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http://dx.doi.org/10.9718/JBER.2018.39.2.80

Clinical Reference of the Maximum Standardized Uptake Values to the Pancreatic Cancer, Pancreatitis and Normal Pancreas in the 18F-FDG PET-CT  

Lee, Jae-Seung (Research institute of R&D Center, Segei Inspection Engineering Technology Co., Ltd.)
Kweon, Dae Cheol (Department of Radiological Science, College of Bioecological Health, Shinhan University)
Publication Information
Journal of Biomedical Engineering Research / v.39, no.2, 2018 , pp. 80-86 More about this Journal
Abstract
The aim of this study were to establish the clinical references and guidelines for the maximum standardized uptake ($SUV_{max}$) value of pancreatic cancer, pancreatitis, and normal pancreas in $^{18}F-FDG$ PET-CT examinations for pancreatic disease. For this purpose, we performed the statistical analysis on the descriptive statistics, percentiles and inter quartiles range (IQR), normal distribution, and using the probability density function for pancreatic cancer, pancreatitis, and normal pancreas. As a result, the clinical reference of $SUV_{max}$ for the pancreatic cancer, pancreatitis, and normal pancreas was more than 3.45, 1.91 to 2.62, and less than 1.91, respectively. Also, optimal cut-off value for applying the dual time point PET-CT examination was determined to be 2.62. The results of this study are summarized as follows: first, we suggests the clinical reference and guideline for the pancreatic cancer, pancreatitis, and normal pancreas, and second, suggests a scientific approach to improve diagnostic accuracy of pancreatic disease by deviating from an approximate experience approach.
Keywords
Normal pancreas; Pancreatitis; Pancreatic cancer; PET-CT; $SUV_{max}$;
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1 D. Delbeke, D.M. Rose, W.C. Chapman, C.W. Pinson, and J.K. Wright, "Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma," J. Nucl. Med., vol. 40, no. 4, pp. 1784-1791, 1999.
2 B.S. Chang, and J.H. Kim, "Usefulness of scan position change on dual time point PET-CT in Pancreas cancer," J. Korean Soc. Radiol., vol. 10, no. 5, pp. 299-305, 2016.   DOI
3 H. Zhuang, M. Pourdehnad, E.S. Lambright, A.J. Yamamoto, M. Lanuti, P. Li, P.D. Mozley, M.D. Rossman, S.D. Albelda, and A. Alavi, "Dual time point $^{18}F$-FDG PET imaging for differentiating malignant from inflammatory processes," J. Nucl. Med., vol. 42, no. 9, pp. 1412-1417, 2001.
4 P. Berberat, H. Friess, M. Kashiwagi, H.G. Beger, and M.W. Buchler, "Diagnosis and staging of pancreatic cancer by positron emission tomography," World J. Surg., vol. 23, no. 9, pp. 882-887, 1999.   DOI
5 Y.D. Seo, S.M. Kim, K.H. Kim, and J.R. Kim, "$^{18}F$-FDG PET/CT for the preperative diagnosis of papillary thyroid microcarcinoma: the value of dual time point imaging," Nucl. Med. Mol. Imaging, vol. 43, no. 6, pp. 543-556, 2009.
6 A. Danve, and J. O'Dell, "The role of $^{18}F$ Fluorodeoxyglucose positron emission tomography scanning in the diagnosis and management of systemic vasculitis," Int. J. Rheum. Dis., vol. 18, no. 7, pp. 714-724, 2015.   DOI
7 G. Lucignani, G. Paganelli, and E. Bombardieri, "The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective," Nucl. Med. Commun,. vol. 25, no. 7, pp. 651-656, 2004.   DOI
8 M. S. Woo, C.I. Baek, J.U.Yoo, J.W. Song, I.C. Im, J.C. Son, S.D. Cho, and J.S. Lee, "Clinical correlation between the autoimmune thyroid disease for the thyroid autoimmune antibodies and the maximum standardized uptake value: base on the Hashimoto's thyroiditis and the Graves' disease," J. Korean Soc. Radiol., vol. 8, no. 5, pp. 240-248, 2014.
