• Korean Journal of Acupuncture
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• 제21권1호
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• pp.175-199
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• 2004

Objectives : To study acupuncture and moxibution treatments for stomatopathy( aphthae, oral ulceration, mycolic stomatitis, halitosis, thirst, bitter) the ancient and the present literatures were reviewed. Methods : We've got compared and analyzed 55 kinds of literatures. Results and Conclusions : 1. The acupuncture meridians used frequently for stomatopathy were $Su-yangmy\bar{o}ng-Taejang-ky\bar{o}ng(LI),\;Chok-yangmy\bar{o}ng-Wi-Ky\bar{o}ng(S),\;Immaek-Ky\bar{o}ng(CV)$. 2. The acupoints used frequently for aphthae were $Sungjang(CV_{24}),\;Yomchon(CV_{23}),\;Hapkok(LI_4),\;Nogung(P_8),\;Chok-samni(S_{36}),\;Hyopko(S_6),\;Sugu(GV_{26})$. 3. The acupoints used frequently for oral ulceration were $Hapkok(LI_4),\;Nogung(P_8),\;Chok-samni(S_{36}),\;Kokchi(LI_{11}),\;Sotaek(SI_1),\;Pisu(B_{20}),\;Wisu(B_{21}),\;Samgan(LI_3),\;Yomchon(CV_{23}),\;Chichang(S_4)$. 4. The acupoints used frequently for mycolic stomatitis were $Hapkok(L_4),\;Chichang(S_4),\;Hyopko\;(LI_4),\;Sungjang(CV_{24}),\;Samumgyo(SP_6)$. 5. The acupoints used frequently for halitosis were $Naejong(S_{44}),\;Chok-samni(S_{36}),\;Chung-wan\;(CV_{12}),\;Sang-wan(CV_{13}),\;Hawan(CV_{10}),\;Kongson(SP_4),\;Wisu(B_{21}),\;Nogung(P_8),\;Sugu(GV_{26}),\;Sungjang(CV_{24})$. 6. The acupoints used frequently for thirst were $Sosang(L_{11}),\;Sangyang(LI_1),\;Sotaek(SI_1),\;Kwanch'ung(TE_1),\;Ch'\bar{o}kt'aek(L_5),\;T'ae-gye(K_3),\;Kokt'aek(P_3),\;Sugu(GV_{26}),\;Samgan(LI_3),\;Igan(LI_2),\;T'aech'ung(Liv_3),\;Sojangsu(B_{27})$. 7. The acupoints used frequently for bitter were $Yangn\bar{u}ngch'\bar{o}n(G_{34}),\;Hy\bar{o}njong(G_{39}),\;Kwanch'ung(TE_1),\;Tamsu(B_{19}),\;Chokkyu\bar{u}m(G_{44}),\;Y\bar{o}n-gok(K_2),\;Shinmun(H_7),\;Chok-Samni(S_{36})$.

• 한국식생활문화학회지
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• 제24권6호
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• pp.588-596
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• 2009

To determine the relationships between soybean food intake, dietary isoflavone intake, and osteoporosis incidence, questionnaire surveys, bone mineral density measurements, and dietary surveys by food record were performed with 19 postmenopausal women ($57.6{\pm}7.3$ yrs of age) in Daejeon city. The subjects were divided into two groups: an 'osteoporosis group' (OG, n=10) and a 'normal group' (NG, n=9). Mean age, height, and body weight were similar between the two groups but BMI was higher in OG than in NG. Mean age at menarche was not different between the two groups. However, mean number of childbirths was greater in OG than in NG and mean total period of lactation was shorter in OG. Mean exercise time per week was similar between the two groups, and mean time of sunlight exposure tended to be shorter in OG. Mean daily intake of calcium was lower in OG whereas sodium intake was higher in OG. Mean daily intakes of total soybean food (OG: $203.8{\pm}84.6\;g/d$, NG: $285.0{\pm}146.3\;g/d$) and total dietary isoflavone (OG: $29.1{\pm}14.3\;mg/d$, NG: $38.3{\pm}23.1\;mg/d$) were not different between the two groups. However, greater intakes of soybean food and dietary isoflavone were associated with higher bone mineral density, respectively. The above results indicate that osteoporosis incidence tends to be influenced by BMI, maternal factors, dietary nutrient intakes, soybean food intakes, and dietary isoflavone intakes in postmenopausal women; although no significant differences in soybean food and dietary isoflavone intake were found between the two groups. This tendency implies that greater intakes of soybean food and dietary isoflavone lead to lower incidence of osteoporosis in postmenopausal women.

