• The Korean Journal of Nuclear Medicine Technology
• /
• v.21 no.2
• /
• pp.28-30
• /
• 2017

Purpose Anti-Glutamic acid decarboxylase antibody test (GAD Ab) has been used as a predictor of type 1 diabetes. GAD Ab has also been shown to be highly potent in cerebrospinal fluid (CSF) of patients with suspected diabetic peripheral neuropathy. Recently, it has been known that clinical significance of GAD Ab using CSF is useful for the neurological disorders. However, the reference value of anti-GAD Ab has been provided only for serum. In this experiment, we estimated the reference value of anti-GAD antibody for CSF in neurological patients. Materials and Methods A total of 211 neurological patients were enrolled. Serum and CSF were analyzed by radioimmunoassay (RIA) using commercial RIA anti-GAD Ab kit (RSR, London, United Kingdom). Normal saline was used as the normal CSF control because CSF is most similar to 0.9% normal saline. Results The mean value of normal CSF control was 1.97 U/mL, and two standard deviations (2SD) was 1.44 U/mL. Based on this data, the expected reference range of CSF could be estimated from 0.54 U/mL to 3.40 U/mL Conclusion The reference range of normal CSF control using normal saline obtained with Hoffmann's method. However, there will be a need to validate the CSF reference values using human normal CSF.

• Journal of Biomedical Engineering Research
• /
• v.39 no.2
• /
• pp.80-86
• /
• 2018

The aim of this study were to establish the clinical references and guidelines for the maximum standardized uptake ($SUV_{max}$) value of pancreatic cancer, pancreatitis, and normal pancreas in $^{18}F-FDG$ PET-CT examinations for pancreatic disease. For this purpose, we performed the statistical analysis on the descriptive statistics, percentiles and inter quartiles range (IQR), normal distribution, and using the probability density function for pancreatic cancer, pancreatitis, and normal pancreas. As a result, the clinical reference of $SUV_{max}$ for the pancreatic cancer, pancreatitis, and normal pancreas was more than 3.45, 1.91 to 2.62, and less than 1.91, respectively. Also, optimal cut-off value for applying the dual time point PET-CT examination was determined to be 2.62. The results of this study are summarized as follows: first, we suggests the clinical reference and guideline for the pancreatic cancer, pancreatitis, and normal pancreas, and second, suggests a scientific approach to improve diagnostic accuracy of pancreatic disease by deviating from an approximate experience approach.

• Journal of Integrative Natural Science
• /
• v.14 no.3
• /
• pp.116-122
• /
• 2021

Properties and comparison of multivariate CUSUM and EWMA charts for monitoring Σ of multivariate normal N(${\underline{\mu}}$, Σ) process has considered. Comparison of the performances of the considered charts, the numerical values are obtained by simulation with 10,000 iteration in terms of ATS, ANSS and ANSW. We found that EWMA chart with small values of smoothing constant more effectively detects the process changes than with large smoothing constant. And we also found that CUSUM chart with small value of reference value is more effectively detecting the process change than with large reference value. If a process engineer has interest in detecting small amount of shift rather than large shift, he/she can be recommended to use small smoothing constant in EWMA chart and small reference value in CUSUM chart.

• 한국HCI학회:학술대회논문집
• /
• 2008.02a
• /
• pp.195-199
• /
• 2008

We present an approach to detect real plane for line base recognition and pose estimation Given 3D line segments, we set up reference plane for each line pair and measure the normal distance from the end point to the reference plane. And then, normal distances are measured between remains of line endpoints and reference plane to decide whether these lines are coplanar with respect to the reference plane. After we conduct this coplanarity test, we initiate visibility test using z-buffer value to prune out ambiguous planes from reference planes. We applied this algorithm to real images, and the results are found useful for evidence fusion and probabilistic verification to assist the line based recognition as well as 3D pose estimation.

• Journal of Applied Reliability
• /
• v.16 no.2
• /
• pp.147-154
• /
• 2016

Purpose: To evaluate statistical differences among three measurements of range of motion (ROM) with Rapael Smart Glove (RSG) group 1, 2 and manual goniometer group. To investigate reference value of the kinematic analysis for range of motion (ROM) of distal upper extremity with Rapael Smart Glove (RSG). Methods: Sixteen normal persons without limitation of motion (LOM) enrolled in the study. The study was performed at two separate times and by two investigators on 16 normal adults. We compared ROM with RSG for measuring joint angles. We compared degrees of forearm supination/pronation, wrist flexion/extension and radial deviation/ulnar deviation during ROM of 16 participants using RSG. After one week, degrees of each motion were measured in the same way by other investigator to evaluate the reliability. Results: Statistical differences among three groups were showed. Most results of paired t-test between two RSG groups were over 0.05 and exceptions are supination, extension, and finger %. Conclusion: Our findings demonstrate that ROM of normal persons obtained by kinematic analysis with RSG are not valid as normal reference value for distal upper extremity motion. But, the reliability of between two RSG groups was showed with paired t-test and Pearson's correlation except supination, extension and finger %.