9 M.B. Ospina, J. Horton, J. Seida, B. Vandermeer, G. Liang, A.J. McEwan, and K. Gulenchyn, "Positron emission tomography for nine cancers (bladder, brain, cervical, kidney, ovarian, pancreatic, prostate, small cell lung, testicular)," Rockville M.D., Agency for Healthcare Research and Quality U.S., 2008.
10 K.A. Busing, S.O. Schonberg, J. Brade, and K. Wasser, "Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on $^{18}F$-FDG PET/CT," Nucl. Med. Biol., vol. 40, no. 2, pp. 206- 213, 2013.   DOI
11 P. Berberat, H. Friess, M. Kashiwagi, H.G. Beger, and M.W. Buchler, "Diagnosis and staging of pancreatic cancer by positron emission tomography", World J. Surg., vol. 23, no. 9, pp. 882-887, 1999.   DOI
12 C.Y. Wong, J. Thie, K.J. Parling-Lynch, D. Zakalik, J.H. Margolis, M. Gaskill, J. Hill, F. Qing, D. Fink-Bennett, and C. Nagle, "Glucose-normalized standardized uptake value from (18)F-FDG PET in classifying lymphomas," J. Nucl. Med., vol. 46, no. 10, pp. 1659-1663, 2005.
13 N. Dobert, C. Menzel, M. Diehl, N. Hamscho, K. Zaplatnikov, and F. Grunwald, "Increased FDG bone marrow uptake after intracoronary progenitor cell therapy," Nuklearmedizin, vol. 44, no. 1, pp. 15-19, 2005.   DOI
14 L.A. Orlando, S.L. Kulasingam, and D.B. Matchar, "Metaanalysis: the detection of pancreatic malignancy with positron emission tomography," Aliment. Pharmacol. Ther., vol. 20, no. 10, pp. 1063-1070, 2004.   DOI
15 K.R. Zasadny, and R. L. Wahl, "Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D- glucose: variations with body weight and a method for correction," Radiology, vol. 189, no. 3, pp. 847-850, 1993.   DOI
16 Y. Kitasato, M. Yasunaga, K. Okuda, H. Kinoshita, H. Tanaka, Y. Okabe, A. Kawahara, M. Kage, H. Kaida, and M. Ishibashi, "Maximum standardized uptake value on $^{18}F$-fluoro- 2-deoxy-glucose positron emission tomography/computed tomography and glucose transporter-1 expression correlates with survival in invasive ductal carcinoma of the pancreas," Pancreas, vol. 43, no. 7, pp. 1060-1065, 2014.   DOI
17 M. Yun, and B.I. Kim, "Roles of F-18 FDG PET or PET/CT for the evaluation of gastrointestinal malignancies," Korean J. Gastroenterol., vol. 48, no. 6, pp. 378-387, 2006.
18 B.K. Goh, "Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness," Ann. Surg., vol. 243, no. 5, pp. 709-710l, 2006.   DOI
19 A.J. Lemke, S.M. Niehues, N. Hosten, H. Amthauer, M. Boehmig, C. Stroszczynski, T. Rohlfing, S. Rosewicz, and R. Felix, "Retrospective digital image fusion of multidetector CT and $^{18}F$-FDG PET: clinical value in pancreatic lesions a prospective study with 104 patients," J. Nucl. Med., vol. 45, no. 8, pp. 1279-1286, 2004.
20 C. Catalano, A. Laghi, F. Fraioli, F. Pediconi, A. Napoli, M. Danti, I. Reitano, and R. Passariello, "Pancreatic carcinoma: the role of high-resolution multislice spiral CT in the diagnosis and assessment of resectability," Eur. Radiol., vol. 13, no. 1, pp. 149-156, 2003.   DOI
21 R.J. Hyndman, and Y. Fan, "Sample quantiles in statistical packages," Am. Stat., vol. 50, no. 4, pp. 361-365, 1996.
22 K.D. Min, and H.Y. Back, "Box-Cox power transformation using Minitab Macros," J. Korean Data Anal. Soc., vol. 12, no. 6, pp. 3339-3350, 2010.
23 J.K. Kim, and E.H. Park, "Process capability analysis algorithm using Johnson Transformation," J. Korea Saf. Manag. Sci., vol. 20, no. 1, pp. 249-263, 2000.