• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.72-72
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• 2018

The root of Angelica gigas Nakai (AGN) is used as a traditional herbal medicine in Korea for the treatment of many diseases. However, a major challenge associated with the usage of the active compounds from AGN is their poor water solubility. Therefore, this work aimed to enhance the solubility of active compounds by a chemical (viz. surfactant) and physical (hot melt extrusion) crosslinking method (CPC). Infrared Fourier transform spectroscopy (FT-IR) revealed multiple peaks in extrudate solids representing new functional groups including carboxylic acid, alkynes and benzene derivatives. Differential scanning calorimetry (DSC) analysis of the extrudate showed lower glass transition temperature (Tg) and lower enthalpy (${\Delta}H$) (Tg: $43^{\circ}C$; ${\Delta}H$: <6 (J/g)) compared to the non-extrudate (Tg $68.5^{\circ}C$; ${\Delta}H$: 123.2) formulations. X-ray powder diffraction (XRD) analysis revealed amorphization of crystal materials in extrudate solid. In addition, nanonization, enhanced solubility and higher extraction of phenolic compounds were achieved in the extrudate solid. Among the different extrudates, acetic acid- and Span 80-mediated formulations showed superior extractions. We conclude that the CPC method successfully enhanced the production of amorphous nano dispersions from extrudate solid formulations.

• 대한조선학회지
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• 제27권1호
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• pp.24-34
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• 1990

본 연구에서는 축력과 굽힘모멘트의 조합하중(組合荷重)을 받는 손상원통부재의 최종강도(最終强度)를 해석하기위하여 간이유한요소해석이론을 정식화한다. 여기서, 굽힘 및 국부손상이 존재하는 원통부재(圓筒部材)를 보요소로 모델링하며, 각요소의 접선탄성강성행렬(接線彈性剛性行列)은 기하학적 비선형 효과를 고려하여 updated Lagrangian 기법에 의하여 도출한다. 이때, 국부손상부위의 강성이 외력에 대한 저항에 기여하는 정도는 비교적 작다고 생각되므로 요소의 강성평가시에 국부손상부위의 강성은 무시한다. 요소의 소성화는 국부손상부위의 영향을 고려한 전단면(全斷面) 소성강도(塑性强度) 상관관계식을 적용하여 요소의 각절점에서 판정하며, 접선(接線) 탄소성(彈塑性) 강성행렬(剛性行列)은 소성절점법(塑性節點法)에 의하여 계산한다. 마지막으로 본 연구에서 정식화한 해석법을 바탕으로 컴퓨터프로그램을 작성하고 실험 등에 의하여 얻어진 기존의 결과에 대해 재해석하여 본해석법의 정도와 유용성을 확인한다.

• 천문학회보
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• 제41권1호
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• pp.38.2-38.2
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• 2016

The mapping of dark matter clustering from real to redshift spaces introduces the anisotropic property to the measured density power spectrum in redshift space, known as the Redshift Space Distortion (hereafter RSD) effect. The mapping formula is intrinsically non-linear, which is complicated by the higher order polynomials due to the indefinite cross correlations between the density and velocity fields, and the Finger-of-God (hereafter FoG) effect due to the randomness of the peculiar velocity field. Furthermore, the rigorous test of this mapping formula is contaminated by the unknown non-linearity of the density and velocity fields, including their auto- and cross-correlations, for calculating which our theoretical calculation breaks down beyond some scales. Whilst the full higher order polynomials remains unknown, the other systematics can be controlled consistently within the same order truncation in the expansion of the mapping formula, as shown in this paper. The systematic due to the unknown non-linear density and velocity fields is removed by separately measuring all terms in the expansion using simulations. The uncertainty caused by the velocity randomness is controlled by splitting the FoG term into two pieces, 1) the non-local FoG term being independent of the separation vector between two different points, and 2) the local FoG term appearing as an indefinite polynomials which is expanded in the same order as all other perturbative polynomials. Using 100 realizations of simulations, we find that the best fitted non-local FoG function is Gaussian, with only one scale-independent free parameter, and that our new mapping formulation accurately reproduces the observed power spectrum in redshift space at the smallest scales by far, up to k ~ 0.3 h/Mpc, considering the resolution of future experiments.

