상을 위한 R-IPC프로토콜 성능분석)

  • 김수동;조경록
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.8 no.6
    • /
    • pp.1096-1101
    • /
    • 2004
  • By a tremendous expansion of Internet users, there's a number effects that cause the phenomenon of bottlenecked switching packets from routers. In order to tear down this problem, distributed system is applicable to almost every highly performed router systems. The main processor of distributed system, which manages routing table, commands IPC to delivering the forwarding table line processor that eases functionalities of the router. This makes the system having wired-speed forwarding function based on the hardware so that the performance of the network can be enhanced. Therefore, IPC, which assign a part of router, is necessary to exchange data smoothly and the constitution of IPC using Ethernet is widely adapted as a method for saving investment. In this paper, R-IPC mechanism improve the packet-processing rate over 10% through changed from defect of conventional Ethernet IPC, that is, 2 layer processing to TCP/IP or UDP/ IP into 1 layer processing for efficient packet forwarding.

A Study on the Power Feeding for ISDN Subscriber Loop (ISDN 가입자 선로에 대한 망급전 연구)

  • 한운영;남윤석;이홍우;차균현
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.19 no.12
    • /
    • pp.2508-2519
    • /
    • 1994
  • In this thesis, two possible schemes for power feeding are considered. The first one is the network power feeding, and the other is the power feeding from the rechargeable battery. Though each scheme has its merits and demerits, the domestic network operator has proposed the latter due to the large deviation of line resistance, high power loss, and safety. This scheme, however, has several problems. The usage is limited by the life of battery leading to the failure of minimal voice service for many hours. The space occupation of that battery is another serious problem. Moreover, the network opeator should have overhead of maintenance and repair. In order to alleviate such the difficulties, the sealing current is introduced through the subscriber loop. Flowing the current into the loop prevents from rusting. This thesis designs a power controller using PEB2025 to control various amount, duration, and period of this sealing current, to achieve the optimum current supply for sealing.

  • PDF

Study to Select a Strategic Fisheries for the Encouragement of a Long Term Planning Project in the Korean Fishing Industry. (한국어업의 장기적 진흥계획을 위한 전략 업종 선정에 관한 연구)

  • 장수호
    • The Journal of Fisheries Business Administration
    • /
    • v.1 no.1
    • /
    • pp.19-68
    • /
    • 1970
  • This is a study of a long term project to encourage the Korean fishing industry. It seeks to supply a sound theoretical background in an attempt to liberalize the capital investment of the industry. However, the discussions developed in this thesis are based on, the existing world's fisheries resources, the possibility of their prospective cultivation, and the analysis of the evolution of Korean fisheries and fisheries organization. According to the reasults of the analysis ; out of the prospective world fisheries resources which are estimated at about 200 millions m/t the total yield per year is only about 70 millions m/t (1969), and Korea occupies only 850 thousands m/t. This therefore means that the Korean fishing industry allows much room for further growth. But the purpose of Korea's existing fishing industry organizations is entirely directed toword coastal fisheries and their functions never reache beyond the limit of off-shore fisheries. Thus almost 99% of the fisheries population engage in small scale fisheries along the coast line. The result is that the resource are almost exhausted by such over-exploitation. Being faced by this fact, it is of urgent necessity to modernize the management of fisheries as well as to encourage larger scale management of fisheries industries. This should be accompanied by the liberalization of capital investment. For this purpose this study also recommends the unification or annexation of small organizations to establish larger ones that will function for a larger scale industry. and further this study recommends that, in order to reorganize the existing fisheries organizations, a principle of selection should be applied in the areas of (1) maximum sustainable yields, (2) the possibility of forming an enterprise and (3) the maintenance of organization stability.

  • PDF

Differential Roles of Lung Dendritic Cell Subsets Against Respiratory Virus Infection

  • Kim, Tae Hoon;Lee, Heung Kyu
    • IMMUNE NETWORK
    • /
    • v.14 no.3
    • /
    • pp.128-137
    • /
    • 2014
  • Respiratory viruses can induce acute respiratory disease. Clinical symptoms and manifestations are dependent on interactions between the virus and host immune system. Dendritic cells (DCs), along with alveolar macrophages, constitute the first line of sentinel cells in the innate immune response against respiratory viral infection. DCs play an essential role in regulating the immune response by bridging innate and adaptive immunity. In the steady state, lung DCs can be subdivided into $CD103^+$ conventional DCs (cDCs), $CD11b^+$ cDCs, and plasmacytoid DCs (pDCs). In the inflammatory state, like a respiratory viral infection, monocyte-derived DCs (moDCs) are recruited to the lung. In inflammatory lung, discrimination between moDCs and $CD11b^+$ DCs in the inflamed lung has been a critical challenge in understanding their role in the antiviral response. In particular, $CD103^+$ cDCs migrate from the intraepithelial base to the draining mediastinal lymph nodes to primarily induce the $CD8^+$ T cell response against the invading virus. Lymphoid $CD8{\alpha}^+$ cDCs, which have a developmental relationship with $CD103^+$ cDCs, also play an important role in viral antigen presentation. Moreover, pDCs have been reported to promote an antiviral response by inducing type I interferon production rather than adaptive immunity. However, the role of these cells in respiratory infections remains unclear. These different DC subsets have functional specialization against respiratory viral infection. Under certain viral infection, contextually controlling the balance of these specialized DC subsets is important for an effective immune response and maintenance of homeostasis.

Anomaly Detection System in Mechanical Facility Equipment: Using Long Short-Term Memory Variational Autoencoder (LSTM-VAE를 활용한 기계시설물 장치의 이상 탐지 시스템)

  • Seo, Jaehong;Park, Junsung;Yoo, Joonwoo;Park, Heejun
    • Journal of Korean Society for Quality Management
    • /
    • v.49 no.4
    • /
    • pp.581-594
    • /
    • 2021
  • Purpose: The purpose of this study is to compare machine learning models for anomaly detection of mechanical facility equipment and suggest an anomaly detection system for mechanical facility equipment in subway stations. It helps to predict failures and plan the maintenance of facility. Ultimately it aims to improve the quality of facility equipment. Methods: The data collected from Daejeon Metropolitan Rapid Transit Corporation was used in this experiment. The experiment was performed using Python, Scikit-learn, tensorflow 2.0 for preprocessing and machine learning. Also it was conducted in two failure states of the equipment. We compared and analyzed five unsupervised machine learning models focused on model Long Short-Term Memory Variational Autoencoder(LSTM-VAE). Results: In both experiments, change in vibration and current data was observed when there is a defect. When the rotating body failure was happened, the magnitude of vibration has increased but current has decreased. In situation of axis alignment failure, both of vibration and current have increased. In addition, model LSTM-VAE showed superior accuracy than the other four base-line models. Conclusion: According to the results, model LSTM-VAE showed outstanding performance with more than 97% of accuracy in the experiments. Thus, the quality of mechanical facility equipment will be improved if the proposed anomaly detection system is established with this model used.