• The Journal of the Society of Korean Medicine Diagnostics
• /
• v.17 no.3
• /
• pp.215-223
• /
• 2013

Objectives Although tongue diagnosis is one of major diagnostic methods in east Asian traditional medicine, the standard of normal tongue color have not established. So we tried to suggest the method to establish the standard of normal tongue color range and the pilot data about the normal range. Materials and methods: 22 precedent study papers that presented the numerical data of normal (light red) tongue color were analyzed. At the same time, 46 adult people tongue color data were also collected and analyzed. Results Precedent studies showed remarkable fluctuations of the range of normal tongue color. Collected tongue color data of the 46 people showed mean Hue value 2 and standard deviation 14 in HSB system. Additionally, 3 ways of standard establishment for normal tongue color were suggested. Conclusion We suggest statistical method as a reasonable method for tongue color standard establishment and $2{\pm}14$ as a reference Hue value for normal tongue color.

• The Korea Journal of Herbology
• /
• v.24 no.4
• /
• pp.87-93
• /
• 2009

Objectives : Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏) are not commonly prescribed, but are necessary for some clinical conditions, despite of the fact that some negative effects have been known to occur with these medicines. This study shows the consequences for aspartate aminotransferase (AST), alanine aminotransferase (ALT) due to herbal medicines, including Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏). Methods : From 1st June 2007 to 10th May 2009, the results were analyzed for 64 patients belonging to the OO Oriental Medical Hospital who took herbal medicine, including Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏), more than 20 days. This is the study about the comparison and the investigation of AST, ALT. And the results were taken upon their hospitalization and to their departure. The Criteria of Diagnosis in Liver Injury of CIOMS was used as a standard for their examinations. Results : AST, ALT (total 64). The number of patients who were within normal reference value : 49. The number of patients who exceed the normal reference value after dosage, without satisfying the Criteria of Diagnosis in Liver Injury : 5. The number of patients who were recovered in normal reference value after dosage : 9. The number of patients who satisfying the Criteria of Diagnosis in Liver Injury after dosage : 1. Conclusions : This results suggest that these herbal medicines, including Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏), didn't cause adverse side-effects on AST, ALT of the patients who are taking them.

• Proceedings of the KIEE Conference
• /
• 2003.11c
• /
• pp.705-708
• /
• 2003

In this paper, we have evaluated the methods to generate the reference signal for the diagnosis of multi-channel signals. The channel signal integrity can be known by the difference between the reference signal and each channel value. The generation method of reference signal is important in the diagnosis of multi-channel measurement system. The continuous weighting average method rejects the abnormal signal using weighting method and makes the reference signal using sumation of all channel values. This gives the simple and reasonable reference signal. The principle component analysis, one of the multivariate analysis methods, and the neural network method give the reliable reference signal by using signal models, and learning algorithm. Two methods can make the reliable reference if all signals are normal, but any signal having the drift have an effect on the reference.

• Journal of Korean Society for Quality Management
• /
• v.34 no.4
• /
• pp.102-109
• /
• 2006

This paper investigates the effects of non-normality on the performance of univariate and multivariate cumulative sum(CUSUM) control charts for monitoring the process mean. In-control and out-of-control average run lengths of the charts are examined for the univariate/multivariate lognormal and t distributions. The effects of the reference value and the correlation coefficient under the non-normal distributions are also studied. Simulation results show that the CUSUM charts with small reference values are robust to non-normality but those with moderate or large reference values are sensitive to non-normal data especially to process data from skewed distributions. The performance of the chart to detect mean shift of a process is not invariant to the direction of the shift for skewed distributions.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.14 no.1
• /
• pp.143-146
• /
• 2010

Purpose: Insulin is involved in carbohydrate metabolism and also it's very important because it increases storage of glycogen, synthesis of fatty acids, absorption of amino acid, synthesis of protein. Insulin is clinically useful when we evaluate fasting patients in hypoglycemia, classify and predict diabetes, assess the activity of ${\beta}$-cell, research insulin resistance. We are going to increase usability of insulin assay by establishing normal reference value according to statistical analysis. Material & Method: We selected 6,648 patients who visited asan health medical center from May to August in 2008. We set exclusion criteria as family of diabetes, diabetes medication, the past history of blood glucose rise, more than 100 mg/dL in normal fasting blood glucose, outside the scope of BMI 18.5~22.9 $kg/m^2$, and more than HbA1c 6.5%. We determine whether the subgroup is portioned as sex and age or not and establish normal reference value by conducting statistical analysis as Bayesian's method and Hoffman's method. Result: Portioning of subgroup as sex and age is not needed. By statistical analysis of Bayesian method, results 1.5-11.0 uIU/mL. By statistical analysis of Hoffman method, results 1.8~12.8 uIU/mL. Conclusion: We established 1.8~12.8 uIU/mL as Insulin normal reference value by Hoffman method. This is a similar value with reporting reference value 1.7~11.8 uIU/mL in kit. This will enhance the usability of insulin assay by establishing normal reference value.