• 분석과학
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• 제17권6호
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• pp.481-488
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• 2004

Salen[N,N'-bis (salicylidene)ethylenediamine]을 리간드로 사용하여 해수에 존재하는 극미량의 Ni(II)을 클로로포름 용매로 추출하는 방법에 관하여 연구하였다. Ethylenediamine과 salicylaldehyde를 사용하여 축합반응에 의해 salen을 합성하였다. Salen과 Ni(II)은 수용액에서 1 : 1 착물을 형성한다는 사실을 확인 할 수 있었으며 추출과정의 추출상수는 $10^{5.12}$ 이었다. 해수 중 Ni(II)의 분석과정을 최적화하기 위해 실제 해수와 조성이 비슷한 인공해수를 실험실에서 만들어 수용액의 pH, 리간드로 사용한 salen의 양, 추출시간, 역추출을 위한 산의 종류와 농도, 방해이온의 영향 등에 대해서 조사하였다. 그 결과 수용액의 pH가 8 이상인 약한 염기성 영역에서 10분 정도 흔들어주면 정량적으로 극미량의 Ni(II)이 용매로 추출되었다. 수용액에서 salen의 농도가 $1.2{\times}10^{-4}mol/L$ 이상이면 정량적인 추출이 가능하였는데, 이는 몰 비로 Ni(II)의 180배에 해당하는 양이었다. 이상의 최적화된 실험조건을 바탕으로 한국 인근해안의 해수를 채취하여 분석한 결과 모두 검출한계 이하의 값을 나타내었으며, 40 ng/mL의 Ni(II)을 첨가하여 구한 회수율은 평균 98% 이었으며, 검출한계는 1.3 ng/mL 이었다. 이와 같은 결과로부터 salen형태의 Schiff-염기가 극미량 금속원소의 정량에 킬레이트 시약으로 응용될 수 있음을 알았다.

• Advances in Traditional Medicine
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• 제4권1호
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• pp.53-59
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• 2004

The effect of aqueous and alcoholic extract of the leaves of Ocimum. sanctum was studied on the spontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m.) complex of Setaria cervi (S. cervi) and on the survival of microfilariae (m.f.) in vitro. Both the extracts caused inhibition of the spontaneous motility of the w.w. and n.m. complex of S. cervi characterized by initial stimulation followed by reversible paralysis, aqueous extract at a higher concentration showed immediate effect and irreversible paralysis. The concentration required to inhibit the movements of n.m. complex was $1/4^{th}$ for aqueous and $1/3^{rd}$ for alcoholic extract compared to that for the w.w., suggesting a cuticular permeability barrier. On the m.f. the lethal concentration (LC 50 and LC 90) were 35 and 50 ng/ml for aqueous whereas, 60 and 85 ng/ml for alcoholic extracts respectively.

• 분석과학
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• 제16권3호
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• pp.249-260
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• 2003