• 대한지리학회지
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• 제36권5호
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• pp.516-526
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• 2001

이 연구는 농촌지역에 있어 컴퓨터의 보급, 또는 보다 광범위하게 정보화의 확산이 지역발전에 미치는 영향을 밝히는 데에 목적이 있다. 이를 위하여 강원도 원주시의 정보화시범마을로 지정된 황둔 송계마을을 사례지역으로 하여 컴퓨터의 보급 활용의 특성으로부터 지역발전의 시사점을 도출하였다. 마을주민들의 컴퓨터사용은 인터넷, 이메일, 마을홈페이지 활용 등의 측면에서 초보적인 수준이지만, 라이프스타일과 마을공동체의 형성에 있어 긍정적인 변화를 가져올 잠재력이 높고 따라서 지역발전의 도구로 사용될 수 있음이 발견된다. 이러한 긍정적인 변화는 주민들이 컴퓨터사용으로부터 얻는 경제적, 사회적, 문화적 혜택을 증대시킴으로써 가능하다고 보인다. 무엇보다도 필요한 것은 컴퓨터의 보급은 외적 동기에 의하여 이루어졌지만 이를 내적 동기로 전환시키고 보다 활발하게 컴퓨터를 사용할 수 있도록 유도하는 일이다.

• 한국지반공학회논문집
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• 제21권8호
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• pp.37-43
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• 2005

암반의 거동을 예측하기 위해 1980년 발표된 Hoek-Brown 모델은 지속적인 개선과 더불어 수많은 문제들을 해결하기 위해 널리 사용되고 있다. 그러나 Hoek-Brown 모델의 유한요소법 등 수치해석에 대한 적용성에 관한 연구는 미미한 실정이다. 본 논문에서는 Hoek-Brown 모델을 일반적 소성론 절차에 따라 구성모델로 정식화하여 그 특징을 살펴보았고, 수치적 문제점을 유발하게 되는 항복면의 모서리부를 곡면으로 처리한 Rounded Hoek-Brown 모델을 제시하였다. 제안모델은 탄소성 구성모델로서의 요구조건들을 만족하며, 압축측에서 원래의 Hoek-Brown 모델과 동일한 항복면을 갖는다. 제안 모델을 일반적인 비선형 유한요소해석에 적용하기 위하여 제안 모델의 구성방정식을 수립하였다.

• Geomechanics and Engineering
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• 제2권4호
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• pp.253-280
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• 2010

A new prediction model is derived for the uplift capacity of suction caissons using a hybrid method coupling genetic programming (GP) and simulated annealing (SA), called GP/SA. The predictor variables included in the analysis are the aspect ratio of caisson, shear strength of clayey soil, load point of application, load inclination angle, soil permeability, and loading rate. The proposed model is developed based on well established and widely dispersed experimental results gathered from the literature. To verify the applicability of the proposed model, it is employed to estimate the uplift capacity of parts of the test results that are not included in the modeling process. Traditional GP and multiple regression analyses are performed to benchmark the derived model. The external validation of the GP/SA and GP models was further verified using several statistical criteria recommended by researchers. Contributions of the parameters affecting the uplift capacity are evaluated through a sensitivity analysis. A subsequent parametric analysis is carried out and the obtained trends are confirmed with some previous studies. Based on the results, the GP/SA-based solution is effectively capable of estimating the horizontal, vertical and inclined uplift capacity of suction caissons. Furthermore, the GP/SA model provides a better prediction performance than the GP, regression and different models found in the literature. The proposed simplified formulation can reliably be employed for the pre-design of suction caissons. It may be also used as a quick check on solutions developed by more time consuming and in-depth deterministic analyses.

• Steel and Composite Structures
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• 제10권3호
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• pp.207-222
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• 2010

Fire incident in buildings is common, so the fire safety design of the framed structure is imperative, especially for the unprotected or partly protected bare steel frames. However, software for structural fire analysis is not widely available. As a result, the performance-based structural fire design is urged on the basis of using user-friendly and conventional nonlinear computer analysis programs so that engineers do not need to acquire new structural analysis software for structural fire analysis and design. The tool is desired to have the capacity of simulating the different fire scenarios and associated detrimental effects efficiently, which includes second-order P-D and P-d effects and material yielding. Also the nonlinear behaviour of large-scale structure becomes complicated when under fire, and thus its simulation relies on an efficient and effective numerical analysis to cope with intricate nonlinear effects due to fire. To this end, the present fire study utilizes a second-order elastic/plastic analysis software NIDA to predict structural behaviour of bare steel framed structures at elevated temperatures. This fire study considers thermal expansion and material degradation due to heating. Degradation of material strength with increasing temperature is included by a set of temperature-stress-strain curves according to BS5950 Part 8 mainly, which implicitly allows for creep deformation. This finite element stiffness formulation of beam-column elements is derived from the fifth-order PEP element which facilitates the computer modeling by one member per element. The Newton-Raphson method is used in the nonlinear solution procedure in order to trace the nonlinear equilibrium path at specified elevated temperatures. Several numerical and experimental verifications of framed structures are presented and compared against solutions in literature. The proposed method permits engineers to adopt the performance-based structural fire analysis and design using typical second-order nonlinear structural analysis software.

