• Journal of Animal Science and Technology
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• 제47권2호
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• pp.167-176
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• 2005

PIGK(phosphatidylinositol glycan, class K) is a subunit of GPI transamidase that cleaves the signal peptide in proproteins and replaces it with GPI. In addition, the structure and synthesis of GPI are critically involved in some of the cellular actions of insulin. Therefore, PIGK would be essential for mammalian development and many specific cellular functions as well as for metabolic activity of insulin associated with GPI. Two types of" full-length cDNAs of porcine PIGK were cloned through RT-PCR and RACE experiments. One is thought to be a normal form(consist of 395 amino acids) and the other is considered as an alternative spliced form(consist of 371 amino acids) which contains additional 63 bps in intron 7. Since a stop codon was contained within the insertion, the spliced form has a shorter coding sequence than that of normal form. A missense mutation (T314I) in exon 6 was detected and used for genotyping to estimate association with the growth and fat deposition traits for 545 $F_2$ animals(Korean native boars ${\times}$ Landrace). From the PCR-RFLP analysis using HpyCH4III, CT genotype showed highly significant relationship(P< 0.01) with carcass fat contents.

• 폴리머
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• 제39권3호
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• pp.359-364
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• 2015

A self-oscillating interpenetrating polymer network (IPN) poly(acrylic acid)/poly(ethylene glycol) (PAA/PEG) hydrogel was prepared by using radical polymerization with a two-step method. The IPN hydrogel was characterized by FTIR spectroscopy and morphological analysis. The results indicated that the chains of PEG and PAA twined to form porous structure which is beneficial to water molecules entering inside of the hydrogel. In addition, the pH-responsive behavior, salt sensitivity, swelling/de-swelling oscillatory behaviors and self-oscillation in a closed pH oscillator were also studied. The results showed that the prepared hydrogel exhibited pH-sensitivity, good swelling/de-swelling reversibility and excellent salt sensitivity. The self-oscillating behavior of swelling/de-swelling for the prepared hydrogel was caused by pH alteration coupled with the external media. This study may create a new possibility as biomaterial including new self-walking actuators and other related devices.

• 품질경영학회지
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• 제30권3호
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• pp.66-78
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• 2002

Process capability indices are being used as indicators for measurements of process capability for SPC of quality assurance system in industries. In view of the enhancement of customer satisfaction, process capability indices in which loss functions are used to deal with the economic loss In the processes deviated from the target, are in an adequate representation of the customer's perception of quality In this connection, the loss function has become increasingly important in quality assurance. Taguchi uses a modified form of the quadratic loss function to demonstrate the need to consider the proximity to the target while assessing its quality. But this traditional quadratic loss function is inadequate to assessing the quality and quality improvement since different processes have different sets of economic consequences on the manufacturing, Thereby, a flexible approach to the development of the loss function needs to be desired. In this paper, we introduce an easily understood loss function, based on reflection of probability density function of the normal distribution. That is, the Reflected Normal Loss function can be adapted to an asymmetric loss as well as to a symmetric loss around the target. We propose that, instead of the process variation, a new capability index, CpI using the Reflected Normal Loss Function that can accurately reflect the losses associated with the process and a new capability index CpI Is compared with the classical indices as $C_{p}$ , $C_{pk}$, $C_{pm}$ and $C_{pm}$ $^{+}$.>.+/./.

• 대한기계학회논문집
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• 제19권9호
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• pp.2283-2296
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• 1995

Experiments of normal shock wave/turbulent boundary layer interaction were conducted in a supersonic diffuser. The flow Mach number just upstream of the normal shock wave was in the range of 1.10 to 1.70 and Reynolds number based upon the turbulent boundary layer thickness was varied in the range of 2.2*10$^{[-994]}$ -4.4*10$^{[-994]}$ . The wall pressures in streamwise and spanwise directions were measured for two test cases, in which the turbulent boundary layer thickness incoming into the supersonic diffuser was changed. The results show that the interactions of normal shock wave with turbulent boundary layer in the supersonic diffuser can be divided into three patterns, i.e., transonic interaction, weak interaction and strong interaction, depending on Mach number. The weak interactions generate the post-shock expansion which its strength is strong as the Mach number increases and the strong interactions form the pseudo-shock waves. From the spanwise measurements of wall pressure, it is known that if the flow Mach number is low, the interacting flow fields essentially appear two-dimensional, but they have an apparent 3-dimensionality for the higher Mach numbers.

• 대한치과교정학회지
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• 제23권1호
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• pp.115-122
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• 1993

This study was undertaken to compare the activity of masticatory muscle between normal occlusion and anterior openbite. 33 subjects without the experience of orthodontic treatment, missing teeth and the symptom of T. M. disorders were selected for this study : 25 subjects were normal occlusion and 8 subjects were anterior openbite. The ten items were measured from the cephalometric headplates, and EMG recordings of the anterior temporal and masseter muscle were taken at rest position and during maximum clenching at centric occlusion. All data were analyzed and processed with the computer statistical method. The following results were obtained : 1. At rest position, the muscle activities of both temporal and masseter muscle were higher in anterior openbite than in normal occlusion. 2. During maximum clenching, the muscle activities of both temporal and masseter muscle were prominently lower in anterior openbite than in normal occlusion. 3. At rest position, the temporal muscle of anterior openbite showed the highest muscle activity, but showed the lowest muscle activity during maximum clenching. 4. Anterior openbite showed closer interrelationship between facial morphology and the muscle activity, and the muscle activity was more influenced by the form of mandible than that of maxilla.