한강에서 채취한 원수에 염소소독제인 hypochlorite를 $10{\mu}g/m{\ell}$의 농도로 투여한 후 1시간~14일까지 TOC (total organic carbon), 잔류염소량 및 탁도 등을 측정하고 THMs (trihalomethanes), HANs (haloacetonitriles), HKs (haloketones), chloral hydrate 및 HAAs (haloacetic acids) 등의 염소소독 부산물의 생성율을 조사하였다. 그 결과 잔류염소량은 투여후 1시간 경과 시 $6{\mu}g/m{\ell}$ 이상에서 14일째에 $1.23{\mu}g/m{\ell}$으로 감소하였으며 TOC 및 탁도는 큰 차이가 없었다. 7일 후 발생한 총 소독부산 물의 농도는 $101.3ng/m{\ell}$ (789.6 nM)이며 이 중 THMs이 69%로 가장 큰 비중을 차지하였다. 그 외에 HAAs가 19%, chloral hydrate가 10% 정도 검출되었으며, HANs와 HKs 및 chloropicrin 등은 미량 검출되었다. THMs 중에서는 chloroform이 $61.5ng/m{\ell}$로 총 THMs 중 약 89% 정도를 차지하였으며 HANs 중에서는 DCAN이 95%인 $0.72ng/m{\ell}$, HAAs 중에서는 TCAA가 50% 등으로 가장 높은 비율로 검출되었다. 각 부산물의 발생량의 상관관계를 조사한 결과 THMs과 HANs의 경우 THMs의 농도가 $40ng/m{\ell}$인 지점을 경계로 HANs과 경쟁적 발생관계가 있음이 나타났다. HAAs의 경우는 특별한 경향성을 나타내지 않았으나 전체적으로 초기에 산화상태가 큰 화합물에서 산화상태가 작은 화합물로 점차 변화하는 것으로 관찰되었다.

• Annals of Pediatric Endocrinology and Metabolism
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• 제23권4호
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• pp.210-214
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• 2018

Purpose: Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5-8 years) and age and body mass index (BMI) matched controls. Methods: Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done. Results: PA girls (n=76) were matched to control girls (n=12) for age (mean${\pm}$standard deviation) ($6.7{\pm}1years$ vs. $6.2{\pm}1.3years$) and BMI ($20{\pm}10kg/m^2$ vs. $17.8{\pm}2.7kg/m^2$). Dehydroepiandrostenedione sulfate ($63.3{\pm}51.3{\mu}g/dL$ vs. $29.8{\pm}17.3{\mu}g/dL$, P<0.001) and testosterone levels ($11.4{\pm}4.8ng/dL$ vs. $8.2{\pm}2.9ng/dL$, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49-3.15 ng/mL) were $3.2{\pm}2.2ng/mL$ vs. $4.6{\pm}3.2ng/mL$ respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were $39.5{\pm}30.5ng/dL$ vs. $36.8{\pm}19.8ng/dL$ in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups. Conclusion: Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.

• Preventive Nutrition and Food Science
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• 제1권2호
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• pp.220-226
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• 1996

To investigate the effect of long chain n-3 polyunsaturated fatty acids on breast cancer cell growth, estrogen-dependent MCF-7 human breast cancer cells were cultured serum-free DMEM media containing 0.5$\mu\textrm{g}$/ml of differnet kinds of fatty acids; linoleic acid(LA), arachidonic acid(AA), eicosapentaenoic acid(EPA) and docosahexaenoic acid acid(DHA) and 1, 0.1, 0.2, 0.5and 1.0ng/ml 17$\beta$-estradiol as well as 10$\mu\textrm{g}$/mi insulin and 1.25 mg/ml delipidized bovine serum albumin for 3 days. Cell growth monitored by MTT assay was lower in DHA and EPA treatments as compared to LA treatment, but not with AA treatment. Estrogen concentrations at which cell growth was initially stimulated were 0.1ng/ml for LA and DHA treatments and 0.2ng/ml for EPA and AA treatments, but the degree of stimulation was 25~30% lower in DHA and EPA treatments than in LA treatment. Fatty acid analysis showed that each fatty acid in culture medium was well incoporated into celluar lipid. Protein kinase C activity of cells was most elevated in LA treatment from 2 to 8 hours of culture followed by DHA, EPA, and AA treatments. It is concluded that inhibitions of n-3 DHA and EPA on breast cancer cell growth as compard with n-6 LA is mediated via changes in membrane fatty acid composition reducing estrogen sensitivity and increasing protein kinase C activity.