• 대한기계학회논문집
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• 제18권1호
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• pp.139-149
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• 1994

A numerical simulation of unsteady axisymmetric turbulent flow was performed for a reciprocating engine including port/valve assembly. The governing equations based on a nonorthogonal coordinate formulation with Cartesian velocity components were used and discretised by the finite volume method with non-staggered variable arrangements. The modified $\kappa-\xi$. turbulence model which included the effect of compressibility was used. The results of twodimensional transient calculation for the axisymmetric configuration were compared with the experimental data. Although slightly low rms velocity was predicted compared to the experimental data, predicted velocity distributions at the valve exit and in-cylinder region showed good agreements with the experimental data. The flow at the valve exit was separated at the same valve lift position with the experimental data. Two vortices incylinder region were generated during the initial intake process. The clockwise main vortex became strong and moved upward to the top wall. The counter-clockwise second vortex became weak and stick to the upper left corner of the cylinder. After middle intake process, new vortex adjacent to upper cylinder wall appeared by the piston motion and therefore, the in-cylinder flow was formed into three vortices. The cylinder pressure just before bottom dead center of piston was higher than inlet pressure and then the reverse flow occured at the valve exit. The in-cylinder flow characteristics were strongly dependent on piston motion, but insensitive to valve motion.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 1999년도 IFSCC . ASCS 학술대회 발표 논문
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• pp.111-121
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• 1999

Acne vulgaris, the most common skin disease. can be formed as only a few comedons or severe inflammatory lesions. The pathogenesis of acne involves various factors; excessive androgen, excessive sebum production, abnormal alteration of follicular epithelium, proliferation of Propionibacterium acnes, and inflammation. We investigated acne therapy using oriental herbs described in the Korean traditional medical book (Dong-ui-bo-gam). Oriental herbs (Angleica daurica. Arctium lappa. Coptidis rhizoma, and glycyrrhiza glabra) were chosen based on their respective property of sebum control, anti-inflammatory activity, and anti-bacterial activity. We examined the effect of acne treatment, in terms of chemotactic inhibition, lipogenesis inhibition, and anti-bacterial activity for P. acnes. 1. Neutrophil chemotaxis assay ; P acnes secrete chemotactic factors and other pro-inflammatory extracellular products. Neutrophil chemotactic activity of P. acnes was measured by 48-well chemotaxis method. Angelica daurica clearly suppressed chemotactic activity of P. acens. 2. Using sebaceous gland of hamster ear lipogenesis assay; Sebaceous lipogenesis was measured using ear biopsies by incubation of $C^{14}$ -acetate in culture media. The $C^{14}$ -labeled lipids were extracted and determined by liquid scintilation counting, Coptidis rhizoma markedly inhibited sebum production, 3. Anti-bacterial assay for P. acnes (MIC test) Glycyrrhiza glabra showed anti-bacterial activity. P. acnes did not develop resistance against Glycyrrhiza glabra. Retinoids are effectively to inhibit sebum production and regulate follicular keratinization process, with little anti-inflammatory activity. Angelica daurica suppressed neutrophil chemotaxis. Coptidis rhizoma inhibited sebum production, and Glycyrrhiza glabra showed anti-bacterial activity against P. acnes. A combined formulation of Angelica daurica. Coptidisr hizoma and Glycyrrhiza glabra is expected to provide effective acne treatment.ent.ive acne treatment.

• 한국인구학
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• 제29권3호
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• pp.139-157
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• 2006

본 연구는 우리나라에 도래한 고령화 사회에서 나타나는 노부모 가족부양의 한계 및 노부모 부양에 대한 기혼자녀세대의 인식과 국가정책에의 기대를 파악한다. 자료는 기혼자녀 30대와 40대 응답자들을 나이, 성별, 부모동거 경험여부에 따라 각 5-6명씩 구성된 총 8개 집단의 초점집단토론(FGD:Focus Group Discussions)을 통해 수집되었다. 연구결과 노부모부양의 우선적인 책임은 가족에 있다는 인식이 지배적이지만 노부모 가족부양의 부담감이나 부모와 동거시의 애로사항도 제시된다. 특히 부모가 더 연로해지거나 건강이 나빠질 경우에 예상되는 동거부양에 대한 부담감이 크게 나타났다. 우리사회에서 노부모는 가족이 부양해야 한다는 의식이 여전히 높게 나타나고 있지만 고령화에 따른 노인부양과 복지문제의 심각성을 고려하면 가족이 부모부양을 전담하는 것은 점차 어려워질 것으로 예상된다. 따라서 노인부양에 대해 국가 및 지역 사회의 책임 비중 및 기대 또한 증대됨을 전망할 수 있다.