Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)
- 1999.10a
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- Pages.111-121
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- 1999
STUDIES OF ACNE TREATMENT USING ORIENTAL HERBS (New Approach to select anti-acne agents)
- Chunja Nam (Skin&Applied Research Institute, Pacific R&D Center) ;
- Y.G. Han (Skin & Applied Research Institute, Pacific R&D Center) ;
- Kim, S.J. (Skin&Applied Research Institute, Pacific R&D Center) ;
- Kim, J.H. (Skin&Applied Research Institute, Pacific R&D Center) ;
- Oh, J.Y. (Skin&Applied Research Institute, Pacific R&D Center)
- Published : 1999.10.01
Abstract
Acne vulgaris, the most common skin disease. can be formed as only a few comedons or severe inflammatory lesions. The pathogenesis of acne involves various factors; excessive androgen, excessive sebum production, abnormal alteration of follicular epithelium, proliferation of Propionibacterium acnes, and inflammation. We investigated acne therapy using oriental herbs described in the Korean traditional medical book (Dong-ui-bo-gam). Oriental herbs (Angleica daurica. Arctium lappa. Coptidis rhizoma, and glycyrrhiza glabra) were chosen based on their respective property of sebum control, anti-inflammatory activity, and anti-bacterial activity. We examined the effect of acne treatment, in terms of chemotactic inhibition, lipogenesis inhibition, and anti-bacterial activity for P. acnes. 1. Neutrophil chemotaxis assay ; P acnes secrete chemotactic factors and other pro-inflammatory extracellular products. Neutrophil chemotactic activity of P. acnes was measured by 48-well chemotaxis method. Angelica daurica clearly suppressed chemotactic activity of P. acens. 2. Using sebaceous gland of hamster ear lipogenesis assay; Sebaceous lipogenesis was measured using ear biopsies by incubation of