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Role of GSTM1 Copy Number Variant in the Prognosis of Thai Colorectal Cancer Patients Treated with 5-FU-based Chemotherapy

  • Pongtheerat, Tanett;Saelee, Pensri
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.10
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    • pp.4719-4722
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    • 2016
  • Background: Glutathione S-transferase M1 (GSTM1) is involved in the detoxification of carcinogenic agents. DNA copy number variants of GSTM1 may be associated with cancer progression and may result in reduced survival time of various cancers. Determination of DNA copy number variants was here used to assess the association between GSTM1 copy number variant and pathological status and survival time of colorectal-cancer patients treated with 5-fluorouracil-based chemotherapy. Methods: One hundred thirteen Thai colorectal-cancer patients were investigated for GSTM1 copy number variant by real-time PCR. Relationships between gene copy number variants and clinico-pathological parameters were determined. Result: Associations were evident between GSTM1 copy number and stage of tumor (P = 0.026) and metastasis at diagnosis (P = 0.049), with odds ratio values of 0.2 and 0.3 respectively. Conclusions: GSTM1 copy number variant was here not related with reduced overall survival for the colorectal-cancer patients receiving 5-FU-based chemotherapy.

A SYMBOLIC POWER OF THE IDEAL OF A STANDARD 𝕜-CONFIGURATION IN 𝕡2

  • Shin, Yong-Su
    • The Pure and Applied Mathematics
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    • v.25 no.1
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    • pp.31-38
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    • 2018
  • In [4], the authors show that if ${\mathbb{X}}$ is a ${\mathbb{k}}-configuration$ in ${\mathbb{P}}^2$ of type ($d_1$, ${\ldots}$, $d_s$) with $d_s$ > $s{\geq}2$, then ${\Delta}H_{m{\mathbb{X}}}(md_s-1)$ is the number of lines containing exactly $d_s-points$ of ${\mathbb{X}}$ for $m{\geq}2$. They also show that if ${\mathbb{X}}$ is a ${\mathbb{k}}-configuration$ in ${\mathbb{P}}^2$ of type (1, 2, ${\ldots}$, s) with $s{\geq}2$, then ${\Delta}H_{m{\mathbb{X}}}(m{\mathbb{X}}-1)$ is the number of lines containing exactly s-points in ${\mathbb{X}}$ for $m{\geq}s+1$. In this paper, we explore a standard ${\mathbb{k}}-configuration$ in ${\mathbb{P}}^2$ and find that if ${\mathbb{X}}$ is a standard ${\mathbb{k}}-configuration$ in ${\mathbb{P}}^2$ of type (1, 2, ${\ldots}$, s) with $s{\geq}2$, then ${\Delta}H_{m{\mathbb{X}}}(m{\mathbb{X}}-1)=3$, which is the number of lines containing exactly s-points in ${\mathbb{X}}$ for $m{\geq}2$ instead of $m{\geq}s+1$.

The Effects of Female Shell Size on Reproductive Potential of the Egg Capsule in Rapa Whelk Rapana venosa in Three Regions of Different Salinities

  • Chung, Ee-Yung;Park, Kwan Ha;Lee, Chang-Hoon;Park, Young Jae
    • Development and Reproduction
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    • v.17 no.1
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    • pp.25-35
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    • 2013
  • We investigated the effects of shell height on reproductive potential of the female Rapana venosa in three regions of different salinities (the coastal zone of the Gwangyang Bay (S-1); the upper reaches (S-3); lower reaches (S-2) of the Seomjin River). The number of egg capsules, egg capsule height, and fecundity associated with reproductive potential of larger female rapa whelks were higher than those of smaller individuals in all three regions. Correlation analyses showed that there is a significant positive correlation between egg capsule and female shell height. Mean of shell heights, egg capsule heights, the number of egg capsules in an egg mass, and fecundity in an egg capsule produced from female individuals inhabiting S-1 region were markedly higher than those inhabiting S-2 and S-3 regions. In particular, the fecundity of the rapa whelk increased with the salinity and shell height. Although large rapa whelks produced a large number of egg capsules at S-1 region, those at S-3 habitat laid less egg capsules with smaller size. If these rapa whelks were put into S-2 region, the number of egg capsules produced by a female at S-2 region was slightly larger than those produced by a female at S-3 region. This provides a clear evidence that the number of the egg capsules can be controlled by the salinity. In the coastal zone of the Gwangyang Bay and the upper reaches of Seomjin River, the fecundity of this species was estimated to be approximately 182,000-1,302,000 eggs/ind./yr.