• 대한치과교정학회지
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• 제14권1호
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• pp.115-125
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• 1984

A comparative study was undertaken to investigate the collapse of maxillary dental arch and palate in unilateral cleft lip and palate individuals. The material for this study consisted of 39 subjects with repaired unilateral cleft lip and palate (30 males, 9 females). The measurements of unilateral cleft lip and palate individuals were compared with the measurements of normal individuals (30 males, 30 females). All the subjects were in the mixed dentition stage and the mean age was almost the same. The following conclusions were obtained. 1. A large number of the maxillary dental arch of the unilateral cleft lip and palate individuals showed ${\Omega}$-shape, and the arch length was shorter than that of normal individuals. The intermolar width did not show significant difference between cleft group and group, but the intercanine width was mcuh smaller than that of normal individuals. 2. The palate of the unilateral cleft lip and palate subjects showed shorter and shallower form than that of normal subjects. 3. The palatal area of the unilateral cleft lip and palate subjects was smaller than that of normal subjects, and the cleft side area was much smaller than the opposing side area. 4. There was no significant sexual difference in measurements of maxillary dental arch and palate of the unilateral cleft lip and palate subjects.

• 약학회지
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• 제41권6호
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• pp.730-736
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• 1997

Distribution of radioactivity in the skin tissues, subcutaneous tissues, blood and body organs was examined following topical application of $^{125}I-rhEGF$(0.4 ${\mu}Ci$), in the form of a Pluronic F-127 gel, on the normal and damaged (burned and stripped) skins of SD male rats. The radioactivity in the skin tissues and subcutaneous tissues was 3-5 times higher for the damaged skins than for the normal skin. But pretreatment of the skin with rhEGF (1${\mu}g$)) twice at 24 hr dose intervals affected the distribution of the radioactivity yielding the order of burned skin> stripped skin=normal skin. The decrease for the stripped skin by the pretreatment might be related either to the pathophysiological change of the skin or to the down regulation of the EGF receptor. Liver showed the highest radioactivity in amount following single and multiple administration of the drug to the normal and damaged skins. But,in concentration, the kidney and stomach showed higher value than the liver which is consistent with that kidney is a major eliminating organ of EGF and that EGF exerts its pharmacological effect specifically for the stomach.

• 한국정보통신학회논문지
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• 제13권3호
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• pp.451-457
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• 2009

컴퓨터그래픽스에서 다루어지는 대부분의 물체들은 메쉬 형태로 표현된다. 보다 다양한 형태로의 변형이나 현실감 있는 렌더링을 얻기 위해서는 정점에서의 올바른 법선벡터 계산이 필수적이다. 이에 대한 기존 연구들은 정점의 기하학적 특성을 단순하게 반영하는 가중치를 사용하였다. 본 논문에서는 국지적 기하학 특성을 종합적으로 반영하는 등각사상과 이웃 정점과의 상호관계를 연속적으로 표현할 수 있는 중간값 좌표계를 사용하는 방법을 제안한다. 논문에서 제시된 방법이 기존 다른 방법에 비해서 보다 정확한 법선벡터를 계산할 수 있음을 실험을 통해서 알 수 있다.

• BMB Reports
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• 제53권9호
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• pp.453-457
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• 2020

The right-handed double-helical structure of DNA (B-DNA), which follows the Watson-Crick model, is the canonical form of DNA existing in normal physiological settings. Even though an alternative left-handed structure of DNA (Z-DNA) was discovered in the late 1970s, Z-form nucleic acid has not received much attention from biologists, because it is extremely unstable under physiological conditions, has an ill-defined mechanism of its formation, and has obscure biological functions. The debate about the physiological relevance of Z-DNA was settled only after a class of proteins was found to potentially recognize the Z-form architecture of DNA. Interestingly, these Z-DNA binding proteins can bind not only the left-handed form of DNA but also the equivalent structure of RNA (Z-RNA). The Z-DNA/RNA binding proteins present from viruses to humans function as important regulators of biological processes. In particular, the proteins ADAR1 and ZBP1 are currently being extensively re-evaluated in the field to understand potential roles of the noncanonical Z-conformation of nucleic acids in host immune responses and human disease. Despite a growing body of evidence supporting the biological importance of Z-DNA/RNA, there remain many unanswered principal questions, such as when Z-form nucleic acids arise and how they signal to downstream pathways. Understanding Z-DNA/RNA and the sensors in different pathophysiological conditions will widen our view on the regulation of immune responses and open a new door of opportunity to develop novel types of immunomodulatory therapeutic possibilities.

• 대한인간공학회지
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• 제12권2호
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• pp.63-83
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• 1993

The primary objective of the research is to develop a mathematical method to incorporate the variability of anthropometric body dimensions and joint strengths of individuals in a biomechanical analysis. A multivariate normal simulation model estimated anthropometric body dimensions and joint strengths of the random link-person, based on the assumptions that the vari- ables of body dimensions and joint strengths are correlated and follow normal distributions. Statistical comparative analysis demonstrated that the random link-person represented a more realistic human-like form in an anthropometric sense than the proportional link-person whose body dimensions were estimated proportionally. Estimated joint strengths for the random link-person, however, did not match the measured joint strengths as closely as the estimated body dimensions. The random link-person will allow biomechanical analysis of manual materials handling tasks to be individualized with respect to the anthropometry and a static strength.