• 생명과학회지
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• 제19권11호
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• pp.1514-1521
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• 2009

혈장 cathepsin B 활성도 측정이 갑상선암 및 결절성 증식증의 수술 전 진단에 도움이 되는지를 알아보고자 분화갑상선암 32례, 결절성 증식증 7례, 대조군 5례의 혈장 cathepsin B 발현양상을 대조군과 함께 관찰하였다. 수술시 제거된 여포선암의 암조직, 결절성 증식증 조직의 cathepsin B 발현을 정상 조직과 비교하였다. 혈장 Cathepsin B 활성도는 정상 대조군에서 $168.94{\pm}15.10$ (${\times}10^{-2}$, mU), 결절성 증식증에서 $255.45{\pm}95.68$ (${\times}10^{-2}$, mU), 악성종양에서 $284.87{\pm}79.32$ (${\times}10^{-2}$, mU)로써 악성종양군과 결절성 증식증군에서 cathepsin B 발현이 정상 대조군보다 비교적 높게 나타났다(p<0.05). 혈장 cathepsin B의 정량적 비교를 위한 immunoassay결과에서도 결절성 증식증군($17.64{\pm}7.49\;ng/ml$)과 악성종양군($15.50{\pm}7.86\;ng/ml$)에서 정상대조군($4.85{\pm}0.61\;ng/ml$)보다 높은 수치를 나타내었다(p<0.05). 결절성 증식증 및 악성종양군의 조직 내 cathepsin B mRNA발현이 정상 조직에서보다 높게 나타났다. 따라서 혈장 cathepsin B는 갑상선세포의 비정상적인 증식시에 증가됨을 알 수 있으며, 갑상선암 혹은 결절성 증식증을 스크리닝하는데 이용될 수 있을 것으로 사료된다.

• 한국잠사학회:학술대회논문집
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• 한국잠사학회 2001년도 제44회 춘계 학술연구 발표자료
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• pp.17-17
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• 2001

No Abstract. See Full-text

• Asian-Australasian Journal of Animal Sciences
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• 제5권1호
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• pp.101-106
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• 1992

Secretory patterns of serum tri-iodothyronine, thyroxin and testosterone were analysed by specific radioimmunoassay in Kaghani (n = 42), Rambouilet (n = 42) and Kaghani ${\times}$ Rambouillet (n = 42) male sheep to determine age and breed related changes. Animals were examined at 1-2 wk, 8, 10, 12, 20, 22 and 24 months of age (n = 6/age group). All animals were maintained under standard conditions of feeding and management. $T_3$ and $T_4$ concentrations were maximal (p < 0.01) in 1-2 wk old lambs of all breeds studied ($207.4{\pm}14.9-276.8{\pm}20.4ng/dl$ and $5.76{\pm}0.3-7.23{\pm}0.9{\mu}g/dl$, respectively). For all the breeds, concentrations of $T_3$ declined markedly (p < 0.01) at 8 month of age and then varied in a narrow range ($44.5{\pm}14.0-87.0{\pm}4.8ng/dl$) up to the age of 24 month. While, serum $T_4$ concentrations decreased (p < 0.01) to nadir ($0.97{\pm}0.1-1.43{\pm}0.3{\mu}g/dl$) at 10 months of age in all the 3 breeds. Afterwards, $T_4$ levels increased gradually and attained a small peak at 20 months before declining again at 22 and 24 months of age. Serum $T_3$ and $T_4$ concentrations were correlated significantly (p < 0.05) and their ratio was constant at all ages in the different breeds. Age significantly (p < 0.01) influenced the secretion of testosterone in the breeds examined but the breed differences were comparable. Mean serum concentrations of testosterone were low from 1-2 wk to 10 months of age in the Kaghani, Rambouillet and Kaghani ${\times}$ Rambouillet animals. Peak testosterone levels were noted in the 12 months old Kaghani ($1.75{\pm}0.4ng/ml$), Rambouillet ($1.30{\pm}0.2ng/ml$) and their $T_3$ cross animals ($1.16{\pm}0.08ng/ml$). Mean testosterone levels, thereafter, decreased at 20 months and then at 22 and 24 months remained variable but higher than observed at 1-2 wk -10 months of age. The findings of the present study indicate a significant influence of age but not of breed on the peripheral concentrations of thyroid hormones and testosterone. Serum concentrations of $T_3$ and $T_4$ were not related to testosterone levels. High thyroid secretory activity observed at prenatal phase of development may play an important role in preparing the lambs to extrauterine environments.