CUSP FORMS IN S40 (79)) AND THE NUMBER OF REPRESENTATIONS OF POSITIVE INTEGERS BY SOME DIRECT SUM OF BINARY QUADRATIC FORMS WITH DISCRIMINANT -79

  • Kendirli, Baris
    • Bulletin of the Korean Mathematical Society
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    • v.49 no.3
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    • pp.529-572
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    • 2012
  • A basis of a subspace of $S_4({\Gamma}_0(79))$ is given and the formulas for the number of representations of positive integers by some direct sums of the quadratic forms $x^2_1+x_1x_2+20x^2_2$, $4x^2_1{\pm}x_1x_2+5x^2_2$, $2x^2_1{\pm}x_1x_2+10x^2_2$ are determined.

Depositions of Egg Capsules by Female Shell Heights and Comparisons of Sizes at 50% of Group Sexual Maturities of the Female Rapa Whelk Rapana venosa in Three Different Salinity Concentration Regions

  • Lee, Il Ho;Chung, Ee-Yung;Son, Pal Won;Lee, Ki-Young
    • The Korean Journal of Malacology
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    • v.30 no.2
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    • pp.139-153
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    • 2014
  • We investigated fecundities in egg capsules and sizes at 50% of group sexual maturities in female Rapana venosa in three different salinity concentration regions (S-1, S-2, and S-3). In three different salinities, egg capsule heights, the number of egg capsules and the number of eggs and embryos were remarkably increased with the increase of female shell heights (or ages) and also increased with the increase of salinity concentrations. Heights of egg capsules, the number of egg capsules and fecundities (the number of eggs and embryos) were the maximum at S-1 (Gwangyang Bay (average 31.5 psu)) and the minimum at S-3 (the upper reaches of Seomjin River (average 15.5 psu)). Total numbers of fecundities of R. venosa $individual^{-1}year^{-1}$ were about $1{\times}10^6$ at S-1 region, about $8{\times}10^5$ at S-2 region, and about $2{\times}10^5$ at S-3 region. Rates (50%) of individuals reaching first sexual maturities in three different salinity regions (S-1, S-2 and S-3) were over 50% in females measuring 7.1-8.0 cm in shell height (considered to be two years old), and 100% in those > 10.1 cm (considered to be five years old). Biological minimum sizes ($RM_{50}$) in females in three different regions are 72.0 mm SH at S-1 region, 70.9 mm SH at S-2 region, and 74.6 mm SH at S-3 region, respectively. Exceptionally, smaller individuals (considered to be one year old) were participated in reproduction.

The Changes of the Garbage Problem Importance through the Number of Articles, Column Headings and Contents of Dong A Ilbo (동아일보 기사 수, 단수, 내용을 통한 쓰레기 문제의 중요도 변천분석 : 1920-1990년사이)

  • 신경주
    • Journal of the Korean housing association
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    • v.13 no.3
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    • pp.1-9
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    • 2002
  • Desolation of the earth due to environmental pollution is rising as a world wide problem and concern. At this point we need to look into the problem and set up a direction for the future. In order to reveal the change of garbage problems in our county's civil life, a researcher analyzed 369 garbage related articles from the first edition of Dong A Ilbo up to 1990. The following is the result of data from garbage related articles. It is organized by age and era(10 years). 1) Number of articles by year roses in 1921 after first publication of garbage problem article. In the 1930s, the number of articles drastically increased in 1937. From then on, the number of articles declined until early 1970s but roses again from 1978. 2) Yearly change in articles was a mere 1.2 columns in between 1920 to 1960. In the 1970's, relative importance increased and over 5 columns were published. Articles rose in the 1980s with over 3.4 and 5 columns. 3) The contents of the articles can be classified into cleaning problems, collecting and transporting, expenses, and recycling. Garbage disposal problems continued until the 1970s. Regarding garbage collecting problems, form of collecting container and location was discussed. Laws were revised after garbage disposal areas were discussed in the 1920s. Expenses were levied from the 1930s and rising cost and double charge problems were subjected. Garbage recycling began in the 1920s and continued until 1900s.

CYCLOTOMIC UNITS AND DIVISIBILITY OF THE CLASS NUMBER OF FUNCTION FIELDS

  • Ahn, Jae-Hyun;Jung, Hwan-Yup
    • Journal of the Korean Mathematical Society
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    • v.39 no.5
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    • pp.765-773
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    • 2002
  • Let $textsc{k}$$F_{q}$(T) be a rational function field. Let $\ell$ be a prime number with ($\ell$, q-1) = 1. Let K/$textsc{k}$ be an elmentary abelian $\ell$-extension which is contained in some cyclotomic function field. In this paper, we study the $\ell$-divisibility of ideal class number $h_{K}$ of K by using cyclotomic units.s.s.

A Step-by-Step Primality Test (단계적 소수 판별법)

  • Lee, Sang-Un
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.13 no.3
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    • pp.103-109
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    • 2013
  • Miller-Rabin method is the most prevalently used primality test. However, this method mistakenly reports a Carmichael number or semi-prime number as prime (strong lier) although they are composite numbers. To eradicate this problem, it selects k number of m, whose value satisfies the following : m=[2,n-1], (m,n)=1. The Miller-Rabin method determines that a given number is prime, given that after the computation of $n-1=2^sd$, $0{\leq}r{\leq}s-1$, the outcome satisfies $m^d{\equiv}1$(mod n) or $m^{2^rd}{\equiv}-1$(mod n). This paper proposes a step-by-step primality testing algorithm that restricts m=2, hence achieving 98.8% probability. The proposed method, as a first step, rejects composite numbers that do not satisfy the equation, $n=6k{\pm}1$, $n_1{\neq}5$. Next, it determines prime by computing $2^{2^{s-1}d}{\equiv}{\beta}_{s-1}$(mod n) and $2^d{\equiv}{\beta}_0$(mod n). In the third step, it tests ${\beta}_r{\equiv}-1$ in the range of $1{\leq}r{\leq}s-2$ for ${\beta}_0$ > 1. In the case of ${\beta}_0$ = 1, it retests m=3,5,7,11,13,17 sequentially. When applied to n=[101,1000], the proposed algorithm determined 96.55% of prime in the initial stage. The remaining 3% was performed for ${\beta}_0$ >1 and 0.55% for ${\beta}_0$ = 1.

ON THE FIXING NUMBER OF FUNCTIGRAPHS

  • Fazil, Muhammad;Javaid, Imran;Murtaza, Muhammad
    • Bulletin of the Korean Mathematical Society
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    • v.58 no.1
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    • pp.171-181
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    • 2021
  • The fixing number of a graph G is the smallest order of a subset S of its vertex set V (G) such that the stabilizer of S in G, ��S(G) is trivial. Let G1 and G2 be the disjoint copies of a graph G, and let g : V (G1) → V (G2) be a function. A functigraph FG consists of the vertex set V (G1) ∪ V (G2) and the edge set E(G1) ∪ E(G2) ∪ {uv : v = g(u)}. In this paper, we study the behavior of fixing number in passing from G to FG and find its sharp lower and upper bounds. We also study the fixing number of functigraphs of some well known families of graphs like complete graphs, trees and join graphs.

A Study on Sensitivity of Pollutant Dispersion to Inflow Wind Speed and Turbulent Schmidt Number in a Street Canyon (도시 협곡에서 유입류 풍속과 난류 슈미트수에 대한 대기오염물질 확산의 민감도 연구)

  • Wang, Jang-Woon;Kim, Jae-Jin
    • Atmosphere
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    • v.25 no.4
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    • pp.659-667
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    • 2015
  • In this study, sensitivity of inflow wind speed and turbulent Schmidt number to pollutant dispersion in an urban street canyon is investigated, by comparing CFD-simulated results to wind-tunnel results. For this, we changed systematically inflow wind speed at the street-canyon height ($1.5{\sim}10.0m\;s^{-1}$ with the increment of $0.5m\;s^{-1}$) and turbulent Schmidt number (0.2~1.3 with interval of 0.1). Also, we performed numerical experiments under the conditions that turbulent Schmidt numbers selected with the magnitude of mean kinetic energy at each grid point were assigned in the street canyon. With the increase of the inflow wind speed, the model underestimated (overestimated) pollutant concentration in the upwind (downwind) side of the street canyon because of the increase of pollutant advection. This implies that, for more realistic reproduction of pollutant dispersion in urban street canyons, large (small) turbulent Schmidt number should be assigned for week (strong) inflow condition. In the cases of selectively assigned turbulent Schmidt number, mean bias remarkably decreased (maximum 60%) compared to the cases of constant turbulent Schmidt number assigned. At week (strong) inflow wind speed, root mean square error decreases as the area where turbulent Schmidt number is selectively assigned becomes large (small).